CN1107348A - "Tiange" oral liquid and its preparing process - Google Patents

Abstract

The Tiange oral liquid is made up through decocting gastrodia tuber, Chinese angelica root dregs, eucommia bark, etc. in water and alcohol precipitation; decocting ginseng, astragalus root and tuckahoe in water, settling and filtering; mashing young dove, addition of acid, heating while pressurizing, recovering acid, diluting hydrolytic liquid, addition of activated carbon, obtaining supernatant and going through ion exchange resin; mixing above-mentioned obtained intermediates; filtering; and sterilization.

Description

"Tiange" oral liquid and its preparing process

The present invention with contain squab, Chinese medicine, health care oral liquid are relevant.Traditional newborn pigeon health goods and preparation method thereof are many to be that major ingredient is equipped with Fructus Lycii to boil, to stew composition steaming, stir-fry or the very low person of having of alcohol extraction nutrition recovery rate with squab, and Fructus Jujubae is given birth to Chinese medicines such as Rhizoma Imperatae, through baking, soaks, and precipitation is filtered and made health promoting wine.Method for making is with the squab unhairing, go to be placed on behind the intestinal fire go up roasting sallow to meat, other medicines (giving birth to except the Rhizoma Imperatae), also same roasting fragrant to doing, be mixed into while hot in the cylinder pond, with rice steeping in wine bubble.

The purpose of this invention is to provide a kind of nutritiously, have tonify deficiency, calm the nerves, defying age, resisting fatigue, raise immunity, Fructus Alpiniae Oxyphyllae support must effect " Tiange " oral liquid and the high preparation method of newborn pigeon nutrient composition recovery rate.

The present invention gets by Chinese medicine extraction liquid such as squab hydrolyzed solution and Rhizoma Gastrodiae are mixed.

Component of the present invention and consumption are as follows: weight %

Squab 10-20

Rhizoma Gastrodiae 1-15

Radix Ginseng 2-8

Radix Astragali 2-10

Radix Paeoniae Alba 5-20

Radix Angelicae Sinensis 2.5-10

Semen Ziziphi Spinosae 5-20

Poria 10-25

Rhizoma Polygonati 3-10

Cortex Eucommiae 1.5-10

Preparation method of the present invention is made up of following operation:

(1), stays Radix Angelicae Sinensis decocting liquid and residue with the Radix Angelicae Sinensis distillating extracting oil.

(2) with Rhizoma Gastrodiae, Radix Angelicae Sinensis residue, the Cortex Eucommiae, Semen Ziziphi Spinosae, Rhizoma Polygonati, Radix Paeoniae Alba decocting, precipitate with ethanol system liquid.

(3) with Radix Ginseng, the Radix Astragali, the Poria decocting boils, and system liquid is filtered in sedimentation.

(4) with the meat pigeon unhairing, remove internal organs, muddy flesh is worn in chopping, adds acid, heats, and after the pressurized treatments, reclaim under reduced pressure acid with the hydrolyzed solution thin up, adds activated carbon, and insulated and stirred gets clear liquid, and clear liquid is crossed ion exchange resin, measures the amino acid content of hydrolyzed solution.

(5) each operation system liquid merging of above-mentioned (1)-(4) is stirred evenly, filter, sterilization, fill, packing promptly gets oral liquid of the present invention.

Each component of operation of the present invention (2) decocts with water secondary, and each 2 hours, twice decocting liquid merging is concentrated into 1: each component gross weight of 1(: concentrated solution weight) adding ethanol to ethanol content was 60%, leaves standstill, and filters, and reclaims ethanol and must make liquid;

Each component of operation (3) decocts with water three times, and each 1.5 hours, decocting liquid merged and to be concentrated into 2: each component gross weight of 1(: concentrated solution weight), leave standstill, filter system liquid;

Operation (4) adds 5 times of amount 6N hydrochloric acid in the squab muddy flesh, be warmed to 110--120 ℃, and pressurization 100kpa handled 12 hours, filter hydrolyzed solution, reclaim under reduced pressure hydrochloric acid is thick to hydrolyzed solution, add the dilution of an amount of water after, add 3.5% active carbon, 80 ℃ of insulated and stirred 30 minutes, clear liquid, the weak-base anion-exchange resin of crossing by the 2N naoh treatment, collect effluent in hopper, till the solution pH value is 4.5-5.0 in groove.Measure the amino acid content of hydrolyzed solution, it is 500～1000 milligrams/100 milliliters hydrolyzed solutions that thin up makes amino acid content.

Oral liquid of the present invention is made up of Chinese medicine extract such as squab and Rhizoma Gastrodiae, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, has YIN nourishing, nourishes blood, effect such as calm the nerves, can be used for due to the deficiency of YIN dizzy, fatigue.But defying age, skin care strengthens body immunity.Press the pertinent regulations of " provisions for new drugs approval " through Chengdu Traditional Chinese Medical College institute of Chinese materia medica, from tonify deficiency, anti-peroxidation, immunomodulating, anti-stress, five aspects such as tranquillizing and allaying excitement are studied it and are cured mainly relevant main pharmacodynamics index with function.Pharmacodynamic experiment is the result show, the present invention has the nourishing YIN and benefiting blood effect, and can significantly increase the vigor of aged animal body endoperoxide enzyme, promotes the removing of cylinder super-oxidation lipid, can promote body's immunity, and certain resisting fatigue and tranquilizing effect are arranged.These pharmacological actions and clinical treatment effect of the present invention match.Oral liquid of the present invention is through animal acute toxicity test, and conclusion is that peroral administration maximum tolerated dose is more than the 240g/kg, is equivalent to 360 times of Coming-of-Age Day consumption; The maximum tolerated dose of intraperitoneal injection is more than the 80g/kg, is equivalent to 120 times of Coming-of-Age Day consumption.Clinical use is safe.Through long-term toxicity test for animals, result of the test shows: the present invention was to the continuous gastric infusion of large, medium and small three dosage groups 28 days, growth promoter to animal, liver, renal function and hematology all do not have the overt toxicity detrimental effect, through PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM, the heart of animal, liver, spleen, lung, kidney, adrenal gland do not see the pathomorphology infringement yet.This shows that the present invention has no side effect to human body, safety is good.

Preparation technology's refine of the present invention, rigorous.Physicochemical property at the contained effective active matter of various components adopts different process to extract respectively.Squab adopts acid-hydrolysis method to produce aminoacid, and nutrition recovery rate height is 130 times of traditional handicraft.

Following is embodiments of the invention:

Component of the present invention and consumption are as follows:

Preparation technology for Radix Angelicae Sinensis by distill distillate (), its residue and Rhizoma Gastrodiae, the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Ziziphi Spinosae, Rhizoma Polygonati decoct with water secondary, each 2 hours, the secondary decocting liquid merged and to be concentrated into 1: 1, adding alcohol is 60% to containing the alcohol amount, leaves standstill, and filters.Reclaim ethanol and get (two).Radix Ginseng, the Radix Astragali, Poria decoct with water three times, and each 1.5 hours, decocting liquid merged and to be concentrated into 2: 1, leaves standstill, filter (three).The squab unhairing is removed internal organs, chopping, wear into muddy flesh, add 5 times of amount 6N hydrochloric acid, heat between 110-120 ℃, pressurization 100kpa handled 12 hours, filtered reclaim under reduced pressure hydrochloric acid, be thick to hydrolyzed solution, add the dilution of an amount of water after, add 3.5% activated carbon, 80 ℃ of insulated and stirred 30 minutes, clear liquid, the weak-base anion-exchange resin of crossing by the 2N naoh treatment is collected effluent solution pH value in hopper and is till 4.5～5.0.Measure amino acid content and get (four).Merge with (one), (two), (three) with by (four) of content ratio and to stir evenly filtration, sterilization, fill, packing promptly.

Claims (4)

1, " Tiange " oral liquid is characterized in that being mixed by Chinese medicine extraction liquid such as edible squab hydrolyzed solution and Rhizoma Gastrodiaes.

2, " Tiange " oral liquid according to claim 1 is characterized in that component and consumption are as follows: weight %

Edible squab 10-20

Rhizoma Gastrodiae 1-15

Radix Ginseng 2-8

Radix Astragali 2-10

Radix Paeoniae Alba 5-20

Radix Angelicae Sinensis 2.5-10

Semen Ziziphi Spinosae 5-20

Poria 10-25

Rhizoma Polygonati 3-10

Cortex Eucommiae 1.5-10

3, " Tiange " oral liquid preparation method is characterized in that being made up of following operation:

(1), stays Radix Angelicae Sinensis decocting liquid and residue with the Radix Angelicae Sinensis distillating extracting oil.

(2) with Rhizoma Gastrodiae, Radix Angelicae Sinensis residue, the Cortex Eucommiae, Semen Ziziphi Spinosae, Rhizoma Polygonati, Radix Paeoniae Alba water decoction-alcohol sedimentation system liquid.

(3) with Radix Ginseng, the Radix Astragali, the Poria decocting boils, and system liquid is filtered in sedimentation.

(4) with the meat pigeon unhairing, remove internal organs, muddy flesh is worn in chopping, adds acid, heats, and after the pressurized treatments, reclaim under reduced pressure acid with the hydrolyzed solution thin up, adds activated carbon, and insulated and stirred gets clear liquid, and clear liquid is crossed ion exchange resin, measures the amino acid content of hydrolyzed solution.

(5) each operation system liquid merging of above-mentioned (1)-(4) is stirred evenly, filter, sterilization, fill, packing is promptly.

4, " Tiange " oral liquid preparation method according to claim 3 is characterized in that each component prescription is: weight %

Edible squab (trophophase is in March) 10-20

Rhizoma Gastrodiae 1-15

Radix Ginseng 2-8

Radix Angelicae Sinensis 2-10

Radix Astragali 5-10

Cortex Eucommiae 2.5-10

Radix Paeoniae Alba 5-20

Semen Ziziphi Spinosae 10-25

Poria 3-10

Rhizoma Polygonati 1.5-10

Each component of operation (2) decocts with water secondary, and each 2 hours, twice decocting liquid merging is concentrated into 1: each component gross weight of 1(: concentrated solution weight), adding ethanol to ethanol content was 60%, leaves standstill, and filters, and reclaims ethanol and must make liquid;

Each component of operation (3) decocts with water three times, and each 1.5 hours, decocting liquid merged and to be concentrated into 2: each component gross weight of 1(: concentrated solution weight), leave standstill, filter system liquid;

Operation (4) adds 5 times of amount 6N hydrochloric acid in the squab muddy flesh, be warmed to 110--120 ℃, and pressurization 100kpa handled 12 hours, filter hydrolyzed solution, reclaim under reduced pressure hydrochloric acid is thick to hydrolyzed solution, add the dilution of an amount of water after, add 3.5% active carbon, 80 ℃ of insulated and stirred 30 minutes, clear liquid, the weak-base anion-exchange resin of crossing by the 2N naoh treatment, collect effluent in hopper, till the solution pH value is 4.5-5.0 in groove.Measure the amino acid content of hydrolyzed solution, it is 500～1000 milligrams/100 milliliters hydrolyzed solutions that thin up makes amino acid content.