CN1032405C - Fleabane injection - Google Patents
Fleabane injection Download PDFInfo
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- CN1032405C CN1032405C CN 93104701 CN93104701A CN1032405C CN 1032405 C CN1032405 C CN 1032405C CN 93104701 CN93104701 CN 93104701 CN 93104701 A CN93104701 A CN 93104701A CN 1032405 C CN1032405 C CN 1032405C
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- extractum
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- under reduced
- low temperature
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Abstract
The present invention relates to a breviscapine injection liquid preparation process and a product thereof, which is mainly characterized in that a raw material is directly extracted by water, is settled by ethanol, and is depressed and concentrated at a low temperature; thereby, extraction paste is obtained; a pH value is adjusted, refine extraction is carried out by ethyl acetate (CH3COOC2H5), and the extraction paste is obtained by low temperature decompression and concentration; sodium chloride (NaCl) is added for blending and dissolution, and then a medicine solution is obtained; a finished product is formed by filtration and encapsulation. The present invention has the advantages of advanced technology, stable product quality, high total flavonoid content, and high product purity; auxiliary solvent is unnecessarily added; the present invention has the advantages of obvious clinical treating effect and no any side effect. The product is Chinese patent medicine which treats frequently encountered diseases such as paralysis, a coronary heart disease, etc., and a common disease, is made of natural plants, and is used for emergency.
Description
The present invention relates to a kind of preparation technology who treats the fleabane injection of diseases such as apoplectic hemiplegia, coronary heart disease, angina pectoris.
Herba Erigerontis, have another name called Herba Erigerontis, (Erigeronbrevs Capus (Vant)-Hand-Mazz) is the distinctive natural plant in Yunnan Province to belong to the short booth Herba Erigerontis aceris of Compositae platymiscium, it has blood circulation promoting and blood stasis dispelling, the cold expelling detoxifcation, relaxing muscles and tendons to promote blood circulation, the effect of expelling wind and removing dampness, the diseases such as apoplectic hemiplegia, coronary heart disease, angina pectoris that are used for the treatment of for a long time among the people, effect is remarkable.1981 are gone out with the Yunnan Herba Erigerontis by four manufacturer production such as Yunnan bio-pharmaceuticals factories is the injection of primary raw material, but this injection effective component content is low, only 2.5 milligrams of milliliter general flavone contents, and unstable product quality, deposit about half a year and can produce precipitation, can only intramuscular injection can not be used as intravenous injection.
These defectives that above-mentioned fleabane injection production technology is brought have been the objective of the invention is to overcome, provide a kind of and can produce steady quality, active constituent content height, good effect, medication be the production technology of fleabane injection easily, and this craft science rationally and be convenient to produce.
Technical scheme of the present invention is such, adopting the Herba Erigerontis herb is that raw material is directly used the sedimentation of water extraction ethanol, is extractum with resulting extracting solution concentrate under reduced pressure at low temperature, and adjust pH is no more than 5, carry with the ethyl acetate essence that is at least 2 times of extractum weight, be extractum with the refining liquid concentrate under reduced pressure at low temperature again, add sodium chloride, stir evenly to dissolving, add the injection water, adjust pH is neutral, filters the embedding sterilization.Wherein, ethyl acetate is chemical pure or analytical pure.
Annotate the fleabane injection product purity height that empty two lattice are produced, every milliliter contains at least 4.5 milligrams of total flavones amounts, and steady quality is deposited did not at least have precipitation in 2 years, did not contain cosolvent.
By the enforcement of above technical scheme, can reach purpose of the present invention substantially.Yunnan fleabane injection preparation technology has changed classical extraction separation, has adopted the organic solvent extraction partition method, extract fully, separate thoroughly, make that effective component content increases substantially in the product, contain 2.5 milligrams of total flavones from original every milliliter and bring up to present every milliliter and contain 4.5 milligrams; Constant product quality, the pharmaceutical purity height both can be used for intramuscular injection, also can be used for intravenous injection.Pharmacological research proves: the product of producing with technical scheme proposed by the invention has remarkable cerebral blood flow increasing amount, reduces cerebral vascular resistance, improve the brain blood barrier permeability, increase the myocardial nutrition blood flow, and obviously improve human body giant cell immunologic function, have function such as hypoxic-ischemic due to the antagonism pituitrin simultaneously.
Because technology advanced person of the present invention, constant product quality, clinical efficacy is remarkable, and is without any side effects, is again simultaneously that commonly encountered diseases such as sequela paralysis due to the cerebrovascular accident and coronary heart disease, the Chinese Traditional Medicines that the natural plants of frequently-occurring disease is made are treated in smelting.Do not produce waste gas and pollutant in the whole process of production, waste water is few, environmentally safe, energy resource consumption is few during production, therefore the present invention is a kind of less investment, the output height has remarkable social benefit and economic benefit, and new technology, the new product of the Yunnan fleabane injection production of bright prospects and development prospect arranged.
