CN1083273C

CN1083273C - Chinese medicine detoxication preparation of giant gold silkwork

Info

Publication number: CN1083273C
Application number: CN98115850A
Authority: CN
Inventors: 钟起哲
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-07-13
Filing date: 1998-07-13
Publication date: 2002-04-24
Anticipated expiration: 2018-07-13
Also published as: CN1241430A

Abstract

The present invention relates to a Dajinchan Chinese medicine preparation used for detoxification, which is a detoxification medicine prepared from Chinese herbal medicines according to a scientific prescription. The prescription comprises the following components: rhubarb, honeysuckle flower, stiff silkworm, cicada slough, peppermint, bupleurum root and turmeric. The preparation comprises the following dosage forms: tablets, pills, medicinal powder, medicinal granules, oral medicinal liquid and injection, has good therapeutic effects on epidemic febrile diseases, internal heating and exopathic diseases, and has obviously therapeutic effects, such as allergy resistance, wind-evil elimination and itching alleviation on the treatment of urticaria.

Description

Giant gold silkwork Chinese medicine detoxicating preparation

Described giant gold silkwork Chinese medicine detoxicating preparation relates to the medicine that is used for antidotal therapy produced by a kind of science prescription with Chinese medicinal herbs, and it has fairly obvious curative effect to treatment viral influenza, urticaria etc.

The treatment that Chinese medicine is applied to the detoxifcation aspect records many prescriptions and medicine preparation technique on medical literature, also have many these class patent medicine and different preparation to use for treatment on the medical market.As adapt to the various detoxifying pills of common cold treatment, the electuary of bringing down a fever, adapt to some detoxicating preparations such as fangfeng tongsheng pill of urticaria treatment etc.The detoxifcation medicine of these different cultivars all has adaptability separately, and the state of an illness that adapts to is all had certain or significant curative effect.According to this quasi drugs being understood and the effect of treatment practice sees that some medicines mostly have reasonable special effect, the double preferably effect of controlling is arranged and the treatment of different viral infection just can not manifested.Some have the disease of viral infection, and as this common, multiple diseases such as flu, urticarias, certain detoxifcation medicine if can all adapt to treatment to this class disease, all has better curative effect will more meet medical meaning.

Direct purpose of the present invention provides a kind ofly has the double new drug of controlling effect to antidotal therapy, and promptly providing a kind of not only has significant curative effect to epidemic febrile disease, interior-heat diseases caused by exogenous pathogenic factor, and the detoxifcation Chinese medicine preparation of tangible antiallergic, deintoxication, relieving itching can be arranged on the treatment urticaria again.

Detoxicating preparation of the present invention is on the basis of the prescription studied providing, and the several formulations that can be made into also is provided.On the prescription composition, Radix Et Rhizoma Rhei (claiming Radix Et Rhizoma Rhei etc. again), Flos Lonicerae (titles such as Flos Lonicerae are arranged), Bombyx Batryticatus (also claiming flying worm etc.), Periostracum Cicadae (also claiming Cicadae shell etc.), Herba Menthae (also claiming southern Herba Menthae etc.), Radix Bupleuri (comprising other title), Rhizoma Curcumae Longae Chinese medicinal herbses such as (comprising other call) are arranged.When specifically producing, the amount ratio of each composition (dry weight ratio) is that Radix Et Rhizoma Rhei accounts for 27～32, and Flos Lonicerae accounts for 27～32, Bombyx Batryticatus 13～18, Periostracum Cicadae 6～9, Herba Menthae 6～9, Radix Bupleuri 6～9, Rhizoma Curcumae Longae 2～4.The medicament of making is divided into tablet, pill, powder, electuary, oral liquid, injection.Processing to concrete composition all need be made inter-level earlier, and the need that have are processed separately, have can with other composition hybrid process, various processing methods all can take known technical method to carry out.For making medicine is sheet, ball, diffusing solid-state when taking agent, and the inter-level that Radix Et Rhizoma Rhei, Flos Lonicerae are formed respectively is the fine powder through pulverizing; It is inter-level that Herba Menthae will be carried volatile oil earlier, and recrement can boil with other composition; Remaining Bombyx Batryticatus, Periostracum Cicadae, Radix Bupleuri, Rhizoma Curcumae Longae, Herba Menthae recrement will be endured through adding decocting in water, filter, concentrate and formation thick paste inter-level.Utilize these acquired inter-levels, make required sheet, ball, the diffusing various solid-state dosage forms of taking again respectively.When making medicine and be electuary, oral liquid, each material composition all must make liquid inter-level earlier, just Radix Et Rhizoma Rhei should take the alcohol solvent solvent extraction method to carry out, Herba Menthae still needs to extract volatile oil earlier, and Flos Lonicerae, Herba Menthae recrement can together be taked to add decocting in water with Bombyx Batryticatus, Periostracum Cicadae, Radix Bupleuri, Rhizoma Curcumae Longae and endure method and produce inter-level.Afterwards, can make the water-soluble electuary that is made into the diffusing type of grain, liquid oral liquid respectively.Producing for the processing of injection liquor is to take the way of distillation on the basis that obtains injection stock solution, doses auxiliary element again and makes.

The major advantage of described Chinese medicine antidote is: it has the treatment of significantly holding concurrently to imitate to the antidotal therapy of diseases such as epidemic febrile disease, interior-heat diseases caused by exogenous pathogenic factor, urticaria, and existing disease-resistant bacterium, antiviral effect have the effect of antiallergic, deintoxication, relieving itching again; The raw material sources that use are abundant, cheap, preparation method is simple; Can be made into multiple dosage form, conveniently take, family can be standing.

Several embodiment are provided below, the method for making of described Chinese medicine detoxicating preparation in conjunction with concrete dosage form is further described below.In the embodiment that provides, the use amount of each composition has only adopted a kind of in the prescribed limit, because no matter adopt which kind of ratio combination not influence producing of predetermined dosage form, though can make drug effect different, all have result of use.The amount ratio that each composition is taked is (by a dry weight): Radix Et Rhizoma Rhei 32, Flos Lonicerae 29, Bombyx Batryticatus 16, Periostracum Cicadae 8, Herba Menthae 6, Radix Bupleuri 6, Rhizoma Curcumae Longae 3.

Embodiment 1: this example is the method for making of tablet, pill, powder.In producing, make earlier each inter-level respectively.

Produce Radix Et Rhizoma Rhei, Flos Lonicerae fine powder: through cleaning, after the cutting, taking circulation sterilization 45 minutes, the oven dry of carrying out again below 70 ℃ is handled, and rolls into 100 order fine powders altogether with the disintegrating apparatus that cleans afterwards with Radix Et Rhizoma Rhei, Flos Lonicerae, inter-level and standby.

Produce Herba Menthae Haplocalycis volatile oil: Herba Menthae is placed volatile oil extractor, add 10～12 times in water, extract volatile oil.Recrement is again with all the other composition lixiviates.

Produce the mixed thick paste of Bombyx Batryticatus, Periostracum Cicadae, Radix Bupleuri, Rhizoma Curcumae Longae and Herba Menthae recrement: decocting in water be added together carry twice, obtain lixiviating solution.Add 8 times in water for the first time, boiled 2 hours, add 6 times in water for the second time, boiled 1 hour.To twice lixiviating solution system of filtering, mixed, concentrated, make it to form spissated mixed thick paste.

Utilize acquired inter-level to make required dosage form more respectively.Radix Et Rhizoma Rhei, Flos Lonicerae fine powder are added in the mixed thick paste of Bombyx Batryticatus, Periostracum Cicadae, Radix Bupleuri, Rhizoma Curcumae Longae, Herba Menthae slag, stir.Then, be divided into fritter, dry naturally or oven drying at low temperature.After doing, make 80～100 order fine powders again, and fine powder is made soft material, made the granule of 16～18 mesh sieves again with 50% ethanol.After treating that granule is done, evenly sprayed Oleum menthae also airtight 2 hours.After this, utilize 0.5% hard magnesium even mixed again, just can make tablet, pill, powder respectively.

Embodiment 2: this example is the method for making of electuary, oral solutions.

Produce big yellow filtrate: Radix Et Rhizoma Rhei powder is broken into coarse powder, makes solvent with the ethanol of concentration 60%, flooded 24 hours, filter with the speed of 1～3 milliliter of per minute, collect filtrate just, other deposits; Surplus person continues diafiltration, to the filtrate color light till, and it is concentrated into thick.Afterwards, add filtrate mixing just, add 60% ethanol dilution again, leave standstill, clarify, refilter, promptly get big yellow filtrate as inter-level.

Produce Herba Menthae Haplocalycis volatile oil: it is added 10～12 times in water, adopt volatile oil extractor to produce, standby.

Produce mixed digestion liquid: Flos Lonicerae, Bombyx Batryticatus, Periostracum Cicadae, Radix Bupleuri, Rhizoma Curcumae Longae and Herba Menthae recrement are added decocting in water together carry twice.Add 8 times of water for the first time, boiled 2 hours, add 6 times of water for the second time, boiled 1 hour, filter twice leach cooking liquid of system, merge it, standby.

Big yellow filtrate, mixing digestion liquid are merged the clear paste that mixes and be concentrated into than 1.38～1.40.When need are made electuary, promptly press clear paste and be standard for 1 part, other fills out, and 3 parts of auxiliary element sucrose, 1 part in dextrin and adequate amount of ethanol are mixed makes granule, and after drying, spray mixes Oleum menthae, promptly gets required electuary.When need are made oral liquid, be standard with 1 part of clear paste, with the suitable quantity of water dilution, filter, add simple syrup, sodium benzoate, add 2 parts in water again, cold preservation filters, and is packaged in the 10ml ampoule, promptly gets required oral liquid in 30 minutes with 100 ℃ of sterilizations.

Embodiment 3: this example is the method for making of injection.

Radix Et Rhizoma Rhei, Flos Lonicerae, Bombyx Batryticatus, Periostracum Cicadae, Herba Menthae, Radix Bupleuri, Rhizoma Curcumae Longae are added 4～5 times of clear water together to be soaked, treat fully to soak and carry out primary distillation after expanding, again acquired distillate is just carried out the multiple level distillation of secondary, obtain the tween 80 that multiple distillate adds conventional amount used, Herba Menthae Haplocalycis volatile oil is dissolved fully, so just produce injection stock solution through shake, injection stock solution is dosed sodium chloride, added the injection water, add 0.5% active carbon, mix homogeneously, filtration have promptly obtained practical injection.Carry out packing, the sterilization can provide medical.

Claims

1, giant gold silkwork Chinese medicine detoxicating preparation, the prescription composition that it is characterized in that this detoxicating preparation has Radix Et Rhizoma Rhei, Flos Lonicerae, Bombyx Batryticatus, Periostracum Cicadae, Herba Menthae, Radix Bupleuri, Rhizoma Curcumae Longae, each composition in the producing of preparation by the shared proportioning of dry weight is: Radix Et Rhizoma Rhei 27-32, Flos Lonicerae 27-32, Bombyx Batryticatus 13-18, Periostracum Cicadae 6-9, Herba Menthae 6-9, Radix Bupleuri 6-9, Rhizoma Curcumae Longae 2-4.

2, detoxicating preparation according to claim 1 is characterized in that its preparation type has tablet, pill, powder, electuary, oral solutions, injection liquor.