CN110075198A - A kind of Chinese medicine composition and its preparation method and application for treating tonsillitis - Google Patents
A kind of Chinese medicine composition and its preparation method and application for treating tonsillitis Download PDFInfo
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Abstract
The invention belongs to pharmaceutical technology fields, and in particular to a kind of Chinese medicine composition and its preparation method and application for treating tonsillitis.The formula of the Chinese medicine composition is rhizoma atractylodis 70-90 parts by weight, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 parts by weight, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 parts by weight, shell of areca nut 110-125 parts by weight, dried pinellia 70-90 parts by weight, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2 parts by volume and perilla leaf oil 0.2-0.6 parts by volume.The drug of the treatment tonsillitis of the Chinese medicine composition preparation, effective component of chinese medicine therein have antiinflammatory and bacteriostatic functions, have a better effect to tonsillitis tool.Meanwhile mildly safety, Small side effects not will cause bacterial resistance to Chinese medicine composition, the treatment suitable for all ages time patient.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of Chinese medicine composition for treating tonsillitis and its preparation side
Method and application.
Background technique
Tonsillitis can be divided into acute tonsillitis and chronic tonsillitis.Its pathogenic factor mainly due to bacterium and is divided
Secretion, which lodges in tonsillar pit, to be caused, and pathogenic bacteria are mainly streptococcus or staphylococcus.Acute tonsillitis is amygdaline one
The non-specific acute inflammation of kind is often accompanied by the not equal pharynx mucous membrane hyperemia of light and heavy degree, is mainly in teenager.Current primary treatment
Method is antibiotic treatment, and oral or intravenous administration is selected according to severity degree；It is concurrent for having formed the part such as angina tonsillaris
The patient of disease, feasible abscess incision drainage or direct removal of tonsils.Chronic tonsillitis mostly by acute tonsillitis repeatedly
Breaking out, it is chronic to switch to, and common sympton shows as recurrent exerbation pharyngalgia, halitosis, antiadoncus etc..General treatment method includes
It is daily brush teeth to gargle keep oral cleaning, the buccal crystalline flake of iodine takes vitamin C etc.；Tonsillotome hypertrophy or repeatedly acute attack
Patient or can only be treated surgically.
From the point of view of urgency/chronic tonsillitis treatment method conventional at present, mainly based on antibiotic antimicrobial therapy, to protect
It holds supplemented by oral cleaning, still prevent at all/inhibit bacteria breed.For recurrent exerbation, angina tonsillaris patient even only
It can be with operative treatment.However abuse of antibiotics has become the serious problems that the whole world faces at present, unreasonably uses antibiosis
Element can aggravate the case where bacterial resistance.Currently, bacterial resistance situation very severe.Net is detected according to China's bacterial resistance
Data in 2009, at home in 100 Yu Jia hospitals in the bacterium of detection, staphylococcus (staphylococcus aureus and epidermis Portugal
Grape coccus), a variety of common antibiotics such as methicillin, macrolides, quinolones are had more than with 50% resistant rate, greatly
Enterobacteria also all 50% or more, and has 66.2% Escherichia coli can be with the resistant rate of quinolone and third generation cephalosporin
Generate extended spectrumβ-lactamase.Incessantly in this way, " superbacteria " that most antibacterials cannot all kill also is stepped on one after another
?.In the past, people solved resistance problems by developing new antibiotic, but the speed of exploitation antibiotics is much now
It is unable to catch up with the step of bacterial resistance, therefore, slows down the sprawling of drug-resistant bacteria by controlling antibiotic usage, or even treated with new
Scheme replaces the use of antibiotic just to become very necessary.
The present invention provides a kind of Chinese medicine composition for treating tonsillitis, and effective component of chinese medicine therein has broad-spectrum antibacterial
Property, therefore bacterium infection tool is had a better effect.Meanwhile mildly safety, Small side effects not will cause bacterium to Chinese medicine composition
Drug resistance, the treatment suitable for all ages time patient.
Summary of the invention
In view of this, an object of the present invention is to provide a kind of Chinese medicine composition for treating tonsillitis.
To achieve the above object, using following scheme:
The formula of the Chinese medicine composition is as follows: rhizoma atractylodis 70-90 parts by weight, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 weight
Measure part, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 parts by weight, shell of areca nut 110-125 parts by weight, dried pinellia 70-90 weight
Part, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2 parts by volume and perilla leaf oil 0.2-0.6 parts by volume.
Preferably, the Traditional Chinese medicine composition formula is as follows: rhizoma atractylodis 80-85 parts by weight, dried orange peel 80-85 parts by weight, Cortex Magnoliae Officinalis 80-
85 parts by weight, root of Dahurain angelica 120-125 parts by weight, Poria cocos 120-125 parts by weight, shell of areca nut 120-125 parts by weight, dried pinellia 80-85
Parts by weight, extract of licorice root 8-12 parts by weight, patchouli oil 0.8-1.2 parts by volume and perilla leaf oil 0.4-0.6 parts by volume.
It is furthermore preferred that the Traditional Chinese medicine composition formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 weight of Cortex Magnoliae Officinalis
Part, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 weight of extract of licorice root
Part, 0.4 parts by volume of 0.8 parts by volume of patchouli oil and perilla leaf oil.
Such as without special specified, the unit of weight of the parts by weight in the traditional chinese medicine composition of the invention formula and the volume list of parts by volume
Position is matching relationship.That is: when the unit of weight of parts by weight is Kg, the volume unit of parts by volume is L；When the weight list of parts by weight
When position is g, the volume unit of parts by volume is mL.The preferred ginger Cortex Magnoliae Officinalis of Cortex Magnoliae Officinalis mentioned by the present invention.
The second object of the present invention is the provision of a kind of preparation method of tonsillitis Chinese medicine composition.
To achieve the above object, the present invention uses following scheme:
A kind of preparation method of the Chinese medicine composition for treating tonsillitis, comprising the following steps:
1) it takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；It will be described in formula ratio
Rhizoma atractylodis, the dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；By the big abdomen of the formula ratio
Skin water is decocted and is filtered, and obtains shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to
70-90 DEG C, to sufficiently infiltrating and filtering, obtains Poria cocos temperature immersion liquid；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains the tuber of pinellia
Soak；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, the mixing for obtaining the tuber of pinellia and rhizoma zingiberis is impregnated
Liquid；
2) by the ethanol extract, distillation extract mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and
The mixed soaking solution of rhizoma zingiberis is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the Radix Glycyrrhizae of formula ratio is added
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol by medicinal extract, and addition auxiliary material Tween 80 is wide with the formula ratio
The aqueous medium of palchouli oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value to 5.8-6.2 with sodium hydroxide, obtains the Chinese medicine
Composition.
The third object of the present invention is to provide a kind of application of Chinese medicine composition for treating tonsillitis.
To achieve the above object, the present invention uses following scheme:
Application of the Chinese medicine composition in preparation tonsillitis drug.
Further, the Chinese medicine composition can be any pharmaceutically acceptable dosage form；The tonsillitis drug also wraps
Include pharmaceutical acceptable carrier and/or auxiliary agent.The pharmaceutically acceptable dosage form includes Chinese medicine composition of the invention and optional
One or more pharmaceutically acceptable carriers, diluent or excipient and the addition of suitable step in above-mentioned preparation process.
Term " pharmaceutically acceptable " used in the present invention refers to such compound, raw material, composition and/or dosage form, they
Within the scope of reasonable medical judgment, be suitable for contacted with patient tissue and without excessive toxicity, irritation, allergy or with conjunction
Interests/Hazard ratio of reason symmetrical other problems and complication, and effective for given application.
Preferably, the pharmaceutical dosage form is oral solution and/or tablet.
Further, the tablet includes one or more of lozenge, chewable tablets, fuse, oral disintegrating tablet.
A kind of drug for treating tonsillitis, the drug include the described in any item Chinese medicine compositions of claim 1-3.
Pharmaceutical preparation is suitable for being administered by any suitable approach, for example, by take orally (including oral cavity or sublingual), rectum,
Nose, part (including oral cavity, sublingual or percutaneous), vagina or parenteral (including subcutaneous, intradermal, intramuscular, intra-articular, intrasynovial, chest
Bone is interior, intrathecal, intralesional, intravenous or intradermal injection or infusion) approach.It can be by any known method of art of pharmacy
This kind of preparation is prepared, such as by mixing active constituent with carrier or excipient.It is preferred that being administered orally.Suitable for oral administration
Pharmaceutical preparation is provided by independent unit, such as solution or suspension in aqueous or non-aqueous liquid；Capsule or tablet；
Powder or granule；Edible foam formulations or foaming preparations etc..
For example, for oral administration in form of tablets, active medicine component can take orally with pharmaceutically acceptable
Inert carrier (such as glycerol, mannitol, sorbierite, water etc.) mixes.By the way that composition/compound powder is broken into properly
Fine sizes, and mix with the pharmaceutical carrier that is equally crushed to prepare powder.Corrigent, preservative, dispersion also may be present
Agent and colorant.It by preparing pulverulent mixture as described above, and is loaded into the gelatin shell of forming, to prepare capsule.
Before filling operation, can by glidant and lubricant (such as colloidal silicon dioxide, talcum powder, magnesium stearate, calcium stearate or
Solid polyethylene glycol) it is added in pulverulent mixture.The disintegration that drug utilizability will be improved when taking capsule can also be added
Agent or solubilizer (such as agar, calcium carbonate or sodium carbonate).
When furthermore needing or is required, suitable adhesive, lubricant, disintegrating agent and colorant can also be mixed mixture
In.Suitable adhesive includes starch, gelatin, natural sugar (such as glucose or beta lactose), corn sweetener, natural and synthesis
Gummy (such as gum arabic, tragacanth or mosanom), carboxymethyl cellulose, polyethylene glycol etc..For these dosage forms
Lubricant includes enuatrol, sodium chloride etc..
Oral liquid such as solution, syrup and elixir can be prepared with dosage unit form, so that specified rate contains
There is the compound of predetermined amount.Syrup can be prepared by the way that compound to be dissolved in suitably seasoned aqueous solution, and elixir can lead to
It crosses using non-toxic vehicle and prepares.Can also be added preservative, flavoring additive (such as peppermint oil or natural sweetener or saccharin or
Other artificial sweeteners) etc..
Pharmaceutical preparation can be in unit dosage forms, and each unit dose contains the active constituent of predetermined amount.Dose regimen can be used as growing
Phase or short-term therapy.Mixing with carrier material will be according to disease to be treated, disease to prepare the amount of the active constituent of single formulation
Disease severity, administration time, administration route, the discharge rate of compound used therefor, treatment time and patient age, gender,
Weight and situation and change.Preferred unit dosage forms are the daily dose containing above-mentioned active constituent or divided dose or its appropriate fraction
Unit dosage forms.It can start to treat with the low dose of already clearly below compound optimal dose.Hereafter, it is increased with lesser increment
Dosage until reaching optimum efficiency in this case.In general, the concentration level for most desirably giving compound is usual
Effective result can be provided without regard to causing any harmful or toxic side effect in anti-virus aspect.
The beneficial effects of the present invention are:
1) the present invention provides a kind of Chinese medicine composition for treating tonsillitis, effective component of chinese medicine therein has wide spectrum
Biocidal property, therefore bacterium infection tool is had a better effect.Meanwhile mildly safety, Small side effects not will cause Chinese medicine composition
Bacterial resistance, the treatment suitable for all ages time patient.
2) the preparation method simple process of the traditional chinese medicine composition of the invention, not high and free from environmental pollution to equipment requirement is suitble to
Industrialized production.
Specific embodiment
Illustrated embodiment is in order to which preferably the present invention will be described, but is not that the contents of the present invention are limited only to institute
For embodiment.So those skilled in the art according to foregoing invention content to embodiment carry out it is nonessential improvement and
Adjustment, still falls within protection scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition for treating tonsillitis, the Traditional Chinese medicine composition formula are as follows: 80 parts by weight of rhizoma atractylodis, dried orange peel
80 parts by weight, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 weight of dried pinellia
Measure part, 0.4 parts by volume of 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf oil.
Embodiment 2
A kind of Chinese medicine composition for treating tonsillitis, the Traditional Chinese medicine composition formula are as follows: 70 parts by weight of rhizoma atractylodis, dried orange peel
70 parts by weight, 70 parts by weight of Cortex Magnoliae Officinalis, 110 parts by weight of the root of Dahurain angelica, 110 parts by weight of Poria cocos, 110 parts by weight of the shell of areca nut, 70 weight of dried pinellia
Measure part, 0.2 parts by volume of 5 parts by weight of extract of licorice root, 0.5 parts by volume of patchouli oil and perilla leaf oil.
Embodiment 3
A kind of Chinese medicine composition for treating tonsillitis, the Traditional Chinese medicine composition formula are as follows: 90 parts by weight of rhizoma atractylodis, dried orange peel
90 parts by weight, 90 parts by weight of Cortex Magnoliae Officinalis, 125 parts by weight of the root of Dahurain angelica, 125 parts by weight of Poria cocos, 125 parts by weight of the shell of areca nut, 90 weight of dried pinellia
Measure part, 0.6 parts by volume of 15 parts by weight of extract of licorice root, 1.2 parts by volume of patchouli oil and perilla leaf oil.
Embodiment 4
A kind of preparation method of Chinese medicine composition that treating tonsillitis
1) it takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；It will be described in formula ratio
Rhizoma atractylodis, the dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；By the big abdomen of the formula ratio
Skin water is decocted and is filtered, and obtains shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to
70-90 DEG C, to sufficiently infiltrating and filtering, obtains Poria cocos temperature immersion liquid；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains the tuber of pinellia
Soak；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, the mixing for obtaining the tuber of pinellia and rhizoma zingiberis is impregnated
Liquid；
2) by the ethanol extract, distillation extract mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and
The mixed soaking solution of rhizoma zingiberis is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the Radix Glycyrrhizae of formula ratio is added
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol by medicinal extract, and addition auxiliary material Tween 80 is wide with the formula ratio
The aqueous medium of palchouli oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value to 5.8-6.2 with sodium hydroxide, obtains the Chinese medicine
Composition.
Embodiment 5
Acute tonsillitis effect disquisition
1. sufferer totally 50.
2. treatment method: treatment group is treated using traditional Chinese medicine for oral administration, by embodiment 1-3 prescription and formula ratio, and according to this hair
Oral solution is made in bright preparation method.Patient is oral, a 10ml, 2 times a day.
3. clinical effectiveness
4. conclusion:
The drug of Chinese medicine composition preparation of the invention, treatment acute tonsillitis total effective rate are 94%.
Embodiment 6
Chronic tonsillitis effect disquisition
1. sufferer totally 66.
2. treatment method: treatment group is treated using traditional Chinese medicine for oral administration, by embodiment 1-3 prescription and formula ratio, and according to this hair
Then plus the obtained lozenge such as cane sugar powder, mannitol, sorbierite Chinese medicine composition is made in bright preparation method,.Patient is oral, and one day
2 times, one time 2.
3. clinical effectiveness
4. conclusion:
The drug of Chinese medicine composition preparation of the invention, treatment chronic tonsillitis total effective rate are 97%.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the scope of the claims of invention.
Claims (9)
1. a kind of Chinese medicine composition for treating tonsillitis, which is characterized in that the formula of the Chinese medicine composition is as follows: rhizoma atractylodis
70-90 parts by weight, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 parts by weight, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 weight
Part, shell of areca nut 110-125 parts by weight, dried pinellia 70-90 parts by weight, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2 body
Product part and perilla leaf oil 0.2-0.6 parts by volume.
2. a kind of Chinese medicine composition for treating tonsillitis according to claim 1, which is characterized in that the Chinese traditional medicine composition
Composition formula is as follows: rhizoma atractylodis 80-85 parts by weight, dried orange peel 80-85 parts by weight, Cortex Magnoliae Officinalis 80-85 parts by weight, root of Dahurain angelica 120-125 parts by weight,
It is Poria cocos 120-125 parts by weight, shell of areca nut 120-125 parts by weight, dried pinellia 80-85 parts by weight, extract of licorice root 8-12 parts by weight, wide
Palchouli oil 0.8-1.2 parts by volume and perilla leaf oil 0.4-0.6 parts by volume.
3. a kind of Chinese medicine composition for treating tonsillitis according to claim 2, which is characterized in that the Chinese traditional medicine composition
Composition formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 weight of Poria cocos
Part, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf
Oily 0.4 parts by volume.
4. a kind of preparation method for the Chinese medicine composition for treating tonsillitis described in claim 1-3 any one, including with
Lower step:
1) it takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；By the rhizoma atractylodis of formula ratio,
The dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；The shell of areca nut of the formula ratio is used
Water is decocted and is filtered, and obtains shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to 70-90
DEG C to sufficiently infiltrating and filtering, Poria cocos temperature immersion liquid is obtained；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains tuber of pinellia immersion
Liquid；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, obtains the mixed soaking solution of the tuber of pinellia and rhizoma zingiberis；
2) mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and rhizoma zingiberis are extracted into the ethanol extract, distillation
Mixed soaking solution be sufficiently mixed, be concentrated into density be 1.10-1.20 paste, and be added formula ratio the Radix Glycyrrhizae leaching
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol, the wide leaves of pulse plants of auxiliary material Tween 80 and the formula ratio is added by cream
The aqueous medium of sesame oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value to 5.8-6.2 with sodium hydroxide, obtains the Chinese medicine group
Close object.
5. application of the Chinese medicine composition described in claim 1-3 any one in preparation tonsillitis drug.
6. application according to claim 5, which is characterized in that the Chinese medicine composition can connect for any pharmacy
By dosage form；The tonsillitis drug further includes pharmaceutical acceptable carrier and/or auxiliary agent.
7. according to application described in right 6, which is characterized in that the pharmaceutical dosage form is oral solution and/or tablet.
8. application according to claim 7, which is characterized in that the tablet includes that lozenge, chewable tablets, fuse, mouth collapse
One or more of piece.
9. a kind of drug for treating tonsillitis, which is characterized in that the drug includes during claim 1-3 is described in any item
Drug composition.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112057532A (en) * | 2020-09-10 | 2020-12-11 | 王红军 | Nasal drops for treating upper respiratory tract inflammation and preparation method thereof |
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2019
- 2019-06-03 CN CN201910475257.5A patent/CN110075198A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112057532A (en) * | 2020-09-10 | 2020-12-11 | 王红军 | Nasal drops for treating upper respiratory tract inflammation and preparation method thereof |
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Application publication date: 20190802 |