CN1282472C - Anthemonhagic medicament for quick blood coagulation and diminish inflammation - Google Patents
Anthemonhagic medicament for quick blood coagulation and diminish inflammation Download PDFInfo
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- CN1282472C CN1282472C CN 200410077578 CN200410077578A CN1282472C CN 1282472 C CN1282472 C CN 1282472C CN 200410077578 CN200410077578 CN 200410077578 CN 200410077578 A CN200410077578 A CN 200410077578A CN 1282472 C CN1282472 C CN 1282472C
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- CN
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- Prior art keywords
- medicament
- chitosan
- chlorhexidine
- blood coagulation
- anthemonhagic
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- 206010061218 Inflammation Diseases 0.000 title claims abstract description 21
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 230000023555 blood coagulation Effects 0.000 title claims abstract description 13
- 229920001661 Chitosan Polymers 0.000 claims abstract description 18
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 12
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 12
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 12
- 230000002439 hemostatic effect Effects 0.000 claims abstract description 12
- 230000023597 hemostasis Effects 0.000 claims abstract description 11
- 229920002635 polyurethane Polymers 0.000 claims abstract description 10
- 239000004814 polyurethane Substances 0.000 claims abstract description 10
- 241000411851 herbal medicine Species 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229940030225 antihemorrhagics Drugs 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 4
- 239000002874 hemostatic agent Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000002137 ultrasound extraction Methods 0.000 claims description 3
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 2
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 claims description 2
- 239000000469 ethanolic extract Substances 0.000 claims description 2
- 238000005325 percolation Methods 0.000 claims description 2
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical group CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 2
- 238000007560 sedimentation technique Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 10
- 208000027418 Wounds and injury Diseases 0.000 abstract description 10
- 208000032843 Hemorrhage Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 abstract description 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 2
- 230000002147 killing effect Effects 0.000 abstract description 2
- 235000017595 Callicarpa japonica Nutrition 0.000 abstract 2
- 240000003690 Callicarpa japonica Species 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 206010039203 Road traffic accident Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000001784 detoxification Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000000025 haemostatic effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a hemostatic medicament for quick blood coagulation and inflammation alleviation, which uses chlorhexidine, chitosan and the Chinese herbal medicines of beautyberries and notoginseng as main constituents and also comprises polyurethane substrates with strong adsorption capacity. The hemostatic medicament comprises 0.2 to 2 wt% of chlorhexidine, 3 to 25 wt% of chitosan, 15 to 35 wt% of notoginseng, 15 to 35 wt% of beautyberries and 15 to 25 wt% of polyurethane substrates. The hemostatic medicament can be made into hemostatic plasters for quick blood coagulation and inflammation alleviation, hematostatic gel, hematostatic sponges or hematostatic powder, has strong effects on inflammation alleviation, detoxification, quick hemostasis, pain alleviation, stasis removal and tissue regeneration, has strong suppressing and killing functions to staphylococcus aureus, salmonella typhi, pseudomonas aeruginosa, etc., and can be used for the hemorrhage of wounds, battlefields, traffic accidents and surgical operation wounds.
Description
(1) technical field
The present invention relates to the absorbable anti-inflammation hemostasia material that uses at tissue surface behind a kind of wound, the surgical operation, is a kind of Anthemonhagic medicament for quick blood coagulation and diminish inflammation specifically.
(2) background technology
Wound, battlefield, vehicle accident and surgical incision occur hemorrhage, hemostatic material plays an important role.Many to the research of hemostatic material in recent years, wherein selling on the market is at most " hemostasis is pasted ", and in numerous " hemostasis are pasted ", many contain the antiinflammatory composition and do not contain hemostatic compositions, so its haemostatic effect is relatively poor, can only be used for little wound; Some contains hemostatic compositions (as the Chinese herbal medicine hemostatic compositions) and does not contain the antiinflammatory composition, though haemostatic effect is arranged, can not prevent wound inflammation well.
(3) summary of the invention
The present invention is directed to the deficiency of hemostatic material in the market, and a kind of Anthemonhagic medicament for quick blood coagulation and diminish inflammation with powerful eliminating inflammation and expelling toxin, quick-acting haemostatic powder pain relieving, blood stasis dispelling granulation promoting effect is provided.
By a kind of Anthemonhagic medicament for quick blood coagulation and diminish inflammation of this purpose design, it is characterized in that its prescription is chlorhexidine, chitosan and Chinese herbal medicine Radix Notoginseng, Folium Callicarpae Formosanae, and polyurethane base material; The weight ratio of its composition is formed by following proportioning:
Chlorhexidine 0.2～2%
Chitosan 3～25%
Radix Notoginseng 15～35%
Folium Callicarpae Formosanae 15～35%
Polyurethane base material 15～25%
Chlorhexidine in the prescription is chlorhexidine acetate, Chlorhexidine hydrochloride or chlorhexidine gluconate; Chitosan is acetyl chitosan, carboxymethyl chitosan or other chitosan derivatives.
Chinese herbal medicine Radix Notoginseng, Folium Callicarpae Formosanae add in the hemostatic agent after extracting simmer down to extractum or fluid extract with ultrasonic extraction, conventional decoction and alcohol sedimentation technique, ethanol extract from water precipitation or percolation.
The present invention combines the antibacterial and anti-inflammation functions of chlorhexidine on Recipe, the potent quick-acting haemostatic powder effect of chitosan, cooperate Chinese herbal medicine Radix Notoginseng, the hemostasis and pain-relieving of Folium Callicarpae Formosanae, blood stasis dispelling promoting muscle growth functions, be aided with the polyurethane base material that contains strong absorbability, wound there is better biocompatibility, can form an enclosed environment in wound circumference, promote tissue to absorb healing.The hemostatic agent that the present invention makes has powerful eliminating inflammation and expelling toxin, quick-acting haemostatic powder pain relieving, blood stasis dispelling granulation promoting effect, staphylococcus aureus, Bacillus typhi, bacillus pyocyaneus etc. there are strong inhibitory or killing effect, can be used for the hemorrhage of wound, battlefield, vehicle accident and surgical incision.
(4) specific embodiment
Pasting with hemostasis is example, and its prescription (weight ratio) is as follows:
Chlorhexidine 0.5～2%
Chitosan 5～25%
Radix Notoginseng 20～35%
Folium Callicarpae Formosanae 20～35%
Polyurethane base material 18～25%
Method for making:
(1) Chinese herbal medicine Radix Notoginseng, Folium Callicarpae Formosanae are ground into coarse powder, add 65% soak with ethanol 2 hours, in the ultrasonic extraction machine, extracted 45 minutes for 60 ℃ with ultrasound wave, so extract secondary, merge extractive liquid,, concentrate and reclaim ethanol, the concentrated solution aqueous precipitation impurity such as removing by filter resin, natural gum that spends the night is condensed into fluid extract.
(2) under cleaning condition, chlorhexidine, chitosan are dissolved in the acetum, add polyurethane base material and (a 1) Chinese herbal medicine fluid extract that extracts, mix gel, evenly coat airing in the no gauze that has been cut into suitable shape, packing promptly gets the rapid hardening anti-inflammation hemostasia and pastes.
The use that the gel hemostasis is pasted is the same simple with common hemostasis subsides, has powerful anti-inflammation hemostasia effect, makes the very fast healing of wound.Except that hemostasis was pasted, it also can be made into hemostasis gel, styptic sponge used, hemostatic gauze (binder) or styptic powder according to the practical application needs.
Claims (6)
1, a kind of Anthemonhagic medicament for quick blood coagulation and diminish inflammation is characterized in that its prescription is chlorhexidine, chitosan and Chinese herbal medicine Radix Notoginseng, Folium Callicarpae Formosanae, and polyurethane base material; The weight ratio of each composition is formed by following proportioning:
Chlorhexidine 0.2～2%
Chitosan 3～25%
Radix Notoginseng 15～35%
Folium Callicarpae Formosanae 15～35%
Polyurethane base material 15～25%.
2, Anthemonhagic medicament for quick blood coagulation and diminish inflammation according to claim 1 is characterized in that the weight ratio of its composition is formed by following proportioning:
Chlorhexidine 0.5～2%
Chitosan 5～25%
Radix Notoginseng 20～35%
Folium Callicarpae Formosanae 20～35%
Polyurethane base material 18～25%.
3, Anthemonhagic medicament for quick blood coagulation and diminish inflammation according to claim 1 is characterized in that used chlorhexidine is chlorhexidine acetate, Chlorhexidine hydrochloride or chlorhexidine gluconate.
4, Anthemonhagic medicament for quick blood coagulation and diminish inflammation according to claim 1 is characterized in that used chitosan is acetyl chitosan, carboxymethyl chitosan or other chitosan derivatives.
5, Anthemonhagic medicament for quick blood coagulation and diminish inflammation according to claim 1 is characterized in that used Chinese herbal medicine Radix Notoginseng, Folium Callicarpae Formosanae add in the hemostatic agent after extracting simmer down to extractum or fluid extract with ultrasonic extraction, conventional decoction and alcohol sedimentation technique, ethanol extract from water precipitation or percolation.
6, Anthemonhagic medicament for quick blood coagulation and diminish inflammation according to claim 1 is characterized in that making hemostasis subsides, hemostasis gel, styptic sponge used, hemostatic gauze/binder or styptic powder according to the practical application needs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410077578 CN1282472C (en) | 2004-12-15 | 2004-12-15 | Anthemonhagic medicament for quick blood coagulation and diminish inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410077578 CN1282472C (en) | 2004-12-15 | 2004-12-15 | Anthemonhagic medicament for quick blood coagulation and diminish inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1660254A CN1660254A (en) | 2005-08-31 |
| CN1282472C true CN1282472C (en) | 2006-11-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410077578 Active CN1282472C (en) | 2004-12-15 | 2004-12-15 | Anthemonhagic medicament for quick blood coagulation and diminish inflammation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1282472C (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358555C (en) * | 2005-09-08 | 2008-01-02 | 广州中一药业有限公司 | Chinese medicine for treating internal hemorrhage and its prepn process |
| CN103405801B (en) * | 2012-07-12 | 2015-06-24 | 葛礼双 | Preparation method of polyurethane bandage with functions of promoting blood circulation and removing blood stasis and bandage prepared by method |
| CN103405802B (en) * | 2012-07-12 | 2015-02-18 | 绍兴立德生物科技有限公司 | Preparation method of polyurethane bandage with functions of sterilization and itch relief and bandage manufactured by method |
| CN102793732A (en) * | 2012-08-07 | 2012-11-28 | 大连雄伟医用卫生品有限公司 | Medical biological hemostatic gel and preparation method thereof |
| CN103099899B (en) * | 2012-12-10 | 2014-09-03 | 宋爱民 | Traditional Chinese medicine preparation externally used for treating traumatic synovitis of knee joint |
| CN103550820A (en) * | 2013-10-12 | 2014-02-05 | 安徽金马药业有限公司 | Wound plaster |
| CN104147646A (en) * | 2014-08-19 | 2014-11-19 | 张秀华 | Compound Callicarpa macrophylla Vahl sponge for surgical hemostasis, and preparation method thereof |
| CN104174063A (en) * | 2014-08-19 | 2014-12-03 | 张秀华 | Callicarpae sponge for stopping bleeding of internal hemorrhoid surgery and preparation method of callicarpae sponge |
| CN105435301A (en) * | 2015-12-28 | 2016-03-30 | 王书美 | Medical dressing used for stopping bleeding of traumas and preparation method |
| CN105497961A (en) * | 2015-12-28 | 2016-04-20 | 王书美 | Medical film having skin wound repair promoting function and preparation method |
| CN105435294A (en) * | 2015-12-28 | 2016-03-30 | 王书美 | Bandage for diminishing inflammation and stopping bleeding of injury and preparation method thereof |
| CN108478848A (en) * | 2018-04-17 | 2018-09-04 | 代清燕 | A kind of antibiotic property medical hemostatic degreasing cotton gauze and preparation method thereof |
-
2004
- 2004-12-15 CN CN 200410077578 patent/CN1282472C/en active Active
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| Publication number | Publication date |
|---|---|
| CN1660254A (en) | 2005-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: ShunFeng Pharmaceutical Co., Ltd. Assignor: Liu Xianying|Lin Wenhong Contract fulfillment period: 2007.7.5 to 2017.7.4 contract change Contract record no.: 2008440000283 Denomination of invention: Anthemonhagic medicament for quick blood coagulation and diminish inflammation Granted publication date: 20061101 License type: Exclusive license Record date: 20081024 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.7.5 TO 2017.7.4; CHANGE OF CONTRACT Name of requester: GUANGDONG SHUNFENG PHARMACEUTICAL CO., LTD. Effective date: 20081024 |
|
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: LIN WENHONG Effective date: 20130130 Owner name: GUANGDONG SHUNFENG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: LIU XIANYING Effective date: 20130130 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130130 Address after: Shunde street Daliang District Guangdong city Foshan province 528300 mouth kumquat Patentee after: GUANGDONG CHINA RESOURCES SHUNFENG PHARMACEUTICAL CO., LTD. Address before: 528300 Guangdong Province, Foshan city Shunde District Daliang Jingui garden of Yang Lin Street No. 816 Patentee before: Liu Xianying Patentee before: Lin Wenhong |