CN1246021C - Non-scar plaster for treating trauma and its preparing process and usage - Google Patents
Non-scar plaster for treating trauma and its preparing process and usage Download PDFInfo
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- CN1246021C CN1246021C CN 02115250 CN02115250A CN1246021C CN 1246021 C CN1246021 C CN 1246021C CN 02115250 CN02115250 CN 02115250 CN 02115250 A CN02115250 A CN 02115250A CN 1246021 C CN1246021 C CN 1246021C
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- 239000011505 plaster Substances 0.000 title claims abstract description 22
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- 230000008733 trauma Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title description 5
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to non-scar plaster for treating trauma, a preparation method thereof and a use. The non-scar plaster is a medicament prepared from 50 to 80 wt% of water-soluble chitosan, 9 to 16 wt% of extract polysaccharide body and bletilla hyacinthina gum of effective components of Chinese herbal medicine bletilla striata, 6 to 16 wt% of extract saponin of effective components of Chinese herbal medicine notoginseng root, 2 to 10 wt% of extract emodin, catechin and chrysophanic acid of effective components of Chinese herbal medicine rhubarb and 2 to 8 wt% of extract dracorubin of effective components of Chinese herbal medicine dragon blood, wherein the water-soluble chitosan is prepared from chitosan crude products by biochemical treatment, separation and purification treatment; the effective components of Chinese herbal medicine are extracted by the steps of water extraction, alcohol precipitation, separation, filtration, concentration, drying, etc. The present invention provides non-scar plaster for treating trauma. The non-scar plaster has good physiological activity and skin regenerative function, is capable of strengthening wound healing capability, has no rejection to a human body and is easily absorbed by the skin so that the fine skin is rapidly generated and is not scared after healing. The non-scar plaster can be used as treatment medicine for multiple trauma.
Description
Technical field
The present invention relates to Chinese medicine, particularly relate to a kind of traumatism treatments such as burn, scald, wound that are mainly used in, can stop blooding, pain relieving, plaster that the treatment wound of no cicatrix is used behind the wound healing and its production and use.
Background technology
In life, people often can see various traumatic patients, and common wound comprises burn, scald, wound etc., and various wounds are not only brought the pain of injury on the health to the patient, and also can stay the defective that cicatrix etc. can't remedy after healing.Though modern medicine has complete theory and abundant clinical practice aspect the wound in treatment, as repairing some injury by methods such as skin-grafting, not only perform the operation complexity and costing an arm and a leg of this class surgical operation.China's Chinese medicine also has systematic research and practice to traumatism treatment, and there is a large amount of Chinese medicinal formulaes to can be used for the treatment of wound, and has curative effect preferably, Chinese medicine YUNNAN BAIYAO as well known and present widely used adhesive bandage etc., though these medicines have obvious curative effects, but its limitation also is conspicuous, wherein adhesive bandage is a kind of narrower strip patch, its two ends are adhesive portion, a fritter is provided with the hemostasis and anti-inflammation medicine in the middle of only having, during use it is pasted on wound site, is used for hemostasis and anti-inflammatory analgetic.This adhesive bandage is powerless for larger area wound and burn, scald.And for large-area burn, scald, though there are many medicines can make its healing, but wound healing is slow, cycle is long, particularly can stay tangible cicatrix behind the wound healing, this mainly be since this class medicine lack the physiologically active that promotes cell activation mostly, to the affinity of human body cell relatively poor due to.Still do not have at present and relevant can either be applicable to the large tracts of land wound, and wound healing is rapid, the report of the plaster medicine of preventing from scar again after the healing.
Summary of the invention
The present invention is intended to fast effectively treatment large tracts of land wound, and provide a kind of have good physiologically active and skin regeneration function, can strengthen the wound healing ability, human body there is not rejection, be easy to be skin absorbs, and generate careful skin rapidly and plaster that the treatment wound of leaving no scar after healing is used; The present invention also aims to provide the preparation method of this plaster and the application of conduct treatment wound medicine thereof.
