CN1616065A - Zhengchaihuyin dripping pill - Google Patents
Zhengchaihuyin dripping pill Download PDFInfo
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- CN1616065A CN1616065A CN 200410080515 CN200410080515A CN1616065A CN 1616065 A CN1616065 A CN 1616065A CN 200410080515 CN200410080515 CN 200410080515 CN 200410080515 A CN200410080515 A CN 200410080515A CN 1616065 A CN1616065 A CN 1616065A
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Abstract
The present invention discloses a kind of orally taken medicine preparation for treating disease caused by exogenous wind and cold, fever, aversion to cold, headache, etc., and is especially Zhengchaihuyin dripping pill with the extract of traditional Zhengchaihuyin recipe and possessing antiviral and antibacterial effect. The Zhengchaihuyin dripping pill of the present invention has high bioavailability, fast medicine release, quick acting, less toxic side effect, pollution-free production process and low cost. The Zhengchaihuyin dripping pill of the present invention is prepared based on traditional recipe.
Description
Technical field
The present invention relates to a kind of medicine oral formulations that cures mainly diseases such as affection of exogenous wind-cold, fever with chills, headache, general pain, the extract that is particularly related to Zhengchaihuyin Chinese medicine Cheng Fang is an active constituents of medicine, and has the oral drop pills of antiviral, antibacterial action.
Background technology
" Zhengchaihuyin " is the flat side of representative that looses of inducing sweat in the Ming Dynasty well-known doctor Zhang Jingyue Jing-Yue Complete Works, formed by Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, had dispersing wind-cold, the effect of antipyretic analgesic, cure mainly affection of exogenous wind-cold from the beginning of, fever with aversion to cold, lossless, headache, nasal obstruction, sneeze, itching throat cough, diseases such as extremities aching pain.Jing-Yue Complete Works is recording six and is being named as the prescription of " Radix Bupleuri drink ", preceding 5 cry respectively " Radix Bupleuri drink 1, Radix Bupleuri drink 2 ..., Radix Bupleuri drink 5 ".The 6th is on the basis of 5 prescriptions of pro-, and further summary is improved and got, and is the diffusing side of representative of Xin Ganping, is named as " Zhengchaihuyin ", and the reasonability of its prescription is well-known at home and abroad, especially Japan, Korea S etc.This prescription clinical practice by hundreds of years, its effect has obtained effective confirmation, does not find tangible toxicity.Zhengchaihuyin pair 10 kind virus, the especially influenza virus relevant with upper respiratory tract infection have significant broad-spectrum disease resistance toxic action
[1]
To studies confirm that of Zhengchaihuyin capsule, Zhengchaihuyin to try nine kinds in 10 strain virus, has the parainfluenza-1, RSV, the ECHO that belong to the RNA type at 4mg/ml through relevant
11, CoxB
4, B
5, B
6Virus; The AdV that belongs to DNA viruses is arranged
3, HSV-I, II type.The effect of the pathological changes caused by virus of inhibition is all arranged, and similar effect is arranged to the positive control drug virazole.In vivo, irritate the stomach mice with Zhengchaihuyin 6,12,24g/kg/d, pneumonopathy due to the influenza virus infecting mouse is become significant inhibitory effect, and can significantly reduce the proliferative amount of influenza virus in the Mus lung.Similar in suppression ratio and the development process.Result of the test shows, Zhengchaihuyin is at external not only 6 strain virus that belong to RNA to being tried, and 3 strain virus that belong to DNA are all had the effect of the pathological changes caused by virus of inhibition, and its antiviral spectrum is wider.In vivo the degree of viral pneumonia due to the influenza virus infecting mouse and the proliferative amount in the virus infected mice lung all there are significant inhibitory effect, and have all kept the efficacy strength in the development process
[2]
The Zhengchaihuyin peroral dosage form that utilizes prior art to obtain has only electuary and capsule through looking into.Yet, owing to reasons such as technologies of preparing, exist all after the oral formulations of most drug is taken that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect, especially Chinese medicine preparation is all the more so.
In addition, conventional oral peroral dosage form because technical processs such as dry powder blend, granulation are arranged, therefore can produce bigger dust pollution in preparation process, and the health to the staff works the mischief to a certain extent, also can cause certain pollution to environment.Simultaneously, conventional oral formulations complex manufacturing, production cost is higher, is unfavorable for the poor slightly patient of economic condition with regard to medical drugs, therefore is necessary to seek better Zhengchaihuyin oral formulations to satisfy the needs that clinical treatment and family use.
Summary of the invention
Purpose of the present invention, be to replenish the existing deficiency that is used to cure mainly the oral drug preparation of diseases such as affection of exogenous wind-cold, fever with chills, headache, general pain, a kind of bioavailability height is provided, release fast, quick produce effects, toxic and side effects is littler, and produce pollution-free, the pure Chinese medicine composition composition oral preparation Zhengchaihuyin dripping pill that production cost is lower.
The Zhengchaihuyin dripping pill that reaches of the present invention is a raw material with the pure Chinese medicine of 6 flavors such as Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis, forms through specific prepared.Be prepared by the following technical solutions, can obtain pulse invigorating pill involved in the present invention:
[prescription of raw material of Chinese medicine and extraction]
1. be unit with g or kg, according to the weight portion meter, 4 parts of Radix Bupleuri, 2 parts of Radix Saposhnikoviaes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 4 parts of the Radix Paeoniae Albas, 2 parts of Rhizoma Zingiberis;
2. with Radix Bupleuri, Radix Saposhnikoviae, Rhizoma Zingiberis water logging 30 minutes, extracted volatile oil 6 hours, volatile oil is standby, simultaneously decocting liquid is filtered, medicinal liquid A is standby;
3. the medicinal residues after will filtering add Pericarpium Citri Reticulatae, the Radix Paeoniae Alba and Radix Glycyrrhizae, are using water logging 30 minutes, and heating makes little boiling 30 minutes, and 2 times, filter, get liquor B;
4. preceding gained medicinal liquid A, B are merged, left standstill 24 hours, filter, filtrate concentrated into density be? extractum, or be concentrated into density and be? the time the direct spray-dried dry powder of making.
The method of extracting is a lot, has only provided a kind of method here, but has been not limited to this kind method.
[preparation of drop pill]
1. fill a prescription
1.1 raw material: extractum that contains active pharmaceutical ingredient or dry powder through extracting;
1.2 substrate: Polyethylene Glycol
2000～20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate 40 esters, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate one or more mixture wherein;
1.3 (with g or kg is unit to proportioning, by weight): extractum (or dry powder): substrate=1: 1～1: 9.
2. according to the given ratio of prescription, accurately take by weighing extractum (perhaps dry powder) and substrate, the substrate that is taken by weighing is placed heating while stirring in the heating container, treat complete fusion, add extractum again and stir, obtain containing the pharmaceutical composition mixed liquor of active pharmaceutical ingredient and substrate;
3. adopt homemade or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on (50～90) ℃, the temperature cooling of condensing agent also remains on (40～-5) ℃;
4. treating that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively is in above the 2nd step during desired state of temperature, the pharmaceutical composition mixed liquor that will contain active pharmaceutical ingredient and substrate places in the water dropper storage vat of drop pill machine, splashes in the condensing agent by water dropper with suitable speed.
Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
4. will shrink the drop pill taking-up of molding by the outlet of drop pill machine, remove the surface condensation agent, be drying to obtain.
Beneficial effect
The Zhengchaihuyin peroral dosage form that utilizes prior art to obtain has only electuary and capsule through looking into.Yet, owing to reasons such as technologies of preparing, exist all after the oral formulations of most drug is taken that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect, especially Chinese medicine preparation is all the more so.
In addition, conventional oral peroral dosage form because technical processs such as dry powder blend, granulation are arranged, therefore can produce bigger dust pollution in preparation process, and the health to the staff works the mischief to a certain extent, also can cause certain pollution to environment.Simultaneously, conventional oral formulations complex manufacturing, production cost is higher, is unfavorable for the poor slightly patient of economic condition with regard to medical drugs, therefore is necessary to seek better Zhengchaihuyin oral formulations to satisfy the needs that clinical treatment and family use.
Zhengchaihuyin dripping pill involved in the present invention is compared with other oral formulations, has following beneficial effect:
1. Zhengchaihuyin dripping pill involved in the present invention; utilize surfactant to be substrate; make solid dispersion with extractum that contains active constituents of medicine or dry powder; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases, and substrate is hydrophilic, and medicine is had wetting action; can make that medicine is rapidly molten to loose into microgranule or solution, thereby make the dissolving of medicine and absorb and accelerate.Thereby improved bioavailability, brought into play efficient, quick-acting effects etc.
