WO2004056336A3 - Controlled release, multiple unit drug delivery systems - Google Patents

Controlled release, multiple unit drug delivery systems Download PDF

Info

Publication number
WO2004056336A3
WO2004056336A3 PCT/IB2003/006101 IB0306101W WO2004056336A3 WO 2004056336 A3 WO2004056336 A3 WO 2004056336A3 IB 0306101 W IB0306101 W IB 0306101W WO 2004056336 A3 WO2004056336 A3 WO 2004056336A3
Authority
WO
WIPO (PCT)
Prior art keywords
coating layer
carvedilol
multiple unit
controlled release
core
Prior art date
Application number
PCT/IB2003/006101
Other languages
French (fr)
Other versions
WO2004056336A2 (en
Inventor
Girish Kumar Jain
Seetharaman Sritharan
Ashok Rampal
Original Assignee
Ranbaxy Lab Ltd
Girish Kumar Jain
Seetharaman Sritharan
Ashok Rampal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Girish Kumar Jain, Seetharaman Sritharan, Ashok Rampal filed Critical Ranbaxy Lab Ltd
Priority to AU2003288608A priority Critical patent/AU2003288608A1/en
Publication of WO2004056336A2 publication Critical patent/WO2004056336A2/en
Publication of WO2004056336A3 publication Critical patent/WO2004056336A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to controlled release multiple unit system of carvedilol for oral administration, and methods of preparing the system, which can be easily compressed into tablets or filled into capsules or sachets without affecting the desired release characteristics of the pharmaceutical active ingredient incorporated within the system. The multiple unit system includes multiple units. Each unit includes at least one core and having an outer surface; a first coating layer surrounding at least a portion of the outer surface of the core and having an outer surface, the coating layer including carvedilol; a second rate controlling coating layer surrounding at least a portion of the outer surface of the first coating layer and having an outer surface, the coating layer including one or more sustained release polymers and one or more enteric polymers. The multiple unit system may optionally contain a seal coat between inert core and carvedilol layer, or between carvedilol layer and rate controlling polymer layer. The units are finally compressed into tablet or filled into capsule/sachet.
PCT/IB2003/006101 2002-12-20 2003-12-19 Controlled release, multiple unit drug delivery systems WO2004056336A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003288608A AU2003288608A1 (en) 2002-12-20 2003-12-19 Controlled release, multiple unit drug delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1293DE2002 2002-12-20
IN1293/DEL/2002 2002-12-20

Publications (2)

Publication Number Publication Date
WO2004056336A2 WO2004056336A2 (en) 2004-07-08
WO2004056336A3 true WO2004056336A3 (en) 2004-09-10

Family

ID=32676756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/006101 WO2004056336A2 (en) 2002-12-20 2003-12-19 Controlled release, multiple unit drug delivery systems

Country Status (2)

Country Link
AU (1) AU2003288608A1 (en)
WO (1) WO2004056336A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105997893A (en) * 2016-07-01 2016-10-12 张学怀 High-density pellet core and preparation method thereof

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002472A1 (en) 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Carvedilol hydrobromide
CN101898995B (en) 2002-06-27 2013-05-01 史密斯克莱·比奇曼（科克）有限公司 Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
JP2007512372A (en) 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド Carvedilol salts, corresponding compositions, delivery and / or treatment methods
WO2007010501A2 (en) * 2005-07-22 2007-01-25 Ranbaxy Laboratories Limited A pharmaceutical composition comprising a combination of beta blocker and an ace inhibitor
HU227490B1 (en) * 2005-08-26 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Sustained release pharmaceutical preparation containing carvedilol
WO2008070072A2 (en) * 2006-12-01 2008-06-12 Mutual Pharmaceutical Company, Inc. Carvedilol forms, compositions, and methods of preparation thereof
ITMI20070022A1 (en) 2007-01-09 2008-07-10 I P S Internat Products & Services Srl FORMULATION OF SOLID-RELEASED CONTROLLED PRODUCTS FOR ORAL USE IN SINGLE-DOSE BAGS AND RELATED PREPARATION PROCEDURE
HU227881B1 (en) * 2007-02-23 2012-05-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Sustained release pharmaceutical preparation containing carvedilol
WO2009006299A2 (en) * 2007-06-29 2009-01-08 Dr. Reddy's Laboratories Ltd. Multi-particulate systems
WO2009047800A2 (en) * 2007-10-09 2009-04-16 Lupin Limited Oral controlled release composition of carvedilol
WO2010089760A2 (en) * 2008-05-29 2010-08-12 Alkem Laboratories Ltd. Controlled release, multiple unit pharmaceutical compositions
WO2012004231A1 (en) * 2010-07-05 2012-01-12 Jagotec Ag Dosage form
EP2663294B1 (en) 2011-01-11 2015-09-30 Capsugel Belgium NV New hard capsules comprising pullulan
KR20150060882A (en) 2012-09-24 2015-06-03 아지노모토 가부시키가이샤 Liquid cleanser comprising sterol ester
KR102241487B1 (en) * 2013-02-20 2021-04-16 주식회사 종근당 Pharmaceutical composition consisting of sustained-release pellets
BR112016017244A2 (en) * 2014-01-30 2017-08-08 Omniactive Health Tech Limited COMPOSITIONS OF OILY, PUNGENT AND ODORIFYING SUBSTANCES AND THE PROCESS OF PREPARING THEM
GB201607548D0 (en) * 2016-04-29 2016-06-15 Univ Central Lancashire Solid dosage form
CN106619531A (en) * 2016-10-02 2017-05-10 上海奥科达生物医药科技有限公司 Preparation method of stable oral slow-release suspension
CN110678555B (en) 2017-04-14 2023-10-13 比利时胶囊公司 Method for preparing pullulan
JP2020516653A (en) 2017-04-14 2020-06-11 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ Pullulan capsule

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024017A1 (en) * 1997-11-12 1999-05-20 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Bechman Corporation Limited Partnership No.1 Novel oral dosage form for carvedilol
US6056968A (en) * 1997-03-11 2000-05-02 Darwin Discovery Limited Pharmaceutical drug dosage forms providing different release rates
US6284271B1 (en) * 1997-07-01 2001-09-04 Astrazeneca Ab Multiple unit effervescent dosage form
US6365184B1 (en) * 1996-01-08 2002-04-02 Astrazeneca Ab Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID
WO2003028649A2 (en) * 2001-10-02 2003-04-10 Smithkline Beecham Corporation Novel composition of carvedilol
WO2003103637A2 (en) * 2002-01-10 2003-12-18 Ranbaxy Laboratories Limited Modified release, multiple unit drug delivery systems

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365184B1 (en) * 1996-01-08 2002-04-02 Astrazeneca Ab Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID
US6056968A (en) * 1997-03-11 2000-05-02 Darwin Discovery Limited Pharmaceutical drug dosage forms providing different release rates
US6284271B1 (en) * 1997-07-01 2001-09-04 Astrazeneca Ab Multiple unit effervescent dosage form
WO1999024017A1 (en) * 1997-11-12 1999-05-20 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Bechman Corporation Limited Partnership No.1 Novel oral dosage form for carvedilol
WO2003028649A2 (en) * 2001-10-02 2003-04-10 Smithkline Beecham Corporation Novel composition of carvedilol
WO2003103637A2 (en) * 2002-01-10 2003-12-18 Ranbaxy Laboratories Limited Modified release, multiple unit drug delivery systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105997893A (en) * 2016-07-01 2016-10-12 张学怀 High-density pellet core and preparation method thereof

Also Published As

Publication number Publication date
WO2004056336A2 (en) 2004-07-08
AU2003288608A1 (en) 2004-07-14
AU2003288608A8 (en) 2004-07-14

Similar Documents

Publication Publication Date Title
WO2004056336A3 (en) Controlled release, multiple unit drug delivery systems
WO2003103637A3 (en) Modified release, multiple unit drug delivery systems
WO2004112756A8 (en) Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
CA2408956C (en) Method and form of a drug delivery device,such as encapsulating a toxic core within a non-toxic region in an oral dosage form
EP1043977B1 (en) Oral pharmaceutical pulsed release dosage form
EP2836207B1 (en) Composite formulation comprising multi-unit spheroidal tablet (must) encapsulated in hard capsule and method for preparing same
US20120100221A1 (en) Pharmaceutical compositions containing a combination of an antihistamine and a decongestant
MXPA03012041A (en) Gastric retention controlled drug delivery system.
WO2011077451A3 (en) Controlled release pharmaceutical composition
WO2008132712A3 (en) Combination pharmaceutical compositions
CA2375714A1 (en) Delayed total release two pulse gastrointestinal drug delivery system
EP2279729A3 (en) Controlled release preparations
CA2566278A1 (en) Formulations with controlled release of active ingredient
CA2348090A1 (en) Oral pulsed dose drug delivery system
CA2305762A1 (en) Delayed total release gastrointestinal drug delivery system
CN107708677B (en) Pharmaceutical or health-care product composition resistant to influence of ethanol
WO2006040779A3 (en) Controlled release gastric floating matrix formulation containing imatinib
KR20150132399A (en) Pharmaceutical compositions comprising everolimus
WO2008117814A1 (en) Oral pharmaceutical preparation for colon-specific delivery
WO2010020856A3 (en) Rate modulated delivery of drugs from a composite delivery system
WO2008140461A1 (en) Solid form
EP2474307A3 (en) Proliposomal drug delivery system
WO2007086079A3 (en) Sustained release dosage form of phenothiazine derivatives containing channelizer
WO2005051350A3 (en) Water dispersible tablet
CA2611938A1 (en) Modified release ticlopidine compositions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP