CN1280266C - 酰基苯基脲衍生物,其制备方法和作为药物的用途 - Google Patents

酰基苯基脲衍生物,其制备方法和作为药物的用途 Download PDF

Info

Publication number
CN1280266C
CN1280266C CNB018108016A CN01810801A CN1280266C CN 1280266 C CN1280266 C CN 1280266C CN B018108016 A CNB018108016 A CN B018108016A CN 01810801 A CN01810801 A CN 01810801A CN 1280266 C CN1280266 C CN 1280266C
Authority
CN
China
Prior art keywords
alkyl
phenyl
compound
cooh
alkylidene group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018108016A
Other languages
English (en)
Chinese (zh)
Other versions
CN1434796A (zh
Inventor
E·德弗萨
T·克拉邦德
H-J·伯格
A·赫林
K-H·巴林豪斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001116768 external-priority patent/DE10116768A1/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of CN1434796A publication Critical patent/CN1434796A/zh
Application granted granted Critical
Publication of CN1280266C publication Critical patent/CN1280266C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018108016A 2000-06-09 2001-05-26 酰基苯基脲衍生物,其制备方法和作为药物的用途 Expired - Fee Related CN1280266C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10028175.3 2000-06-09
DE10028175 2000-06-09
DE10116768.7 2001-04-04
DE2001116768 DE10116768A1 (de) 2001-04-04 2001-04-04 Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
CN1434796A CN1434796A (zh) 2003-08-06
CN1280266C true CN1280266C (zh) 2006-10-18

Family

ID=26005991

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018108016A Expired - Fee Related CN1280266C (zh) 2000-06-09 2001-05-26 酰基苯基脲衍生物,其制备方法和作为药物的用途

Country Status (27)

Country Link
US (1) US6506778B2 (cg-RX-API-DMAC7.html)
EP (1) EP1294682B1 (cg-RX-API-DMAC7.html)
JP (1) JP4510372B2 (cg-RX-API-DMAC7.html)
KR (1) KR20030007934A (cg-RX-API-DMAC7.html)
CN (1) CN1280266C (cg-RX-API-DMAC7.html)
AR (1) AR030230A1 (cg-RX-API-DMAC7.html)
AT (1) ATE265424T1 (cg-RX-API-DMAC7.html)
AU (2) AU6231801A (cg-RX-API-DMAC7.html)
BR (1) BR0111457A (cg-RX-API-DMAC7.html)
CA (1) CA2411082A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20024003A3 (cg-RX-API-DMAC7.html)
DE (1) DE50102147D1 (cg-RX-API-DMAC7.html)
DK (1) DK1294682T3 (cg-RX-API-DMAC7.html)
EE (1) EE200200634A (cg-RX-API-DMAC7.html)
ES (1) ES2215902T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20020968A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0301749A2 (cg-RX-API-DMAC7.html)
IL (1) IL153273A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02011458A (cg-RX-API-DMAC7.html)
NO (1) NO20025879L (cg-RX-API-DMAC7.html)
NZ (1) NZ523034A (cg-RX-API-DMAC7.html)
PL (1) PL359178A1 (cg-RX-API-DMAC7.html)
PT (1) PT1294682E (cg-RX-API-DMAC7.html)
SK (1) SK17252002A3 (cg-RX-API-DMAC7.html)
TR (1) TR200401029T4 (cg-RX-API-DMAC7.html)
WO (1) WO2001094300A1 (cg-RX-API-DMAC7.html)
YU (1) YU91002A (cg-RX-API-DMAC7.html)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125567B4 (de) * 2001-05-25 2004-08-26 Aventis Pharma Deutschland Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
DE10139416A1 (de) * 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10215908B4 (de) * 2002-04-11 2005-08-18 Aventis Pharma Deutschland Gmbh Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel
US7223796B2 (en) 2002-04-11 2007-05-29 Sanofi-Aventis Deutschland Gmbh Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
US7078404B2 (en) 2002-04-11 2006-07-18 Sanofi-Aventis Deutschland Gmbh Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use
DE10225635C1 (de) * 2002-06-07 2003-12-24 Aventis Pharma Gmbh N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
US7049341B2 (en) 2002-06-07 2006-05-23 Aventis Pharma Deutschland Gmbh N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use
US7262220B2 (en) 2002-07-11 2007-08-28 Sanofi-Aventis Deutschland Gmbh Urea- and urethane-substituted acylureas, process for their preparation and their use
JP4374428B2 (ja) * 2002-07-11 2009-12-02 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 尿素置換されたおよびウレタン置換されたアシル尿素、それらの製造方法および医薬としてのそれらの使用方法
EP1523475B1 (de) * 2002-07-12 2009-12-23 Sanofi-Aventis Deutschland GmbH Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE10231627B4 (de) * 2002-07-12 2006-03-09 Sanofi-Aventis Deutschland Gmbh Heterozyklisch substituierte Benzoylharnstoffe und ihre Verwendung als Arzneimittel
US20040157922A1 (en) * 2002-10-04 2004-08-12 Aventis Pharma Deutschland Gmbh Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments
DE10246434B4 (de) * 2002-10-04 2005-08-04 Aventis Pharma Deutschland Gmbh Carboxyalkoxy-substituierte Acyl-carboxyphenyl-harnstoffderivate und ihre Verwendung als Arzneimittel
US7179941B2 (en) * 2003-01-23 2007-02-20 Sanofi-Aventis Deutschland Gmbh Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use
DE10302452B4 (de) * 2003-01-23 2005-02-24 Aventis Pharma Deutschland Gmbh Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
US7196114B2 (en) * 2003-02-17 2007-03-27 Sanofi-Aventis Deutschland Gmbh Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use
DE10306502B4 (de) * 2003-02-17 2005-03-17 Aventis Pharma Deutschland Gmbh Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308355A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308351A1 (de) * 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10309929B4 (de) * 2003-03-07 2006-02-23 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
US7501440B2 (en) 2003-03-07 2009-03-10 Sanofi-Aventis Deutschland Gmbh Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
DE10335092B3 (de) 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
US7241787B2 (en) 2004-01-25 2007-07-10 Sanofi-Aventis Deutschland Gmbh Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
DE602004004631D1 (de) 2004-04-01 2007-03-22 Sanofi Aventis Deutschland Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
US7963448B2 (en) * 2004-12-22 2011-06-21 Cognex Technology And Investment Corporation Hand held machine vision method and apparatus
WO2006113650A1 (en) * 2005-04-18 2006-10-26 Khan Saeed R Design and synthesis of novel tubulin polymerization inhibitors: bonzoylphenyluria (bpu) sulfur analogs
EP1884513A4 (en) * 2005-05-23 2010-04-28 Japan Tobacco Inc PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2096111A1 (en) * 2006-11-20 2009-09-02 Japan Tobacco Inc. Pyrazoles and use thereof as drugs
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
MX2019004321A (es) 2016-10-14 2019-06-12 Tes Pharma S R L Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa.
IL283182B2 (en) 2018-11-20 2025-10-01 Tes Pharma S R L Alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase inhibitors
CN117603095B (zh) * 2023-11-24 2025-08-29 中国烟草云南进出口有限公司 灭幼脲半抗原、抗原、抗体、检测装置及其制备和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH516578A (de) * 1967-11-02 1971-12-15 Bayer Ag Verfahren zur Herstellung von heterocyclische Acylaminogruppen enthaltenden Arylsulfonylharnstoffen mit blutdrucksenkender Wirkung
ZA793186B (en) * 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
ATE43788T1 (de) * 1983-09-01 1989-06-15 Duphar Int Res Benzoylharnstoffe mit antitumoraler wirkung.
JPS60237056A (ja) * 1984-05-08 1985-11-25 Ishihara Sangyo Kaisha Ltd Ｎ−ベンゾイル−ｎ′−フエニルウレア系化合物及びそれらを含有する殺虫剤
ATE40111T1 (de) * 1984-07-05 1989-02-15 Duphar Int Res Benzoylharnstoffverbindungen sowie solche enthaltende insektizide und akarizide zusammensetzungen.
DE3504749A1 (de) * 1985-02-08 1986-08-14 Schering AG, 1000 Berlin und 4709 Bergkamen Acylharnstoffe, insektizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung
JPH0791248B2 (ja) * 1988-06-29 1995-10-04 富士写真フイルム株式会社 アルコキシもしくはアリールオキシベンゼン化合物の製造方法
DE4208778C1 (cg-RX-API-DMAC7.html) * 1992-03-17 1993-09-23 Schering Ag Berlin Und Bergkamen, 13353 Berlin, De
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
US20020151586A1 (en) 2002-10-17
US6506778B2 (en) 2003-01-14
PT1294682E (pt) 2004-09-30
PL359178A1 (en) 2004-08-23
NO20025879L (no) 2003-01-29
HUP0301749A2 (hu) 2003-09-29
CZ20024003A3 (cs) 2003-03-12
WO2001094300A1 (de) 2001-12-13
TR200401029T4 (tr) 2004-06-21
CA2411082A1 (en) 2002-12-05
ES2215902T3 (es) 2004-10-16
IL153273A0 (en) 2003-07-06
KR20030007934A (ko) 2003-01-23
DE50102147D1 (de) 2004-06-03
BR0111457A (pt) 2003-06-24
DK1294682T3 (da) 2004-08-02
HK1056715A1 (en) 2004-02-27
EE200200634A (et) 2004-04-15
HRP20020968A2 (en) 2005-02-28
EP1294682A1 (de) 2003-03-26
CN1434796A (zh) 2003-08-06
JP2003535843A (ja) 2003-12-02
NZ523034A (en) 2004-07-30
YU91002A (sh) 2006-05-25
MXPA02011458A (es) 2003-04-25
ATE265424T1 (de) 2004-05-15
AU2001262318B2 (en) 2005-09-08
JP4510372B2 (ja) 2010-07-21
AR030230A1 (es) 2003-08-13
NO20025879D0 (no) 2002-12-06
SK17252002A3 (sk) 2003-05-02
EP1294682B1 (de) 2004-04-28
AU6231801A (en) 2001-12-17

