CN1273116A - Process for refining astragalus injection - Google Patents
Process for refining astragalus injection Download PDFInfo
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- CN1273116A CN1273116A CN 99106225 CN99106225A CN1273116A CN 1273116 A CN1273116 A CN 1273116A CN 99106225 CN99106225 CN 99106225 CN 99106225 A CN99106225 A CN 99106225A CN 1273116 A CN1273116 A CN 1273116A
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- ethanol
- equivalent
- crude drug
- cold preservation
- precipitate
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- Medicines Containing Plant Substances (AREA)
Abstract
A refined astragalus injection is prepared through decocting astragalus, root, filtering, concentrating, then depositing 70%, 80% and 85% alcohol; after each deposition, cold storage at 0 deg.C for several hr, recovering alcohol, concentrating, diluting with water for injection, cold storage at 0-4 deg.C for 24 hr, filtering, regulating pH value with 20% solution of sodium hydroxide, boiling, adding activated carbon, further regulating pH value with 20% solution of sodium hydroxide, filtering, sealing and sterilization. Its advantages include high stability and long effective period up to 2-3 years.
Description
The present invention relates to a kind of process for refining astragalus injection.
The Radix Astragali has Yiqiyangyuan, strengthening vital QI to eliminate pathogenic factors, nourish heart promote blood circulation, effect such as invigorating spleen to remove dampness, in prescriptions of Chinese medicine, obtain the use of wide model, in order to improve result of use, be made into injection and be used for clinical use, because present preparation technology exists problems such as precipitate with ethanol weak effect, cause the injection less stable, only can reach that year promptly easily to produce medicinal liquid half a year to 1 muddy and opalescence occurs its effect duration.
The purpose of this invention is to provide a kind of precipitate with ethanol and remove the process for refining astragalus injection that impurity is thorough, improve liquid medicine stability, extend the expiration date and limit.
The present invention includes the following step:
1, a kind of process for refining astragalus injection, it is characterized in that: preparation technology comprises the following steps:
(1) get the Radix Astragali and decoct with water 2 times, each 1-1.5 hour, collecting decoction filtered through filter;
(2) filtrate normal pressure heating is concentrated into every 1ml and is equivalent to crude drug 1-2g;
(3) handle 3 times with ethanol precipitation,
The first time, adding content in filtrate was 70% ethanol, and behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
Add for the second time content again and be 80% ethanol, behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
Add content for the third time again and be 85% ethanol, behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
(4) reclaim ethanol and be concentrated into the 10g that 1ml is equivalent to crude drug;
(5) be diluted to the 0.75-1g that every 1ml is equivalent to crude drug with water for injection, cold preservation to 0 ℃-4 ℃ was placed 24 hours;
(6) filtration, filter liquor concentration cool off to the 5-6g that every 1ml is equivalent to crude drug;
(7) regulate pH value to 7.3-8 with 20% sodium hydroxide solution;
(8) boil the active carbon that adds 0.125%-0.175% and stir, and boiled filtered while hot 5 minutes;
(9) add 20% sodium hydroxide solution again, regulate pH value to 7.5;
(10) filtration at last, embedding, sterilization, quality inspection, packing form.
Owing to adopt three precipitate with ethanol, and the concentration of precipitate with ethanol improves one by one by 70%, 80%, 85%, can precipitate the various impurity in the medicinal liquid so effectively, thereby improve the purity of medicinal liquid and the stability of medicinal liquid, prolonged expiry date, can reach 2-3, make the medicinal liquid in effect duration the muddy and opalescence phenomenon of medicinal liquid not occur.
Introduce two embodiment of the present invention below
Embodiment 1
A kind of process for refining astragalus injection comprises the following steps:
(1) get Radix Astragali 2000g and decoct with water 2 times, each 1.5 hours, collecting decoction filtered through filter;
(2) filtrate normal pressure heating is concentrated into every 1ml and is equivalent to crude drug 1g;
(3) handle 3 times with ethanol precipitation,
Add for the first time content and be 3 liters of 70% ethanol in filtrate, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
Add for the second time content again and be 2 liters of 80% ethanol, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
Add content for the third time again and be 3 liters of 85% ethanol, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
(4) reclaim ethanol and be concentrated into the 10g that 1ml is equivalent to crude drug;
(5) be diluted to the 0.8g that every 1ml is equivalent to crude drug with water for injection, cold preservation to 0 ℃ was placed 24 hours;
(6) filtration, filter liquor concentration cool off to the 5.5g that every 1ml is equivalent to crude drug;
(7) regulate pH value to 7.3 with 20% sodium hydroxide solution;
(8) boil and add 0.125% active carbon and stir, and boiled 5 minutes, be cooled to 50 ℃ and use the filter filtered while hot, add the injection water and make into 1000ml;
(9) add 20% sodium hydroxide solution 2mol/L again, regulate pH value to 7.5;
(10) filtration at last, embedding, sterilization, quality inspection, packing form.
Embodiment 2
A kind of process for refining astragalus injection comprises the following steps:
(1) get Radix Astragali 2000g and decoct with water 2 times, each 2 hours, collecting decoction filtered through filter;
(2) filtrate normal pressure heating is concentrated into every 1ml and is equivalent to crude drug 2g;
(3) handle 3 times with ethanol precipitation,
Add for the first time content and be 5 liters of 70% ethanol in filtrate, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
Add for the second time content again and be 3 liters of 80% ethanol, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
Add content for the third time again and be 5 liters of 85% ethanol, behind the precipitate with ethanol, cold preservation was placed 6 hours for 0 ℃,
(4) reclaim ethanol and be concentrated into the 10g that 1ml is equivalent to crude drug;
(5) be diluted to the 1g that every 1ml is equivalent to crude drug with water for injection, cold preservation to 0 ℃ was placed 24 hours;
(6) filtration, filter liquor concentration cool off to the 6g that every 1ml is equivalent to crude drug;
(7) regulate pH value to 8 with 20% sodium hydroxide solution;
(8) boil and add 0.175% active carbon and stir, and boiled 5 minutes, be cooled to 50 ℃ and use the filter filtered while hot, add the injection water and make into 1000ml;
(9) add 20% sodium hydroxide solution 2mol/L again, regulate pH value to 7.5;
(10) filtration at last, embedding, sterilization, quality inspection, packing form.
Claims (1)
1, a kind of process for refining astragalus injection, it is characterized in that: preparation technology comprises the following steps:
(1) get the Radix Astragali and decoct with water 2 times, each 1-1.5 hour, collecting decoction filtered through filter;
(2) filtrate normal pressure heating is concentrated into every 1ml and is equivalent to crude drug 1-2g;
(3) handle 3 times with ethanol precipitation,
The first time, adding content in filtrate was 70% ethanol, and behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
Add for the second time content again and be 80% ethanol, behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
Add content for the third time again and be 85% ethanol, behind the precipitate with ethanol, cold preservation is placed a few hours for 0 ℃,
(4) reclaim ethanol and be concentrated into the 10g that 1ml is equivalent to crude drug;
(5) be diluted to the 0.75-1g that every 1ml is equivalent to crude drug with water for injection, cold preservation to 0 ℃-4 ℃ was placed 24 hours;
(6) filtration, filter liquor concentration cool off to the 5-6g that every 1ml is equivalent to crude drug;
(7) regulate pH value to 7.3-8 with 20% sodium hydroxide solution;
(8) boil the active carbon that adds 0.125%-0.175% and stir, and boiled filtered while hot 5 minutes;
(9) add 20% sodium hydroxide solution again, regulate pH value to 7.5;
(10) filtration at last, embedding, sterilization, quality inspection, packing form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99106225 CN1273116A (en) | 1999-05-05 | 1999-05-05 | Process for refining astragalus injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99106225 CN1273116A (en) | 1999-05-05 | 1999-05-05 | Process for refining astragalus injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1273116A true CN1273116A (en) | 2000-11-15 |
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ID=5272336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99106225 Pending CN1273116A (en) | 1999-05-05 | 1999-05-05 | Process for refining astragalus injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1273116A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895294A (en) * | 2012-10-30 | 2013-01-30 | 黑龙江珍宝岛药业股份有限公司 | Astragalus mongholicus injection and preparation method thereof |
| CN106236820A (en) * | 2016-08-26 | 2016-12-21 | 黑龙江珍宝岛药业股份有限公司 | A kind of Radix Astragali injection and preparation method thereof and pharmaceutical composition |
-
1999
- 1999-05-05 CN CN 99106225 patent/CN1273116A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895294A (en) * | 2012-10-30 | 2013-01-30 | 黑龙江珍宝岛药业股份有限公司 | Astragalus mongholicus injection and preparation method thereof |
| CN102895294B (en) * | 2012-10-30 | 2014-09-03 | 黑龙江珍宝岛药业股份有限公司 | Astragalus mongholicus injection and preparation method thereof |
| CN106236820A (en) * | 2016-08-26 | 2016-12-21 | 黑龙江珍宝岛药业股份有限公司 | A kind of Radix Astragali injection and preparation method thereof and pharmaceutical composition |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |