CN1277558C - Chinese traditional medicine preparation for treating chronic enteritis, colitis and proctitis - Google Patents
Chinese traditional medicine preparation for treating chronic enteritis, colitis and proctitis Download PDFInfo
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- CN1277558C CN1277558C CN 200310115815 CN200310115815A CN1277558C CN 1277558 C CN1277558 C CN 1277558C CN 200310115815 CN200310115815 CN 200310115815 CN 200310115815 A CN200310115815 A CN 200310115815A CN 1277558 C CN1277558 C CN 1277558C
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Abstract
The present invention relates to a Chinese traditional medicine for treating chronic enteritis, colitis and proctitis, which is prepared from pulsatilla roots, purslane, phellodendron bark, red sage roots and catechu by weight proportion through a traditional processing technology. The medicine mainly treats diarrhea, abdominal pain, abdominal distention, tenesmus and white and blood dysentery, and has the therapeutic artificial law of clearing away heat and toxic material, thickening intestines, relieving diarrhea, excreting dampness, relieving dysentery, growing muscle and removing necrotic tissue. All the components of the medicine interact with each other, so that the present invention has the functions of clearing away heat and toxic material, thickening intestines, relieving diarrhea, excreting dampness, relieving dysentery, growing muscle and removing necrotic tissue, and is suitable for treating abdominal pain, diarrhea, tenesmus and pus and blood stool or bloody stool. The present invention belongs to a damp-heat internal warm type distinguished by traditional Chinese physicians. The Chinese traditional medicine prepared of pure Chinese traditional herbs has the advantages of internal and external therapy, conspicuous curative effect, no adverse reaction, no toxic and side effect, quick disappearance of clinical symptoms and no rebound phenomenon after cure.
Description
Technical field:
The present invention relates to treat the Chinese medicine preparation of colitis class disease, particularly disclose a kind of Chinese medicine preparation for the treatment of chronic enteritis, colitis, proctitis, belong to the Chinese medicine and pharmacy technical field.
Background technology:
Enteritis particularly chronic non-specific ulcerative colitis belongs to " dysentery ", " having loose bowels " of the traditional Chinese medical science, the category of " dysentery due to damp-heat ", and the course of disease is long, the cause of disease is complicated.Therefore, many Western medicine are relief of symptoms to the treatment of this type of disease, can't cure, and cure the symptoms, not the disease; And other Chinese medicine preparation has certain curative effect in therapeutic process, but the case of recurrence is also a lot, so bring a lot of miseries to suffering from this sick patient.
Summary of the invention:
The invention provides a kind of Chinese medicine preparation and production technology thereof for the treatment of chronic enteritis, colitis, proctitis, have evident in efficacy, the characteristics for the treatment of both the principal and secondary aspects of a disease.
According to the theory of Chinese medical science of China pathogenesis for treatment chronic enteritis, colitis, proctitis, the card that the present invention led is diarrhoea, stomachache, abdominal distention, tenesmus, the red white pus and blood of dysentery.Be the treatment legislation from heat-clearing and toxic substances removing, intestines strengthening and diarrhea checking, eliminating dampness by diuresis dysentery relieving, granulation promoting removing the necrotic tissue, the pure Chinese herbal medicine of selected following all flavors is made by traditional Chinese medicine processing technology.Concrete prescription following (by ratio of weight and the number of copies):
The Radix Pulsatillae 210～400, Herba Portulacae 100～200, Cortex Phellodendri 100～200,
Radix Salviae Miltiorrhizae 80～150, catechu 20～40.
Optimum ratio of the present invention is (ratio of weight and number)
The Radix Pulsatillae 300, Herba Portulacae 150, Cortex Phellodendri 150, Radix Salviae Miltiorrhizae 100, catechu 30.
Processing procedure is as follows:
Take by weighing above-mentioned raw materials add 4～8 times of water/time, decoct 1～3 time, when gradient subtracted in each 3.0,2.5,1.5 hours, merge medicinal liquid, the simmer down to relative density is 1.00～1.08 concentrated liquid, and the pure liquid that adds 5 times of amounts makes it contain the alcohol amount to reach 60～85%, mixing, placement, filtration, get relative density that supernatant reclaims pure liquid and be 1.10～1.25 fluid extract, add Mel, benzoic acid and water and make oral liquid.
Usage and consumption: oral.Formulation rate of the present invention can be according to variations such as route of administration, patient age, body weight, disease type and the orders of severity, and 2 times/day, 15～30ml/ time, one month is a course of treatment.
Function: heat-clearing and toxic substances removing, intestines strengthening and diarrhea checking, eliminating dampness by diuresis dysentery relieving, granulation promoting removing the necrotic tissue.
Be suitable for: treatment stomachache, diarrhoea, tenesmus, bloody purulent stool or hemafecia belong to the retention of damp-heat in the interior type of differential diagnosis in tcm.
The present invention is principal agent according to the etiology and pathogenesis of chronic ulcerative colitis with the Radix Pulsatillae, MAZHIXIAN, the sliding sharp intestinal of heat-clearing and toxic substances removing, and removing food stagnancy dirt stopping leak rushes down.Cortex Phellodendri is a minister, is longer than bladder damp-heat in the large intestine clearly especially, the pathogenic fire purging nourishing YIN, and dampness-eliminating and dysentery-stopping, the doctor has loose bowels, attached principal drug assistance, the eliminating dampness by diuresis heat clearing away is dismissed the damp and hot turbid dirt that accumulates between strongly fragrant intestinal, attached gas and smooth, and have loose bowels from ending, with Tu Qiben.Assistant is used Radix Salviae Miltiorrhizae, walks the blood system network of promoting blood circulation, the blood stasis dispelling subduing inflammation that stagnates, having has benefit in logical, go and broken characteristics, must join monarch-minister drug, blood prosperous without obstacle is capable, more help to dismiss the gesture that wet-heat of intestines is tied mutually, abdomen gas is not smooth with blood, make with catechu granulation promoting removing the necrotic tissue, analgesic therapy, giving consideration to both the incidental and fundamental, no medicine share, and plays the effect of heat-clearing and toxic substances removing, intestines strengthening and diarrhea checking, eliminating dampness by diuresis dysentery relieving and flesh removing the necrotic tissue altogether.
Good effect of the present invention is: each all medicine of distinguishing the flavor of complements each other, and specially controls mucosal ulcer, hyperemia, and edema, pained thick intestinal stopping leak rushes down and hard, does not hold back evil disadvantage.Preparation is that pure Chinese herbal medicine is made, and is higher for the curative effect of arteriosclerosis, and treating both the principal and secondary aspects of a disease is evident in efficacy, has no adverse reaction, and has no side effect, and clinical symptom disappearance is rapid, cures the no rebound phenomena in back.
For showing the therapeutic effect of medicine of the present invention, select 40 routine chronic enteritiss, colitis, proctitis patient to treat, wherein: male's 24 examples, women's 16 examples by taking medicine of the present invention.20～29 years old 5 age example, 30～39 years old 8 example, 40～49 years old 6 example, 50～59 years old 5 example, 60～69 years old 16 example, 50.1 years old mean age, the course of disease is the shortest to be half a year, the longest is 3 years, average 3 years.
According to clinical diagnosis is to accumulate card in the damp-heat in the large intestine, and the outpatient service and the inpatient that belong to the chronic noninfective intestinal tract disease are all included the test case in.Age under-18s or over-65s, gestation or women breast-feeding their children, allergic constitution reaches this medicine allergy sufferers, be associated with serious diseases such as cardiovascular, cerebrovascular, Liver and kidney and hemopoietic system, spiritual patient has severe complication, as local stenosis, intestinal obstruction, intestinal perforation, rectal polyp, toxic colonic dilatation, colon cancer, rectal cancer and anus etc. does not meet the standard of including in, do not take medicine in accordance with regulations, can't judge that not congruent influence of curative effect or data or safety judgement person are the discharge case.
The itemized record diseases changes before and after the treatment, the observation body of the tongue, establishes platform, pulse condition, measures heart rate, blood pressure, the blood test routine, and even if routine urinalysis is just routine cultivation, liver function, kidney merit.
Adopt the method for the preceding own control of treatment to carry out safety and health giving quality evaluation.
Comprehensive therapeutic effect criterion:
Clinical cure: clinical symptom disappearance, colonoscope etc. check that intestinal mucosa recovers normal, observe after the drug withdrawal and do not have recurrence in 6 months.
