CN1240146A - Medicine for treating skin ringworm and dermatitis and preparation process - Google Patents
Medicine for treating skin ringworm and dermatitis and preparation process Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine for curing dermatophyte, tinea and dermatitis and its preparation method. The prescription of said medicine includes 25-35g of Dragon's blood, 80-120 g of curcuma tuber, 100-200g of coptis root, 80-120 g of alum, 100-200g of areca nut, 80-120 g of aloe, 40-60g of hydnocarpus seed, 100-150g of kochia fruit and 40-60g of mylabris. Said medicine can be made into tincture or vinegar preparation, and contains no antibiotic. Its toxicity is low, side-effect is small, therapeutic effect is high and exping period is long. It not only possesses obvious antifungal action for dermatophyte, but also has the good fungicidal action.
Description
The present invention relates to a kind of medicine for the treatment of the especially various scytitiss of skin, ringworm, the invention still further relates to the preparation method of this medicine.
The skin ringworm is commonly encountered diseases, frequently-occurring disease in dermatosis, not only painfully itches violently, makes the people be difficult to stand, and secondary infection sometimes causes General Symptoms.Though the medicine of treatment is a lot of at present, as JIAOXIAN YICIJING, often needs for a long time repeatedly medication, and zest is arranged more, corrosivity is big, phenomenons such as skin exfoliation, mashed foot occur, and what have is only effective to tinea manus and pedis, invalid to kill bacteria.
The purpose of this invention is to provide a kind of curative effect height, zest little, produce effects make good use of, a kind of medicine for the treatment of skin ringworm, inflammation easy to use and preparation method thereof.
Another object of the present invention provides the preparation method of this medicine.
The object of the present invention is achieved like this: a kind of medicine for the treatment of skin ringworm, inflammation and preparation method thereof is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Sanguis Draxonis 25-35 gram Radix Curcumae 80-120 gram
Rhizoma Coptidis 100-200 gram Alumen 80-120 gram
Semen Arecae 100-200 gram Aloe 80-120 gram
Semen Hydnocarpi 40-60 gram Fructus Kochiae 100-150 gram
Mylabris 40-60 gram
Its optimum weight proportioning:
Sanguis Draxonis 30 gram Radix Curcumaes 100 gram Rhizoma Coptidis 150 grams
Alumen 100 gram Semen Arecaes 150 gram Aloes 100 grams
The Semen Hydnocarpi 50 gram Fructus Kochiae 150 gram Mylabris 50 grams
Above-mentioned medicament is tincture or acetum.Its tincture adopts 10000 milliliters, and concentration is 70% alcohol-pickled above-mentioned medicament, and normal temperature and pressure 7-10 days, filtration got final product.The preparation method of acetum adopts the conventional method preparation.
It is the preparation of principal agent that the present invention adopts the Chinese medicine Rhizoma Coptidis, and dosage form is tincture or acetum, does not wherein contain antibiotic, and toxicity is low, side effect is little, curative effect is high, effect duration is long, can not only tangible antibacterial action be arranged to dermatophytosis, also has bactericidal action preferably.
Below in conjunction with implementing to describe in detail the present invention
Embodiment one: take by weighing raw material by following proportioning:
Sanguis Draxonis 25 gram Radix Curcumaes 80 gram Rhizoma Coptidis 100 grams
Alumen 80 gram Semen Arecaes 100 gram Aloes 80 grams
The Semen Hydnocarpi 40 gram Fructus Kochiae 100 gram Mylabris 40 grams
Embodiment two: take by weighing raw material by following proportioning
Sanguis Draxonis 35 gram Radix Curcumaes 120 gram Rhizoma Coptidis 200 grams
Alumen 120 gram Semen Arecaes 200 gram Aloes 120 grams
The Semen Hydnocarpi 60 gram Fructus Kochiae 150 gram Mylabris 60 grams
Embodiment three: take by weighing raw material by following best proportioning
Sanguis Draxonis 30 gram Radix Curcumaes 100 gram Rhizoma Coptidis 150 grams
Alumen 100 gram Semen Arecaes 150 gram Aloes 100 grams
The Semen Hydnocarpi 50 gram Fructus Kochiae 150 gram Mylabris 50 grams
Pharmacopoeia of People's Republic of China (95 editions) is all adopted in the preparation of above-mentioned raw materials medicine.
The preparation method of above-mentioned tincture is: with 10000 ml concns is 75% alcohol-pickled said components medicament, and room temperature often soaked 7-10 days down, filters bottling and can use.
The experiment of the anti-dermatophytosis of the present invention
Culture medium: sabouraud culture medium (SabouraudShi agar glucose) strain: Candida albicans (C andidaalbicans) trichophyton (Trichophyton rubrum) trichophyton gypseum (T.interdigitale) acrothesium floccosum (Epidermophylon floccosu)
Method:
1, prepare sabouraud culture medium, adorn triangular flask, use autoclaving.
2, get dermatophytes with aseptic method and inject (the plate diameter is 10cm), impouring Sha Shi base (every ware 20ml) then in the disinfectant plate.
3, every ware is inoculated above-mentioned four kinds of mycetes (diameter is 0.5 millimeter a cenobium).
4, preserve moisture and cultivate 37 ℃, one week the back observed result.
5, observational technique: measure colony diameter (mm) and compare, observe the colony growth state and have or not varied bacteria growing.
As can be seen from Table 1, the present invention all has tangible antibacterial action as the clotrimazole tinea liquid to dermatophytosis (trichophyton, trichophyton gypseum and acrothesium floccosum) and deep fungal Candida albicans, makes bacterium colony dwindle (n=5, P＜0.001).From table 1, also get and find out, antifungic action of the present invention is greater than the clotrimazole tinea liquid, mainly show two aspects: one: the clotrimazole tinea liquid is when diluting 60 times, its antibacterial action promptly disappears, the present invention still has antibacterial action (n=5, P＜0.001) significantly to colony diameter when diluting 120 times near matched group (n=5.P＞005).Its two: clotrimazole tinea liquid and 10 times of diluents thereof can only make bacterium colony dwindle, and the present invention and 60 times of diluents thereof then make the bacterium colony of dermatophytosis in the culture medium (red, stone, wadding) disappear, and 120 times of diluents still can make the bacterium colony of acrothesium floccosum disappear.Prompting clotrimazole tinea liquid can only suppress fungi growth, and the present invention may also have bactericidal action.From table, it can also be seen that the present invention disappears (n=5, P＞0.05) substantially to the oidiomycetic effect of white when 60 times of diluents, and 120 times of diluents still there is antibacterial action (n=5, P＜0.001) significantly to dermatophytosis (red, stone, wadding).The antibacterial action of pointing out his-and-hers watches dermophyte of the present invention is greater than the effect to deep fungal.
Table 2: the present invention treats skin ringworm example efficacy analysis
| Name of disease | The example number | Cure (people) | Produce effects (people) | Take a turn for the better (people) | Invalid (people) | Effective percentage (%) | Recurrence (people) | Relapse rate (%) |
| Tinea pedis | ??268 | ??180 | ???60 | ???28 | ???0 | ??100 | ???67 | ??25 |
| The tinea manuum | ??54 | ??26 | ???20 | ???8 | ???0 | ??100 | ???19 | ??35 |
| Tinea corporis and cruris | ??21 | ??16 | ???3 | ???5 | ???0 | ??100 | ???5 | ??23.8 |
| Tinea capitis | ??9 | ??4 | ???2 | ???2 | ???1 | ???1 | ??11 | |
| Add up to | ??352 | ??226 | ???85 | ???40 | ???1 | ??99.7 | ???92 | ??26.1 |
Clinical observation on the therapeutic effect:
From year February in May, 1992 to 1998, at Medical College, Hubei Sanxia College department of dermatologry, Yichang City central hospital department of dermatologry, cadre's sanitarium, Yichang hospital clinic is treated various skin ringworm 352 examples, wherein male 182 examples, women 170 examples altogether.
Using method: cleaning skin, treat to embrocate this medicine on sick surface, every day 2-3 time after the xerosis cutis.
Curative effect judging standard: 1. clinical cure: the pruritus of skin ringworm, desquamation decortication, disappearances of chapping, skin color recovers normally; 2. produce effects: the chapping of skin ringworm, desquamation decortication disappear, and still have skin pruritus; 3. take a turn for the better: the disappearance of chapping of skin ringworm, the desquamation decortication alleviates, and still has pruritus; 4. invalid: nothing is clearly better after the medication; 5. recurrence: continuous use is the end-of-dose failure person after three months.
Rhizoma Coptidis is Ranunculaceae herbaceos perennial Rhizoma Coptidis (Copitischinesis Franch) rhizome, root hair and a leaf.Motherland's medical science thinks Rhizoma Coptidis nature and flavor bitter cold to have the effect of heat clearing and damp drying, eliminating fire and detoxication.Cure mainly diseases such as carbuncle furuncle fire-toxin, eczema are had an itch, conjunctival congestion and swelling pain, for oral administration, external all has good effect.Modern medicine thinks that Rhizoma Coptidis has broad-spectrum antibacterial action, multiple G+, G-antibacterials such as Hemolytic streptococcus, meningococcus, Diplococcus pneumoniae, staphylococcus aureus and dysentery bacterium, diphtheria corynebacterium, bacillus subtilis, clostridium tetani, tubercule bacillus all there are strong bacteriostasis, the common pathogenic fungus of kind surplus ten is also had extensively and significant inhibitory effect.That the little Pi's alkali of effective ingredient in the Rhizoma Coptidis still has is analgesic, analgesia drawn game anaesthetic effect.
Antibacterial action of the present invention and treatment skin infection curative effect of disease are analyzed:
Experimentation
Material: culture broth agar
Strain staphylococcus aureus, Bacillus typhi, escherichia coli, bacillus pyocyaneus all are that Medical College, Hubei Sanxia College microorganism teaching and research room preserves strain.
Medicine skin health tincture is made up of tens flavor Chinese medicines such as Rhizoma Coptidis, and used Chinese medicine all is that Yichang City Chinese medicine pharmacy of central hospital provides; Gentamicin injection liquid is produced by Yichang Pharmaceutical Plant, Hubei Prov..
The animal rabbit is provided by Wuhan Tongji Medical Univ.'s Experimental Animal Center.
Method and result:
6 hours meat soup bacterium liquid of cultivation is got in the antibacterium test, and (bacterial population is 900,000,000/mL), and Sterile Saline is diluted to 1/500.Get 50 aseptic plates of diameter 9cm, add four kinds of dilution bacterium liquid 1mL respectively, pour into then to dissolve and be chilled to 45 ℃ of agar culture medium 30mL, rotate mixing immediately.After solidifying, on flat board, make a call to 5 holes with external diameter 6mm sterilization glass-tube, and take out agar in the hole.Add 75% ethanol, gentamycin sulfate (gentamicin) injection, 100% medicament of the present invention (stock solution), 1.67% medicament of the present invention (1: 60 diluent) and each 100uL of 0.83% medicament of the present invention (1: 120 diluent) in 5 holes respectively.Cultivated 24 hours in 37 ℃ of incubators, measure inhibition zone.
Medicament of the present invention by table 3 visible 100%, 1.67% and 0.83% all has tangible bacteriostasis to golden Portugal bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, and this effect is all greater than 75% ethanol, and Chinese medicine ingredients and 75% ethanol among prompting the present invention have antibiotic synergism.From table, it can also be seen that its stock solution to the antibacterial action of bacillus pyocyaneus and golden Portugal bacterium all greater than gentamicin injection liquid, this may be the present invention to burn, scald the eutherapeutic theoretical foundation of back traumatic infection.
