CN1255147C - Oral liquid for preserving one's longevity - Google Patents

Abstract

The present invention relates to a pure Chinese medicine preparation, particularly to oral liquid for preserving longevity, which has good curative effect on patients who have kidney-yin deficiency symptoms. The oral liquid is prepared from medicinal indianmulberry root, wolfberry fruit, rehmannia root, fleece-flower root, broomrape, dodder, palmleaf raspberry fruit, atractylodes macrocephala, himalayan teasel root, radix cyathulae, tuckahoe, manchurian wildginger, plantain seed, polygala, grassleaf sweelflag rhizome, chrysanthemum and wolfberry bark according to specific portions. The oral liquid has the functions of tonifying five visceras, strengthening tendons and bones, blackening hair, dredging venation, preventing and curing presenility, preserving longevity, prolonging life, resisting tiredness, preventing senility, losing weight, resisting senility and beautifying faces. The present invention is suitable for the long-term administration of persons in middle and old ages and has the curative effect on patients who have kidney-yin deficiency symptoms. Through 300 cases of clinical tests, the total effective rate of the present invention is 88.3%. The present invention has conspicuous and determined curative effect.

Description

A kind of oral liquid for the treatment of the kidney yin deficient syndrome

[technical field]

The present invention relates to a kind of pure Chinese medicinal preparation, refer to kidney yin deficient syndrome patient is had the Oral liquid for preserving one's longevity of good curing effect especially.

[background technology]

In prior art, the research of life lengthening side's medicine is one of field of very paying attention to, our times various countries.China is the cradle of Chinese medicine, and ancient Chinese medicine doctor leaves many effective life lengthening good recipes, and its development based on inheritance is wide, and the happiness of make health of people longevity, enjoying one's declining years reduces disease, mostly is the mankind and does some contribution, and the act of this sincere supreme good also; Good health and a long life are the common wishes of people.According to The Statistics to nineteen eighty-two the whole world more than 60 years old the old man be about 500,000,000 zero 400 ten thousand, account for 12% of whole world population.China more than 60 years old the old man account for 8% of China's total population, at present the average life of Chinese people just year by year near 70 years old, steps into aged society.The kidney being the origin of congenital constitution, the root of life, and people's aging is the predicament that the old people faces from renal failure.The growth of human body, growth, aging are decided by the prosperity and decline of kidney vital essence, and soreness of the waist and knees, insomnia forgetfulness, alopecia luxated tooth, hyposexuality due to the deficiency of the kidney yin influence life-span of people.At present medicine, the patent of treatment kidney disease are more, and prescription is different, and be in the majority with capsule, oral liquid formulation, but curative effect is general.

[summary of the invention]

The objective of the invention is provides a kind of to control kidney at above-mentioned deficiency, evident in efficacy, and then reaches the Oral liquid for preserving one's longevity of life lengthening purpose.

Technical solution of the present invention is: Oral liquid for preserving one's longevity is characterized in that it is made by the crude drug of following weight and conventional oral liquid additive: Radix Morindae Officinalis, Fructus Lycii, Radix Rehmanniae, Radix Polygoni Multiflori, Herba Cistanches, Semen Cuscutae, Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Radix Achyranthis Bidentatae, Poria, Herba Asari, Semen Plantaginis, Radix Polygalae, Rhizoma Acori Graminei, Flos Chrysanthemi, each 30-60 part of Cortex Lycii.Can also adopt conventional the process of preparing Chinese medicine to handle to Radix Polygoni Multiflori, Radix Rehmanniae.

Radix Morindae Officinalis, Fructus Lycii, Radix Rehmanniae are monarch in the side, are intended to the kidney invigorating; Radix Polygoni Multiflori, Herba Cistanches, Semen Cuscutae, Fructus Rubi be kidney tonifying, essence replenishing also, and assisting the monarch drug the kidney invigorating is ministerial drug; The Rhizoma Atractylodis Macrocephalae, Poria spleen invigorating eliminating dampness by diuresis, Radix Dipsaci, Radix Achyranthis Bidentatae, the strong muscles and bones of Herba Asari, the dispelling wind collateral dredging more has Radix Polygalae, Rhizoma Acori Graminei to feel at ease to repose, the Fructus Alpiniae Oxyphyllae of having one's ideas straightened out, the Flos Chrysanthemi clearing eyes-improving is an adjuvant drug; The Cortex Lycii clearing away heat and cooling blood, reducing the asthenic fever, in case living stagnant, the living heat of invigorating middle warmer, going into kidney again is messenger drug.Characteristics such as full side's tonify without causing stagnation is grown and oiliness, and the invigorating middle warmer residence rushes down, and the property of medicine is gentle, so the energy tonifying five ZANG-organs, muscle reinforcing and bone strengthening is stayed appearance, black hair, the fiber crops pain of loosing, clothes of a specified duration are made light of one's life by commiting suicide anti-old.

