CN109248255A - Propolis drops canker sore is dedicated - Google Patents

Propolis drops canker sore is dedicated Download PDF

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Publication number
CN109248255A
CN109248255A CN201710569843.7A CN201710569843A CN109248255A CN 109248255 A CN109248255 A CN 109248255A CN 201710569843 A CN201710569843 A CN 201710569843A CN 109248255 A CN109248255 A CN 109248255A
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Prior art keywords
canker sore
propolis
drops
dedicated
sore
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CN201710569843.7A
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Chinese (zh)
Inventor
张昊
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Yunnan Yuxing Thai Biotechnology Co Ltd
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Yunnan Yuxing Thai Biotechnology Co Ltd
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Priority to CN201710569843.7A priority Critical patent/CN109248255A/en
Publication of CN109248255A publication Critical patent/CN109248255A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of propolis drops canker sore is dedicated, the effective ingredient of formula is mainly mutually compounded with the extract of the plants such as natural propolis and fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis, the canker sore drops with antibacterial, antiinflammation is made through special process, and inhibit the growth of pathogenic bacteria in oral cavity, it is suitable for a series of heredity canker sore patient health disease areas such as canker sore, aphthae, oral lesions.Present invention is generally directed to there are canker sore recurrent exerbations not specifically for property in market, and stimulating to mucous membrane of mouth at branch containing chemical stimulation, contained perfume ingredient can not fundamentally dispel the pathogenic bacteria of canker sore, microorganism even contained by some canker sore product itselfs just severely exceeds, the disadvantages of serious health for jeopardizing people, special use has antibacterial, the natural propolis and pure plant of antiinflammation are extracted into split-phase compounding, a kind of dedicated propolis drops of plant type canker sore is made, fundamentally dispel the pathogenic bacteria of canker sore, prevent canker sore recurrence, it is pollution-free, it is safe and healthy, it is easy to use.

Description

Propolis drops canker sore is dedicated
Technical field is the present invention relates to a kind of propolis drops canker sore is dedicated, and the effective ingredient of formula is mainly with natural The extract of the plants such as propolis and fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis mutually compounds, and tool is made through special process There is the canker sore drops of antibacterial, antiinflammation, and inhibit the growth of pathogenic bacteria in oral cavity, is suitable for canker sore, dispute life The a series of heredity canker sore patient health disease areas such as sore, oral lesions.Canker sore is oral cavity common at present One of disease, also someone is known as " aphtha ", is a kind of shallow and small, round or oval ulcer.Most common one in canker sore It kind is " recurrent oral ulceration ", it is usually raw on lip, tongue or other positions in oral cavity, and can often recur.Therefore, It is a that for canker sore and the recurrence of prevention canker sore, to have the propolis drops canker sore special product of very good effect be people Eager demand.Present invention is generally directed to there are canker sore recurrent exerbations in market not specifically for property, and containing changing Learn it is irritating at branch's stimulation to mucous membrane of mouth, contained perfume ingredient can not fundamentally dispel the cause of canker sore Microorganism contained by germ or even some canker sore product itselfs just severely exceeds, the serious body for jeopardizing people It is the disadvantages of healthy, special using having antibacterial, the natural propolis of antiinflammation and pure plant to be extracted into split-phase compounding, one kind is made The dedicated propolis drops of plant type canker sore fundamentally dispels the pathogenic bacteria of canker sore, prevention canker sore recurrence, nothing Pollution, it is safe and healthy, it is easy to use.
The appearance of background technique canker sore causes many inconvenience to our life, and causes the factor of canker sore Mainly have: (1), disease of digestive system and dysfunction (2), hormonal change (3), mental element (4), other factors: as lacked Weary trace element zinc, iron, folic acid, vitamin B12, malnutrition etc., can reduce immune function, increase cause canker sore because A possibility that element morbidity;The bacteriums such as Streptococcus sanguis and helicobacter pylori are also in close relations with canker sore.Canker sore is usually pre- Show that body may have potential systemic disease, canker sore and gastric ulcer, duodenal ulcer, ulcerative colitis, limitation Property enteritis, vegetative nerve functional disturbance disease etc. are related.Therefore, a kind of pure natural plant type, can fundamentally dispel oral cavity The dedicated drops of natural propolis canker sore of pathogenic bacteria is the eager demand of people.It is an object of the invention to provide it is a can The pathogenic bacteria of mouth disease are fundamentally dispelled, and the generation of the various mouth diseases of canker sore recurrent exerbation can be prevented, The canker sore drops of the permanent broad-spectrum antibacterial action for keeping propolis.
Summary of the invention is of the invention to be characterized by natural propolis and fritillaria, Radix Astragali, honeysuckle, aloe, cloves, plate indigo plant The plant extract of root mutually compounds, and improves antibacterial, the antiinflammation of each active constituent, while dispelling mouth disease pathogenic bacteria, It can prevent the generation of the various mouth diseases of canker sore recurrent exerbation.
The formula that the present invention selects is following (component and its weight percent %): natural propolis 5.0-8.0;Fritillaria 4.0- 7.0;Radix Astragali 2.0-4.0;Honeysuckle 1.0-3.0;Aloe 5.0-7.0;Cloves 3.0-4.0;Radix Isatidis 1.0-3.0;Purified water adds To 100.
Propolis is a kind of extremely rare natural resources, is known as the title of " purple gold ", the antibacterial having, anti-inflammatory analgetic, It eliminates fungal infection, promote the effect of cytothesis, the illnesss such as canker sore, gastric ulcer, burn and scald, skin Tearing Pain can be treated, Abundant and unique bioactive substance contained by propolis makes it have antibacterial, anti-inflammatory, antipruritic, anti-oxidant, enhancing is immune etc. Multiple functions have extensive medical treatment, health-care effect to human body.Propolis can sterilize, sterilize, sterilizing, is antibacterial, is mould proof, anti-corrosion, solution The defect that antibiotic of having determined only works to single microorganism, and be free from side effects.Have very to mouth disease in daily life Good therapeutic effect.Propolis is natural antiviral substance, has very strong inhibition and killing effect, Neng Goujia to a variety of viruses The healing of fast histocyte regeneration and wound, inhibits the growth of various bacteria and certain viruses, and antibacterial, anti-inflammatory with wide spectrum are made With.
Fritillaria is herbaceos perennial, and Collective Notes to the Canon of Materia medica is said: " being similar to poly- shellfish ", therefore named fritillaria have stronger Anti-inflammatory, antiulcer, it is antiviral the effects of.Can clearing heat and detoxicating, dispersing swelling and dissipating binds, the carbuncle that disappears apocenosis, sore swollen toxin function, can be used to treat Sore, purulence blood, skin swell the diseases such as rotten.
Radix Astragali belongs to state three level protecting plant, has more than 2000 years history, Radix Astragali is sweet in flavor, slightly warm in nature.Beneficial to gas-solid The effect of table, apocenosis, torr sore myogenic, detumescence.With wide antibacterial, antiulcer and antivirus action.
The general designation of honeysuckle plant, has a clearing heat and detoxicating, broad-spectrum antiseptic and antiviral and other effects, 70% or more flu, All contain honeysuckle in anti-inflammatory Chinese patent drug.With " Chinese medicine antibiotic ", " title of antibacterial green element.Resisting pathogenic microbes effect.Gold Honeysuckle flower has certain inhibiting effect to various pathogens such as staphylococcus aureus, Escherichia coli, hemolytic streptococcus etc..To lung Scorching coccus, Pseudomonas aeruginosa, tubercle bacillus, streptococcus mutans etc. have antibacterial and bactericidal effect, and it is swollen can to treat canker sore, boil The diseases such as poison, periodontitis, acute and chronic tonsillitis.
Aloe has bactericidal antiphlogistic, enhancing immune function, glue liquid rich in, and this glue liquid has prevention Ulcer, promotes wound healing, and the effect of stimulating cellular growth and hemostasis can effectively treat each of common skin and body surface Kind disease.Compendium of Material Medica describes a variety of therapeutic effects of aloe, including bactericidal antiphlogistic, prevention colitis and prevention and treatment digestion It systemic disease and improves a poor appetite, to protecting our enteron aisles largely effective.Aloe is rich in the prebiotics of needed by human body, and prebiotics can To supplement " food " to beneficial bacteria of intestinal tract, activation and the intracorporal beneficial flora of proliferation of human are improved strong with promoting microecological balance Health.Therefore, the aloe water rich in prebiotics helps to improve immunity, protects stomach health.
Cloves has antimycotic, the anti-inflammatory effect of wide spectrum, and cloves contains caryophyllus oil, for pathogenic fungus and staphylococcus, Dysentery and Escherichia coli etc. have an inhibiting effect, caryophyllus oil, be plant of clove dry flower through distilling resulting volatile oil, can be with Anti-corrosion, antibacterial and analgesic, are well suited for for preventing disease and inflammation, have good therapeutic effect, cloves to oral cavity, the raw sore of words The caryophyllus oil bactericide processed of branch distillation.
Radix Isatidis: clearing heat and detoxicating, antiviral, antibacterium, it is sarcine, big right to hay bacillus, staphylococcus aureus Diplococcus has very strong killing effect.
Effective component of the present invention is that will have the plant extract component of antibacterial action and have anti-inflammation and sterilization, clear The plant extract of the effects of thermal detoxification mutually compounds, and every kind of ingredient is played power to maximum to antibacterial, anti-inflammatory, collective effect is in prevention Cause the treatment and nursing of canker sore.
The preparation method of the product of the invention is:
1), that fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis is spare after over cleaning, drying, crushing respectively;
2), proportionally fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis and purified water are matched and are added in boiler Plant mixed liquor is extracted after tanning;
3) plant mixed liquor, is purified into plant extracts using special process;
4) plant extracts and natural propolis are added in agitated kettle according to percentage, stirred 25 minutes;
5), stop stirring, it is canned to can be used after filtering, standing 24 as a child.
The invention has the following advantages that
(1) with the antibacterial of natural propolis and plant extracts, anti-inflammation components, the pathogenic bacteria in oral cavity are quickly dispelled;
(2) promote cytothesis, accelerate the healing rate of wound;
(3) anti-inflammatory, sterilizing rate are high;
(4) clearing heat and detoxicating, torr sore myogenic, apocenosis, detumescence;
(5) safe, non-stimulated.
The present invention is described in further detail below with reference to embodiment for specific embodiment:
It is configured according to data (weight percent %) listed in Table and its step:
Formula one:
Natural propolis 5.0-8.0;Fritillaria 4.0-7.0;Radix Astragali 2.0-4.0;Honeysuckle 1.0-3.0;Aloe 5.0-7.0;Cloves 3.0-4.0;Radix Isatidis 1.0-3.0;Purified water adds to 100.
Formula two:
Natural propolis 5.0-6.5;Fritillaria 4.0-5.5;Radix Astragali 2.0-3.0;Honeysuckle 1.0-2.0;Aloe 5.0-6.0;Cloves 3.0-3.5;Radix Isatidis 1.0-2.0;Purified water adds to 100.
Formula three:
Natural propolis 6.5-8.0;Fritillaria 5.5-7.0;Radix Astragali 3.0-4.0;Honeysuckle 2.0-3.0;Aloe 6.0-7.0;Cloves 3.5-4.0;Radix Isatidis 1.5-3.0;Purified water adds to 100.

Claims (2)

1. a kind of propolis drops canker sore is dedicated, it is characterised in that have as following formula (component and its weight percent %): Natural propolis 5.0-8.0;Fritillaria 4.0-7.0;Radix Astragali 2.0-4.0;Honeysuckle 1.0-3.0;Aloe 5.0-7.0;Cloves 3.0- 4.0;Radix Isatidis 1.0-3.0;Purified water adds to 100.
2. the dedicated preparation method of propolis drops canker sore described in a kind of claim 1, it is characterised in that have following step It is rapid:
1), that fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis is spare after over cleaning, drying, crushing respectively;
2), proportionally fritillaria, Radix Astragali, honeysuckle, aloe, cloves, Radix Isatidis and purified water are matched and are added in boiler Plant mixed liquor is extracted after tanning;
3) plant mixed liquor, is purified into plant extracts using special process;
4) plant extracts and natural propolis are added in agitated kettle according to percentage, stirred 25 minutes;
5), stop stirring, it is canned to can be used after filtering, standing 24 as a child.
CN201710569843.7A 2017-07-13 2017-07-13 Propolis drops canker sore is dedicated Pending CN109248255A (en)

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Application Number Priority Date Filing Date Title
CN201710569843.7A CN109248255A (en) 2017-07-13 2017-07-13 Propolis drops canker sore is dedicated

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Application Number Priority Date Filing Date Title
CN201710569843.7A CN109248255A (en) 2017-07-13 2017-07-13 Propolis drops canker sore is dedicated

Publications (1)

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CN109248255A true CN109248255A (en) 2019-01-22

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252690A (en) * 2022-08-05 2022-11-01 河北东医生物科技有限公司 Chinese herbal medicine for improving antibacterial capacity of oral mucosa and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252690A (en) * 2022-08-05 2022-11-01 河北东医生物科技有限公司 Chinese herbal medicine for improving antibacterial capacity of oral mucosa and preparation method thereof

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Application publication date: 20190122