CN1283656C - 用作ICE/ced－3家族半胱氨酸蛋白酶抑制剂的C－端修饰的草氨酰二肽 - Google Patents

用作ICE/ced－3家族半胱氨酸蛋白酶抑制剂的C－端修饰的草氨酰二肽 Download PDF

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Publication number
CN1283656C
CN1283656C CNB028052781A CN02805278A CN1283656C CN 1283656 C CN1283656 C CN 1283656C CN B028052781 A CNB028052781 A CN B028052781A CN 02805278 A CN02805278 A CN 02805278A CN 1283656 C CN1283656 C CN 1283656C
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phenyl
substituted
naphthyl
cycloalkyl
alkyl
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Expired - Fee Related
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CN1525978A (zh
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D·S·卡拉纽斯克
R·J·特南斯克
S·D·林顿
T·迪恩
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Idum Pharmaceuticals Inc
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Idum Pharmaceuticals Inc
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
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CNB028052781A 2001-01-16 2002-01-16 用作ICE/ced－3家族半胱氨酸蛋白酶抑制剂的C－端修饰的草氨酰二肽 Expired - Fee Related CN1283656C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/765,105 2001-01-16
US09/765,105 US7053056B2 (en) 1998-07-02 2001-01-16 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

Publications (2)

Publication Number Publication Date
CN1525978A CN1525978A (zh) 2004-09-01
CN1283656C true CN1283656C (zh) 2006-11-08

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CNB028052781A Expired - Fee Related CN1283656C (zh) 2001-01-16 2002-01-16 用作ICE/ced－3家族半胱氨酸蛋白酶抑制剂的C－端修饰的草氨酰二肽

Country Status (6)

Country Link
US (2) US7053056B2 (https=)
EP (1) EP1351975A2 (https=)
JP (1) JP2004521107A (https=)
CN (1) CN1283656C (https=)
CA (1) CA2433879A1 (https=)
WO (1) WO2002057298A2 (https=)

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KR101125932B1 (ko) * 2006-12-06 2012-03-22 아이디유엔 파마슈티칼즈, 인코포레이티드 (3ｓ)-3-［ｎ-(ｎ'-(2-ｔｅｒｔ-부틸페닐)옥사밀)알라니닐］아미노-5-(2',3',5',6'-테트라플루오로페녹시)-4-옥소펜탄산의 결정 형태
CA2737774A1 (en) 2008-09-19 2010-03-25 Henry Ford Health System Methods, systems, and compositions for calpain inhibition
WO2012021800A2 (en) * 2010-08-13 2012-02-16 Banyan Biomarkers Caspase inhibitors as therapeutics for neural and organ injury and imaging
US9539050B2 (en) * 2011-04-12 2017-01-10 Covidien Lp System and method for process monitoring and intelligent shut-off
ES2751652T3 (es) 2014-05-12 2020-04-01 Conatus Pharmaceuticals Inc Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas
MX378266B (es) 2014-10-06 2025-03-10 Lighthouse Pharmaceuticals Inc Inhibidores de gingipaina de lisina.
EP3265440A1 (en) 2015-03-06 2018-01-10 Concert Pharmaceuticals Inc. Deuterated emricasan
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

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US20050020504A1 (en) 2005-01-27
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