Method for making: 1, Rhizoma Acori Graminei, Herba Asari, Flos Chrysanthemi, the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci are placed the jar decocting in water three times (2,2,1 hours) that extracts volatile oil.Adding for the first time 8 times of water gagings boils and collects volatile oil simultaneously and the volatile oil emulsion is standby.For the second time, add 6 times of water gagings for three times and decoct and filter, merging filtrate is concentrated into relative density more than 1.25, adds the ethanol precipitate with ethanol, makes sedimentation and filtration, decompression, reclaims ethanol, (g/ml) is standby to be concentrated into 1: 1.

2, with the clean Chinese crude drug of remaining 12 flavors 45-55% alcohol reflux three times (3,2,1 hours), filter, reclaim ethanol, merge concentrated solution, water precipitating gets supernatant and Xian's liquid merges filtration, and (g/ml) is standby to be concentrated into 1: 1.

3, sorbic acid filters standby with dissolve with ethanol.

4, drop in the preparation tank 1,2, add the sweet close element of volatile oil emulsion flavoring agent, under constantly stirring, be added dropwise to sorbic acid ethanol liquid, add the proper amount of fresh distilled water, stir, the sucking filtration packing, promptly.

On dosage form, be preferably oral liquid, can also make other regular dosage form in the pharmacy, as tablet, capsule, granule, medicated wine or the like.

Function and indication: tonifying five ZANG-organs, muscle reinforcing and bone strengthening.Can crow must hair color, promotion of blood circulation.Be used for prophylactic treatment senilism, the foster longevity is long-living, and anti-tired anti-old, it is anti-old that the people is made light of one's life by commiting suicide, and appearance is shone.Middle-aged and elderly people can be taken for a long time.Kidney yin deficient syndrome patient there is the good curing effect.

Through Changchun Traditional Chinese Medical College Chinese medicine clinical pharmacology base Oral liquid for preserving one's longevity (claiming again: support long-living oral liquid of longevity) acute toxicity test is shown that particular content safe in utilization is:

Materials and methods:

1, animal: 20 of kunming mices, body weight 18-22g (Changchun Biological Products Institute provides).

2, medicine: support long-living oral liquid of longevity, specification 10ml/ props up, and contains crude drug 1.25g.

3, method: rest long-living oral liquid of longevity with evaporating dish concentrate one times (every milliliter contains crude drug 0.25 gram } after, every mouse stomach gives 0.5ml, i.e. 6.25g/kg body weight is equivalent to the people and intends with dosage 250 times, observed 14 days the reaction that the record animal occurs after the administration continuously.

The result:

Observed 14 days continuously after administration, all animals do not see unusual performance, none death, and The above results shows that the administration of its mouse oral clothes surpasses the 6.25g/kg body weight to the maximum tolerated dose of supporting long-living oral liquid of longevity, is higher than the people and intends with dosage 250 times.

Show that to supporting long-living oral liquid clinical trial of longevity the clinical use of this medicine is safe, and kidney yin deficient syndrome patient is had the good curing effect through the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science.This organizes 400 examples, and 300 examples are organized in treatment, matched group 100 examples.Observed result shows: treatment group (supporting long-living oral liquid of longevity), and 85 examples of fully recovering account for 28.3%, and produce effects 117 examples account for 39.0%, and effective 63 examples account for 21.0%, and invalid 35 examples account for 11.6%, and total effective rate is 88.3%.Matched group (strong kidney calm the nerves liquid), 27 examples of fully recovering account for 27.0%, and produce effects 38 examples account for 38.0%, and effective 20 examples account for 20.0%, and invalid 15 examples account for 15.0%, and total effective rate is 85.0%.Compare P＞0.05 between treatment group and matched group curative effect group.Illustrate that general curative effect treatment group is consistent with matched group.Two groups of the syndrome integrations to the treatment front and back, tcm syndromes change all improve significantly (P＜0.05).Observe evaluation by safety, illustrate and support long-living oral liquid of longevity to blood, urine, just routine, liver, renal function, electrocardiogram have no adverse effects, also the end finds that other is as toxic and side effects such as nausea and vomiting, stomachache, nervous, allergy, the clinical use that this medicine is described is safe, and kidney yin deficient syndrome patient is had the good curing effect.

Advantage of the present invention is: the pure Chinese medicine system that 1, has no side effect, and characteristics such as this product has tonify without causing stagnation, grows and oiliness, and the invigorating middle warmer residence rushes down, and the property of medicine is gentle, thus can be anti-ageing always anti-, life prolonging is applicable to that middle-aged and elderly people takes for a long time.2, be point of penetration to control kidney, reinforcing the kidney and supporting YANG (zest function, the sexual disorder when making old kidney is improved) arranged, strong muscles and bones, expelling wind and removing dampness and invigorating the liver and kidney, promoting the circulation of blood arteries and veins, expelling wind and cold, effects such as the clearind deficient heat and the silt eliminating carbuncle that looses all have benefiting action to the five internal organs, reach the effect of life lengthening.3, can prevent and treat senilism, aging, tonification the five internal organs, strong muscles and bones, crow palpus hair color, promotion of blood circulation, it is anti-old that the people is made light of one's life by commiting suicide, energetic, refreshment, appearance is shone, can treat weakly after being ill, all diseases of senilism and sexual disorder of suffering from a deficiency of the kidney are applicable to that middle-aged and elderly people takes for a long time.

4, through clinical 300 patients are tested, total effective rate is 88.3%, and is evident in efficacy, definite.

Below in conjunction with embodiment the present invention is described in further detail.

[specific embodiment]

Embodiment 1:

Oral liquid for preserving one's longevity is made 500 by the crude drug and the conventional oral liquid additive of following weight, every 10ml: Radix Morindae Officinalis, Fructus Lycii, each 50 gram of Radix Rehmanniae, Radix Polygoni Multiflori, Herba Cistanches, Semen Cuscutae, each 60 gram of Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Radix Achyranthis Bidentatae, Poria, each 40 gram of Herba Asari, Semen Plantaginis, Radix Polygalae, Rhizoma Acori Graminei, Flos Chrysanthemi, each 50 gram of Cortex Lycii.Oral one time one, every day 2-3 time.

Case:

The patient, labor xx, man, 45 years old, senior engineering Cheng Shi.This trouble what is examined over the past half year with dizzy, hypomnesis, hyposexuality in May, 1991, askes its medical history, be since year before the project of tackling problems, a tax on one's mind back of transition and dizzy gradually weak, hypomnesis, poor appetite, soreness of the waist and knees, alopecia, libido are extremely low.Hope that its complexion blackout is matt, two orders do not have god, and tongue body is aged, and pale tongue is dark, and tongue is cheated thin white.The heavy thin unable pair of chi of pulse condition very a little less than.Examine and be vertigo (deficiency of kidney-essence).This is that overwork injures Pi kidney, deficiency of kidney-essence.The logical marrow of kidney governing bones prolongs angry.Deficiency of kidney-essence, brain are become homeless and are supported then dizzy, forgetful, soreness of the waist and knees; Essence and blood can not alternate then " hair is the sign of blood condition " do not have its Rong Ze alopecia.Overstrain impairing the spleen, Pi loses key and transports then poor appetite; Deficiency of kidney-essence then libido is extremely sour low.Study carefully its notes method: be close on six or eight, multiple again because of overstrain, kidney tonifying, essence replenishing is the method for first-selection.This medicine is the effect of " tonifying five ZANG-organs, strengthening bone and muscle are stayed appearance, and black hair looses fiber crops bitterly, and clothes are made light of one's life by commiting suicide, prolonged life for a long time " just.So select this side to fry in shallow oil into oral liquid, put in the refrigerator and obey 10 milliliters, three times on the one at every turn.Dizzy healing after serveing on one month, reminiscence, strength foot, all illness recoveries from illness.

Claims (1)

1, a kind of oral liquid for the treatment of the kidney yin deficient syndrome is characterized in that it is made by the crude drug of following weight and conventional oral liquid additive: Radix Morindae Officinalis, Fructus Lycii, Radix Rehmanniae, Radix Polygoni Multiflori, Herba Cistanches, Semen Cuscutae, Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Radix Achyranthis Bidentatae, Poria, Herba Asari, Semen Plantaginis, Radix Polygalae, Rhizoma Acori Graminei, Flos Chrysanthemi, each 30-60 part of Cortex Lycii.