CN1270710C - 一种治疗皮肤病及口腔溃疡的外用药物溶液 - Google Patents
一种治疗皮肤病及口腔溃疡的外用药物溶液 Download PDFInfo
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Abstract
本发明涉及一种用于治疗皮肤病及口腔溃疡的外用药物，其在10000ml药物溶液中含有如下重量组份：葡萄糖酸锌150-200g、灭滴灵(甲硝哒唑)20-30g、维生素B61-2g、的卡因5-10g、苯甲酸钠10-15g，本发明药物溶液消炎抗感染、修复保护皮肤黏膜、收敛、止疼、止痒促创伤修复愈合，本发明药物溶液适用于顽固性、复发性口腔溃疡，显效速、防复发、对各种皮肤顽疾，如皮肤骚痒症、湿疹、神经性皮炎、痤疮及创伤等均有较好的疗效。
Description
技术领域
本发明涉及一种治疗皮肤病及口腔溃疡的外用药物溶液。
技术背景
目前具有顽固性、复发性的口腔溃疡及各种皮肤顽疾，如皮肤搔痒症、湿疹、寻麻疹、皮炎、痤疮以及褥疮等各类皮肤感染性病变严重影响人们身心健康，人们采取多种药物和医疗手段治疗，但效果均不十分理想。
发明内容
本发明所要解决的技术问题是提供一种具有良好的临床疗效且无毒、副作用及药物依赖性的治疗皮肤病及口腔溃疡的外用药物溶液。
本发明采用如下技术方案：本发明10000ml药物溶液中含有如下重量组份：
葡萄糖酸锌150-200g 灭滴灵(甲硝哒唑) 20-30g
维生素B6 1-2g 的卡因5-10g 苯甲酸钠10-15g
余量为水。
本发明溶液的制备方法为采用如下重量组份：
葡萄糖酸锌150-200g 灭滴灵(甲硝哒唑)20-30g
维生素B6 1-2g 的卡因5-10g 苯甲酸钠10-15g
将上述组份加工成粉剂混合后加水制成10000ml溶液，沉淀24小时后过滤、消毒、分装即制成。
本发明以葡萄糖酸锌为主要成份，药效学实验证明，有机锌吸收理想可快速发挥疗效，实验证实缺锌口腔粘膜增生角化不全，缺锌阻塞味蕾孔，使味觉敏锐度降低；缺锌降低了羟基肽酶A的活力，使消化功能明显下降。锌有加速修复，促进正常皮肤角质生成，有强力的收敛，有止痒、镇痛之功效，可促进皮肤溃疡、外伤、湿疹等病变的愈合及康复，并有增强皮肤抗力及自身免疫的强大作用。
经实验证实及临床观察葡萄糖酸锌高于口服一次量，一倍含量的水溶液外用安全无任何毒、副作用。本发明采用的葡萄糖酸锌粉剂系国营正规药厂生产，药源充足价格较低(每Kg约1000元)。且此原料药品均符合药检质量合格标准。本发明生产工艺条件要求明确，工艺流程简单，制配技术操作易掌握，一般药厂制药车间均可正常生产，不需特殊高尖设备。
本发明药物溶液消炎抗感染、修复保护皮肤黏膜、收敛、止疼、止痒促创伤修复愈合。本发明药物溶液适用于顽固性、复发性口腔溃疡，显效速、防复发、对各种皮肤顽疾，如皮肤骚痒症、湿疹、神经性皮炎、痤疮及创伤等均有较好的疗效。本发明药物溶液含嗽、患部涂擦、湿敷均可。本发明为水剂溶液，每瓶100ml，密封、置阴凉处保存，保存期为2年。由于本发明药物溶液疗效显著(奏效快、远期疗效高、复发率低)治疗范围较广，经多年临床验证疗效高于其他同类产品且无毒、副作用。使用方便无色无味，不沾污衣物。且药源充足，成本低廉，制备简单不需高昂投资，可获显著社会及经济效益。故临床及市场前景十分乐观。
临床疗效观察表：
附表1为治疗复发性、顽固性口腔溃疡。
系统观察70例，其中儿童占78％，且均伴有程度不同的营养不良、免疫功能低下、偏食、厌食、异食等症状。经用药后一周后治愈者59例(占84.3％)，显效11例点15.7％，总有效率达100％。
表1：
附表2为对数种皮肤病疗效观察
共观察153例皮肤病例，其中有痤疮、皮肤搔痒症、湿疹、褥疮疗效显著。疗效见表2：
白癜风、牛皮癣则疗效欠佳。
表2：
| 例数 | 好转(例％) | 治愈(例％) | 无效(例％) | 总有效率 | |
| 痤疮 | 26 | 3 | 22 | 1 | 96％ |
| 皮肤搔痒 | 32 | 4 | 28 | 0 | 100％ |
| 湿疹 | 18 | 4 | 14 | 0 | 100％ |
| 神经皮炎 | 16 | 0 | 16 | 0 | 100％ |
| 灵麻疹 | 14 | 3 | 10 | 1 | 93％ |
| 褥疮 | 24 | 0 | 24 | 0 | 100％ |
| 牛皮癣 | 9 | 5 | 0 | 4 | 55％ |
| 白癜风 | 14 | 3 | 0 | 11 | 21.4％ |
| 总计 | 153 | 22(14.4％) | 114(74.5％) | 17(11.1％) | 88.8％ |
具体实施方式
本发明实施例如表3所示，本发明10000ml药物溶液中含有以下重量组份：
表3：
| 成份 | 含量(重量g) | ||
| 葡萄糖酸锌 | 150 | 175 | 200 |
| 灭滴灵(甲硝哒唑) | 25 | 30 | 20 |
| 维生素B6 | 1 | 1.5 | 2 |
| 的卡因 | 7.5 | 5 | 10 |
| 苯甲酸钠 | 10 | 12.5 | 15 |
Claims (1)
1、一种治疗皮肤病及口腔溃疡的外用药物溶液，其特征在于10000ml药物溶液中含有如下重量组份：
葡萄糖酸锌 150-200g 灭滴灵(甲硝哒唑) 20-30g
维生素B6 1-2g 的卡因 5-10g 苯甲酸钠 10-15g
余量为水。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410064571 CN1270710C (zh) | 2004-11-30 | 2004-11-30 | 一种治疗皮肤病及口腔溃疡的外用药物溶液 |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410064571 CN1270710C (zh) | 2004-11-30 | 2004-11-30 | 一种治疗皮肤病及口腔溃疡的外用药物溶液 |
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| Publication Number | Publication Date |
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| CN1650861A CN1650861A (zh) | 2005-08-10 |
| CN1270710C true CN1270710C (zh) | 2006-08-23 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4799957B2 (ja) * | 2005-08-23 | 2011-10-26 | 興和株式会社 | 口内炎の治療のための医薬組成物 |
| FR2899475A1 (fr) * | 2006-04-10 | 2007-10-12 | Galderma Res & Dev | Composition pharmaceutique pour le traitement de la rosacee |
| CN105748516A (zh) * | 2016-03-30 | 2016-07-13 | 黄宇松 | 一种治疗反复性口腔溃疡的药物组合物 |
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