CN1210051C - Medicine for treating diarrhea and its preparation method - Google Patents
Medicine for treating diarrhea and its preparation method Download PDFInfo
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- CN1210051C CN1210051C CN 03111368 CN03111368A CN1210051C CN 1210051 C CN1210051 C CN 1210051C CN 03111368 CN03111368 CN 03111368 CN 03111368 A CN03111368 A CN 03111368A CN 1210051 C CN1210051 C CN 1210051C
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Abstract
The present invention relates to a medicine for curing diarrhea and a preparing method thereof, which belongs to the technical field of Chinese patent medicine production. The medicine for curing diarrhea uses celandine, cinquefoil, tuckahoe, coix seed, myrobalan and white atractylodes rhizome as raw materials, and is prepared through the processes of soaking, decocting with water, ethanol extraction, etc. according to proportion. The preparation is refined by medicines, and is suitable for various kinds of diarrhea which comprises acute and chronic diarrhea, and infection and noninfectious diarrhea. The present invention has the advantages of wide medicinal herbs resources, convenient application and wide indication.
Description
Technical field:
The present invention relates to a kind of treatment diarrheal medicine, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology:
Diarrhoea is clinical common frdquently encountered disease, is one of department of pediatrics four big diseases of China's keypoint control, the ill significant proportion that also accounts in the adult.Its harm is that protracted course of disease can cause malnutrition, influences children's upgrowth and development, and clinical in addition have some complication such as dehydration, electrolyte, acid base imbalance even a shock etc., and severe patient can cause death.
Both at home and abroad to the Drug therapy of primary disease, there is following problem at present:
1. antibiotics only is applicable to and suffers from diarrhoea due to the control of bacterial infection, but for a long time with causing dysbacteriosis, increases the weight of symptom, and the feelings of can causing a disease are delayed.
2. diarrhoea lacks the sure antiviral drugs of curative effect due to viral infection such as the rotavirus, and abuse of antibiotics is treated this type of and suffered from diarrhoea unhelpful and often harmful.
3. some Western medicine diarrhea toxic side effect can cause the reaction of infant stupor as diphenoxylate, and it is unfavorable to children's that bismuth subcarbonate absorbs.
4. microbial ecological agent and intestinal mucosa protection preparation only helps out to diarrhea treatment, and some curative effect of medication is not good enough.
5. intravenous administration treatment is compared slightly poorly than the oral medication curative effect, and is difficult for being accepted by the patient and the head of a family.
6. have several to treat this sick Chinese patent medicine at present, but indication has nothing in common with each other, the patient is difficult to buy medicine to the ill, and curative effect differs.
7. some medicine taste is not good enough, takes difficulty; Or dosage form such as tablet ` capsule etc., child administration inconvenience.
Summary of the invention:
The technical problem to be solved in the present invention is to disclose a kind of method that can treat the diarrheal medicine effectively and prepare this medicine.
The scheme of technical solution problem of the present invention adopts following component to make: (consumption is a weight portion)
Herba Chelidonii 5-30 Herba Potentillae Chinensis 5-25 Poria 8-25
Semen Coicis 6-20 Fructus Chebulae 5-20 Rhizoma Atractylodis Macrocephalae 3-15
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Herba Chelidonii 10-25 Herba Potentillae Chinensis 10-20 Poria 10-15
Semen Coicis 8-15 Fructus Chebulae 10-15 Rhizoma Atractylodis Macrocephalae 5-10
Prescription optimum weight (part) proportioning of medicine of the present invention is:
Herba Chelidonii 15 Herba Potentillae Chinensis 12 Poria 15
Semen Coicis 12 Fructus Chebulaes 15 Rhizoma Atractylodis Macrocephalaes 8
Above-mentioned each component is made medicine production method of the present invention is:
Get said medicine, normal-temperature water was soaked after 30 minutes, decocting 3 times each 1 hour, each amount of water is 2 times of material quantities, collecting decoction, slagging-off, filtration concentrate, cooling, add pharmaceutical ethanol, transfer determining alcohol 70%, stir evenly, left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.25--1.28, boils, filter, and on filter, add the water that newly boiled, and keeping away in the collarium border in cleaning and prepare, fill in time is in the clean dried container of sterilization, 100 milliliters every bottle, put the storage of shady and cool place.
Advantage:
1. pure Chinese medicinal preparation is applicable to all kinds of diarrhoea, comprises acute and chronic diarrhea; Infect and noninfectious diarrhea.
2. this medicine antidiarrheal not only, but infection and alleviate stomachache simultaneously.
3. do not have bitterness sense, be suitable for all kinds of crowds, especially pediatric patients is taken, and features good taste is taken conveniently.
4. the medicine source is wide, is easy to apply, and indication is extensive.
Theory of Chinese medical science is analyzed:
Theory of Chinese medical science thinks that The spleen has the function to transport and transform nutrients, if being invaded by exogenous pathogen, improper diet or sickness influence all can cause spleen fortune not normal, indigestion, and defeatedization of becoming thoroughly decomposed is not normal and to send out be to suffer from diarrhoea.Observe according to clinical case, filter out the medical herbs Herba Chelidonii, toil, tepor, but merit astringing to arrest diarrhea, relieving spasm to stop pain, and antitussive action is arranged." middle traditional Chinese medicines are planted will ": " controlling gastrointestinal distress and ulcer "; " northeast Chinese herbal medicine handbook commonly used is controlled dysentery stomachache with it.It has significant antiviral, antibacterium effect modern pharmacological research, and can alleviate gastrointestinal convulsion, the treatment pertussis.The clinical acute and chronic diarrhea that is used for the treatment of, evident in efficacy.Herba Potentillae Chinensis is bitter flat, returns liver, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery." Guizhou side's medicine among the people collection ": " controlling dysentery "; " Guizhou medicinal herbs among the people ": " heat-clearing and toxic substances removing ".It has antibacterial action modern pharmacological research, and amoeba trophozoite is had killing action.Poria is sweet, and is light, flat, GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming." property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary "; " concise exposition on febrile disease ": " the slow spleen of infiltration "; " curing mainly secret formula " cloud: antidiarrheal.It has diuresis modern pharmacological research, and is antibiotic and fall the effect of gastric acid.Semen Coicis is sweet light, and taste are returned in cold, lung meridian, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus." not Lu ": " sharp the intestines and stomach "; " detailed outline ": " invigorating spleen and reinforcing stomach "; " middle traditional Chinese medicines are planted illustrated handbook ": " controlling chronic gastrointestinal disease ".Modern pharmacological research its have analgesic, antiinflammatory, antibiotic, calmness, cooling effect.Fructus Chebulae's picric acid, puckery flat, return lung, large intestine channel.Astringing intestine to stop diarrhea is astringed the lung, the pathogenic fire reducing sore-throat relieving." Japan hanako materia medica ": " antidiarrheal dysentery, cholera ... digesting and appetizing, hemorrhoidal hamorrhage rushes down blood "; " explaining abstruseness of the canon of materia medica ": " simmer with then can the solid intestinal of warming the stomach ".It has antibiotic (dysentery bacterium) and cardiotonic modern pharmacological research.Rhizoma Atractylodis Macrocephalae hardship, Gan Wen returns the taste warp, invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive." property of medicine opinion ": " the broken dyspepsia that disappears, appetizing ... let out under ending ... preventing or arresting vomiting is contrary, cold type of pain in the abdomen, it is more than to vomit and diarrhoea, and the insufficiency of stomach-QI cold-dysentery "; " medicine origin ": " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, stomach function regulating, born fluid.It has strong, diuresis modern pharmacological research.
Routine case clinical observation surplus 400, curative effect is sure.Select complete person's 50 examples of case history,
The course of disease be this sky to 2 months, the observation period is 9 days, 3 days is a course of treatment.
Instructions of taking: 1-6 month 5 milliliters/time
7-12 month 8 milliliters/time
10 milliliters/time of 1-3 years
15 milliliters/time of 4-6 years
More than 7 years old 20 milliliters/time
Every day 3 times, oral.
The result:
Recovery from illness 38 examples in 3 days, recovery from illness 11 examples in 4-9 days, it is invalid to be only second to example, and effective percentage reaches 98%.
The specific embodiment:
Get Herba Chelidonii 150 grams, Herba Potentillae Chinensis 120 grams, Poria 150 grams, Semen Coicis 120 grams, Fructus Chebulae's 150 grams, the Rhizoma Atractylodis Macrocephalae 80 grams, normal-temperature water was soaked after 30 minutes, decocting 3 times each 1 hour, each amount of water is 2 times of material quantities, collecting decoction, slagging-off, filter, concentrate, cooling adds pharmaceutical ethanol, transfers determining alcohol 70%, stir evenly, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.28 clear paste, add sucrose, boil, filter, and on filter, add the water that newly boiled, keep away in the collarium border in cleaning and to prepare, fill in time 100 milliliters every bottle, is put the storage of shady and cool place in the clean dried container of sterilization.
Claims (4)
1, a kind of treatment diarrheal medicine is characterized in that it is the medicament of being made by the following weight proportion raw material
Herba Chelidonii 5-30 Herba Potentillae Chinensis 5-25 Poria 8-25
Semen Coicis 6-20 Fructus Chebulae 5-20 Rhizoma Atractylodis Macrocephalae 3-15.
2, treatment diarrheal medicine according to claim 1, wherein the weight proportion of each raw material is
Herba Chelidonii 10-25 Herba Potentillae Chinensis 10-20 Poria 10-15
Semen Coicis 8-15 Fructus Chebulae 10-15 Rhizoma Atractylodis Macrocephalae 5-10.
3, treatment diarrheal medicine according to claim 1, wherein the weight proportion of each raw material is
Herba Chelidonii 15 Herba Potentillae Chinensis 12 Poria 15
Semen Coicis 12 Fructus Chebulaes 15 Rhizoma Atractylodis Macrocephalaes 8.
4, according to the preparation method of claim 1,2 or 3 described treatment diarrheal medicines, it is characterized in that:
Get said medicine, normal-temperature water was soaked after 30 minutes, decocting 3 times each 1 hour, each amount of water is 2 times of material quantities, collecting decoction, slagging-off, filtration, concentrate, cooling adds pharmaceutical ethanol, transfer determining alcohol 70%, stir evenly, left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.25--1.28, boils, filter, and on filter, add the water that newly boiled, keep away in the collarium border in cleaning and prepare.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111368 CN1210051C (en) | 2003-04-02 | 2003-04-02 | Medicine for treating diarrhea and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111368 CN1210051C (en) | 2003-04-02 | 2003-04-02 | Medicine for treating diarrhea and its preparation method |
Publications (2)
| Publication Number | Publication Date |
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| CN1533785A CN1533785A (en) | 2004-10-06 |
| CN1210051C true CN1210051C (en) | 2005-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03111368 Expired - Fee Related CN1210051C (en) | 2003-04-02 | 2003-04-02 | Medicine for treating diarrhea and its preparation method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997993A (en) * | 2015-07-09 | 2015-10-28 | 张鑫 | Traditional Chinese medicinal preparation for treating colon infection diarrhoea |
| CN110368436A (en) * | 2019-08-14 | 2019-10-25 | 昆明科晔生物技术有限公司 | It is a kind of to treat chronic diarrhea Chinese medicine composition and preparation method thereof |
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2003
- 2003-04-02 CN CN 03111368 patent/CN1210051C/en not_active Expired - Fee Related
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| CN1533785A (en) | 2004-10-06 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050713 |