CN1280424C - 制造d-丝氨酸的方法 - Google Patents
制造d-丝氨酸的方法 Download PDFInfo
- Publication number
- CN1280424C CN1280424C CNB018216250A CN01821625A CN1280424C CN 1280424 C CN1280424 C CN 1280424C CN B018216250 A CNB018216250 A CN B018216250A CN 01821625 A CN01821625 A CN 01821625A CN 1280424 C CN1280424 C CN 1280424C
- Authority
- CN
- China
- Prior art keywords
- serine
- intestinal bacteria
- cell
- microorganism
- deaminase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
菌株 | 质粒 | 反应时间(小时) | L-丝氨酸总分解量(g/l) | D-丝氨酸浓度(g/l) | L-丝氨酸浓度(g/l) | 相对活性 |
DH5α | pTrS30 | 1221 | 1.4 | 23.2 | 21.5 | 1.0 |
DH5α | pHIB | 1221 | 19.8 | 24.9 | 0.0 | 14.1 |
NM522 | pHIA1 | 1121 | 21.6 | 23.7 | 0.0 | 16.8 |
ME5386 | pHIA2 | 12 | 23.5 | 25.6 | 0.0 | 16.8 |
MM294 | pHIA1 | 1022 | 20.3 | 17.4 | ||
pHIA2 | 1022 | 19.4 | 24.3 | 0.0 | 16.6 | |
pHIB | 1022 | 8.5 | 7.3 |
Claims (8)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000334751 | 2000-11-01 | ||
JP334751/00 | 2000-11-01 | ||
JP334751/2000 | 2000-11-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1531599A CN1531599A (zh) | 2004-09-22 |
CN1280424C true CN1280424C (zh) | 2006-10-18 |
Family
ID=18810608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018216250A Expired - Fee Related CN1280424C (zh) | 2000-11-01 | 2001-10-29 | 制造d-丝氨酸的方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US7186532B2 (zh) |
EP (1) | EP1331274B1 (zh) |
JP (1) | JP4308521B2 (zh) |
KR (1) | KR100815085B1 (zh) |
CN (1) | CN1280424C (zh) |
AT (1) | ATE518962T1 (zh) |
AU (1) | AU2002212690A1 (zh) |
WO (1) | WO2002036803A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2602319B1 (en) | 2004-10-13 | 2016-12-07 | Mitsui Chemicals, Inc. | DNA encoding novel enzyme having D-serine synthase activity, method of producing the enzyme and method of producing D-serine by using the same |
WO2007063866A1 (ja) | 2005-11-29 | 2007-06-07 | Kyowa Hakko Kogyo Co., Ltd. | 新規蛋白質および該蛋白質をコードするdna |
CN101168513B (zh) * | 2007-11-28 | 2012-06-27 | 上海化学试剂研究所 | Dl-丝氨酸的制备方法 |
DE102010025124A1 (de) | 2010-06-25 | 2011-12-29 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von D-Aminosäuren, Mikroorganismus, sowie Vektor |
CN117736959B (zh) * | 2024-01-26 | 2024-05-14 | 湖北大学 | 运动发酵单胞菌的工程菌株、制备方法及应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0591895A (ja) * | 1991-08-12 | 1993-04-16 | Mitsubishi Petrochem Co Ltd | D−セリンの製造法 |
US5728555A (en) | 1996-09-30 | 1998-03-17 | Monsanto Company | Preparation of d-amino acids by direct fermentative means |
-
2001
- 2001-10-29 AU AU2002212690A patent/AU2002212690A1/en not_active Abandoned
- 2001-10-29 US US10/415,107 patent/US7186532B2/en not_active Expired - Fee Related
- 2001-10-29 CN CNB018216250A patent/CN1280424C/zh not_active Expired - Fee Related
- 2001-10-29 JP JP2002539546A patent/JP4308521B2/ja not_active Expired - Fee Related
- 2001-10-29 WO PCT/JP2001/009482 patent/WO2002036803A1/ja active Application Filing
- 2001-10-29 KR KR1020037006087A patent/KR100815085B1/ko not_active IP Right Cessation
- 2001-10-29 EP EP01980931A patent/EP1331274B1/en not_active Expired - Lifetime
- 2001-10-29 AT AT01980931T patent/ATE518962T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100815085B1 (ko) | 2008-03-20 |
AU2002212690A1 (en) | 2002-05-15 |
JP4308521B2 (ja) | 2009-08-05 |
US7186532B2 (en) | 2007-03-06 |
US20040072308A1 (en) | 2004-04-15 |
EP1331274B1 (en) | 2011-08-03 |
ATE518962T1 (de) | 2011-08-15 |
EP1331274A4 (en) | 2005-08-10 |
KR20030066648A (ko) | 2003-08-09 |
WO2002036803A1 (fr) | 2002-05-10 |
EP1331274A1 (en) | 2003-07-30 |
CN1531599A (zh) | 2004-09-22 |
JPWO2002036803A1 (ja) | 2004-03-11 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: XIEHE FERMENTATION BIOCHEMICAL CO., LTD. Free format text: FORMER OWNER: KYOWA HAKKO KOGYO CO., LTD. Effective date: 20090619 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090619 Address after: Tokyo, Japan, Japan Patentee after: Kyowa Hakko Bio Co., Ltd. Address before: Tokyo, Japan, Japan Patentee before: Kyowa Hakko Kogyo Co., Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061018 Termination date: 20161029 |