AU2001273303B8 - Use of 2alpha-methyl-19-nor-20(s)-1alpha,25-dihydroxyvitamin D3 to increase bone strength - Google Patents
Use of 2alpha-methyl-19-nor-20(s)-1alpha,25-dihydroxyvitamin D3 to increase bone strength Download PDFInfo
- Publication number
- AU2001273303B8 AU2001273303B8 AU2001273303A AU2001273303A AU2001273303B8 AU 2001273303 B8 AU2001273303 B8 AU 2001273303B8 AU 2001273303 A AU2001273303 A AU 2001273303A AU 2001273303 A AU2001273303 A AU 2001273303A AU 2001273303 B8 AU2001273303 B8 AU 2001273303B8
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- Prior art keywords
- methyl
- strength
- bone
- dihydroxyvitamin
- use according
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Classifications
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- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D17/00—Pressure die casting or injection die casting, i.e. casting in which the metal is forced into a mould under high pressure
- B22D17/20—Accessories: Details
- B22D17/22—Dies; Die plates; Die supports; Cooling equipment for dies; Accessories for loosening and ejecting castings from dies
- B22D17/2236—Equipment for loosening or ejecting castings from dies
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D17/00—Pressure die casting or injection die casting, i.e. casting in which the metal is forced into a mould under high pressure
- B22D17/20—Accessories: Details
- B22D17/22—Dies; Die plates; Die supports; Cooling equipment for dies; Accessories for loosening and ejecting castings from dies
- B22D17/24—Accessories for locating and holding cores or inserts
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/616,778 US6306844B1 (en) | 1997-03-17 | 2000-07-14 | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US09/616,778 | 2000-07-14 | ||
| PCT/US2001/021660 WO2002005824A1 (en) | 2000-07-14 | 2001-07-10 | USE OF 2α-METHYL-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2001273303A1 AU2001273303A1 (en) | 2002-05-02 |
| AU2001273303B2 AU2001273303B2 (en) | 2006-02-02 |
| AU2001273303B8 true AU2001273303B8 (en) | 2006-03-09 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001273303A Ceased AU2001273303B8 (en) | 2000-07-14 | 2001-07-10 | Use of 2alpha-methyl-19-nor-20(s)-1alpha,25-dihydroxyvitamin D3 to increase bone strength |
| AU7330301A Pending AU7330301A (en) | 2000-07-14 | 2001-07-10 | Use of 2alpha-methyl-19-nor-20(s)-1alpha,25-dihydroxyvitamin D<sub>3</sub> to increase bone strength |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU7330301A Pending AU7330301A (en) | 2000-07-14 | 2001-07-10 | Use of 2alpha-methyl-19-nor-20(s)-1alpha,25-dihydroxyvitamin D<sub>3</sub> to increase bone strength |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US6306844B1 (enExample) |
| EP (1) | EP1305030B1 (enExample) |
| JP (1) | JP4955895B2 (enExample) |
| KR (1) | KR100572958B1 (enExample) |
| CN (1) | CN1250225C (enExample) |
| AT (1) | ATE359796T1 (enExample) |
| AU (2) | AU2001273303B8 (enExample) |
| BR (1) | BR0112453A (enExample) |
| CA (1) | CA2416187A1 (enExample) |
| DE (1) | DE60127964T2 (enExample) |
| DK (1) | DK1305030T3 (enExample) |
| ES (1) | ES2286129T3 (enExample) |
| IL (2) | IL153908A0 (enExample) |
| MX (1) | MXPA03000405A (enExample) |
| NZ (1) | NZ524018A (enExample) |
| WO (1) | WO2002005824A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| WO2002005823A2 (en) * | 2000-07-14 | 2002-01-24 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH |
| US7858602B2 (en) * | 2000-10-16 | 2010-12-28 | Rodriguez Victorio C | Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growth factors of stem cells |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| CN1277817C (zh) * | 2002-03-29 | 2006-10-04 | 威斯康星校友研究基金会 | 合成1α－羟基－2－亚甲基－19－去甲－高孕钙化醇的方法 |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| EP1598360A4 (en) | 2003-02-25 | 2010-04-07 | Knc Lab Co Ltd | NEW INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF VITAMIN D DERIVATIVES |
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| US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| ES2344989T3 (es) * | 2004-11-22 | 2010-09-13 | Wisconsin Alumni Research Foundation | Analogos de 17,20(e)-deshidro vitamina d y sus usos. |
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| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| JP2010505739A (ja) * | 2006-04-06 | 2010-02-25 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１α，２５−ジヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用 |
| NZ570815A (en) * | 2006-04-06 | 2012-01-12 | Wisconsin Alumni Res Found | 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring |
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| WO2007133747A2 (en) * | 2006-05-15 | 2007-11-22 | Wisconsin Alumni Research Foundation | PULMONARY DELIVERY OF 1α,25-DIHYDROXYVITAMIN D3 AND CO-ADMINISTRATION OF PARATHYROID HORMONE OR CALCITONIN |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| JP5908402B2 (ja) * | 2009-08-03 | 2016-04-26 | ウィスコンシン・アルムニ・リサーチ・ファウンデーションＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 腎疾患の予防方法およびその症状を処置する方法 |
| EP2490695B1 (en) * | 2009-10-21 | 2013-11-20 | Wisconsin Alumni Research Foundation | Method of preventing type 1 diabetes |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| CA2793727C (en) * | 2010-03-23 | 2017-01-03 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3 |
| EP2556053B1 (en) * | 2010-03-23 | 2015-07-29 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1alpha,25-hydroxyvitamin d3 |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| US9205096B2 (en) | 2012-06-29 | 2015-12-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| WO2017184262A1 (en) * | 2016-04-18 | 2017-10-26 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
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| WO1998041500A1 (en) * | 1997-03-17 | 1998-09-24 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin d compounds |
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| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
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| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
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| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
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| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| EP0619306B1 (en) | 1993-04-05 | 1996-09-11 | Wisconsin Alumni Research Foundation | 19-Nor-vitamin D3 compounds with substituent at 2-position |
| WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US5962707A (en) * | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
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- 2000-07-14 US US09/616,778 patent/US6306844B1/en not_active Expired - Lifetime
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- 2001-07-10 AU AU2001273303A patent/AU2001273303B8/en not_active Ceased
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- 2001-07-10 JP JP2002511756A patent/JP4955895B2/ja not_active Expired - Fee Related
- 2001-07-10 KR KR1020037000542A patent/KR100572958B1/ko not_active Expired - Fee Related
- 2001-07-10 DE DE60127964T patent/DE60127964T2/de not_active Expired - Lifetime
- 2001-07-10 IL IL15390801A patent/IL153908A0/xx unknown
- 2001-07-10 NZ NZ524018A patent/NZ524018A/en not_active IP Right Cessation
- 2001-07-10 BR BR0112453-6A patent/BR0112453A/pt not_active Application Discontinuation
- 2001-07-10 WO PCT/US2001/021660 patent/WO2002005824A1/en not_active Ceased
- 2001-07-10 AU AU7330301A patent/AU7330301A/xx active Pending
- 2001-07-10 DK DK01952566T patent/DK1305030T3/da active
- 2001-07-10 MX MXPA03000405A patent/MXPA03000405A/es active IP Right Grant
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- 2001-07-10 EP EP01952566A patent/EP1305030B1/en not_active Expired - Lifetime
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- 2003-09-29 US US10/673,618 patent/US6939868B2/en not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041500A1 (en) * | 1997-03-17 | 1998-09-24 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin d compounds |
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| KR20030016402A (ko) | 2003-02-26 |
| JP2004509853A (ja) | 2004-04-02 |
| ES2286129T3 (es) | 2007-12-01 |
| IL153908A0 (en) | 2003-07-31 |
| DK1305030T3 (da) | 2007-09-17 |
| IL153908A (en) | 2009-08-03 |
| ATE359796T1 (de) | 2007-05-15 |
| WO2002005824A1 (en) | 2002-01-24 |
| CN1501803A (zh) | 2004-06-02 |
| KR100572958B1 (ko) | 2006-04-24 |
| CA2416187A1 (en) | 2002-01-24 |
| MXPA03000405A (es) | 2003-06-06 |
| US6306844B1 (en) | 2001-10-23 |
| DE60127964D1 (de) | 2007-05-31 |
| EP1305030A1 (en) | 2003-05-02 |
| US20020151528A1 (en) | 2002-10-17 |
| CN1250225C (zh) | 2006-04-12 |
| EP1305030B1 (en) | 2007-04-18 |
| HK1066487A1 (en) | 2005-03-24 |
| JP4955895B2 (ja) | 2012-06-20 |
| US20040072804A1 (en) | 2004-04-15 |
| AU7330301A (en) | 2002-01-30 |
| DE60127964T2 (de) | 2008-01-17 |
| NZ524018A (en) | 2006-06-30 |
| US6939868B2 (en) | 2005-09-06 |
| BR0112453A (pt) | 2003-08-19 |
| AU2001273303B2 (en) | 2006-02-02 |
| US20060003973A1 (en) | 2006-01-05 |
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Free format text: IN VOL 20, NO 4, PAGE(S) 468 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME WISCONSIN ALUMNI RESEARCH FOUNDATION, APPLICATION NO. 2001273303, UNDER INID (54) CORRECT THE TITLE TO READ USE OF 2ALPHA-METHYL-19-NOR-20(S)-1ALPHA, 25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH. |
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