CN1238776A - 制备棒酸盐和酯的方法 - Google Patents

制备棒酸盐和酯的方法 Download PDF

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Publication number
CN1238776A
CN1238776A CN97180163A CN97180163A CN1238776A CN 1238776 A CN1238776 A CN 1238776A CN 97180163 A CN97180163 A CN 97180163A CN 97180163 A CN97180163 A CN 97180163A CN 1238776 A CN1238776 A CN 1238776A
Authority
CN
China
Prior art keywords
clavulanic acid
amine
clavulanate
water
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97180163A
Other languages
English (en)
Chinese (zh)
Inventor
J·博杰
A·范德赫威尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Gist Brocades BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades BV filed Critical Gist Brocades BV
Publication of CN1238776A publication Critical patent/CN1238776A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN97180163A 1996-11-11 1997-11-10 制备棒酸盐和酯的方法 Pending CN1238776A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96203117.5 1996-11-11
EP96203117 1996-11-11

Publications (1)

Publication Number Publication Date
CN1238776A true CN1238776A (zh) 1999-12-15

Family

ID=8224563

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97180163A Pending CN1238776A (zh) 1996-11-11 1997-11-10 制备棒酸盐和酯的方法

Country Status (11)

Country Link
EP (1) EP0937084A1 (pt)
JP (1) JP2001503763A (pt)
CN (1) CN1238776A (pt)
AU (1) AU5551698A (pt)
BR (1) BR9713339A (pt)
CA (1) CA2271847A1 (pt)
NO (1) NO992225D0 (pt)
PL (1) PL333247A1 (pt)
TR (1) TR199901631T2 (pt)
WO (1) WO1998021212A1 (pt)
ZA (1) ZA9710141B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
CA2364342C (en) * 1999-04-01 2011-02-01 Dsm N.V. Agglomerates by crystallisation
WO2001087891A1 (en) * 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
KR20090094261A (ko) * 2006-12-01 2009-09-04 디에스엠 아이피 어셋츠 비.브이. 클라부란산의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법

Also Published As

Publication number Publication date
EP0937084A1 (en) 1999-08-25
NO992225L (no) 1999-05-07
JP2001503763A (ja) 2001-03-21
CA2271847A1 (en) 1998-05-22
BR9713339A (pt) 2000-05-09
PL333247A1 (en) 1999-11-22
WO1998021212A1 (en) 1998-05-22
AU5551698A (en) 1998-06-03
NO992225D0 (no) 1999-05-07
TR199901631T2 (xx) 1999-09-21
ZA9710141B (en) 1998-06-25

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication