CN1235972A - 3－表维生素d3代谢物及类似物的合成 - Google Patents

3－表维生素d3代谢物及类似物的合成 Download PDF

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Publication number
CN1235972A
CN1235972A CN99107232A CN99107232A CN1235972A CN 1235972 A CN1235972 A CN 1235972A CN 99107232 A CN99107232 A CN 99107232A CN 99107232 A CN99107232 A CN 99107232A CN 1235972 A CN1235972 A CN 1235972A
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CN
China
Prior art keywords
compound
formula
solution
ethyl acetate
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99107232A
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English (en)
Chinese (zh)
Inventor
安德鲁·戴维·巴特乔
珀西·萨尔伍德·曼钱德
米兰·拉多耶·乌斯科科维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1235972A publication Critical patent/CN1235972A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN99107232A 1998-05-14 1999-05-13 3－表维生素d3代谢物及类似物的合成 Pending CN1235972A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8552198P 1998-05-14 1998-05-14
US60/085521 1998-05-14

Publications (1)

Publication Number Publication Date
CN1235972A true CN1235972A (zh) 1999-11-24

Family

ID=22192175

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99107232A Pending CN1235972A (zh) 1998-05-14 1999-05-13 3－表维生素d3代谢物及类似物的合成

Country Status (7)

Country Link
US (1) US6040461A (enExample)
EP (1) EP0957098A1 (enExample)
JP (1) JP2000026443A (enExample)
KR (1) KR19990088202A (enExample)
CN (1) CN1235972A (enExample)
CA (1) CA2271414A1 (enExample)
MX (1) MX9904401A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106279239A (zh) * 2015-05-29 2017-01-04 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用
CN111763230A (zh) * 2020-06-23 2020-10-13 重庆华邦胜凯制药有限公司 一种卡泊三醇杂质化合物的制备方法及其应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010007907A1 (en) * 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
JP2009508813A (ja) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア １α−フルオロー２５−ヒドロキシ−１６−２３Ｅ−ジエン−２６，２７−ビスホモ−２０−エピ−コレカルシフェロールの合成
TW200838544A (en) * 2007-01-25 2008-10-01 Bioxell Spa Synthesis of 1 α-fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US20010007907A1 (en) * 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106279239A (zh) * 2015-05-29 2017-01-04 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用
CN106279239B (zh) * 2015-05-29 2019-06-28 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用
CN111763230A (zh) * 2020-06-23 2020-10-13 重庆华邦胜凯制药有限公司 一种卡泊三醇杂质化合物的制备方法及其应用

Also Published As

Publication number Publication date
EP0957098A1 (en) 1999-11-17
KR19990088202A (ko) 1999-12-27
CA2271414A1 (en) 1999-11-14
JP2000026443A (ja) 2000-01-25
US6040461A (en) 2000-03-21
MX9904401A (enExample) 2000-03-01

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