CN1230447C - 识别血小板膜糖蛋白的单克隆抗体及其在抗血栓治疗中的应用 - Google Patents
识别血小板膜糖蛋白的单克隆抗体及其在抗血栓治疗中的应用 Download PDFInfo
- Publication number
- CN1230447C CN1230447C CNB021252270A CN02125227A CN1230447C CN 1230447 C CN1230447 C CN 1230447C CN B021252270 A CNB021252270 A CN B021252270A CN 02125227 A CN02125227 A CN 02125227A CN 1230447 C CN1230447 C CN 1230447C
- Authority
- CN
- China
- Prior art keywords
- monoclonal antibody
- antibody
- platelet
- iiia
- antiplatelet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
Description
抗体 | 阳性细胞百分率(%) | 平均荧光强度 |
PBS鼠-IgGSZ-22R813Y262R813+鼠-IgGR813+SZ-22R813+R813R813+Y262 | 3.226.4890.287.773.686.492.387.688.1 | 2.613.2683.1185.7130.9174.8255.4180.1338.5 |
Claims (6)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021252270A CN1230447C (zh) | 2002-07-17 | 2002-07-17 | 识别血小板膜糖蛋白的单克隆抗体及其在抗血栓治疗中的应用 |
US10/622,231 US6951645B2 (en) | 2002-07-17 | 2003-07-17 | Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy |
EP03016258A EP1382617A1 (en) | 2002-07-17 | 2003-07-17 | Monoclonal antibodies recognizing human platelet GPIIIa and GPIIb/GPIIIa and use thereof in anti-thrombotic therapy |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021252270A CN1230447C (zh) | 2002-07-17 | 2002-07-17 | 识别血小板膜糖蛋白的单克隆抗体及其在抗血栓治疗中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1495199A CN1495199A (zh) | 2004-05-12 |
CN1230447C true CN1230447C (zh) | 2005-12-07 |
Family
ID=29743995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021252270A Expired - Fee Related CN1230447C (zh) | 2002-07-17 | 2002-07-17 | 识别血小板膜糖蛋白的单克隆抗体及其在抗血栓治疗中的应用 |
Country Status (3)
Country | Link |
---|---|
US (1) | US6951645B2 (zh) |
EP (1) | EP1382617A1 (zh) |
CN (1) | CN1230447C (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1712566A4 (en) * | 2004-01-19 | 2007-09-12 | Medical & Biol Lab Co Ltd | INFLAMMATORY CYTOKINE INHIBITOR |
EP2025685B1 (en) * | 2007-08-15 | 2013-06-19 | Canadian Blood Services | Monoclonal antibodies against BETA3 integrins |
CN107082809B (zh) * | 2017-06-13 | 2020-11-10 | 华东理工大学 | 靶向血小板膜糖蛋白GPIbα的抑制肿瘤转移的单克隆抗体及其筛选方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387413A (en) * | 1985-06-14 | 1995-02-07 | The Research Foundation Of State University Of New York | Method of inhibiting thrombus formation by the 7E3 monoclonal antibody |
KR940009084B1 (ko) * | 1988-05-18 | 1994-09-29 | 체크 포인트 시스템스, 인코오퍼레이티드 | 자기 및 공명회로 검출용 안테나 시스템 |
US5770198A (en) * | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
JP2776634B2 (ja) | 1991-09-17 | 1998-07-16 | 帝人株式会社 | グリコプロテイン ▲II▼b/▲III▼aに対するヒト型モノクローナル抗体 |
US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
US20040236079A1 (en) * | 2001-03-26 | 2004-11-25 | Simon Karpatkin | Antibodies that dissolve arterial thrombi |
-
2002
- 2002-07-17 CN CNB021252270A patent/CN1230447C/zh not_active Expired - Fee Related
-
2003
- 2003-07-17 EP EP03016258A patent/EP1382617A1/en not_active Withdrawn
- 2003-07-17 US US10/622,231 patent/US6951645B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1382617A1 (en) | 2004-01-21 |
US20040013666A1 (en) | 2004-01-22 |
US6951645B2 (en) | 2005-10-04 |
CN1495199A (zh) | 2004-05-12 |
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C06 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
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Owner name: SHANGHAI YALIAN ANTIBODY MEDICINE CO., LTD. Free format text: FORMER OWNER: RUAN ZHANGGENG Effective date: 20100412 Free format text: FORMER OWNER: YE QINGWEI |
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Free format text: CORRECT: ADDRESS; FROM: 215002 ROOM 202, BUILDING 11, JIAANBIEYUAN, NO.1, SANDUO LANE, SUZHOU CITY, JIANGSU PROVINCE TO: 201203 FLOOR 3, BUILDING 6, NO.899, ZUCHONGZHI ROAD,PUDONG, SHANGHAI CITY |
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Owner name: WUJIANG DIXING TECHNOLOGIES CO., LTD. Free format text: FORMER OWNER: SHANGHAI YALIAN ANTIBODY MEDICINE CO., LTD. Effective date: 20110311 |
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Free format text: CORRECT: ADDRESS; FROM: 201203 3/F, BUILDING 6, NO. 899, ZUCHONGZHI ROAD, PUDONG, SHANGHAI TO: 215200 BUILDING 6, NO. 2358, CHANG'AN ROAD, WUJIANG CITY, SUZHOU CITY, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20110311 Address after: 215200, building 2358, No. 6, Changan Road, Wujiang, Jiangsu, Suzhou Patentee after: WUJIANG DIXING TECHNOLOGY Co.,Ltd. Address before: Pudong Zuchongzhi road 201203 Shanghai City No. 899, building 6, floor 3 Patentee before: Shanghai Yalian Antibody Medicine Co.,Ltd. |
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ASS | Succession or assignment of patent right |
Owner name: DONGYING LIDA PHARMACEUTICALS CO., LTD. Free format text: FORMER OWNER: SUZHOU DDS BIOTECHNOLOGY PHARMACEUTICAL CO.,LTD. Effective date: 20120516 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Owner name: SUZHOU DDS BIOTECHNOLOGY PHARMACEUTICAL CO.,LTD. Free format text: FORMER NAME: WUJIANG DIXING TECHNOLOGIES CO., LTD. |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 215200 SUZHOU, JIANGSU PROVINCE TO: 257000 DONGYING, SHANDONG PROVINCE |
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CP03 | Change of name, title or address |
Address after: 215200 Jiangsu Wujiang Economic Development Zone Science and Technology Pioneer Park Comprehensive Building Patentee after: Suzhou Dixing Biomedical Technology Co.,Ltd. Address before: 215200, building 2358, No. 6, Changan Road, Wujiang, Jiangsu, Suzhou Patentee before: WUJIANG DIXING TECHNOLOGY Co.,Ltd. |
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TR01 | Transfer of patent right |
Effective date of registration: 20120516 Address after: 257000 Shandong province Dongying district before the new street 59, building B, room 537-1 hatch Patentee after: Dongying Lida Pharmaceutical Co.,Ltd. Address before: 215200 Jiangsu Wujiang Economic Development Zone Science and Technology Pioneer Park Comprehensive Building Patentee before: Suzhou Dixing Biomedical Technology Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051207 Termination date: 20200717 |