CN1250225C - 2α－甲基－19－去甲－20(S)－1α,25－二羟维生素D3生产用于增加骨强度的药物的用途 - Google Patents
2α－甲基－19－去甲－20(S)－1α,25－二羟维生素D3生产用于增加骨强度的药物的用途 Download PDFInfo
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- CN1250225C CN1250225C CNB018155332A CN01815533A CN1250225C CN 1250225 C CN1250225 C CN 1250225C CN B018155332 A CNB018155332 A CN B018155332A CN 01815533 A CN01815533 A CN 01815533A CN 1250225 C CN1250225 C CN 1250225C
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| US09/616,778 | 2000-07-14 | ||
| US09/616,778 US6306844B1 (en) | 1997-03-17 | 2000-07-14 | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
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| CN1501803A CN1501803A (zh) | 2004-06-02 |
| CN1250225C true CN1250225C (zh) | 2006-04-12 |
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| CNB018155332A Expired - Fee Related CN1250225C (zh) | 2000-07-14 | 2001-07-10 | 2α－甲基－19－去甲－20(S)－1α,25－二羟维生素D3生产用于增加骨强度的药物的用途 |
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|---|---|---|---|---|
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| EP1301189A2 (en) * | 2000-07-14 | 2003-04-16 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1$g(a),25-DIHYDROXYVITAMIN D 3? TO INCREASE BONE STRENGTH |
| US7858602B2 (en) * | 2000-10-16 | 2010-12-28 | Rodriguez Victorio C | Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growth factors of stem cells |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
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| AU2005309806B2 (en) * | 2004-11-22 | 2012-03-08 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-1alpha-hydroxy-17-ene-homopregnacalciferol and its uses |
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| JP2009532460A (ja) | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
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| ATE523487T1 (de) * | 2006-04-06 | 2011-09-15 | Wisconsin Alumni Res Found | 2-methylen-1-alpha-dihydroxy-19,21-dinor-vitami - d3-analoga und ihre anwendung |
| US8575136B2 (en) * | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| EP2021321B1 (en) * | 2006-04-06 | 2012-06-20 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
| MX2008012674A (es) * | 2006-04-10 | 2008-10-15 | Wisconsin Alumni Res Found | Compuestos de 1 a-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitamina d con una cadena lateral 1,1-dimetilpropilo. |
| MX2008014418A (es) * | 2006-05-15 | 2008-11-27 | Wisconsin Alumni Res Found | Administracion pulmonar de la 1 alfa, 25-dihidroxivitamina d3 y co-administracion de la homona paratiroidea o calcitonina. |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| CA2764577C (en) * | 2009-08-03 | 2017-12-19 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| ES2437921T3 (es) * | 2009-10-21 | 2014-01-15 | Wisconsin Alumni Research Foundation | Método para prevenir la diabetes tipo 1 |
| US20110237557A1 (en) * | 2010-03-23 | 2011-09-29 | Deluca Hector F | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US8604009B2 (en) * | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| HK1206600A1 (en) | 2012-06-29 | 2016-01-15 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D3 TO TREAT SECONDARY HYPERPARATHYROIDISM |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| WO2017184262A1 (en) * | 2016-04-18 | 2017-10-26 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
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| GB2114570B (en) | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ATE173401T1 (de) | 1990-09-07 | 1998-12-15 | Wisconsin Alumni Res Found | Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US5962707A (en) * | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
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2000
- 2000-07-14 US US09/616,778 patent/US6306844B1/en not_active Expired - Lifetime
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2001
- 2001-07-10 CA CA002416187A patent/CA2416187A1/en not_active Abandoned
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- 2001-07-10 IL IL15390801A patent/IL153908A0/xx unknown
- 2001-07-10 AT AT01952566T patent/ATE359796T1/de active
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- 2001-07-10 MX MXPA03000405A patent/MXPA03000405A/es active IP Right Grant
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- 2001-07-10 AU AU7330301A patent/AU7330301A/xx active Pending
- 2001-07-10 EP EP01952566A patent/EP1305030B1/en not_active Expired - Lifetime
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| EP1305030B1 (en) | 2007-04-18 |
| AU2001273303B8 (en) | 2006-03-09 |
| IL153908A0 (en) | 2003-07-31 |
| HK1066487A1 (en) | 2005-03-24 |
| BR0112453A (pt) | 2003-08-19 |
| DK1305030T3 (da) | 2007-09-17 |
| ES2286129T3 (es) | 2007-12-01 |
| WO2002005824A1 (en) | 2002-01-24 |
| CA2416187A1 (en) | 2002-01-24 |
| KR100572958B1 (ko) | 2006-04-24 |
| ATE359796T1 (de) | 2007-05-15 |
| AU2001273303B2 (en) | 2006-02-02 |
| JP4955895B2 (ja) | 2012-06-20 |
| US20020151528A1 (en) | 2002-10-17 |
| US20060003973A1 (en) | 2006-01-05 |
| DE60127964D1 (de) | 2007-05-31 |
| US6939868B2 (en) | 2005-09-06 |
| MXPA03000405A (es) | 2003-06-06 |
| KR20030016402A (ko) | 2003-02-26 |
| NZ524018A (en) | 2006-06-30 |
| CN1501803A (zh) | 2004-06-02 |
| EP1305030A1 (en) | 2003-05-02 |
| DE60127964T2 (de) | 2008-01-17 |
| US20040072804A1 (en) | 2004-04-15 |
| IL153908A (en) | 2009-08-03 |
| AU7330301A (en) | 2002-01-30 |
| US6306844B1 (en) | 2001-10-23 |
| JP2004509853A (ja) | 2004-04-02 |
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