25 of skin irritation experimental rabbits, body weight 1.5-2kg, male and female dual-purpose.Be divided into five groups at random; The I group is with 75% alcohol rub rabbit, two ears; The II group is embrocated rabbit two ears with gentamicin injection liquid.The III group is embrocated rabbit two ears with stock solution of the present invention; The IV group is embrocated rabbit two ears with 1.67% the present invention; The V group is embrocated rabbit two ears with 0.83% the present invention.Observe and write down two ear skins and have or not skin irritation phenomenons such as erythema, edema.
Result of the test is found, except that the sulphuric acid injection liquid of gentamicin does not have any skin irritation symptom, of short duration erythema appears in stock solution of the present invention, 1.67% all the same with the 75% ethanol rabbit ear that causes with 0.83% concentration, but there are not edema, no blister, disappear after one hour, this may be to spill due to the smart vasodilative effect.Prompting skin health tincture does not have tangible skin irritation.
2, clinical observation on the therapeutic effect
Year February in May, 1992 to 1998, five-year period was treated various skin infection disease 2648 examples, wherein male 865 examples, women 1783 examples altogether at Medical College, Hubei Sanxia College Affiliated Hospital, Yichang City central hospital, cadre's sanitarium, Yichang hospital clinic.Using method: cleaning skin, treat to embrocate this medicine on the focus surface, every day 2-3 time after the xerosis cutis.Points for attention: forbid that this medicine is made the medicine sliver to spread on wound surface or clog in the wound depths.Curative effect determinate standard: 1. clinical cure: scytitis disappears, wound healing; 2. produce effects: scytitis obviously alleviates, and wound surface dwindles more than 80%; 3. take a turn for the better: scytitis alleviates to some extent, and wound surface dwindles more than 60%; 4. invalid: scytitis does not have obvious improvement after the medication; 5. recurrence: recidivist in the comedo patient continuous use 1 month.
As can be seen from Table 4,2648 routine patients cure 216 people, produce effects 312 people, and total effective rate is 99.8%.Comedo patient continuous use is recurrence 87 people in January, and relapse rate is 71%, and total relapse rate has only 3.3%, use still effective continuously.
To general scytitis, get final product produce effects in 24 hours after the medication, many can the healing after three days.To prolonged skin ulceration of not healing, show good astriction after the medication, make the wound surface drying, ulcer surface dwindles, and general continuous use can be fully recovered after two weeks.Traumatic infection (comprising charrin's disease) after burn, the scald is also had good therapeutic effect, and most of patients wound surface after continuous use 1-2 week closes up and fully recovers.
In sum, the present invention is a principal agent with the Chinese medicine Rhizoma Coptidis, and the Chinese medicine preparation that composition of prescription forms does not wherein contain antibiotic, and toxicity is low, side effect is little, the curative effect height.In the process on probation more than 5 years, we find that this medicine has the following advantages: 1. curative effect height: adversary, tinea pedis and skin ringworm, medication can produce antipruritic effect after 10 minutes, continuous use produce effects after one week, most of skin lesion transference cure after January, disease is more after three months for the most of patients continuous use, and relapse rate low (26.1%), if at the beginning of 1 year spring (1-2 month) continuous use 1-2 month again, can stop recurrence, to general scytitis, get final product produce effects in 24 hours after the medication, many can the healing after three days.To prolonged skin ulceration of not healing, show good astriction after the medication, make the wound surface drying, ulcer surface dwindles, and general continuous use can be fully recovered after two weeks.Traumatic infection (comprising charrin's disease) after burn, the scald is also had good therapeutic effect, and most of patients wound surface after continuous use 1-2 week closes up and fully recovers.2. little to skin irritation, because of this medicine is a tincture, contain ethanol, except that wound surface being had the of short duration pain stimulation, can not cause red swelling of the skin, big slabbing skin phenomenon; 3. this product does not contain the corticosteroids material, can not cause pigmentation (this medicine is a Chinese medicine preparation, can stay the light yellow of Chinese medicine itself after embrocating on skin, cleans promptly to fall with suds); 4. this product does not contain antibiotic, and this product life-time service can not produce drug resistance and anaphylaxis; 5. this coating skin penetration power is strong, easy to use, only needs to embrocate gently in wound surface, and medicine just can infiltrate tissue and play a role; 6. this product was valid up to more than 5 years.Table 1: the present invention's (dermatomycosis medicine) is to the antibacterial action of dermatophytes
( x±S)
Bacterium colony (mm) grouping drug level n
Cotton-shaped epidermis tinea 1 blank-12 8.3 of white beads red hair tinea Gypsum Fibrosum sample hair tinea ± 3 36 ± 9 22.9 ± 9 21.0 ± 62 clotrimazole stock solutions 5 0.5 ± 0.2
* *0.6 ± 0.3
* *0.8 ± 0.2
* *0.5 ± 0.2
* *The dilution 5 1.8 ± 0.4 in 1: 10 of 3 clotrimazoles
* *0.8 ± 0.4
* *0.6 ± 0.3
* *1.0 ± 0.1
* *4 clotrimazoles dilution in 1: 60,5 6.5 ± 2 42.0 ± 3 24.0 ± 4 23.2 ± 25 dermatomycosis medicine stock solutions 5 0.8 ± 0.3
* *0
* *0
* *0
* *The dilution 5 5.8 ± 0.8 0 in 1: 60 of 6 dermatomycosis medicines
* *0
* *0
* *7 dermatomycosis medicines 1: 120 5 5.8 ± 0.8 0.18 ± 0.08
* *0.18 ± 0.08
* *0
* *8 dermatomycosis medicines 1: 240 5 6.8 ± 1 41.0 ± 2 24.8 ± 3 21.2 ± 2
Compare with blank: * * * P＜0.001 table 3: antibacterial action of the present invention
Inhibition zone (mm) x ± SD drug level n
(%) golden Fructus Vitis viniferae Bacillus typhi escherichia coli bacillus pyocyaneus ethanol 75 10 7.6 ± 2 7.3 ± 0.8 5.9 ± 0.6 2.0 ± 0.1 gentamycins 6.78 10 15.2 ± 2
* *10.5 ± 0.9
*23.0 ± 2
* *12.7 ± 2
* *The present invention 100 10 23.0 ± 2
* *18.5 ± 0.9
* *22.7 ± 1.5
* *18.2 ± 0.6
* *The present invention 1.67 10 15.6 ± 0.7
* *12.6 ± 0.9
*12.0 ± 1
* *12.5 ± 0.7
* *The present invention 0.83 10 12.6 ± 1
* *10.3 ± 0.8 9.7 ± 0.9
* *8.2 ± 0.6
* *Table 4: the efficacy analysis disease case load that the present invention treats the skin infection disease is cured the produce effects invalid effective percentage recurrence relapse rate that takes a turn for the better
(people) (people) (people) (people) (people) (people) (%) operation of (%) whelk 1,230 986 174 70 0 100 87 7.1 furuncle sore carbuncles 910 758 83 69 0 100 00 and wound infection 230 220 820 100 00 empyrosis infect 192 148 27 17 0 100 00 prolonged more skin ulcers 86 56 20 64 95 00 add up to 2,648 2,168 312 164 4 99.8 87 3.3
Claims (4)
1, a kind of medicine for the treatment of skin ringworm, inflammation and preparation method thereof is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Sanguis Draxonis 25-35 gram Radix Curcumae 80-120 gram
Rhizoma Coptidis 100-200 gram Alumen 80-120 gram
Semen Arecae 100-200 gram Aloe 80-120 gram
Semen Hydnocarpi 40-60 gram Fructus Kochiae 100-150 gram
Mylabris 40-60 gram
2, a kind of medicine for the treatment of skin ringworm, inflammation according to claim 1 and preparation method thereof is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Sanguis Draxonis 30 gram Radix Curcumaes 100 grams
Rhizoma Coptidis 150 gram Alumens 100 grams
Semen Arecae 150 gram Aloes 100 grams
The Semen Hydnocarpi 50 gram Fructus Kochiae 150 grams
Mylabris 50 grams
3, a kind of medicine for the treatment of skin ringworm, inflammation according to claim 1 and preparation method thereof is characterized in that described medicament is tincture or acetum.
4, preparation claim 1 or 3 described a kind of medicines for the treatment of skin ringworm, inflammation and preparation method thereof, it is characterized in that: its tincture adopts 10000 milliliters, and concentration is 70% alcohol-pickled above-mentioned medicament, under the normal temperature and pressure 7-10 days, filters and gets final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116454A CN1095377C (en) | 1999-04-29 | 1999-04-29 | Medicine for treating skin ringworm and dermatitis and preparation process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116454A CN1095377C (en) | 1999-04-29 | 1999-04-29 | Medicine for treating skin ringworm and dermatitis and preparation process |
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| Publication Number | Publication Date |
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| CN1240146A true CN1240146A (en) | 2000-01-05 |
| CN1095377C CN1095377C (en) | 2002-12-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99116454A Expired - Fee Related CN1095377C (en) | 1999-04-29 | 1999-04-29 | Medicine for treating skin ringworm and dermatitis and preparation process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096221A3 (en) * | 2001-06-01 | 2003-01-16 | Mars Uk Ltd | Skin diet |
| KR100975426B1 (en) * | 2007-11-29 | 2010-08-12 | 김진홍 | Composition comprising the crude extract for preventing and treating allergic skin diseases |
| CN102205022A (en) * | 2011-05-25 | 2011-10-05 | 吴培春 | Chinese medicinal preparation for treating mycotic infection and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1048657A (en) * | 1989-07-10 | 1991-01-23 | 郭毅 | The compound method of treatment psoriasis and tinea cruris medicament |
| CN1063412A (en) * | 1991-01-14 | 1992-08-12 | 樊芝芹 | The manufacture method of Yiwohu tinea-curing medicine |
| CN1088811A (en) * | 1992-12-29 | 1994-07-06 | 李太江 | Medicinal liquid for treating tinea |
| CN1080865A (en) * | 1993-01-05 | 1994-01-19 | 梁建奇 | Dermopathic Chinese medicine of a kind of treatment and preparation method |
| CN1078645A (en) * | 1993-04-20 | 1993-11-24 | 谢民福 | Antiphlogistic oil for external use and compound method thereof |
| CN1098301A (en) * | 1993-08-04 | 1995-02-08 | 赵世平 | Skin-care tinea pedis medicine and preparation method thereof |
| CN1056075C (en) * | 1996-06-11 | 2000-09-06 | 谢志庆 | Chinese medicine paste |
-
1999
- 1999-04-29 CN CN99116454A patent/CN1095377C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096221A3 (en) * | 2001-06-01 | 2003-01-16 | Mars Uk Ltd | Skin diet |
| US8647681B2 (en) | 2001-06-01 | 2014-02-11 | Mars, Inc. | Skin diet |
| KR100975426B1 (en) * | 2007-11-29 | 2010-08-12 | 김진홍 | Composition comprising the crude extract for preventing and treating allergic skin diseases |
| CN102205022A (en) * | 2011-05-25 | 2011-10-05 | 吴培春 | Chinese medicinal preparation for treating mycotic infection and preparation method thereof |
| CN102205022B (en) * | 2011-05-25 | 2012-08-22 | 吴培春 | Chinese medicinal preparation for treating mycotic infection and preparation method thereof |
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| Publication number | Publication date |
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| CN1095377C (en) | 2002-12-04 |
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