CN1157162A

CN1157162A - Pulse-engendering injection and preparation method thereof

Info

Publication number: CN1157162A
Application number: CN 96117457
Authority: CN
Inventors: 肖江伟; 郑红
Original assignee: Yaan Sanjiu Pharmaceutical Co Ltd
Current assignee: Yaan Sanjiu Pharmaceutical Co Ltd
Priority date: 1996-02-14
Filing date: 1996-02-14
Publication date: 1997-08-20

Abstract

The present invention relates to an injection preparation-Pulse-Engendering Injection and its preparation method. Said injection can be used for curing cardiogenic and infective shock, myocardosis and coronary heart disease, etc., also can be used as auxiliary medicine for curing carcinosis by means of intramuscular injection, intravenous drip and venous push-injection. Said injection per 1 ml contains 0.1g of red ginseng extract, 0.312g of ophiopogon tuber extract and 0.156g of northern schisandra berry extract. Its preparation method includes: using alcohol immersion and alcohol reflux extraction process to obtain red ginseng and ophiopogon tuber mixed extract; using distillation, decoction and alcohol precipitation process to obtain northern schisandra berry extract; mixing both extracts so as to obtain the invented product.

Description

A kind of SHENGMAI ZHUSHEYE and preparation method thereof

The present invention is a kind of SHENGMAI ZHUSHEYE and preparation method thereof, belongs to drug-preparing technology field.

In the prior art, Chinese patent 93110807.1 discloses a kind of SHENGMAI ZHUSHEYE and preparation technology thereof, and it is a raw material with Radix Ginseng Rubra, Radix Ophiopogonis, Radix Schisandrae Bicoloris, carries out the formulated injection of extraction of active ingredient respectively, its preparation technology is comparatively complicated, and the production cost height.

The objective of the invention is provides SHENGMAI ZHUSHEYE that a kind of production technology is easy, practical, cost is low and preparation method thereof for fear of above-mentioned fault of the prior art.

Purpose of the present invention can reach by following measure:

Contain among the every 1ml of SHENGMAI ZHUSHEYE and be equivalent to primary dose: Radix Ginseng Rubra 0.1g, Radix Ophiopogonis 0.312g, Radix Schisandrae Bicoloris 0.156g.

The preparation method of giving birth to the swimming injection is: get the extraction that Radix Ginseng Rubra, Radix Ophiopogonis, Radix Schisandrae Bicoloris have composition: get Radix Ginseng Rubra and mix with Radix Ophiopogonis, with alcohol flood, the extraction of alcohol reflux technology; Radix Schisandrae Bicoloris with steam distillation, decocting boil, alcohol precipitation technology extracts, two kinds of formulated injection of extracting solution merging that then will be collected, its processing step is:

A, preparation Radix Ginseng Rubra, Radix Ophiopogonis extract

(1), get Radix Ginseng Rubra and mix with Radix Ophiopogonis, use alcohol dipping, filter, collect filtrate, impregnation liquid 1.;

(2), the medicinal residues alcohol reflux, filter, collect filtrate, extracting solution 2.;

(3), the medicinal residues washing with alcohol, filter, collect filtrate, cleaning mixture 3.;

(4), get impregnation liquid 1., extracting solution 2., 3. cleaning mixture merge, cold preservation is left standstill, filter, add the active carbon (by the dosing volume calculation) of 6-9%, stir, filter, decompression recycling ethanol is added an amount of water for injection to there not being the alcohol flavor, and hot reflux is handled, cooling, transfer pH value to 6-8 with sodium hydroxide solution, cold preservation, Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 4.;

B, preparation Radix Schisandrae Bicoloris extracting solution

(5), get Radix Schisandrae Bicoloris, use steam distillation, collect distillate, distillate 5.;

(6), medicinal residues decoct with water, and filter, and concentrate, add ethanol and make and contain the alcohol amount and reach 70-80%, leave standstill, filter, reclaim ethanol, concentrate to there not being the alcohol flavor, add ethanol and make and contain the alcohol amount and reach 85-92%, cold preservation filters, and reclaims ethanol to there not being the alcohol flavor, 5. and add an amount of water for injection add distillate, cold preservation is placed, filter, add the active carbon (by the dosing volume calculation) of 2-3%, stir, filter, transfer pH value to 6-8, get the Radix Schisandrae Bicoloris reserve liquid 6. with sodium hydroxide solution;