Embodiment:
Accompanying drawing 1 is Yunnan fleabane injection technological process of production figure.
Precision takes by weighing 50kg Yunnan Herba Erigerontis (herb) and adds water to submerge, and the water surface surpasses powder 15cm, and heated and boiled is extracted medicinal liquid three times, with the coarse filtration of three gained medicinal liquids, waste.Medicinal liquid is put concentrate under reduced pressure at low temperature in the concentrating under reduced pressure pot, get medicinal liquid 25kg, add 90% ethanol triplication sedimentation, get medicinal liquid, medicinal liquid is put into the concentrating under reduced pressure pot, concentrate under reduced pressure at low temperature is to 12.5K50,000ml adds active carbon and boils half an hour, filters, add sodium chloride to dissolving, stir, measure content, add the injection water to institute's expense, adjust pH is to neutral, filters, embedding, sterilization, detection, lettering, dress box.
Utilization fleabane injection treatment cerebral embolism 345 examples, and establish Radix Salviae Miltiorrhizae Injection matched group 50 examples, the clinical observation contrast, curative effect is as follows:
| The A group | Fleabane injection | 345 examples | Produce effects | Effectively | Invalid | Total effective rate |
| 89 examples | 199 examples | 48 examples | 86 examples | |||
| The B group | Radix Salviae Miltiorrhizae Injection | 50 examples | 9 examples | 16 examples | 25％ | ????50％ |
Claims (3)
1, a kind of preparation technology of fleabane injection, it is with Herba Erigerontis herb water extract-alcohol precipitation, the concentrating under reduced pressure medicinal liquid is an extractum, essence is carried, and the clear extract of concentrating under reduced pressure is an extractum again, thin up, add active carbon and boil, filter, add sodium chloride to dissolving, stir evenly, add the injection water, adjust pH is neutral, filter, embedding sterilization is made, and it is characterized in that it is that concentrated extract pH value at water extract-alcohol precipitation is no more than under 5 the condition that essence is carried, and extracts with the ethyl acetate that is at least 2 times of extractum weight.
2, preparation technology according to claim 1, wherein said ethyl acetate are chemical pure or analytical pure.
3, preparation technology according to claim 1, it is 50 kilograms of Herba Erigerontis herbs to be added water surpass 15 centimetres in medical material face, heated and boiled is extracted three times altogether, merges three extracting solution coarse filtrations, removes slag; Gained medicinal liquid concentrate under reduced pressure at low temperature is obtained 25 kilograms of extractum, the 90% ethanol sedimentation that adds the extractum triplication, be 12.5 kilograms of extractum with gained medicinal liquid concentrate under reduced pressure at low temperature again, add the hydrochloric acid adjust pH and be no more than 5, the ethyl acetate essence that adds 3 times of amounts of extractum is carried and is obtained refining liquid, is 1 kilogram of extractum with gained refining liquid concentrate under reduced pressure at low temperature again, thin up to 50000 milliliter, add active carbon and boil half an hour, filter, add sodium chloride, stir to dissolving, measure content, add the injection water to aequum, adjust pH filters to neutral, embedding, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93104701 CN1032405C (en) | 1993-04-22 | 1993-04-22 | Fleabane injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93104701 CN1032405C (en) | 1993-04-22 | 1993-04-22 | Fleabane injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1091301A CN1091301A (en) | 1994-08-31 |
| CN1032405C true CN1032405C (en) | 1996-07-31 |
Family
ID=4985298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93104701 Ceased CN1032405C (en) | 1993-04-22 | 1993-04-22 | Fleabane injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1032405C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088366C (en) * | 1994-11-25 | 2002-07-31 | 湖南医科大学附属第二医院 | Medicine for treating decline of vision function resulted from glaucoma |
| CN100374120C (en) * | 2003-04-22 | 2008-03-12 | 中国科学院昆明植物研究所 | Powder of flenabane and its preparation method as well as application in making drugs |
| CN102552356A (en) * | 2010-12-22 | 2012-07-11 | 昆明振华制药厂有限公司 | Quality control method of sugar-free erigeron breviscapine mixture |
| CN104473919B (en) * | 2014-04-21 | 2016-03-30 | 林艳和 | The extraction process of caffeic acid ester in Herba Erigerontis |
-
1993
- 1993-04-22 CN CN 93104701 patent/CN1032405C/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1091301A (en) | 1994-08-31 |
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| C35 | Partial or whole invalidation of patent or utility model | ||
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Decision date of declaring invalidation: 20020428 Decision number of declaring invalidation: 3793 |