CN112057532A - Nasal drops for treating upper respiratory tract inflammation and preparation method thereof - Google Patents
Nasal drops for treating upper respiratory tract inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a nasal drop for treating upper respiratory tract inflammation, which comprises the following raw materials in parts by weight: 5-25 parts of rhizoma atractylodis, 5-20 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 5-25 parts of radix angelicae, 5-20 parts of poria cocos, 10-25 parts of pericarpium arecae, 5-20 parts of raw pinellia ternate, 10-25 parts of magnolia flower, 5-25 parts of schizonepeta, 5-20 parts of fructus liquidambaris, 8-15 parts of semen raphani, 8-15 parts of semen brassicae, 5-20 parts of perillaseed, 5-20 parts of fructus schisandrae, 5-15 parts of ligusticum sinense oliver, 5-15 parts of rhizoma cimicifugae and 10-25 parts of sesame oil; the invention has the beneficial effects of removing the attached and deposited pathological products on the mucous membrane surface layer and the submucosal tissue of the upper respiratory tract and thoroughly treating the inflammation of the upper respiratory tract, and is suitable for the field of medicine.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to nasal drops for treating upper respiratory tract inflammation and a preparation method thereof.
Background
The inflammation of the upper respiratory tract is the inflammation of the nose, the pharynx and the larynx, and comprises common cold, rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, adenoid hypertrophy and the like, and the inflammation is often accompanied with symptoms of nasal obstruction, watery nasal discharge, headache, ear pain, hearing loss, phlegm and unsmooth spit of the throat and the like. The inflammation of the upper respiratory tract is mostly caused by cold, and the cold is mostly caused by the reduction of the body resistance, such as lung infection caused by cold, dryness-fire, fatigue, rain and the like. The upper respiratory tract inflammation can be developed in four seasons and at any age, and can be transmitted through droplets, mists or polluted appliances.
The upper respiratory inflammation comprises allergic rhinitis, the allergic rhinitis is a nasal mucosa non-infectious inflammation, the inflammation on the nasal mucosa of a patient with allergic constitution can explode after encountering allergen, and generally, the medicament for treating the allergic rhinitis only can play a role in temporarily relieving and cannot treat the inflammation on the nasal mucosa, so that the allergic rhinitis cannot be completely cured.
At present, the traditional medicine can only temporarily relieve rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, adenoid hypertrophy and other inflammations caused by upper respiratory tract infection, and once a cold is caused, the traditional medicine can be initiated again and cannot completely cure the cold. Therefore, the preparation of the medicament capable of thoroughly curing the upper respiratory tract inflammation is particularly important.
The nasal cavity is complicated in structure, the nasal cavity is connected with eight paranasal sinuses through a pipeline, the nasal cavity is connected with ears through a eustachian tube, the nasal cavity is connected with eyes through a lacrimal duct, and the inflammation of the nasal cavity is the inflammation of the surface layer and the lower layer of the mucous membrane of the nasal cavity. Therefore, the inflammation of the upper respiratory tract can be radically cured, and the inflammation of the upper respiratory tract can be further treated by treating the mucosa of the nasal cavity.
Disclosure of Invention
Aiming at the defects in the related technology, the technical problem to be solved by the invention is as follows: provides a nasal drop for removing attachments on mucous membrane tissues of an upper respiratory tract and thoroughly treating inflammation of the upper respiratory tract and a preparation method thereof.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows: a nasal drop for treating upper respiratory tract inflammation comprises the following raw materials in parts by weight: 5-25 parts of rhizoma atractylodis, 5-20 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 5-25 parts of radix angelicae, 5-20 parts of poria cocos, 10-25 parts of pericarpium arecae, 5-20 parts of raw pinellia ternate, 10-25 parts of magnolia flower, 5-25 parts of schizonepeta, 5-20 parts of fructus liquidambaris, 8-15 parts of semen raphani, 8-15 parts of semen brassicae, 5-20 parts of perillaseed, 5-20 parts of fructus schisandrae, 5-15 parts of ligusticum sinense oliver, 5-15 parts of rhizoma cimicifugae and 10-25 parts of sesame oil.
Preferably, the nasal drop also comprises the following raw materials in parts by weight: 10-25 parts of peppermint oil, 5-15 parts of perilla leaf oil, 5-15 parts of ginger juice, 5-25 parts of glycerol and 10-25 parts of egg yolk oil.
Preferably, the nasal drops comprise the following raw materials in parts by weight: 10 parts of rhizoma atractylodis, 10 parts of dried orange peel, 10 parts of mangnolia officinalis, 10 parts of radix angelicae, 10 parts of poria cocos, 10 parts of pericarpium arecae, 10 parts of unprocessed rhizoma pinelliae, 10 parts of flos magnoliae, 10 parts of herba schizonepetae, 10 parts of fructus liquidambaris, 10 parts of semen raphani, 10 parts of semen brassicae, 10 parts of perillaseed, 10 parts of fructus schizandrae, 10 parts of ligusticum sinense oliver, 10 parts of rhizoma cimicifugae, 10 parts of sesame oil, 10 parts of peppermint oil, 10 parts of perilla leaf oil, 10 parts of ginger juice, 10 parts of glycerol and.
The invention also provides a preparation method of the nasal drops for treating the upper respiratory tract inflammation, which comprises the following steps: (1) weighing raw materials; (2) and (3) brewing: soaking rhizoma Atractylodis, pericarpium Citri Tangerinae, cortex Magnolia officinalis, radix Angelicae Dahuricae, Poria, pericarpium Arecae, rhizoma Pinelliae, flos Magnoliae, herba Schizonepetae, fructus Lipuidambaris, Raphani semen, semen Brassicae Junceae, fructus Perillae, fructus Schisandrae chinensis, rhizoma Ligustici and cimicifugae rhizoma in oleum Sesami for 24 hr; (3) boiling: putting the soaked raw materials and sesame oil into a pot, heating to 70-85 ℃, and cooling to room temperature; then repeating the heating step three times; (4) and (3) filtering: filtering the residue, and collecting the filtrate; (5) adding oleum Menthae Dementholatum, Perilla leaf oil, succus Zingiberis recens, glycerol and egg yolk oil into the filtrate, and mixing.
Preferably, the preparation method of the egg oil comprises the following steps: cooking 15-25 eggs, and taking out egg yolks; frying yolk in a pan until all yolk oil is fried out; filtering to obtain egg yolk oil.
Preferably, the preparation method of the ginger juice comprises the following steps: taking ginger, putting the ginger into a juicer to perform juicing, and filtering to obtain ginger juice.
The invention has the beneficial technical effects that:
1. the invention provides a nasal drop for treating upper respiratory tract inflammation, which comprises the following raw materials in parts by weight: 5-25 parts of rhizoma atractylodis, 5-20 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 5-25 parts of radix angelicae, 5-20 parts of poria cocos, 10-25 parts of pericarpium arecae, 5-20 parts of raw pinellia ternate, 10-25 parts of magnolia flower, 5-25 parts of schizonepeta, 5-20 parts of fructus liquidambaris, 8-15 parts of semen raphani, 8-15 parts of semen brassicae, 5-20 parts of perillaseed, 5-20 parts of fructus schisandrae, 5-15 parts of ligusticum sinense oliver, 5-15 parts of rhizoma cimicifugae and 10-25 parts of sesame oil.
The nasal drops are prepared by reasonably proportioning the raw materials, and can be used for thoroughly treating upper respiratory tract inflammation such as rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, hypertrophy of glands and the like. The nasal drops provided by the invention can penetrate through the deep layer of the mucous membrane, remove deep inflammation and remove the attached and deposited pathological products on the surface layer of the mucous membrane of the upper respiratory tract and the submucosal tissue of the mucous membrane, thereby achieving the effect of thoroughly treating the inflammation of the upper respiratory tract. By dripping the nasal drops prepared by the invention, the nasal drops not only can play a role in treating inflammation in nasal cavity, such as rhinitis, but also can play a role in treating other upper respiratory tract inflammation through a complex nasal cavity structure.
2. The nasal drop also comprises the following raw materials in parts by weight: 10-25 parts of peppermint oil, 5-15 parts of perilla leaf oil, 5-15 parts of ginger juice, 5-25 parts of glycerol and 10-25 parts of egg yolk oil.
According to the invention, the peppermint oil, the perilla leaf oil, the ginger juice, the glycerol and the egg yolk oil are added into the raw materials, so that a better treatment effect on the upper respiratory tract inflammation can be achieved.
3. The preparation method provided by the invention is simple and easy to operate. The prepared nasal drops can effectively remove the attached and deposited pathological products on the mucous membrane surface layer and the submucosal tissue of the upper respiratory tract and thoroughly treat the inflammation of the upper respiratory tract.
4. The preparation method of the egg yolk oil comprises the following steps: cooking 15-25 eggs, and taking out egg yolks; frying yolk in a pan until all yolk oil is fried out; filtering to obtain egg yolk oil. The traditional method for preparing the egg yolk oil is adopted, the operation is simple, the preparation is easy, and a patient can prepare the egg yolk oil by himself.
