CN1247591C - 吲哚衍生物及其医药应用 - Google Patents
吲哚衍生物及其医药应用 Download PDFInfo
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- CN1247591C CN1247591C CNB018221122A CN01822112A CN1247591C CN 1247591 C CN1247591 C CN 1247591C CN B018221122 A CNB018221122 A CN B018221122A CN 01822112 A CN01822112 A CN 01822112A CN 1247591 C CN1247591 C CN 1247591C
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 80
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 75
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 34
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- 229940054051 antipsychotic indole derivative Drugs 0.000 claims abstract description 20
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- -1 chloro, bromo, iodo, hydroxyl Chemical group 0.000 claims description 217
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- 229910052799 carbon Inorganic materials 0.000 claims description 32
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000004423 acyloxy group Chemical group 0.000 claims description 3
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- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- 235000006408 oxalic acid Nutrition 0.000 description 1
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- BOTNYLSAWDQNEX-UHFFFAOYSA-N phenoxymethylbenzene Chemical compound C=1C=CC=CC=1COC1=CC=CC=C1 BOTNYLSAWDQNEX-UHFFFAOYSA-N 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- BDDWSAASCFBVBK-UHFFFAOYSA-N rhodium;triphenylphosphane Chemical compound [Rh].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 BDDWSAASCFBVBK-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP356382/00 | 2000-11-22 | ||
| JP356382/2000 | 2000-11-22 | ||
| JP2000356382 | 2000-11-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1486321A CN1486321A (zh) | 2004-03-31 |
| CN1247591C true CN1247591C (zh) | 2006-03-29 |
Family
ID=18828643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018221122A Expired - Fee Related CN1247591C (zh) | 2000-11-22 | 2001-11-22 | 吲哚衍生物及其医药应用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6770654B2 (enExample) |
| EP (1) | EP1342723B1 (enExample) |
| JP (1) | JP4292738B2 (enExample) |
| KR (1) | KR20030053530A (enExample) |
| CN (1) | CN1247591C (enExample) |
| AT (1) | ATE402179T1 (enExample) |
| AU (2) | AU2408602A (enExample) |
| CA (1) | CA2427931A1 (enExample) |
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| WO (1) | WO2002042309A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1424337A1 (en) * | 2002-11-26 | 2004-06-02 | Solvay Pharmaceuticals GmbH | 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one |
| EP1602374A4 (en) * | 2003-03-07 | 2007-03-07 | Toray Industries | MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE |
| US20060069086A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| WO2008001859A1 (fr) * | 2006-06-30 | 2008-01-03 | School Juridical Person Kitasato Gakuen | AGONISTE DES RÉCEPTEURS δ DES OPIOÏDES |
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| WO2019171333A1 (en) | 2018-03-08 | 2019-09-12 | Victoria Link Ltd | Treatment of demyelinating diseases |
Family Cites Families (1)
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|---|---|---|---|---|
| CA2205664C (en) * | 1995-09-26 | 2008-05-20 | Toray Industries, Inc. | Indole derivatives and medicinal use thereof |
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2001
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- 2001-11-22 ES ES01997196T patent/ES2311034T3/es not_active Expired - Lifetime
- 2001-11-22 AU AU2408602A patent/AU2408602A/xx active Pending
- 2001-11-22 CA CA002427931A patent/CA2427931A1/en not_active Abandoned
- 2001-11-22 DE DE60135016T patent/DE60135016D1/de not_active Expired - Fee Related
- 2001-11-22 JP JP2001357400A patent/JP4292738B2/ja not_active Expired - Fee Related
- 2001-11-22 AT AT01997196T patent/ATE402179T1/de not_active IP Right Cessation
- 2001-11-22 CN CNB018221122A patent/CN1247591C/zh not_active Expired - Fee Related
- 2001-11-22 EP EP01997196A patent/EP1342723B1/en not_active Expired - Lifetime
- 2001-11-22 AU AU2002224086A patent/AU2002224086B8/en not_active Ceased
- 2001-11-22 US US10/432,011 patent/US6770654B2/en not_active Expired - Fee Related
- 2001-11-22 KR KR10-2003-7006870A patent/KR20030053530A/ko not_active Ceased
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| Publication number | Publication date |
|---|---|
| AU2408602A (en) | 2002-06-03 |
| US20040019071A1 (en) | 2004-01-29 |
| KR20030053530A (ko) | 2003-06-28 |
| DE60135016D1 (de) | 2008-09-04 |
| ATE402179T1 (de) | 2008-08-15 |
| WO2002042309A1 (en) | 2002-05-30 |
| CA2427931A1 (en) | 2002-05-30 |
| ES2311034T3 (es) | 2009-02-01 |
| JP2002220391A (ja) | 2002-08-09 |
| EP1342723A4 (en) | 2005-02-09 |
| US6770654B2 (en) | 2004-08-03 |
| EP1342723A1 (en) | 2003-09-10 |
| AU2002224086B1 (en) | 2006-11-16 |
| EP1342723B1 (en) | 2008-07-23 |
| JP4292738B2 (ja) | 2009-07-08 |
| AU2002224086B8 (en) | 2002-06-03 |
| CN1486321A (zh) | 2004-03-31 |
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