Similar Documents

Publication Publication Date Title
CN1280266C (zh) 酰基苯基脲衍生物,其制备方法和作为药物的用途
CN1218936C (zh) 甲酰胺取代的苯基脲衍生物以及用于将其作为药物的制备方法
CN1281606C (zh) 含氮杂环化合物
CN1134434C (zh) 新型2-杂环取代的二氢嘧啶
CN1176080C (zh) 茚并一,萘并一和苯并环庚二氢噻唑衍生物,它们的制备以及它们作为降低食欲药的用途
CN1195747C (zh) 8,8a－二氢茚并[1,2－d]噻唑衍生物、它们的制备方法和制药用途
CN1454204A (zh) Il－8受体拮抗剂
CN1406234A (zh) 在2－位携带具有磺酰胺结构或砜结构的取代基的8,8a－二氢茚并[1,2－d]噻唑衍生物、它们的制备方法和它们作为药物的用途
CN1161120C (zh) 多环2-氨基噻唑体系在预防或治疗肥胖的药物制备中的用途
CN1276783A (zh) 2－苯氧基苯胺衍生物
CN1166623C (zh) 2-苯氧基苯胺类衍生物
CN1126737C (zh) 新型吡咯化合物和其制备方法及含其的药物组合物
CN1141940C (zh) 多环噻唑体系用于制备预防或治疗肥胖的药物的用途
CN1087015C (zh) 吡啶衍生物
CN1255387C (zh) 可用作选择性cox－2抑制剂的嘧啶衍生物
CN1344263A (zh) 多环的2－氨基噻唑体系、它们的制备方法和包含这些化合物的药物
CN1198330A (zh) 治疗原虫感染的方法
CN101074189A (zh) 苯乙烯酸衍生物及其在制备血管靶向剂药物中的应用
CN1594299A (zh) 双苯并异唑酮类化合物及其合成和应用
CN1038278A (zh) 取代的苯衍生物和它们的制备方法及包含它们的抗癌组合物
HK1056715B (en) Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament
CN1847240A (zh) 拉唑类衍生物及其盐和用途
CN1606440A (zh) 取代的咪唑烷类化合物,其制备方法,其作为药物或诊断剂的用途以及含有取代的咪唑烷类化合物的药物
HK1041689A1 (en) ((aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy
HK1065027B (en) Carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee