CN1090185A - SHUANGHUANGLIAN KOUFUYE and preparation method thereof - Google Patents
SHUANGHUANGLIAN KOUFUYE and preparation method thereof Download PDFInfo
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- CN1090185A CN1090185A CN 93101124 CN93101124A CN1090185A CN 1090185 A CN1090185 A CN 1090185A CN 93101124 CN93101124 CN 93101124 CN 93101124 A CN93101124 A CN 93101124A CN 1090185 A CN1090185 A CN 1090185A
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Abstract
The present invention is to provide a kind of medicinal preparation and preparation method.It is a raw material with Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae and sucrose, adopts every flavor medical material is decocted separately, with water precipitating, acid precipitation, precipitate with ethanol, Cryoprecipitation, filter, take off process extraction active ingredient such as charcoal, is mixed with oral liquid.Product of the present invention has antibacterial, antiviral dual function.Easy to use, no pain, have no side effect multiple advantage such as it is long to hold time.Method of the present invention is simple, the extraction ratio height of active ingredient.
Description
The present invention is to provide a kind of medicinal preparation that derives from vegetable material and preparation method thereof.
With the immediate background technology of the present invention be SHUANGHUANGLIAN ZHUSHEYE and preparation method thereof.It is recorded in the 75th page of Heilongjiang Province's drug standard version in 1986.This SHUANGHUANGLIAN ZHUSHEYE has anti-inflammation, antipyretic and antidote functions, is used for the treatment of the various infection of coccus, and its existing maximum deficiency is because it mainly contains effective constituent Radix Scutellariae glycoside stimulated muscle and blood vessel wall causes pain.And use is inconvenient, the cost height.
The object of the present invention is to provide a kind of easy to use, with low cost, bi-coptis-chinensis product of having no side effect and preparation method thereof.
The object of the present invention is achieved like this: the raw material of per 1000 milliliters of oral liquids consists of Flos Lonicerae 300～400 grams, Radix Scutellariae 300～400 grams, Fructus Forsythiae 600～800 grams, sucrose 300～600 grams.
Its preparation method be Radix Scutellariae decoct with water decocting liquid, at 80 ℃, go out=be incubated 30～90 minutes at 1.0～2.0 o'clock, leave standstill, precipitate adds 6～8 times of water gagings, and transfers PH=7.0, adds ethanol and makes it dissolving, filtrate is transferred PH=2.0, be incubated 20～40 minutes down at 60 ℃, leave standstill, precipitation is washed till PH=7.0 with ethanol, wave most ethanol and get radix scutellariae extract, 300～400 Flos Loniceraes, 600～800 grams decoct with water, it is 1.20～1.25(70～80 ℃ surveys that decocting liquid is concentrated into relative density), add ethanol at 40 ℃, make to contain the alcohol amount and reach 75%, leave standstill, filtrate recycling ethanol adds radix scutellariae extract to there not being the alcohol flavor, transfers PH=7.0, cold preservation (4～8 ℃) 72 hours, filter and add 300～600 gram sucrose, an amount of essence, and transfer PH=7.0, transfer to respective amount with distilled water.
The invention provides bi-coptis-chinensis product of a kind of better efficacy easy to use and preparation method thereof.Prove that through pharmacological evaluation SHUANGHUANGLIAN KOUFUYE can suppress various bacteria and virus, have the inhibitory anti-virus dual function.Scope of restraining fungi comprises: Diplococcus pneumoniae, escherichia coli, staphylococcus aureus, streptococcus, yersinia enterocolitica, first type are paid Salmonella, good fortune Salmonella etc. in Bacillus typhi, the Song, have enlarged scope of restraining fungi than SHUANGHUANGLIAN ZHUSHEYE.The susceptible change of this oral liquid convection current, syncytial virus, adenovirus have obvious inhibitory action.This SHUANGHUANGLIAN KOUFUYE has no side effect, produce effects fast, the length of holding time, and safety is good, uses convenient, no pain, is particularly useful for children taking.Preparation method of the present invention is that every flavor medical material is decocted separately, extract active ingredient, adopt water precipitating, acid precipitation, precipitate with ethanol, Cryoprecipitation respectively, filter, take off charcoal etc., the extraction ratio height of active ingredient, the good effect of product, being used for the treatment of upper respiratory tract infection, influenza, pneumonia, tonsillitis, the bronchitis disease total effective rate that pathogenic bacteria and viral infection cause is 92%, treats viral influenza obvious effective rate 78%.
For example the present invention is described in detail below:
The raw material of per 1000 milliliters of oral liquids consists of Flos Lonicerae 375 grams, Radix Scutellariae 375 grams, Fructus Forsythiae 750 grams, sucrose 300 grams.More than three flavors, Radix Scutellariae section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction.Filter, filtrate concentrates and adds hydrochloric acid (2mol) in right amount in the time of 80 ℃, transfers PH=1.0～2.0, is incubated 1 hour, leaves standstill 12 hours, filters; Precipitation adds 6～8 times of water gagings, transfers PH=7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirs and makes dissolving, filter, filtrate is transferred PH=2.0 with hydrochloric acid (2mol/L), and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed till PH=7.0 with ethanol, and it is standby to wave most ethanol.
Flos Lonicerae, Fructus Forsythiae added water logging earlier after 30 minutes, decocted secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25(70～80 ℃ surveys that filtrate is concentrated into relative density), add ethanol at 40 ℃, make to contain the alcohol amount and reach 75%, fully stir, left standstill 12 hours, filtrate is got supernatant, and it is an amount of that residue adds 75% ethanol, stir evenly, reclaim ethanol to there not being the alcohol flavor, add radix scutellariae extract, and it is an amount of to add water, transfer PH=7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation (4～8 ℃) 72 hours filters, filtrate is with sucrose, stirring makes dissolving, and it is an amount of and regulate pH value to 7.0 to add essence again, to transfer to 1000ml with distilled water.Stir evenly and leave standstill 12 hours, filtration, canned, finished product is made in sterilization.
Claims (5)
1, a kind of SHUANGHUANGLIAN KOUFUYE is characterized in that: the raw material of per 1000 milliliters of oral liquids consists of Flos Lonicerae 300～400 grams, Radix Scutellariae 300～400 grams, Fructus Forsythiae 600～800 grams, sucrose 300～600 grams.
2, SHUANGHUANGLIAN KOUFUYE according to claim 1 is characterized in that: the raw material of per 1000 milliliters of oral liquids consists of Flos Lonicerae 375 grams, Radix Scutellariae 375 grams, Fructus Forsythiae 750 grams, sucrose 300 grams.
3, a kind of preparation method of SHUANGHUANGLIAN KOUFUYE is characterized in that: 300～400 the gram Radix Scutellariae decoct with water decocting liquid, at 80 ℃, PH=1.0～2.0 o'clock, be incubated 30～90 minutes, leave standstill, precipitate adds 6～8 times of water gagings, and transfers PH=7.0, add ethanol and make it dissolving, filtrate is transferred PH=2.0, is incubated 20～40 minutes down at 60 ℃, leaves standstill, precipitation is washed till PH=7.0 with ethanol, wave most ethanol and get radix scutellariae extract, 300～400 gram Flos Loniceraes, 600～800 gram Fructus Forsythiaes decoct with water, and it is 1.20～1.25(70～80 ℃ surveys that decocting liquid is concentrated into relative density), add ethanol at 40 ℃, make to contain alcohol amount and reach 75%, leave standstill, filtrate recycling ethanol is to there not being the alcohol flavor, add radix scutellariae extract, transfer PH=7.0, adding 300～600 gram sucrose are filtered in cold preservation (4～8 ℃) 72 hours, an amount of essence, and transfer PH=7.0, transfer to 1000ml with distilled water.
4, the preparation method of SHUANGHUANGLIAN KOUFUYE according to claim 3 is characterized in that: Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction.
5, according to the preparation method of claim 3 or 4 described SHUANGHUANGLIAN KOUFUYE, it is characterized in that: after Flos Lonicerae, Fructus Forsythiae add water temperature earlier and soak 30 minutes, decoct secondary, each 1.5 hours, collecting decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101124 CN1090185A (en) | 1993-01-20 | 1993-01-20 | SHUANGHUANGLIAN KOUFUYE and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101124 CN1090185A (en) | 1993-01-20 | 1993-01-20 | SHUANGHUANGLIAN KOUFUYE and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1090185A true CN1090185A (en) | 1994-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101124 Pending CN1090185A (en) | 1993-01-20 | 1993-01-20 | SHUANGHUANGLIAN KOUFUYE and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1090185A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997025054A1 (en) * | 1996-01-09 | 1997-07-17 | Hong Li | An antibacterial or antiviral pharmaceutical composition and preparation thereof |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| CN102872208A (en) * | 2012-10-23 | 2013-01-16 | 哈药集团三精制药股份有限公司 | Method for manufacturing Shuanghuanglian oral liquid |
-
1993
- 1993-01-20 CN CN 93101124 patent/CN1090185A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997025054A1 (en) * | 1996-01-09 | 1997-07-17 | Hong Li | An antibacterial or antiviral pharmaceutical composition and preparation thereof |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| CN102872208A (en) * | 2012-10-23 | 2013-01-16 | 哈药集团三精制药股份有限公司 | Method for manufacturing Shuanghuanglian oral liquid |
| CN102872208B (en) * | 2012-10-23 | 2014-07-09 | 哈药集团三精制药股份有限公司 | Method for manufacturing Shuanghuanglian oral liquid |
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