Compare with the administering mode of traditional oral formulations, exist essential distinction.Drop pill with the solid dispersion technology preparation can adopt oral and sublingual administration, and effective ingredient is fully contacted with mucomembranous surface, absorbs by mucomembranous epithelial cell, directly enters blood circulation.Owing to directly enter blood circulation without gastrointestinal tract and liver, avoided first pass effect effectively, also avoided gastrointestinal irritation, thereby it is rapid to have an onset, bioavailability height, characteristics such as side effect is little, and medication is convenient.
2. Zhengchaihuyin dripping pill involved in the present invention contacts promptly with saliva and to dissolve rapidly, and is absorbed by oral mucosa, and is not only rapid-action, and the influence of not taken food, and promptly all can containing take after meal ante cibum.
3. production technology, the equipment of preparation drop pill are simple, easy to operate, the automaticity height, and labor intensity is low, the production efficiency height.Workshop does not have dust simultaneously, helps labor protection and environmental protection yet.
The active constituents of medicine of drop pill is uniformly dispersed in substrate, and dosage is accurate, and the ball method of double differences is different little than tablet, and production cost is usually with about 50% of other oral formulations of kind.
4. Zhengchaihuyin dripping pill involved in the present invention mixes the extractum (or dry powder) that contains active constituents of medicine mutually with molten matrix, splashes in the not miscible condensed fluid and makes.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
In sum, make Zhengchaihuyin dripping pill involved in the present invention have the advantage of triple effect (quick-acting, efficient, long-acting), three little (taking dose is little, toxicity is little, side effect little), five convenience (convenient for production, store convenience, convenient transportation, easy to carry, easy to use).
The specific embodiment
Now with the test and the result thereof of three groups of specific embodiments, be described further with regard to the preparation method of Zhengchaihuyin dripping pill involved in the present invention.
[prescription]
1. prescription that provides according to [prescription of raw material of Chinese medicine and extraction] and the technical process extractum or the dry powder that obtain containing active pharmaceutical ingredient;
2. substrate: Polyethylene Glycol
2000,4000,6000,8000,10000,2000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate;
3. proportioning (with g or kg is unit, according to the weight portion meter): extractum (dry powder): substrate=1: (1～9);
[result of the test]
Test 1: for observe extractum or dry powder and different substrates when 1: 1 the proportioning prepared Zhengchaihuyin dripping pill in qualitative difference, according to 1: 1 ratio, with extractum or dry powder respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 15 pharmaceutical compositions that extractum or dry powder and different substrates constituted, and obtain 15 groups of different experimental results and see Table 1.
The group practices of table 1 extractum or dry powder and different substrates (1: 1)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??50.0 | ??70 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 4000 | ??50.0 | ??83 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 6000 | ??50.0 | ??89 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 8000 | ??50.0 | ??92 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 10000 | ??50.0 | ??95 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 20000 | ??50.0 | ??95 | ??＜30 | ??＜10 | +++ |
| Stearic acid | ??50.0 | ??55 | ??＜30 | ??＞10 | + |
| Sodium stearate | ??50.0 | ??68 | ??＜30 | ??＞10 | + |
| Glycerin gelatine | ??50.0 | ??52 | ??＜30 | ??＞10 | + |
| Polyoxyethylene stearate 40 esters | ??50.0 | ??87 | ??＜30 | ??＜10 | +++ |
| Lac | ??50.0 | ??42 | ??＜30 | ??＞10 | + |
| The polyoxyethylene monostearate | ??50.0 | ??73 | ??＜30 | ??＞10 | + |
| Polyethers | ??50.0 | ??86 | ??＜30 | ??＞10 | ++ |
| Carboxymethyl starch sodium | ??50.0 | ??74 | ??＜30 | ??＞10 | + |
| Sodium lauryl sulphate | ??50.0 | ??70 | ??＜30 | ??＞10 | + |
Result by table 1 can see: when extractum or dry powder: during substrate=1: 1, part test rounding rate wherein, the ball method of double differences is different and index such as hardness is all undesirable, and dissolve scattered time limit institute is influenced not obvious.
Test 2: for observe extractum or dry powder and different substrates when 1: 3 the proportioning prepared Zhengchaihuyin dripping pill in qualitative difference, according to 1: 3 ratio, with extractum or dry powder respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 15 pharmaceutical compositions that extractum or dry powder and different substrates constituted, and obtain 15 groups of different experimental results and see Table 2.
The group practices of table 2 extractum or dry powder and different substrates (1: 3)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??25.0 | ??75 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 4000 | ??25.0 | ??90 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 6000 | ??25.0 | ??90 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 8000 | ??25.0 | ??92 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 10000 | ??25.0 | ??95 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 20000 | ??25.0 | ??94 | ??＜30 | ??＜10 | +++ |
| Stearic acid | ??25.0 | ??65 | ??＜30 | ??＞10 | + |
| Sodium stearate | ??25.0 | ??72 | ??＜30 | ??＞10 | + |
| Glycerin gelatine | ??25.0 | ??72 | ??＜30 | ??＞10 | + |
| Polyoxyethylene stearate 40 esters | ??25.0 | ??89 | ??＜30 | ??＜10 | ++ |
| Lac | ??25.0 | ??71 | ??＜30 | ??＞10 | + |
| The polyoxyethylene monostearate | ??25.0 | ??78 | ??＜30 | ??＞10 | + |
| Polyethers | ??25.0 | ??90 | ??＜30 | ??＜10 | ++ |
| Carboxymethyl starch sodium | ??25.0 | ??85 | ??＜30 | ??＜10 | ++ |
| Sodium lauryl sulphate | ??25.0 | ??75 | ??＜30 | ??＞10 | + |
Result by table 2 can see: when extractum or dry powder: during substrate=1: 3, the rounding rate, the ball method of double differences is different and index such as hardness is better than the data of table 1.
Test 3: for observe extractum or dry powder and different substrates when 1: 9 the proportioning prepared Zhengchaihuyin dripping pill in qualitative difference, according to 1: 9 ratio, with extractum or dry powder respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate matches, adopt homemade drop pill machine, be prepared according to the step of stipulating in the preparation method, can obtain the experiment of 15 pharmaceutical compositions that extractum or dry powder and different substrates constituted, and obtain 15 groups of different experimental results and see Table 3.
The group practices of table 3 extractum or dry powder and different substrates (1: 9)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??10.0 | ??78 | ??＜30 | ??＞10 | ++ |
| Polyethylene Glycol 4000 | ??10.0 | ??92 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 6000 | ??10.0 | ??92 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 8000 | ??10.0 | ??94 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 10000 | ??10.0 | ??93 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 20000 | ??10.0 | ??93 | ??＜30 | ??＜10 | +++ |
| Stearic acid | ??10.0 | ??78 | ??＜30 | ??＞10 | + |
| Sodium stearate | ??10.0 | ??79 | ??＜30 | ??＞10 | ++ |
| Glycerin gelatine | ??10.0 | ??73 | ??＜30 | ??＞10 | + |
| Polyoxyethylene stearate 40 esters | ??10.0 | ??90 | ??＜30 | ??＜10 | +++ |
| Lac | ??10.0 | ??78 | ??＜30 | ??＞10 | ++ |
| The polyoxyethylene monostearate | ??10.0 | ??88 | ??＜30 | ??＜10 | ++ |
| Polyethers | ??10.0 | ??89 | ??＜30 | ??＜10 | +++ |
| Carboxymethyl starch sodium | ??10.0 | ??80 | ??＜30 | ??＞10 | +++ |
| Sodium lauryl sulphate | ??10.0 | ??80 | ??＜30 | ??＞10 | ++ |
Result by table 3 can see: when extractum or dry powder: during substrate=1: 9, it is desirable that every index all is tending towards.
(annotate: the hardness method for expressing in the subordinate list, adopt drop pill is placed on the glass plate, press...with one's finger it, observe its metamorphosis."+" expression flicking promptly is out of shape, " ++ " expression distortion of firmly pressing, and " +++" expression is indeformable by it.)
The partial reference data is as follows:
1. restrain in season and win Zhu Qianyong. the pharmacological research of Zhengchaihuyin and clinical practice overview. journal of shanghai Chinese medicine the 37th the 10th phase of volume of October in 2003 is P.58-59;
2. He Yu chisels, high hero, rich heave ho. the 2nd the 1st phase of volume of Chinese experimental pharmacology of Chinese medical formulae magazine .1996 is P.12-15.
Claims (5)
- One kind by the pure Chinese medicine preparation of 6 flavors such as Radix Bupleuri the drug composition oral preparation Zhengchaihuyin dripping pill that cures mainly diseases such as affection of exogenous wind-cold, fever with chills, headache, general pain, with the pure Chinese medicine of Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis etc. 6 flavor mixed extract---extractum or dry powder are raw material, be prepared from pharmaceutically suitable carrier as substrate, wherein:1.1 extractum or dry powder are extracted and get through the extraction process of routine by the pure Chinese medicine of 6 flavors such as Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis, the ratio of Six-element Chinese medicine is: 4 parts of Radix Bupleuri, 2 parts of Radix Saposhnikoviaes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 4 parts of the Radix Paeoniae Albas, 2 parts of Rhizoma Zingiberis;1.2 substrate: Polyethylene Glycol 2000～20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate 40 esters, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate one or more mixture wherein;1.3 proportioning---extractum or dry powder: substrate=1: 1～1: 9.
- 2. Zhengchaihuyin dripping pill as claimed in claim 1 is characterized in that: described substrate is Polyethylene Glycol 2000, Polyethylene Glycol 4000, Polyethylene Glycol 6000, Polyethylene Glycol 8000, Polyethylene Glycol 10000, Polyethylene Glycol 20000
- 3. Zhengchaihuyin dripping pill as claimed in claim 1 is characterized in that: described substrate is polyoxyethylene stearate 40 esters, carboxymethyl starch sodium, sodium lauryl sulphate.
- 4. Zhengchaihuyin dripping pill as claimed in claim 1 is characterized in that: described substrate is polyoxyethylene stearate 40 esters, carboxymethyl starch sodium, sodium lauryl sulphate, Polyethylene Glycol 4000, Polyethylene Glycol 6000, Polyethylene Glycol 8000, Polyethylene Glycol 10000, Polyethylene Glycol 20000In two or more mixture in pharmaceutically suitable carrier.
- 5. as the described any Zhengchaihuyin dripping pill of claim 1～4, it is characterized in that: the ratio of described extractum or dry powder and substrate is 1: 1～1: 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410080515 CN1616065A (en) | 2004-09-30 | 2004-09-30 | Zhengchaihuyin dripping pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410080515 CN1616065A (en) | 2004-09-30 | 2004-09-30 | Zhengchaihuyin dripping pill |
Publications (1)
| Publication Number | Publication Date |
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| CN1616065A true CN1616065A (en) | 2005-05-18 |
Family
ID=34765634
Family Applications (1)
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| CN 200410080515 Pending CN1616065A (en) | 2004-09-30 | 2004-09-30 | Zhengchaihuyin dripping pill |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311806C (en) * | 2005-07-19 | 2007-04-25 | 北京蓝贝望医药科技开发有限公司 | Oral liquor preparation contg. radix bupleuri, and its prepn. method |
| CN100348178C (en) * | 2005-06-10 | 2007-11-14 | 北京正大绿洲医药科技有限公司 | 'Ganjing' dripping pills for treating liver disease and its preparation |
| CN100364513C (en) * | 2005-06-10 | 2008-01-30 | 北京正大绿洲医药科技有限公司 | 'Gansu' dripping pills for treating hepatitis and its preparation method |
| CN106267110A (en) * | 2016-09-28 | 2017-01-04 | 广州凯耀资产管理有限公司 | A kind of preparation method for the flat Chinese medicine extract dissipated that induces sweat |
| CN117530917A (en) * | 2024-01-09 | 2024-02-09 | 北京中科利华医药研究院有限公司 | Bupleurum root suppository |
-
2004
- 2004-09-30 CN CN 200410080515 patent/CN1616065A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100348178C (en) * | 2005-06-10 | 2007-11-14 | 北京正大绿洲医药科技有限公司 | 'Ganjing' dripping pills for treating liver disease and its preparation |
| CN100364513C (en) * | 2005-06-10 | 2008-01-30 | 北京正大绿洲医药科技有限公司 | 'Gansu' dripping pills for treating hepatitis and its preparation method |
| CN1311806C (en) * | 2005-07-19 | 2007-04-25 | 北京蓝贝望医药科技开发有限公司 | Oral liquor preparation contg. radix bupleuri, and its prepn. method |
| CN106267110A (en) * | 2016-09-28 | 2017-01-04 | 广州凯耀资产管理有限公司 | A kind of preparation method for the flat Chinese medicine extract dissipated that induces sweat |
| CN117530917A (en) * | 2024-01-09 | 2024-02-09 | 北京中科利华医药研究院有限公司 | Bupleurum root suppository |
| CN117530917B (en) * | 2024-01-09 | 2024-04-05 | 北京中科利华医药研究院有限公司 | Bupleurum root suppository |
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