C, preparation SHENGMAI ZHUSHEYE

(7), get Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 5., filter, add the tween 80 (by the dosing volume calculation) of 0.1-1%, be heated to and boil, put cold, 6. adding Radix Schisandrae Bicoloris reserve liquid is also mended and is added to the full amount of water for injection, transfer pH value to 6-8 with sodium hydroxide solution, filter embedding, sterilization promptly gets SHENGMAI ZHUSHEYE;

The prescription of d, preparation SHENGMAI ZHUSHEYE is: Radix Ginseng Rubra 100g, Radix Ophiopogonis 312g, Radix Schisandrae Bicoloris 156g, tween 80 is an amount of, water for injection is an amount of, makes the 1000ml injection.

In preparation process, preferably select following parameter for use: the ratio that adds activated carbon dosage: the amount of preparation Radix Ginseng Rubra, Radix Ophiopogonis extract is 7% (by the dosing volume calculation); The amount of preparation Radix Schisandrae Bicoloris extracting solution is 2% (by the dosing volume calculation).The amount that adds tween 80 is 0.5% (by the dosing volume calculation).PH value transfers to 7.4-7.6.

The present invention compared with prior art, the advantage that is had is:

Simplified technology.Adopt Radix Ginseng Rubra and technique for extracting mixed Radix Ophiopogonis, realized the technology of " two-step method " preparation SHENGMAI ZHUSHEYE, not only technology is simple, and constant product quality, reliably.

Reduced production cost.According to statistics, pure consumption can reduce 90%, and the tween 80 consumption can reduce 80%.

Result of use is good.This product shows through pharmacology and clinical practice, has nonspecific antiinflammatory, heart tonifying, boosts, antishock effect, can strengthen the immunologic function of cell, improves body to anoxybiotic tolerance, improves the myocardial blood circulation.Can be used for treating cardiogenic shock, septic shock, cardiomyopathy, coronary heart disease etc., also can be used as the paramedicines of the various cancers of treatment,, promote that the body rehabilitation efficacy is obvious alleviating the untoward reaction after cancer chemotherapy, the radiotherapy cancer.Can supply intramuscular injection, intravenous drip, intravenous injection, safe in utilization effective, do not see untoward reaction.

Be described further below in conjunction with embodiment:

Embodiment

1, prescription: Radix Ginseng Rubra 10kg, Radix Ophiopogonis 31.2kg, Radix Schisandrae Bicoloris 15.6kg, tween 80 is an amount of, water for injection is an amount of, make 100,000 ml injection.

2, processing step

A, preparation Radix Ginseng Rubra, Radix Ophiopogonis extract

(1), get Radix Ginseng Rubra 10kg, pulverize, mixes Radix Ophiopogonis with 31.2kg, with the alcohol dipping of triplication 72 hours, filter, collect filtrate, get impregnation liquid 1.;

(2), medicinal residues are with the ethanol of triplication, reflux, extract, three times, each 2 hours, filter, collect filtrate, extracting solution 2.;

(3), medicinal residues are with the ethanol gradation of qdx washing, filter, and collect cleaning mixture, cleaning mixture 3.;

(4), get impregnation liquid 1., extracting solution 2., 3. cleaning mixture merge, cold preservation was left standstill 12 hours, filter, add 7% active carbon (by the dosing volume calculation), stirred 1 hour, filter, filtrate decompression is recycled to does not have the alcohol flavor, adds water for injection to 7 ten thousand ml, and hot reflux is handled, be chilled to room temperature, transfer pH value to 7.4-7.6 with 10% sodium hydroxide solution, cold preservation 24 hours, Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 4.;

B, preparation Radix Schisandrae Bicoloris extracting solution

(5), get Radix Schisandrae Bicoloris 15.6kg, use steam distillation, collect distillate, distillate 5.;

(6), medicinal residues decoct with water three times, each 30 minutes, filter, merge three times filtrate, be concentrated in right amount, add ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, and filtered, decompression recycling ethanol is to there not being the alcohol flavor, be concentrated into an amount of, add ethanol and make and contain the alcohol amount and reach 85%, cold preservation 24 hours filters, decompression recycling ethanol is to there not being the alcohol flavor, 5. and add water for injection and make its total amount reach 30,000 ml add distillate, cold preservation is placed, filter, the active carbon of adding 2% (by the dosing volume calculation) stirs, and filters, transfer pH value to 7.4-7.6 with 10% sodium hydroxide solution, get the Radix Schisandrae Bicoloris reserve liquid 6.;

