CN1089848A - SHUANGHUANGLIAN JIAONANG and preparation method thereof - Google Patents
SHUANGHUANGLIAN JIAONANG and preparation method thereof Download PDFInfo
- Publication number
- CN1089848A CN1089848A CN 93100903 CN93100903A CN1089848A CN 1089848 A CN1089848 A CN 1089848A CN 93100903 CN93100903 CN 93100903 CN 93100903 A CN93100903 A CN 93100903A CN 1089848 A CN1089848 A CN 1089848A
- Authority
- CN
- China
- Prior art keywords
- radix scutellariae
- grams
- ethanol
- hour
- flos lonicerae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention is to provide a kind of SHUANGHUANGLIAN JIAONANG and preparation method thereof.It is Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae that its raw material is formed.Mixing after Radix Scutellariae and Flos Lonicerae and Fructus Forsythiae extract respectively, is that concentrating under reduced pressure becomes thick paste under 7.0～7.5 the condition at pH value, drying, pulverizes, incapsulates.Method of the present invention is simple, and the product of making has antibacterial widely, antivirus action.Evident in efficacy to the upper respiratory tract infection, influenza, pneumonia, tonsillitis, the bronchitis that cause because of antibacterial and viral infection.
Description
The present invention relates to a kind of pharmaceutical product and preparation method thereof, particularly derive from pharmaceutical product of vegetable material and preparation method thereof.
SHUANGHUANGLIAN ZHUSHEYE is recorded in the 75th page of 86 years version of Heilongjiang Province's standard, is used for the treatment of the various infection of coccus.It mainly adopts Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae is that raw material is processed into aqueous injection or injectable powder.But it exists injection and causes pain, need use very inconveniently in hospital, even occurs phenomenons such as pyrogen reflection, erythra.And its preparation method more complicated.
The object of the present invention is to provide a kind of easy to use, eutherapeutic bi-coptis-chinensis product and preparation method thereof.
The object of the present invention is achieved like this: it is made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae.Per 200 finished products are restrained by Flos Lonicerae 300～400 grams, Radix Scutellariae 300～400 grams, Fructus Forsythiae 600～800, Radix Scutellariae decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filtration, filtrate is concentrated into 3 times of crude drug amount, in the time of 80 ℃, add hydrochloric acid (2mol/l) and transfer pH value to 1.0～2.0, be incubated 1 hour, leave standstill, filter, precipitate is 5 with hot water wash to pH value, and being washed till pH value with 70% ethanol is 7.0.Make Radix Scutellariae glycoside extract.Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.2～1.25(75～80 ℃ surveys that filtrate is concentrated into relative density), slowly add ethanol when being chilled to 40 ℃, make to contain alcohol two and reach 75%, fully stir, leave standstill, it is an amount of that leaching supernatant, residue add 75% ethanol, leave standstill, filter, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor.Add Radix Scutellariae glycoside extract solution, stir evenly, and transfer pH value to 7.0～7.5, concentrating under reduced pressure becomes thick paste, pulverizes after the cold drying, encapsulatedly promptly can be made into product of the present invention.Wherein cold drying also can spray drying.
The present invention is a raw material with Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, and every flavor medical material is decocted separately, extracts active ingredient wherein, spray-dried, capsule is made in packing, compares the advantage that has easy to use, painless, safe and reliable, in light weight, good stability, easily stores and transport with injection.The SHUANGHUANGLIAN JIAONANG that adopts method of the present invention to make proves that through bacteriostatic test shigella, Bao Salmonella, Salmonella, bacillus pyocyaneus etc. are had inhibitory action.Antivirus action is wide, popularity rib adenitis virus, adenovirus type III, Coxsackie B virus
3Type, Chinese mugwort can viral 11 types, herpes simplex virus type 2 has remarkable inhibitory action.Through evidence to disease total effective rates 93% such as upper respiratory tract infection, influenza, pneumonia, tonsillitis, bronchitis, to influenza virus A curative effect obvious effective rate 92.8%, to the public cellular virus curative effect of respiratory tract obvious effective rate 87.5%, to influenza virus second obvious effective rate 75%.