Produce effects: clinical symptoms disappears substantially, and colonoscope etc. check that reaction of intestinal mucosa mild inflammation and part pseudopolyp form.
Effectively: clinical symptoms takes a turn for the better, and inspection mucosa infections such as colonoscope take a turn for the better to some extent.
Invalid: clinical symptoms and colonoscope etc. inspections do not have improvement.
This organizes 40 routine therapeutic outcomes:
The variation of 1, accumulateing symptom in the damp-heat in the large intestine:
| Symptom | Case | Before the treatment | After the treatment | U | P | ||||||
| +++ | ++ | + | - | +++ | ++ | + | - | ||||
| Diarrhoea | 40 | 18 | 22 | 0 | 0 | 0 | 0 | 23 | 17 | 7.958 | ＜0.01 |
| Constipation | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | ＜0.01 |
| Mucous Stool | 40 | 1 | 23 | 13 | 3 | 0 | 0 | 4 | 36 | 7.380 | ＜0.01 |
| Bloody purulent stool | 40 | 0 | 4 | 3 | 33 | 0 | 0 | 2 | 38 | 1.816 | ＜0.01 |
| Tenesmus | 40 | 0 | 5 | 22 | 13 | 0 | 0 | 1 | 39 | 5.997 | ＜0.01 |
| Stomachache | 40 | 1 | 27 | 11 | 1 | 0 | 0 | 11 | 29 | 7.285 | ＜0.01 |
| Abdominal distention | 40 | 0 | 16 | 12 | 12 | 0 | 0 | 13 | 27 | 4.222 | ＜0.01 |
| Indigestion and loss of appetite | 40 | 1 | 36 | 3 | 0 | 0 | 0 | 31 | 9 | 7.949 | ＜0.01 |
Last table as can be known, diarrhoea, Mucous Stool, tenesmus, stomachache, abdominal distention, indigestion and loss of appetite symptom are obviously improved after the medication.
2, the influence of picture of the tongue pulse condition:
| n | Body of the tongue | Tongue fur | Pulse condition | |||||||
| Red | Light red | Yellow greasy | Thick greasy | Bao Bai | Sliding number | Stringy and rapid pulse | Stringy and rolling pulse | Normal pulse | ||
| Before the treatment | 40 | 39 | 1 | 38 | 1 | 1 | 22 | 8 | 10 | 0 |
| After the treatment | 40 | 26 | 14 | 15 | 0 | 25 | 15 | 2 | 3 | 20 |
| The P value | ＜0.05 | ＜0.01 | ＜0.01 | |||||||
The explanation of last table, red tongue, yellowish fur, sliding this group of number of pulse condition are obviously improved after the medication, illustrate the card of retention of damp-heat in the interior controlled with alleviate.
3, to the influence of hemogram (X ± SD)
| Erythrocyte (10 12/L) | Hemoglobin (g/L) | Leukocyte (10 9/L) | |
| n | 40 | 40 | 40 |
| Before the medication | 4.77±0.42 | 142.7±12.3 | 8.46±1.11 |
| After the medication | 4.79±0.35 | 143.9±10.9 | 8.06±0.65 |
| t | 0.644 | 2.918 | 2.171 |
| p | ＜0.05 | ＜0.05 | ＜0.05 |
Last table as seen, red blood cell count(RBC) changes before the treatment not quite after the medication, erythrocyte slightly raises after the medication, numeration of leukocyte has decline slightly, all in range of normal value, so this medicine does not have obvious influence to hemogram.
Comprehensive therapeutic effect is judged:
Produce effects: 21 examples, obvious effective rate 52.5%.
Effective percentage: 17 examples, effective percentage 42.5%.
Invalid: 2 examples, inefficiency 5%.
Total effective rate 95%.
In sum, use medicine of the present invention to 40 routine patient treatments, for the caused diarrhoea of retention of damp-heat in the interior, Mucous Stool, tenesmus, stomachache, abdominal distention, disease such as indigestion and loss of appetite good health care and therapeutic effect are arranged, confirmed the effect of heat-clearing and toxic substances removing of the present invention, hindgut antidiarrheal, eliminating dampness by diuresis dysentery relieving, removing the necrotic tissue and promoting granulation.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limit the present invention by any way, under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope that awaits the reply of the present invention.
Embodiment 1
Get Radix Pulsatillae 300g, Herba Portulacae 150g, Cortex Phellodendri 150g, Radix Salviae Miltiorrhizae 100g, adding 8 times of decoctings after catechu 30g mixes boiled 3 hours, for the second time adding 6 times of decoctings boiled 2.5 hours, adding 6 times of decoctings for the third time boiled 1.5 hours, merge medicinal liquid, (relative density is 1.00～1.08 to be concentrated into about 1000ml, 60 ℃ of hot sides) concentrated liquid, adding ethanol liquid makes it contain alcohol amount to reach 80%, mixing, place, filter, (relative density is 1.10～1.25 to 600ml to get supernatant recovery ethanol, 60 ℃ of hot sides), add 200g Mel, sodium benzoate 2g, water filters packing and makes oral liquid to 1000ml.
Embodiment 2
Get Radix Pulsatillae 240g, Herba Portulacae 200g, Cortex Phellodendri 120g, Radix Salviae Miltiorrhizae 150g, adding 8 times of decoctings after catechu 20g mixes boiled 3 hours, for the second time adding 6 times of decoctings boiled 2.5 hours, adding 4 times of decoctings for the third time boiled 1.5 hours, merge medicinal liquid, (relative density is 1.00～1.08 to be concentrated into about 1000ml, 60 ℃ of hot sides) concentrated liquid, adding ethanol liquid makes it contain alcohol amount to reach 80%, mixing, place, filter, (relative density is 1.10～1.25 to 600ml to get supernatant recovery ethanol, 60 ℃ of hot sides), add 200g Mel, sodium benzoate 2g, water filters packing and makes oral liquid to 1000ml.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of chronic enteritis, colitis, proctitis is characterized in that it being the medicament of being made by the following weight proportion raw material:
The Radix Pulsatillae 210～400, Herba Portulacae 100～200, Cortex Phellodendri 100～200,
Radix Salviae Miltiorrhizae 80～150, catechu 20～40.
2, a kind of Chinese medicine preparation for the treatment of chronic enteritis, colitis, proctitis is characterized in that it being the medicament of being made by the following weight proportion raw material:
The Radix Pulsatillae 300, Herba Portulacae 150, Cortex Phellodendri 150, Radix Salviae Miltiorrhizae 100, catechu 30.
3, the production technology of claim 1 or 2 Chinese medicine preparation, it is characterized in that may further comprise the steps: take by weighing the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Radix Salviae Miltiorrhizae, catechu add 4～8 times of water/time, decoct 1～3 time, when gradient subtracted in each 3.0,2.5,1.5 hours, merge medicinal liquid, the simmer down to relative density is 1.00～1.08 concentrated liquid, adding ethanol liquid makes it contain alcohol amount to reach 60～85%, mixing, placement, filtration, getting supernatant, to reclaim pure liquid to relative density be 1.10～1.25 fluid extract, adds Mel, benzoic acid and water and make oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310115815 CN1277558C (en) | 2003-11-26 | 2003-11-26 | Chinese traditional medicine preparation for treating chronic enteritis, colitis and proctitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310115815 CN1277558C (en) | 2003-11-26 | 2003-11-26 | Chinese traditional medicine preparation for treating chronic enteritis, colitis and proctitis |
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| Publication Number | Publication Date |
|---|---|
| CN1544058A CN1544058A (en) | 2004-11-10 |
| CN1277558C true CN1277558C (en) | 2006-10-04 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336531C (en) * | 2005-11-18 | 2007-09-12 | 李胜利 | Preparation method of Chinese medicine for treating ulcero proctitis |
| CN103816265B (en) * | 2014-02-14 | 2016-04-27 | 刘维忠 | A kind ofly be used for the treatment of medicine of having loose bowels and preparation method thereof |
| CN105012470A (en) * | 2015-07-21 | 2015-11-04 | 江琴 | Medicine liquor for treating cervical cancer complication radiation proctitis through coloclysis |
| CN105456463A (en) * | 2015-12-09 | 2016-04-06 | 长顺县文会虫草种植有限公司 | Traditional Chinese medicine for treating enteritis and hematochezia |
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Granted publication date: 20061004 |