Solution of the present invention is based on the research of chitin and China's traditional medicine understanding and the Therapeutic Principle to wound rehabilitation mechanism such as burn, scald, wounds.The chitin aboundresources, a multitude of names, as chitosan, the carapace king, chitosan etc., its character is highly stable, and water insoluble and diluted alkaline and other solvents are so application facet is restricted.After chitin carried out biochemical treatment-deacetylation again, then obtain to be dissolved in the chitosan (Chitin-Chitosan) of diluted acid.Its solubility then refers to be dissolved in diluted acid (as acetic acid, citric acid, lactic acid, malic acid etc.), and difficulty is directly water-soluble, be applied in the health food aspect, though can be acted on by the gastric acid of human body and gastric enzyme, but be subjected to the influence of infiltration rate after all, the physiological action that it took place is inevitable different, and is also very restricted aspect health food.For the chitosan that is applied in surgery, must possess following condition: 1, degree of deacetylation is more than 95%, low-molecular-weight; 2, chitosan is limpid transparent colloidal solution behind water dissolution; 3, its colloid solution energy film forming, its film just has physiologically active widely.
The plaster that treatment wound of the present invention is used is to press the medicament that column weight amount percentage ratio is made by the active ingredient extract of water-soluble chitosan and the Chinese herbal medicine Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Et Rhizoma Rhei, Sanguis Draxonis:
Water-soluble chitosan 50～80
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract polysaccharide body and Pseudobulbus Bletillae (Rhizoma Bletillae) glue 9～16
Radix Notoginseng active ingredient extract Saponin 6～16
Radix Et Rhizoma Rhei active ingredient extract emodin, catechin and chrysophanol 2～10
Sanguis Draxonis active ingredient extract dracorubin 2～8.
The optimum weight percentage ratio of medicine of the present invention is:
Water-soluble chitosan 65
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract polysaccharide body and Pseudobulbus Bletillae (Rhizoma Bletillae) glue 12
Radix Notoginseng active ingredient extract Saponin 13
Radix Et Rhizoma Rhei active ingredient extract emodin, catechin and chrysophanol 5
Sanguis Draxonis active ingredient extract dracorubin 5.
Wherein, water-soluble chitosan as Main Ingredients and Appearance of the present invention is to make by following method: behind the further deacetylation of the thick chitosan of 80-85%, be dissolved in the acetic acid that is equivalent to the 3-6% that raw material weight 8-10% doubly measures, slowly add 10% alkali liquor to mucus occurring; be cooled to 5-25 ℃; quiet the reuse diluted acid was neutralized to pH value 8-9 to hydrolysis 4 hours, and produced floccule; constantly stir; no longer produce to floccule, filter, can get the water-soluble chitosan elaboration after removing sodium chloride.
Purified water-soluble chitosan has following characteristic:
One, no matter in injured body and external, can induce special cells, promote wound repair, can strengthen the healing ability of wound especially, therefore can healing acceleration for the wound of burn, scald, wound, this is because chitosan is to constitute human body important substance---hyaluronic ultimate unit, can not produce the reaction that human body is repelled;
Two, chitosan has the sterilization and the effect of antiinflammatory, and pair cell has good affinity, can be absorbed by human body skin and ulcer does not take place, so can make skin wound healing good;
Three, chitosan has the effect that promotes cell activation, thereby produces collagen fiber in a large number, and forms careful skin rapidly, so can not stay the cicatrix of wound healing.
Four, the polysaccharide effect that has haemostatic effect and alleviate wound pain can prevent the hemorrhage and oozing of blood of wound affected part, and can not have side effects with the Chinese herbal medicine compatibility of hemostasia and promoting granulation.
The present invention has also selected multiple Chinese herbal medicine with compound multi-term of hemostasis, pain relieving, granulation promoting, and extracts its biological active ingredient, quickens effective therapeutic effect to cooperate chitosan, and the active ingredient extract and the function thereof of its Chinese medicine component are:
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract is polysaccharide body and Pseudobulbus Bletillae (Rhizoma Bletillae) glue, and it has very strong haemostatic effect, and it is hemorrhage to cure mainly incised wound, and it is hemorrhage that lung is hindered, and scalds fiery calcination, the ulcer pain, and the effect of short granulation promoting is arranged.
Radix Notoginseng active ingredient extract is a Saponin, and it has stronger haemostatic effect, and invigorate blood circulation, detumescence, heat clearing away, analgesic effect.
Radix Et Rhizoma Rhei active ingredient extract is emodin, catechin and chrysophanol, and the Radix Et Rhizoma Rhei compatibility has the effect that promotes blood coagulation, because it helps the formation of thrombosis, so the hemostatic of quickening effect is arranged.
Sanguis Draxonis active ingredient extract is a dracorubin, and it can be invigorated blood circulation and can stop blooding, but is used for rapid hemostasis in clinical practice.Recover normal clotting mechanism because of it can improve the lesion blood circulation, and increase local blood capacity power, quicken the epithelial tissue growth, impel wound to heal rapidly.
The active ingredient of above-mentioned medium-height grass is extracted as follows:
(1), the Pseudobulbus Bletillae (Rhizoma Bletillae): with about 2 hours of an amount of Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction under 90-100 ℃ temperature, concentrate the back and add ethanol and left standstill 4-8 hour, filtrate filtered adds ethanol again and leaves standstill about 6 hours after-filtration, and filtrate filtered concentrates, is dried to powder behind water dissolution;
(2), Radix Notoginseng: with an amount of Radix Notoginseng under 50-60 ℃ temperature about 2 hours with ethanol extraction, ethanol (or remaking water extraction) is reclaimed in filtrate filtered fractional distillation under 70 ℃ of left and right sides temperature, separator adds water and leaves standstill about 6 hours after-filtration, and filtrate concentrates, is dried to powder;
(3), Radix Et Rhizoma Rhei, Sanguis Draxonis: with an amount of Radix Et Rhizoma Rhei or Sanguis Draxonis about 2 hours of water extraction in 100 ℃ of temperature, be cooled to room temperature and filter, filtrate is retained, and with filtering residue about 2 hours of water extraction again in 100 ℃ of temperature, filter the back and merge twice filtrate, and concentrate, be dried to powder.
Plaster of the present invention then is that the powder of water-soluble chitosan powder with the active ingredient extract of plurality of Chinese mixed with known method, and makes the paster that varies in size, and can adopt corresponding paster to stick in the affected part according to the size of wound face.
This plaster has purposes widely, and it can be used as the medicine of treatment burn, scald, wound.
The animal test results of this plaster is as follows:
A, respectively in the deep hemostasia and promoting granulations test of two rabbit shanks, wherein one another is tested with spray with the patch test, its otch all can hemostasis immediately in the several seconds, three days internal energy impels the wound granulation promoting that heals rapidly, all healings in the week.
B, with two doggies after the shank unhairing, scald with boiled water and to carry out Wound treating and observe, the application plaster did not have inflammation and infects after one week around the wound surface.In the first quarter moon, open the patch observation and do not find that there be downright bad the infection in epidermal tissue.After 20 days, epidermal tissue is granulation promoting and ruddy smooth.In the time of 37 days, the patch medicine comes off, and wound surface does not have cicatrix.
Contribution of the present invention is, it organically combines the active ingredient of water-soluble chitosan and plurality of Chinese, good physiologically active that existing water-soluble chitosan had and skin regeneration function, can strengthen the wound healing ability, human body there is not rejection, be easy to be skin absorbs, and generate careful skin rapidly and characteristics such as leaving no scar after healing, effects such as hemostasis that plurality of Chinese has, pain relieving, granulation promoting are arranged again, thereby can be widely used in wounds such as burn, scald, wound, energy hemostasis, pain relieving are healed and preventing from scar wound rapidly.It is low, safe in utilization easy that plaster of the present invention also has a production cost, and characteristics such as have no side effect.
The specific embodiment
The following example is to further explanation of the present invention and explanation, and the present invention is not constituted any limitation.
One: getting the thick chitosan of 1000 grams is raw material; behind its further deacetylation, be dissolved in 4% acetic acid of 900 grams, slowly add 10% alkali liquor to mucus occurring; be cooled to 15 ℃; quiet the reuse diluted acid was neutralized to pH value 8 to hydrolysis 4 hours, and produced floccule; constantly stir; no longer produce to floccule, filter, can get the water-soluble chitosan elaboration after removing sodium chloride.
Two: (1), get the Pseudobulbus Bletillae (Rhizoma Bletillae) 500 gram and be ground into granule, adding pure water 2000ml extracts, temperature is no more than 100 ℃, be concentrated into 500ml in 90 ℃ after 2 hours, the ethanol 300ml of adding 95% when being cooled to room temperature, the limit edged stirs, and leaves standstill 6 hours after-filtration, the filtration rear filtrate is a polysaccharose substance, helps biomembrane and forms.
The filtrate continuation that obtains is added ethanol 300ml, and the limit edged stirs, and leaves standstill 6 hours after-filtration, and filtrate filtered adds pure water 800ml, and temperature is controlled at and is concentrated into 400ml after drying composition in 100 ℃ is the water-soluble powder of Pseudobulbus Bletillae (Rhizoma Bletillae) glue.
(2), get Radix Notoginseng 500 grams and be ground into granule, place container to add 95 ethanol 1000ml, in 60 ℃ of extractings of temperature and remove tannin and the resinae material, but the dissolving of part arasaponin is also arranged wherein, so ethanol fine straining hydraulic control temperature reclaims ethanol 70 ℃ of fractional distillation, residue after the recovery adds water 500ml and fully stirs and leave standstill 6 hours after-filtration, and filtrate is concentrated into 300ml, is dried to the powder that composition is a Saponin.
(3), get Radix Et Rhizoma Rhei 500 grams, be ground into granule, place container to add pure water 1000ml, temperature control extracted 2 hours in 100 ℃, was chilled to room temperature and filtered, and filtrate is retained, filtering residue adds pure water 800ml again, temperature control extracted 2 hours in 100 ℃, and room temperature filters, and merges twice filtrate and is spray dried to the powder that Main Ingredients and Appearance is emodin, chrysophanol, catechin.
(4), the same Radix Et Rhizoma Rhei of the extracting method of Sanguis Draxonis.
Three, the water-soluble chitosan powder is mixed by following proportioning (weight %) with the effective components of Chinese medicinal extract:
Water-soluble chitosan 70
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract 11
Radix Notoginseng active ingredient extract 10
Radix Et Rhizoma Rhei active ingredient extract 5
Sanguis Draxonis active ingredient extract 4
Its mixture can be made into the paster that differs in size, and can stick in the trouble face according to the size of wound face.
Claims (5)
1, a kind ofly treat the plaster that wound is used, it is characterized in that, it is to press the medicament that column weight amount percentage ratio is made by the active ingredient extract of water-soluble chitosan and the Chinese herbal medicine Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Et Rhizoma Rhei, Sanguis Draxonis:
Water-soluble chitosan 50～80
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract polysaccharide body and Pseudobulbus Bletillae (Rhizoma Bletillae) glue 9～16
Radix Notoginseng active ingredient extract Saponin 6～16
Radix Et Rhizoma Rhei active ingredient extract emodin, catechin and chrysophanol 2～10
Sanguis Draxonis active ingredient extract dracorubin 2～8.
2, the plaster used of treatment wound according to claim 1 is characterized in that wherein the percentage by weight of the active ingredient extract of the water-soluble chitosan and the Chinese herbal medicine Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Et Rhizoma Rhei, Sanguis Draxonis is:
Water-soluble chitosan 65
Pseudobulbus Bletillae (Rhizoma Bletillae) active ingredient extract polysaccharide body and Pseudobulbus Bletillae (Rhizoma Bletillae) glue 12
Radix Notoginseng active ingredient extract Saponin 13
Radix Et Rhizoma Rhei active ingredient extract emodin, catechin and chrysophanol 5
Sanguis Draxonis active ingredient extract dracorubin 5.
