CN1718235A - Oral liquor preparation contg. radix bupleuri, and its prepn. method - Google Patents
Oral liquor preparation contg. radix bupleuri, and its prepn. method Download PDFInfo
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- CN1718235A CN1718235A CN200510084334.2A CN200510084334A CN1718235A CN 1718235 A CN1718235 A CN 1718235A CN 200510084334 A CN200510084334 A CN 200510084334A CN 1718235 A CN1718235 A CN 1718235A
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- 238000002360 preparation method Methods 0.000 title claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 77
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 70
- 238000003756 stirring Methods 0.000 claims abstract description 37
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 22
- 229930006000 Sucrose Natural products 0.000 claims abstract description 19
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 19
- 239000007864 aqueous solution Substances 0.000 claims abstract description 18
- 230000001954 sterilising effect Effects 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 11
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims description 51
- 241001180876 Saposhnikovia Species 0.000 claims description 18
- 239000005720 sucrose Substances 0.000 claims description 18
- 238000004064 recycling Methods 0.000 claims description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims description 17
- 238000004090 dissolution Methods 0.000 claims description 15
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract 3
- 241000202726 Bupleurum Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 4
- 210000004243 sweat Anatomy 0.000 description 4
- 206010063659 Aversion Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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Abstract
A Chinese medicine 'Zhengchaihu Yin' in the form of oral liquid is prepared from 6 Chinese-medicinal materials including bupleurum root, red peony root, tangerine peel, liquorice root, etc through decocting, filtering, concentrating, adding alcohol, stirring laying aside, filtering, recovering alcohol, concentrating, mixing with the aqueous solution of cane sugar and/or benzoic acid, stirring, filtering, adding water, stirring and sterilizing.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation technology thereof, particularly relate to a kind of Chinese medicine liquid oral medicine and preparation technology thereof.
Background technology
" Zhengchaihuyin " is flat the loosing of inducing sweat in the Ming Dynasty well-known doctor Zhang Jingyue Jing-Yue Complete Works, the representative side of treatment affection of exogenous wind-cold, compound preparation by Radix Bupleuri (Radix Bupleuri), Pericarpium Citri Reticulatae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are formed has dispersing wind-cold, the effect of antipyretic analgesic.
" the tcm clinical practice pharmacology of Chinese medical formulae " stated and is affection of exogenous wind-cold, and battalion defends and becomes estranged, and controls suitable Xie Biaoheying, and with the hot pathogenic factor in the exterior that looses of Radix Bupleuri, expelling pathogenic factors from muscles is diathermanous.Radix Paeoniae tonifying YIN and battalion, both compatibilities, expelling pathogenic factors from muscles and battalion to be controlling the cold and heat general pain, Radix Saposhnikoviae, the hot temperature of Rhizoma Zingiberis Recens is evacuated, and helps the Radix Bupleuri expelling pathogenic factors from the exterior that induces sweat, and Pericarpium Citri Reticulatae compatibility Radix Bupleuri regulating functional activities of vital QI, gets rid of evils and goes out.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.We's property of medicine is gentle, is the flat agent of loosing of Xie Biaoheying.
Hot cool evacuation of " tcm prescription logical releases " Radix Bupleuri induced sweat, but it hotly coolly is not inconsistent with card, so the Radix Saposhnikoviae of the hot warm dispersing wind-cold of compatibility, Rhizoma Zingiberis Recens to be to supervise, and compatibility like this has the diffusing wind of Xin Liang and must not tremble with fear, and hot temperature cold expelling and do not help the advantage of heat is so there is the meaning of flat dispersing wind and cold.The Radix Paeoniae relieving spasm to stop pain, Pericarpium Citri Reticulatae regulating qi-flowing for harmonizing stomach, preventing phlegm from forming and stopping coughing, the side of being like this, though hot cool and Xin Wen and usefulness, suffering is warm greater than hot cool, light diaphoretic prescription warm partially, dispersing wind-cold that the suffering of can yet be regarded as is put down.
" Zhengchaihuyin " is principal agent with Radix Bupleuri, is equipped with Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens to disperse the wind and cold at table, removes heating, aversion to cold; Join Radix Paeoniae with He Yingwei, and Radix Paeoniae is joined Radix Glycyrrhizae energy relieving spasm to stop pain, symptoms such as alleviation headache, extremities aching pain; It is pungent and sweet flavors can be used for dispersing, hot flat good agent of inducing sweat that Rhizoma Zingiberis Recens is joined Radix Glycyrrhizae.Its combination rationally, compatibility is rigorous, and is particularly outstanding to the effect of removing symptoms such as wind and cold bundle phenotype flu patient heating, aversion to cold, headache, extremities aching pain, and its former side enjoys ancient Chinese medicine doctor to praise highly, continue to use, treatment is definite reliable.Case observation confirms that said preparation treatment wind and cold bundle phenotype flu total effects reaches 100%, and symptoms such as patient's heating, aversion to cold, headache, extremities aching pain are had a better role.
The Chinese medicine preparation dosage form of Zhengchaihuyin has electuary (granule), capsule at present, and the leading dosage form of existing market is an electuary.
The Zhengchaihuyin liquid oral medicine has overcome incomplete, the shortcomings such as bioavailability is low, slow curative effect of absorption that the oral back of hard capsule exists because of physical-chemical reactions such as disintegrate and strippings; Shortcomings such as inconvenience that electuary (granule) takes and mouthfeel difference have been overcome.
Goal of the invention:
The objective of the invention is to overcome the defective of prior art, provide a kind of evident in efficacy, bioavailability is high, mouthfeel good, taking convenience, the acceptable Zhengchaihuyin liquid oral medicine of patient and preparation method thereof.
The object of the invention adopts following technical scheme to realize.
5 parts of Radix Bupleuri, 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts of Six-elements of Rhizoma Zingiberis Recens decoct with water, and collecting decoction filters, and filtrate concentrates; Add ethanol and make pure content reach 50%, stir, standing over night filters, and filtrate recycling ethanol is concentrated into clear paste; Sucrose and/or benzoic acid aqueous solution are joined in the clear paste, and mixing filters, and filtrate adds water and stirs evenly, embedding, and sterilization, promptly.
Beneficial effect:
Zhengchaihuyin liquid oral medicine oral administration can directly be absorbed after entering gastrointestinal tract, so absorb soon, produce effects is rapid, absorbs fully, and is evident in efficacy and mouthfeel good.
The specific embodiment:
Further specify the present invention below by specific embodiment.
Embodiment one:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, add 8 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.05～1.15 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.20～1.25 (50 ℃).With 2 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment two:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, add 8 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 2 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment three:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 2 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment four:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 8 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 2 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment five:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 2 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment six:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 2.5 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment seven:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens decocts with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, for the second time add 6 times of water gagings, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃): add ethanol and make pure content reach 50%, stir standing over night, filter, filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1.5 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment eight:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1 part of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
Embodiment nine:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1.5 parts of the water dissolution sucrose of clear paste amount 30%, 0.03 part in benzoic acid joins above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
Embodiment ten:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1.5 parts of the water dissolution sucrose of clear paste amount 30%, 0.04 part in benzoic acid joins above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
Embodiment 11:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1 part of the water dissolution sucrose of clear paste amount 30%, 0.03 part in benzoic acid joins above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
Embodiment 12:
5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, 1.5 hours for the first time, 1.5 hours for the second time, add 6 times of water gagings for the first time, add for the second time 6 times of water gagings, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1 part of the water dissolution sucrose of clear paste amount 30%, 0.04 part in benzoic acid joins above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
Claims (9)
1. a Zhengchaihuyin liquid oral medicine is characterized in that it is the medicament of being made by the raw material of following weight component: 5 parts of Radix Bupleuri, 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens.
2. Zhengchaihuyin liquid oral medicine according to claim 1 is characterized in that Radix Bupleuri is Radix Bupleuri in the described raw material.
3. Zhengchaihuyin liquid oral medicine according to claim 1 and 2 is characterized in that adding sucrose and/or benzoic acid again in the weight proportion of described raw material.
4. according to the described Zhengchaihuyin liquid oral medicine of claim 1-3, it is characterized in that adding sucrose 1.0-2.5 part and/or benzoic acid 0.02-0.06 part.
5. according to the described Zhengchaihuyin liquid oral medicine of claim 1-4, it is characterized in that its liquid oral medicine is oral liquid or mixture.
6. according to the described Zhengchaihuyin liquid oral medicine of claim 1-5, it is characterized in that its preparation method: 5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, Six-element decocts with water, collecting decoction filters, and filtrate concentrates; Add ethanol and make pure content reach 50%, stir, standing over night filters, and filtrate recycling ethanol is concentrated into clear paste; An amount of sucrose and/or benzoic acid aqueous solution are joined in the clear paste, and mixing filters, and filtrate adds water and stirs evenly, embedding, and sterilization, promptly.
7. according to the described Zhengchaihuyin liquid oral medicine of claim 1-6, it is characterized in that its preparation method: 5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water more than 1 time, decocting time is 1-2 hour, and amount of water is 6-8 times, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.05～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.20～1.35 (50 ℃).Water dissolution 1.0-2.5 part and/or benzoic acid 0.02-0.06 part with clear paste amount 30% join above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
8. according to the described Zhengchaihuyin liquid oral medicine of claim 1-7, it is characterized in that its preparation method: 5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water 2 times, each 1.5 hours, each amount of water was 6 times, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1.5 parts of the water dissolution sucrose of clear paste amount 30%, above-mentioned aqueous solution is joined in the clear paste, mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stirs evenly, embedding, sterilization, promptly.
9. according to the described Zhengchaihuyin liquid oral medicine of claim 1-8, it is characterized in that its preparation method: 5 parts of Radix Bupleuri (north), 4 parts of Radix Saposhnikoviaes, 7.5 parts of Radix Paeoniae Rubra, 5 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 3.5 parts in Rhizoma Zingiberis Recens, decoct with water secondary, each 1.5 hours, each amount of water was 6 times, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.20 (50 ℃); Add ethanol and make pure content reach 50%, stir, standing over night filters, filtrate recycling ethanol, and being concentrated into relative density is the clear paste of 1.25～1.30 (50 ℃).With 1.5 parts of the water dissolution sucrose of clear paste amount 30%, 0.04 part in benzoic acid joins above-mentioned aqueous solution in the clear paste, and mixing filters, and filtrate adds water and adjusts total amount to 1000ml, stir evenly, and sterilization, promptly.
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| CNB2005100843342A CN1311806C (en) | 2005-07-19 | 2005-07-19 | Oral liquor preparation contg. radix bupleuri, and its prepn. method |
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| CN1311806C CN1311806C (en) | 2007-04-25 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951494B (en) * | 2006-09-29 | 2010-05-26 | 北京汉典中西药研究开发中心 | Compound Chinese medicinal preparation for treating affection of external wind and cold and preparation method thereof |
| CN103272037A (en) * | 2013-06-20 | 2013-09-04 | 宋新 | Medicine for curing otitis media and preparation method thereof |
| CN104667144A (en) * | 2013-11-26 | 2015-06-03 | 天津中敖生物科技有限公司 | Traditional Chinese medicine oral liquid for treating ox influenza and preparation method thereof |
| CN106267110A (en) * | 2016-09-28 | 2017-01-04 | 广州凯耀资产管理有限公司 | A kind of preparation method for the flat Chinese medicine extract dissipated that induces sweat |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081906A (en) * | 1993-08-26 | 1994-02-16 | 河北省承德市中药厂 | Technology for producing granular preparation of bupleurum root |
| CN1616065A (en) * | 2004-09-30 | 2005-05-18 | 北京正大绿洲医药科技有限公司 | Zhengchaihuyin dripping pill |
-
2005
- 2005-07-19 CN CNB2005100843342A patent/CN1311806C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951494B (en) * | 2006-09-29 | 2010-05-26 | 北京汉典中西药研究开发中心 | Compound Chinese medicinal preparation for treating affection of external wind and cold and preparation method thereof |
| CN103272037A (en) * | 2013-06-20 | 2013-09-04 | 宋新 | Medicine for curing otitis media and preparation method thereof |
| CN104667144A (en) * | 2013-11-26 | 2015-06-03 | 天津中敖生物科技有限公司 | Traditional Chinese medicine oral liquid for treating ox influenza and preparation method thereof |
| CN106267110A (en) * | 2016-09-28 | 2017-01-04 | 广州凯耀资产管理有限公司 | A kind of preparation method for the flat Chinese medicine extract dissipated that induces sweat |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1311806C (en) | 2007-04-25 |
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