For example the present invention is described in detail below:
The raw material of per 200 capsules consists of Flos Lonicerae 375 gram, Radix Scutellariae 375 grams, Fructus Forsythiae 750 and restrains.Its preparation technology is: the Radix Scutellariae section decocts with water 2 hours for the first time three times, second, three times each 1 hour, collecting decoction filtered, filtrate is concentrated into 3 times of crude drug amount, in the time of 80 ℃, add the hydrochloric acid that concentration is 2mol/l, transfer pH value to 1.0～2.0, be incubated 1 hour, left standstill 24 hours, and filtered, precipitate with hot water wash to PH=5, be washed till PH=7.0 with 70% ethanol and make Radix Scutellariae glycoside, Flos Lonicerae, Fructus Forsythiae adds water temperature and soaked 0.5 hour, decocts secondary, each 1.5 hours, collecting decoction filtered, it is 1.2～1.25(75～80 ℃ surveys that filtrate is concentrated into relative density), slowly add ethanol when being chilled to 40 ℃, make to contain the alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stirs evenly, left standstill 12 hours, filter the back and merge ethanol liquid, reclaim ethanol, add Radix Scutellariae glycoside extract solution to there not being the alcohol flavor, transfer pH value to 7.0～7.5, concentrating under reduced pressure becomes thick paste, cold drying, pulverize, incapsulate and make 200 granule products.
Claims (3)
1, a kind of SHUANGHUANGLIAN JIAONANG is characterized in that: the raw material of per 200 capsules consists of Flos Lonicerae 300～400 grams, Radix Scutellariae 300～400 grams, Fructus Forsythiae 600～800 grams.
2, SHUANGHUANGLIAN JIAONANG according to claim 1 is characterized in that: the raw material of per 200 capsules consists of Flos Lonicerae 375 grams, Radix Scutellariae 375 grams, Fructus Forsythiae 750 grams.
3, a kind of preparation method of SHUANGHUANGLIAN JIAONANG is characterized in that: 300～400 gram Radix Scutellariae sections decoct with water three times, 2 hours for the first time, second, three times each 1 hour, collecting decoction, filter, add the hydrochloric acid of 2mol/l when filtrate is concentrated in 80 ℃, transfer pH value to 1.0～2.0, be incubated 1 hour, leave standstill, filter, precipitate, is washed till PH=7.0 with 70% ethanol and makes the Radix Scutellariae glycoside to PH=5 with hot water wash, 300～400 gram Flos Loniceraes, 600～800 gram Fructus Forsythiaes add water temperature and soaked 0.5 hour, decoct secondary, each 1.5 hours, collecting decoction, filter, it is 1.2～1.25 that filtrate is concentrated into relative density, slowly adds ethanol when being chilled to 40 ℃, makes to contain the alcohol amount and reach 75%, the leaching supernatant, it is an amount of that residue adds 75% ethanol, leaves standstill, and filters the back and merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae glycoside extract solution, transfer pH value to 7.0～7.5, concentrating under reduced pressure becomes thick paste, cold drying, pulverize, incapsulate and make 200 granule products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100903 CN1089848A (en) | 1993-01-15 | 1993-01-15 | SHUANGHUANGLIAN JIAONANG and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100903 CN1089848A (en) | 1993-01-15 | 1993-01-15 | SHUANGHUANGLIAN JIAONANG and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089848A true CN1089848A (en) | 1994-07-27 |
Family
ID=4983302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93100903 Pending CN1089848A (en) | 1993-01-15 | 1993-01-15 | SHUANGHUANGLIAN JIAONANG and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1089848A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997025054A1 (en) * | 1996-01-09 | 1997-07-17 | Hong Li | An antibacterial or antiviral pharmaceutical composition and preparation thereof |
| WO1999034812A1 (en) * | 1998-01-12 | 1999-07-15 | Kai Jian Xu | Pharmaceutical compositions and method of using same |
| CN1079248C (en) * | 1998-09-29 | 2002-02-20 | 唐亮军 | Medicine for treating chronic trachitis and bronchitis and its preparing process |
| CN1083273C (en) * | 1998-07-13 | 2002-04-24 | 钟起哲 | Chinese medicinal detoxifying preparation for giant silkworm |
| CN1309399C (en) * | 2000-10-25 | 2007-04-11 | 国家中药制药工程技术研究中心 | Compound 'Shuanghuanglian' preparation and preparing process thereof |
| CN1322874C (en) * | 2004-07-19 | 2007-06-27 | 张永春 | Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit |
| CN1240356B (en) * | 1996-07-09 | 2011-09-07 | 蔡修贤 | Antiviral agents from plant extracts and use for treatment of viral infections |
| CN101480451B (en) * | 2008-12-18 | 2012-10-17 | 无锡济民可信山禾药业股份有限公司 | Prescription for treating upper respiratory tract infection and use thereof |
| CN104523895A (en) * | 2014-11-22 | 2015-04-22 | 李任 | Traditional Chinese medicine for treating parotitis |
| CN112569285A (en) * | 2020-06-10 | 2021-03-30 | 山东汉方制药有限公司 | Application of compound cortex phellodendri composition in preparation of medicines for preventing and treating viral respiratory tract infection |
-
1993
- 1993-01-15 CN CN 93100903 patent/CN1089848A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997025054A1 (en) * | 1996-01-09 | 1997-07-17 | Hong Li | An antibacterial or antiviral pharmaceutical composition and preparation thereof |
| CN1240356B (en) * | 1996-07-09 | 2011-09-07 | 蔡修贤 | Antiviral agents from plant extracts and use for treatment of viral infections |
| WO1999034812A1 (en) * | 1998-01-12 | 1999-07-15 | Kai Jian Xu | Pharmaceutical compositions and method of using same |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| AU765951B2 (en) * | 1998-01-12 | 2003-10-02 | Kai Jian Xu | Pharmaceutical compositions and method of using same |
| CN1083273C (en) * | 1998-07-13 | 2002-04-24 | 钟起哲 | Chinese medicinal detoxifying preparation for giant silkworm |
| CN1079248C (en) * | 1998-09-29 | 2002-02-20 | 唐亮军 | Medicine for treating chronic trachitis and bronchitis and its preparing process |
| CN1309399C (en) * | 2000-10-25 | 2007-04-11 | 国家中药制药工程技术研究中心 | Compound 'Shuanghuanglian' preparation and preparing process thereof |
| CN1322874C (en) * | 2004-07-19 | 2007-06-27 | 张永春 | Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit |
| CN101480451B (en) * | 2008-12-18 | 2012-10-17 | 无锡济民可信山禾药业股份有限公司 | Prescription for treating upper respiratory tract infection and use thereof |
| CN104523895A (en) * | 2014-11-22 | 2015-04-22 | 李任 | Traditional Chinese medicine for treating parotitis |
| CN112569285A (en) * | 2020-06-10 | 2021-03-30 | 山东汉方制药有限公司 | Application of compound cortex phellodendri composition in preparation of medicines for preventing and treating viral respiratory tract infection |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105725200A (en) | Processing method for soluble dendrobium officinale freeze-dried powder | |
| CN103120348A (en) | Honeysuckle flower distillate beverage and production method thereof | |
| CN101204424B (en) | Composite of traditional Chinese traditional medicine for clearing away heat and toxic, antiinflammatory, detumescence and preparation method thereof | |
| CN1089848A (en) | SHUANGHUANGLIAN JIAONANG and preparation method thereof | |
| CN102640929A (en) | Health care composition capable of clearing heat, removing toxicity, protecting liver and dispelling fire | |
| CN102805776B (en) | Traditional Chinese medicine composition and preparation method of traditional Chinese medicine composition | |
| JP2972807B2 (en) | Anti-aging food and method for producing the same | |
| CN102961414A (en) | Chinese herbal medicine raw stock and application thereof | |
| CN103504437A (en) | Forsythia leaf beverage | |
| CN103505395B (en) | Forsythia leaf traditional Chinese medicinal toothpaste | |
| CN110934963A (en) | Uric acid reducing composition, preparation method thereof, oral medicine and application | |
| CN101085962A (en) | Wine of bamboo and cogongrass | |
| CN103520287B (en) | Forsythia suspense leaves refreshing sugar | |
| CN100450371C (en) | Throat clearing tea and its preparing method | |
| CN105616785A (en) | Jasmine scented tea capable of relaxing bowels | |
| CN101695400A (en) | Japanese hop honeysuckle beverage and preparation process thereof | |
| CN1168485C (en) | Medicine for treating stranguria | |
| CN101380376A (en) | Wean Qingkailing dispersible tablets | |
| CN100539860C (en) | Strong fire-toxin releasing herb tea | |
| CN1325045C (en) | Qingkailing dispersing tablet | |
| CN103783524A (en) | Fructus forsythiae leaf buccal tablets and preparation method thereof | |
| CN108271890A (en) | A kind of heat-clearing and fire-reducing chrysanthemum tea and preparation method thereof | |
| CN1090185A (en) | SHUANGHUANGLIAN KOUFUYE and preparation method thereof | |
| KR102490447B1 (en) | Composition for anti-inflammation comprising Epimedii herba, Polygalae Radix and Polyporus | |
| CN107970381A (en) | A kind of Xuancheng's pawpaw tea of resolving sputum and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |