CN1242199A - Process for producing powder injection of compound red sage root medicine - Google Patents
Process for producing powder injection of compound red sage root medicine Download PDFInfo
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- CN1242199A CN1242199A CN 98103032 CN98103032A CN1242199A CN 1242199 A CN1242199 A CN 1242199A CN 98103032 CN98103032 CN 98103032 CN 98103032 A CN98103032 A CN 98103032A CN 1242199 A CN1242199 A CN 1242199A
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Abstract
The present invention discloses the prepn. technology of composite salvia miltiorrhiza powder injection. The salvia miltiorrhiza and lignum dalbergiae odoriferae are extracted and refined into mixed medicinal liquid, then freeze-drying or spray-drying to obtain powder of composite salvia root for injection, which is suitable for treating coronary heart disease, myocardial infarction, angina pectoris, etc.
Description
The present invention relates to the preparation technology of compound Salviae Miltiorrhizae injection, specifically a kind of preparation technology of powder injection of compound red sage root medicine.
The compound Salviae Miltiorrhizae aqueous injection is in China's production history of existing several years.This product has blood circulation promoting and blood stasis dispelling, and the effect of freeing vessels and nourishing heart is mainly used in diseases such as treatment coronary heart disease, uncomfortable in chest, angina pectoris, myocardial infarction, welcome by numerous medical workers and patient.But there is the problem of a poor stability that can not be ignored in this product always, after storing a period of time, is prone to precipitation, and pH value reduces.Also there is the problem that is difficult for transportation in addition.
The objective of the invention is to want to provide a kind of storage period quality stable than liquid drugs injection, the powder injection of compound red sage root medicine that is easy to transport.
Technical scheme of the present invention is: the composition of raw materials of powder injection of compound red sage root medicine is: (parts by weight) Radix Salviae Miltiorrhizae: Lignum Dalbergiae Odoriferae equals 1: 1.After Radix Salviae Miltiorrhizae extract and the merging of Lignum Dalbergiae Odoriferae extracting solution, regulating PH is 5.0～7.0, all can make injectable powder by freeze drying process and drying process with atomizing respectively.
Freeze drying process: with total mixed liquor concentrating under reduced pressure, filter, filtrate is sub-packed in the cillin bottle, cooling made the plate temperature reach-14 ℃～18 ℃ after 4 hours in the freeze dryer and be placed on, and products temperature reaches-20 ℃～-25 ℃, condensation temperature reaches-34 ℃～-41 ℃, evacuation, and the plate temperature slowly is increased to 20 ℃ subsequently, products temperature increases to 20 ℃, condensation temperature is constant, unpacks after 24 hours, makes dried frozen aquatic products, gland, labeling get powder injection of compound red sage root medicine.
Spray-dired technology: air after filtration, the heating, go into by the spray drying tower jacking.Total admixing medical solutions forms droplet by the nozzle of cat head, contacts with hot-air, and exsiccant powder enters in the finished container, and waste gas is through cyclone separator, and bag is filtered the back and discharged, and collects powder, the bottling gland, and labeling gets powder injection of compound red sage root medicine.
During spray drying, main points of processes control is: inlet temperature: 115～120 ℃, leaving air temp is 85～90 ℃, flow: 360m
3/ hour, rate of drying: 4～5L/ hour, sprinkler pressure: 2.3～2.5kg/cm
3, cloth bag powder pressure: 400mm water column.Advantage of the present invention is to compare with the liquid drugs injection dosage form, and effect duration obtains prolonging, and is easy to storing.Every technical specification meets Pharmacopoeia of the People's Republic of China requirement.
Below in conjunction with embodiment the present invention is further described:
Embodiment 1: prescription: Radix Salviae Miltiorrhizae 1000g, Lignum Dalbergiae Odoriferae 1000g;
Preparation technology:
1, Radix Salviae Miltiorrhizae extract: take by weighing the Radix Salviae Miltiorrhizae of putting in order and clean, after the flushing of reuse water, the decocting with 8 times, 6 times, 5 times amounts boils 3 times respectively.2 hours for the first time, second and third time each 1 hour half merged medicinal liquid, is concentrated to every 1mL and is equivalent to crude drug in whole 1.5～2g.After cold, adding ethanol to solution gradually, to contain alcohol amount be 75%, cold preservation 40 hours, filter, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3g, and adding ethanol to solution again, to contain alcohol amount be 85%, and cold preservation is after 40 hours, add 1% activated carbon decolorizing, filter, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3～5g, adds 13 times of amount waters for injection, left standstill 16 hours, filter, filtrate is concentrated into every 1ml and is equivalent to crude drug in whole 3～5g and adds 13 times of amount waters for injection, leave standstill 16 hours after, filter, filtrate is concentrated to every 1ml and is equivalent to crude drug in whole 3g, and adding ethanol to solution, to contain the alcohol amount be 80%, leave standstill 24 hours after, filter, filtrate concentrates the suitable crude drug in whole 3g of every 1mL.Being diluted to every 1mL with an amount of water for injection, to be equivalent to crude drug in whole 2g surplus, regulates about PH to 7.0 heated and boiled with 10% caustic lye of soda, after 1 hour, add 1% active carbon and boiled 15 minutes, cold slightly after, filter, be diluted to every 1mL with water for injection and be equivalent to crude drug in whole 2g.
2, Lignum Dalbergiae Odoriferae extracting solution: do not have crude drug in whole with water logging, distill, collect half that the distillation amount is equivalent to crude drug in whole approximately, cold preservation 24 hours divides and removes the upper strata oil reservoir.
3, merge above-mentioned two kinds of medicinal liquids, get the 1000mL mixed liquor, regulating PH is 5.0～7.0.
4, lyophilization: total mixed liquor is evaporated to 1/4 of original volume, passes through the G3 sintered glass filter-bulb with the filter press pressurization, microporous filter membrane (0.65 μ), filtrate is sub-packed in the cillin bottle, and every dress 2.5mL adorns 100 cillin bottles altogether.And be placed in the freeze dryer, cool off after 4 hours, make the plate temperature reach-15 ℃～17 ℃, products temperature reaches-20 ℃～-22 ℃, condensation temperature reaches-35 ℃～-38 ℃, evacuation, and the plate temperature is slow subsequently is increased to 20 ℃, products temperature increases to 20 ℃, condensation temperature is constant, unpacks after 24 hours, makes dried frozen aquatic products, gland, card are signed, and get powder injection of compound red sage root medicine.
Embodiment 2:
Prescription: Radix Salviae Miltiorrhizae 1000g Lignum Dalbergiae Odoriferae 1000g
Preparation technology: 1,2,3 parts are all with embodiment 1.
4, spray drying:
Air heats after filtration, is gone into by the spray drying tower jacking.Total mixed liquor forms droplet by the nozzle of cat head, contacts with hot-air, and exsiccant powder enters in the finished container, waste gas is discharged after the filter of cyclone separator bag, collects powder, bottling (every bottled powder 0.4g in XiLin) gland, labeling gets powder injection of compound red sage root medicine.
During spray drying, main points of processes control is: inlet temperature: 115～120 ℃, and leaving air temp: 85～90 ℃, air mass flow: 360m
3About/hour, rate of drying: 4～5L/ hour, sprinkler pressure: 2.3～2.5kg/cm
3, cloth bag powder pressure: 400mm water column.
Claims (3)
1, a kind of preparation technology of powder injection of compound red sage root medicine, its parts by weight prescription is a Radix Salviae Miltiorrhizae: Lignum Dalbergiae Odoriferae equals 1: 1, it is characterized by, with the admixing medical solutions concentrating under reduced pressure, filter, filtrate is sub-packed in the cillin bottle, and cooling made the plate temperature reach-14 ℃～-18 ℃ after 4 hours in the freeze dryer and be placed on, products temperature reaches-20 ℃～-25 ℃, condensation temperature reaches-34 ℃～-41 ℃, evacuation, and the plate temperature slowly is increased to 20 ℃ subsequently, products temperature increases to 20 ℃, condensation temperature is constant, unpacks after 24 hours, makes dried frozen aquatic products.
2, a kind of preparation technology of powder injection of compound red sage root medicine, its parts by weight prescription is: Radix Salviae Miltiorrhizae: Lignum Dalbergiae Odoriferae etc. were done 1: 1, it is characterized by, and air heats after filtration, goes into by the spray drying tower jacking.Admixing medical solutions forms droplet by the nozzle of cat head, contacts with hot-air, and exsiccant powder enters in the finished container, and waste gas is through cyclone separator, and bag is filtered the back and discharged, and collects powder, and bottling gets powder injection of compound red sage root medicine; During spray drying, main points of processes control is: inlet temperature is 115～120 ℃, and leaving air temp is 85～90 ℃, air mass flow: 360m3/ hour, and rate of drying: 4～5L/ hour, sprinkler pressure: 2.3～2.5kg/cm3, cloth bag powder pressure: 400mm water column.
3, as claim 1 and the described total mixed liquor of claim 2, its feature is as follows: Radix Salviae Miltiorrhizae is cleaned, and after the flushing of reuse water, the decocting with 8 times, 6 times, 5 times amounts boils 3 times respectively.2 hours for the first time, second and third time each 1 hour half merged medicinal liquid, is concentrated to every 1mL and is equivalent to crude drug in whole 1.5～2g.After cold, adding ethanol to solution gradually, to contain alcohol amount be 75%, cold preservation 40 hours, filter, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3g, and adding ethanol to solution again, to contain the alcohol amount be 85%, after the cold preservation 40 hours, add 1% activated carbon decolorizing, filter, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3～5g, add 13 times of amount waters for injection, left standstill 16 hours, and filtered, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3～5g, it is 80% that adding ethanol to solution contains the alcohol amount, after leaving standstill 24 hours, filter, filtrate is concentrated into every 1mL and is equivalent to crude drug in whole 3g, being diluted to 1mL with an amount of water for injection, to be equivalent to crude drug in whole 2g surplus, regulate about PH to 7.0 with 10% caustic lye of soda, heated and boiled is after 1 hour, adding 1% active carbon boiled 15 minutes, after cold slightly, filter, be diluted to every 1mL with water for injection and be equivalent to crude drug in whole 2g; Above-mentioned Radix Salviae Miltiorrhizae extract and Lignum Dalbergiae Odoriferae extracting solution are merged, get mixed liquor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98103032 CN1242199A (en) | 1998-07-17 | 1998-07-17 | Process for producing powder injection of compound red sage root medicine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98103032 CN1242199A (en) | 1998-07-17 | 1998-07-17 | Process for producing powder injection of compound red sage root medicine |
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| CN1242199A true CN1242199A (en) | 2000-01-26 |
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| CN 98103032 Pending CN1242199A (en) | 1998-07-17 | 1998-07-17 | Process for producing powder injection of compound red sage root medicine |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297279C (en) * | 2004-07-28 | 2007-01-31 | 广东天之骄生命科技有限公司 | Medicinal composition containing danshensu, total ara-saponin and camphol and its preparation and use |
| CN1297278C (en) * | 2004-07-28 | 2007-01-31 | 广东天之骄生命科技有限公司 | Medicinal composition containing salvianolic acid B, total ara-saponin and camphol and its preparation and use |
| CN100446831C (en) * | 2006-07-19 | 2008-12-31 | 深圳万乐药业有限公司 | Method for removing organic solvent from heavy-bodied liquid |
| CN1778346B (en) * | 2004-11-26 | 2010-05-12 | 天津天士力制药股份有限公司 | Medicine for treating coronary heart disease |
| CN1778353B (en) * | 2004-11-26 | 2010-09-08 | 天津天士力制药股份有限公司 | Chinese medicine dropping ball for treating cardiovascular disease |
| CN1778352B (en) * | 2004-11-26 | 2010-11-10 | 天津天士力制药股份有限公司 | Chinese medicine composition for treating cardiovascular disease |
| CN104027387A (en) * | 2014-07-09 | 2014-09-10 | 湖北天圣康迪制药有限公司 | Method for preparing dalbergia wood distillate |
-
1998
- 1998-07-17 CN CN 98103032 patent/CN1242199A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297279C (en) * | 2004-07-28 | 2007-01-31 | 广东天之骄生命科技有限公司 | Medicinal composition containing danshensu, total ara-saponin and camphol and its preparation and use |
| CN1297278C (en) * | 2004-07-28 | 2007-01-31 | 广东天之骄生命科技有限公司 | Medicinal composition containing salvianolic acid B, total ara-saponin and camphol and its preparation and use |
| CN1778346B (en) * | 2004-11-26 | 2010-05-12 | 天津天士力制药股份有限公司 | Medicine for treating coronary heart disease |
| CN1778353B (en) * | 2004-11-26 | 2010-09-08 | 天津天士力制药股份有限公司 | Chinese medicine dropping ball for treating cardiovascular disease |
| CN1778352B (en) * | 2004-11-26 | 2010-11-10 | 天津天士力制药股份有限公司 | Chinese medicine composition for treating cardiovascular disease |
| CN100446831C (en) * | 2006-07-19 | 2008-12-31 | 深圳万乐药业有限公司 | Method for removing organic solvent from heavy-bodied liquid |
| CN104027387A (en) * | 2014-07-09 | 2014-09-10 | 湖北天圣康迪制药有限公司 | Method for preparing dalbergia wood distillate |
| CN104027387B (en) * | 2014-07-09 | 2017-06-27 | 湖北天圣药业有限公司 | A kind of preparation method of dalbergia wood distillate |
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