3, the preparation method of the plaster used of treatment wound according to claim 1; it is characterized in that; water-soluble chitosan prepares as follows: behind the further deacetylation of the thick chitosan of 80-85%; be dissolved in the acetic acid that is equivalent to the 3-6% that raw material weight 8-10% doubly measures; slowly add 10% alkali liquor to mucus occurring; be cooled to 5-25 ℃; quiet to hydrolysis 4 hours; the reuse diluted acid is neutralized to pH value 8-9; and the generation floccule, constantly stir, no longer produce to floccule; filter, can get the water-soluble chitosan elaboration after removing sodium chloride.
4, the preparation method of the plaster used of treatment wound according to claim 1 is characterized in that, the Chinese herbal medicine active ingredient is extracted respectively as follows:
(1), the Pseudobulbus Bletillae (Rhizoma Bletillae): with about 2 hours of an amount of Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction under 90-100 ℃ temperature, concentrate the back and add ethanol and left standstill 4-8 hour, filtrate filtered adds ethanol again and leaves standstill about 6 hours after-filtration, and filtrate filtered concentrates, is dried to powder behind water dissolution;
(2), Radix Notoginseng: with an amount of Radix Notoginseng under 50-60 ℃ temperature with ethanol extraction about 2 hours, filtrate filtered fractional distillation under 70 ℃ of left and right sides temperature was reclaimed ethanol or is remake water extraction, and separator adds water and leaves standstill about 6 hours after-filtration, and filtrate concentrates, is dried to powder;
(3), Radix Et Rhizoma Rhei, Sanguis Draxonis: with an amount of Radix Et Rhizoma Rhei or Sanguis Draxonis about 2 hours of water extraction in 100 ℃ of temperature, be cooled to room temperature and filter, filtrate is retained, and with filtering residue about 2 hours of water extraction again in 100 ℃ of temperature, filter the back and merge twice filtrate, and concentrate, be dried to powder.
5, the application of the plaster used of a kind of treatment wound as claimed in claim 1 in the medicine of preparation treatment burn, scald, wound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02115250 CN1246021C (en) | 2002-05-15 | 2002-05-15 | Non-scar plaster for treating trauma and its preparing process and usage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02115250 CN1246021C (en) | 2002-05-15 | 2002-05-15 | Non-scar plaster for treating trauma and its preparing process and usage |
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| Publication Number | Publication Date |
|---|---|
| CN1382480A CN1382480A (en) | 2002-12-04 |
| CN1246021C true CN1246021C (en) | 2006-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 02115250 Expired - Fee Related CN1246021C (en) | 2002-05-15 | 2002-05-15 | Non-scar plaster for treating trauma and its preparing process and usage |
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| CN (1) | CN1246021C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389756C (en) * | 2005-01-14 | 2008-05-28 | 西北大学 | Powdery wound paste with instant soluble seal and production thereof |
| CN1895546B (en) * | 2006-06-08 | 2010-05-26 | 李高霖 | Lycium chinensis polyose medicinal composition with therapeutic and health-care functions |
| CN103356843A (en) * | 2012-03-28 | 2013-10-23 | 苏州瑞美科生物技术有限公司 | Chitosan oligosaccharide compound preparation and application thereof to preparation of drugs for treating skin ulcers |
| CN105726962A (en) * | 2016-02-29 | 2016-07-06 | 山东大学第二医院 | Traditional Chinese medicine composition for promoting wound healing and preparation method thereof |
| CN108434332A (en) * | 2018-05-23 | 2018-08-24 | 陈月爱 | Burn compound spray of anion chitosan and preparation method thereof |
| CN109793918B (en) * | 2018-12-29 | 2021-02-12 | 中国人民解放军总医院 | Plant composite dressing capable of promoting large-area wound hair follicle regeneration |
| CN109700747A (en) * | 2019-01-24 | 2019-05-03 | 广州元合生物科技有限公司 | A kind of skin care compositions and preparation method thereof with skin repair function |
| CN116808141A (en) * | 2023-06-21 | 2023-09-29 | 浙江医鼎医用敷料有限公司 | Wound care ointment and preparation method thereof |
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2002
- 2002-05-15 CN CN 02115250 patent/CN1246021C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1382480A (en) | 2002-12-04 |
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