In order to show the treatment effect of the nasal drops provided by the invention, patients who drip the nasal drops provided by the invention are observed.
1. The using method comprises the following steps: it is applied by dripping into nose for 2-4 times per day.
2. The therapeutic effect judgment standard is as follows: refer to the relevant standard regulation of the clinical research guideline of new Chinese medicine.
And (3) curing: the symptoms of upper respiratory tract inflammation such as rhinitis, allergic rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, gland hypertrophy and the like disappear;
the method has the following advantages: the symptoms of upper respiratory tract inflammation such as rhinitis, allergic rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, gland hypertrophy and the like are relieved.
3. The treatment effect is as follows:
in patients who drip the nasal drops provided by the invention, patients of 0-15 years old can be cured, the attack rate is 80% after the patients are cured, and the symptoms of upper respiratory tract inflammation can be cured after the patients of 0-15 years old drip the nasal drops for 10-30 days.
The effective rate of the patient aged over 15 years is 85%, the non-attack rate after healing is 50%, and the symptoms of upper respiratory tract inflammation can be cured after the patient aged over 15 years is dripped for 10-40 days and is matched with anti-inflammatory drugs.
The therapeutic effects are further specified by exemplifying several typical cases.
Typical case one:
li A. male, 45 years old. Symptoms are: in 2007, the patient is treated, the patient does not breathe freely, has full head and distending pain, and has two swollen pains protruding outwards, the patient can see eyes in the department of ophthalmology hospital to be diagnosed as arteriovenous fistula in the orbit, the patient can take the eyeball, the patient can go to Shanxi Taiyuan hospital to be checked as carotid artery cavernous fistula, the patient can go to craniotomy, and the patient can go to Beijing one hospital to be diagnosed as nasosinusitis. After no fruit treatment, all symptoms disappear after the treatment is recommended by friends to come from my treatment for 40 days, and the disease returns to 7 months in 2019 without further treatment.
Typical case two:
senior, female, 50 years old. Symptoms are: the patient is introduced to the patient by friends at 5 and 8 days in 2005, the patient is diagnosed with nasosinusitis after examination at 11-3 points in the middle of each day, symptoms disappear after 10 days of treatment, the patient attacks again in 2016, or the patient attacks the headache at 11-3 points in the middle of each night, the symptoms disappear after 10 days of treatment, and the patient does not relapse after 6 months of return visit in 2020.
Typical case three:
somebody in horse, male, 12 years old. Symptoms are: the rhinitis, sneezing, rhinorrhea and stuffy nose and stuffiness are reported to be stuffy in the treatment of the rhinitis in 2010, asthma is reported to be in the treatment of the rhinorrhea, the edema and hypertrophy of double nasal concha are detected in the rhinoscopy of the position, the treatment by nasal drip is combined with amoxicillin drinking for one month, and the disease is cured after 8 visits in 2019 without relapse.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments, and it is obvious that the described embodiments are some embodiments, but not all embodiments, of the present invention; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In embodiments one to five, the preparation method of the nasal drops for treating upper respiratory tract inflammation comprises the following steps:
(1) weighing raw materials;
(2) and (3) brewing: soaking rhizoma Atractylodis, pericarpium Citri Tangerinae, cortex Magnolia officinalis, radix Angelicae Dahuricae, Poria, pericarpium Arecae, rhizoma Pinelliae, flos Magnoliae, herba Schizonepetae, fructus Lipuidambaris, Raphani semen, semen Brassicae Junceae, fructus Perillae, fructus Schisandrae chinensis, rhizoma Ligustici and cimicifugae rhizoma in oleum Sesami for 24 hr;
(3) boiling: putting the soaked raw materials and sesame oil into a pot, heating to 70-85 ℃, and cooling to room temperature; then repeating the heating step three times;
(4) and (3) filtering: filtering the residue, and collecting the filtrate;
(5) adding oleum Menthae Dementholatum, Perilla leaf oil, succus Zingiberis recens, glycerol and egg yolk oil into the filtrate, and mixing.
Further, the preparation method of the egg yolk oil comprises the following steps: cooking 15-25 eggs, and taking out egg yolks; frying yolk in a pan until all yolk oil is fried out; filtering to obtain egg yolk oil.
Further, the preparation method of the ginger juice comprises the following steps: taking ginger, putting the ginger into a juicer to perform juicing, and filtering to obtain ginger juice.
Specifically, the peppermint oil, the perilla leaf oil and the glycerol adopted by the invention are common raw materials in the market and can be directly purchased.
The preparation method provided by the invention is simple and easy to operate. The prepared nasal drops can effectively remove the attached and deposited pathological products on the mucous membrane surface layer and the submucosal tissue of the upper respiratory tract and thoroughly treat the inflammation of the upper respiratory tract.
The traditional method for preparing the egg yolk oil is adopted, the operation is simple, the preparation is easy, and a patient can prepare the egg yolk oil by himself.
Specifically, the weight parts of the raw materials correspond to the grams when the nasal drops are actually prepared.
Furthermore, 1 part of the nose drops with the proportion equal to 1g is prepared in the actual preparation.
Weighing the following raw materials in proportion:
example one
10g of rhizoma atractylodis, 10g of dried orange peel, 10g of mangnolia officinalis, 10g of radix angelicae, 10g of poria cocos, 10g of pericarpium arecae, 10g of unprocessed rhizoma pinelliae, 10g of flos magnoliae, 10g of schizonepeta, 10g of fructus liquidambaris, 10g of semen raphani, 10g of semen brassicae, 10g of perillaseed, 10g of fructus schizandrae, 10g of ligusticum sinense oliver, 10g of rhizoma cimicifugae, 10g of sesame oil, 10g of peppermint oil, 10g of perilla leaf oil, 10g of ginger juice, 10g of glycerol and 10.
Example two
5g of rhizoma atractylodis, 15g of dried orange peel, 10g of mangnolia officinalis, 5g of radix angelicae, 15g of poria cocos, 10g of pericarpium arecae, 10g of unprocessed rhizoma pinelliae, 20g of biond magnolia flower, 25g of schizonepeta, 10g of fructus liquidambaris, 8g of semen raphani, 8g of semen brassicae, 20g of perillaseed, 10g of fructus schizandrae, 15g of ligusticum sinense oliver, 10g of rhizoma cimicifugae, 25g of sesame oil, 10g of peppermint oil, 15g of perilla leaf oil, 5g of ginger juice, 10g of glycerol and.
EXAMPLE III
15g of rhizoma atractylodis, 20g of dried orange peel, 20g of mangnolia officinalis, 15g of radix angelicae, 20g of poria cocos, 20g of pericarpium arecae, 20g of raw pinellia ternate, 15g of biond magnolia flower, 15g of schizonepeta, 5g of fructus liquidambaris, 10g of semen raphani, 10g of semen brassicae, 15g of perillaseed, 5g of fructus schizandrae, 10g of ligusticum sinense oliver, 5g of rhizoma cimicifugae, 10g of sesame oil, 15g of peppermint oil, 10g of perilla leaf oil, 5g of ginger juice, 25g of glycerol and 15.
Example four
10g of rhizoma atractylodis, 5g of dried orange peel, 25g of mangnolia officinalis, 10g of radix angelicae, 5g of poria cocos, 25g of pericarpium arecae, 15g of unprocessed rhizoma pinelliae, 10g of flos magnoliae, 5g of herba schizonepetae, 20g of fructus liquidambaris, 10g of semen raphani, 10g of semen brassicae, 10g of perillaseed, 15g of fructus schizandrae, 5g of ligusticum sinense oliver, 15g of rhizoma cimicifugae, 20g of sesame oil, 20g of peppermint oil, 5g of perilla leaf oil, 10g of ginger juice, 15g of glycerol and.
EXAMPLE five
25g of rhizoma atractylodis, 10g of dried orange peel, 15g of mangnolia officinalis, 25g of radix angelicae, 10g of poria cocos, 15g of pericarpium arecae, 5g of raw pinellia ternate, 25g of biond magnolia flower, 5g of schizonepeta, 15g of fructus liquidambaris, 15g of semen raphani, 15g of semen brassicae, 5g of perillaseed, 20g of fructus schizandrae, 10g of ligusticum sinense oliver, 15g of rhizoma cimicifugae, 20g of sesame oil, 25g of peppermint oil, 5g of perilla leaf oil, 15g of ginger juice, 5g of glycerol and 25.
The nasal drops are prepared by reasonably proportioning the raw materials, and can be used for thoroughly treating upper respiratory tract inflammation such as rhinitis, pharyngitis, tracheitis, tonsillitis, asthma, hypertrophy of glands and the like. The nasal drops provided by the invention can penetrate through the deep layer of the mucous membrane, remove deep inflammation and remove the attached and deposited pathological products on the surface layer of the mucous membrane of the upper respiratory tract and the submucosal tissue of the mucous membrane, thereby achieving the effect of thoroughly treating the inflammation of the upper respiratory tract. By dripping the nasal drops prepared by the invention, the nasal drops not only can play a role in treating inflammation in nasal cavity, such as rhinitis, but also can play a role in treating other upper respiratory tract inflammation through a complex nasal cavity structure.
According to the invention, the peppermint oil, the perilla leaf oil, the ginger juice, the glycerol and the egg yolk oil are added into the raw materials, so that a better treatment effect on the upper respiratory tract inflammation can be achieved.
In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
It will be appreciated that the relevant features of the method, apparatus and system described above are referred to one another. In addition, "first", "second", and the like in the above embodiments are for distinguishing the embodiments, and do not represent merits of the embodiments.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. A nasal drop for treating upper respiratory tract inflammation is characterized in that: the feed comprises the following raw materials in parts by weight: 5-25 parts of rhizoma atractylodis, 5-20 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 5-25 parts of radix angelicae, 5-20 parts of poria cocos, 10-25 parts of pericarpium arecae, 5-20 parts of raw pinellia ternate, 10-25 parts of magnolia flower, 5-25 parts of schizonepeta, 5-20 parts of fructus liquidambaris, 8-15 parts of semen raphani, 8-15 parts of semen brassicae, 5-20 parts of perillaseed, 5-20 parts of fructus schisandrae, 5-15 parts of ligusticum sinense oliver, 5-15 parts of rhizoma cimicifugae and 10-25 parts of sesame oil.
2. The nasal drop for treating upper respiratory tract inflammation according to claim 1, wherein:
the nasal drop also comprises the following raw materials in parts by weight: 10-25 parts of peppermint oil, 5-15 parts of perilla leaf oil, 5-15 parts of ginger juice, 5-25 parts of glycerol and 10-25 parts of egg yolk oil.
3. The nasal drops for treating inflammation of the upper respiratory tract according to claim 2, wherein:
the nasal drops comprise the following raw materials in parts by weight: 10 parts of rhizoma atractylodis, 10 parts of dried orange peel, 10 parts of mangnolia officinalis, 10 parts of radix angelicae, 10 parts of poria cocos, 10 parts of pericarpium arecae, 10 parts of unprocessed rhizoma pinelliae, 10 parts of flos magnoliae, 10 parts of herba schizonepetae, 10 parts of fructus liquidambaris, 10 parts of semen raphani, 10 parts of semen brassicae, 10 parts of perillaseed, 10 parts of fructus schizandrae, 10 parts of ligusticum sinense oliver, 10 parts of rhizoma cimicifugae, 10 parts of sesame oil, 10 parts of peppermint oil, 10 parts of perilla leaf oil, 10 parts of ginger juice, 10 parts of glycerol and.
4. A method for preparing a nasal drop for treating upper respiratory tract inflammation according to any one of claims 1 to 3, wherein: the method comprises the following steps:
(1) weighing raw materials;
(2) and (3) brewing: soaking rhizoma Atractylodis, pericarpium Citri Tangerinae, cortex Magnolia officinalis, radix Angelicae Dahuricae, Poria, pericarpium Arecae, rhizoma Pinelliae, flos Magnoliae, herba Schizonepetae, fructus Lipuidambaris, Raphani semen, semen Brassicae Junceae, fructus Perillae, fructus Schisandrae chinensis, rhizoma Ligustici and cimicifugae rhizoma in oleum Sesami for 24 hr;
(3) boiling: putting the soaked raw materials and sesame oil into a pot, heating to 70-85 ℃, and cooling to room temperature; then repeating the heating step three times;
(4) and (3) filtering: filtering the residue, and collecting the filtrate;
(5) adding oleum Menthae Dementholatum, Perilla leaf oil, succus Zingiberis recens, glycerol and egg yolk oil into the filtrate, and mixing.
5. The method for preparing a nasal drop for treating upper respiratory tract inflammation according to claim 4, wherein the nasal drop comprises the following steps: the preparation method of the egg yolk oil comprises the following steps: cooking 15-25 eggs, and taking out egg yolks; frying yolk in a pan until all yolk oil is fried out; filtering to obtain egg yolk oil.
6. The method for preparing a nasal drop for treating upper respiratory tract inflammation according to claim 4, wherein the nasal drop comprises the following steps: the preparation method of the ginger juice comprises the following steps: taking ginger, putting the ginger into a juicer to perform juicing, and filtering to obtain ginger juice.
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Application publication date: 20201211 |