C, preparation SHENGMAI ZHUSHEYE

(7), get Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 5., filter, add 0.5% tween 80 (by the dosing volume calculation), be heated to 100 ℃, 30 minutes, be chilled to room temperature, 6. adding Radix Schisandrae Bicoloris reserve liquid adds to the full amount of water for injection with benefit and reaches 100,000 ml, transfer pH value to 7.4-7.6 with 10% sodium hydroxide solution, filter embedding, sterilization promptly gets 100,000 ml SHENGMAI ZHUSHEYE.Contain among every 1ml and be equivalent to primary dose: Radix Ginseng Rubra 0.1g, Radix Ophiopogonis 0.312g, Radix Schisandrae Bicoloris 0.156g.

Claims

1, a kind of SHENGMAI ZHUSHEYE is characterized in that containing in every 1ml injection and is equivalent to primary dose: Radix Ginseng Rubra 0.1g, Radix Ophiopogonis 0.312g, Radix Schisandrae Bicoloris 0.156g.

2, the preparation method of SHENGMAI ZHUSHEYE as claimed in claim 1 is characterized in that getting Radix Ginseng Rubra and mixes with Radix Ophiopogonis, extracts with alcohol dipping, alcohol reflux; Radix Schisandrae Bicoloris with steam distillation, decocting boil, alcohol precipitation extracts, two kinds of formulated injections of extracting solution merging that then will be collected, its processing step is:

A, preparation Radix Ginseng Rubra, Radix Ophiopogonis extract

(1) gets Radix Ginseng Rubra and mix, use alcohol dipping, filter, collect filtrate, get impregnation liquid 1. with Radix Ophiopogonis;

(2) medicinal residues alcohol reflux filters, and collects filtrate, gets extracting solution 2.;

(3) medicinal residues washing with alcohol filters, and collects filtrate, gets cleaning mixture 3.;

(4) get impregnation liquid 1., extracting solution 2., 3. cleaning mixture merge, cold preservation is left standstill, filter, add the active carbon (by dispense liquid and calculating) of 6-9%, stir, filter, decompression recycling ethanol is added an amount of water for injection to there not being the alcohol flavor, and hot reflux is handled, cooling, transfer pH value to 6-8 with sodium hydroxide solution, cold preservation, Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 4.;

B, preparation Radix Schisandrae Bicoloris extracting solution

(6), medicinal residues decoct with water, and filter, concentrate, add ethanol and make and contain the alcohol amount and reach 70-80%, leave standstill, filter, reclaim ethanol to there not being the alcohol flavor, concentrate, add ethanol and make and contain the alcohol amount and reach 85-92%, cold preservation is placed, and filters, add the active carbon (by the dosing volume calculation) of 2-3%, stir, filter, transfer pH value to 6-8 with sodium hydroxide solution, get northern flavor reserve liquid 6.;

C, preparation SHENGMAI ZHUSHEYE

(7), get Radix Ginseng Rubra, Radix Ophiopogonis reserve liquid 5., filter, add the tween 80 (each calculates by dispense liquid) of 0.1-1%, be heated to and boil, 6. and mend and add to the full amount of water for injection put coldly, add the Radix Schisandrae Bicoloris reserve liquid, transfer pH value to 6-8, filter with sodium hydroxide solution, embedding, sterilization promptly gets pulse invigorating injection;

The prescription of d, preparation SHENGMAI ZHUSHEYE is: Radix Ginseng Rubra 100g, Radix Ophiopogonis, 312g, Radix Schisandrae Bicoloris 156g, an amount of water for injection of tween 80 were an amount of, made the 1000ml injection.

3, the preparation method of SHENGMAI ZHUSHEYE as claimed in claim 2 is characterized in that adding the ratio of activated carbon dosage: the amount of preparation Radix Ginseng Rubra, Radix Ophiopogonis extract is 7% (by the dosing volume calculation); The amount of preparation Radix Schisandrae Bicoloris extracting solution is 2% (by the dosing volume calculation)

4, as the preparation method of claim 2 or 3 described SHENGMAI ZHUSHEYE, the amount that it is characterized in that adding tween 80 is 0.5% (by the dosing volume calculation)

5, the preparation method of SHENGMAI ZHUSHEYE as claimed in claim 2 is characterized in that pH value transfers to 7.4-7.6.