CN1272003C - 苦参总碱凝胶制剂及该凝胶制剂的制备方法 - Google Patents
苦参总碱凝胶制剂及该凝胶制剂的制备方法 Download PDFInfo
- Publication number
- CN1272003C CN1272003C CN 03115198 CN03115198A CN1272003C CN 1272003 C CN1272003 C CN 1272003C CN 03115198 CN03115198 CN 03115198 CN 03115198 A CN03115198 A CN 03115198A CN 1272003 C CN1272003 C CN 1272003C
- Authority
- CN
- China
- Prior art keywords
- radix sophorae
- sophorae flavescentis
- preparation
- total alkaloids
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- 229960001631 carbomer Drugs 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003729 cation exchange resin Substances 0.000 claims abstract description 7
- 229930013930 alkaloid Natural products 0.000 claims description 46
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 239000003480 eluent Substances 0.000 claims description 11
- 229910021529 ammonia Inorganic materials 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000005325 percolation Methods 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- 239000002156 adsorbate Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000002689 soil Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 abstract description 4
- 230000001070 adhesive effect Effects 0.000 abstract description 4
- 210000004877 mucosa Anatomy 0.000 abstract description 4
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 210000001215 vagina Anatomy 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 5
- 239000000829 suppository Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 2
- 238000005341 cation exchange Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229930015582 oxymatrine Natural products 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03115198 CN1272003C (zh) | 2003-01-27 | 2003-01-27 | 苦参总碱凝胶制剂及该凝胶制剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03115198 CN1272003C (zh) | 2003-01-27 | 2003-01-27 | 苦参总碱凝胶制剂及该凝胶制剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1520816A CN1520816A (zh) | 2004-08-18 |
CN1272003C true CN1272003C (zh) | 2006-08-30 |
Family
ID=34284171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 03115198 Expired - Lifetime CN1272003C (zh) | 2003-01-27 | 2003-01-27 | 苦参总碱凝胶制剂及该凝胶制剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1272003C (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1297251C (zh) * | 2004-10-12 | 2007-01-31 | 马宏英 | 辣椒风湿凝胶 |
CN100418528C (zh) * | 2006-02-28 | 2008-09-17 | 上海华拓医药科技发展有限公司 | 一种含苦参碱类生物碱的热敏凝胶剂及其制备方法 |
CN101336958B (zh) * | 2008-02-15 | 2013-01-16 | 上海海天医药科技开发有限公司 | 苦参中提取的生物碱在治疗支原体、衣原体和真菌引起的疾病中的药物用途 |
CN101647854B (zh) * | 2008-08-13 | 2012-08-29 | 代龙 | 一种用离子交换树脂分离苦参总生物碱的方法 |
CN101797304B (zh) * | 2010-03-23 | 2011-08-03 | 杨霞 | 一种调节女性阴道微生态的凝胶 |
CN105663029A (zh) * | 2016-01-13 | 2016-06-15 | 杭州市儿童医院 | 用于口腔给药的生物粘附性缓释凝胶制剂及其制备方法 |
CN106204351A (zh) * | 2016-07-20 | 2016-12-07 | 宁波公众信息产业有限公司 | 一种餐饮服务系统 |
CN107624769B (zh) * | 2017-09-20 | 2020-06-23 | 青岛科技大学 | 苦参碱微囊凝胶复合系统缓释制剂及其制备方法和应用 |
CN108014140A (zh) * | 2018-02-02 | 2018-05-11 | 上海哈美实业发展有限公司 | 一种阴道粘膜抗菌凝胶剂及其制备方法 |
CN111529568A (zh) * | 2020-05-29 | 2020-08-14 | 贵阳新天药业股份有限公司 | 苦参总碱在制备治疗外阴硬化性苔癣的药物中的应用 |
-
2003
- 2003-01-27 CN CN 03115198 patent/CN1272003C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1520816A (zh) | 2004-08-18 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Sophocarpidine gel preparation and its process Effective date of registration: 20101013 Granted publication date: 20060830 Pledgee: Guizhou science and Technology Venture Capital Co.,Ltd. Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2010990000913 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20110920 Granted publication date: 20060830 Pledgee: Guizhou science and Technology Venture Capital Co.,Ltd. Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2010990000913 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Sophocarpidine gel preparation and its process Effective date of registration: 20110920 Granted publication date: 20060830 Pledgee: Guizhou Tianxin Company limited by guarantee Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2011990000363 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20120911 Granted publication date: 20060830 Pledgee: Guizhou Tianxin Company limited by guarantee Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2011990000363 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Sophocarpidine gel preparation and its process Effective date of registration: 20141127 Granted publication date: 20060830 Pledgee: Bank of Guiyang Limited by Share Ltd. Wudang branch Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2014990001010 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20170623 Granted publication date: 20060830 Pledgee: Bank of Guiyang Limited by Share Ltd. Wudang branch Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: 2014990001010 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Sophocarpidine gel preparation and its process Effective date of registration: 20190819 Granted publication date: 20060830 Pledgee: Industrial Commercial Bank of China Ltd. Guiyang Wudang branch Pledgor: Shanghai Haitian Medical Technology Development Co.,Ltd. Registration number: Y2019520000004 |
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CX01 | Expiry of patent term |