CN1217656C - 用于调节脂浓度的方法和药物组合物 - Google Patents

用于调节脂浓度的方法和药物组合物 Download PDF

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Publication number
CN1217656C
CN1217656C CN961980109A CN96198010A CN1217656C CN 1217656 C CN1217656 C CN 1217656C CN 961980109 A CN961980109 A CN 961980109A CN 96198010 A CN96198010 A CN 96198010A CN 1217656 C CN1217656 C CN 1217656C
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CN
China
Prior art keywords
phenyl
methylethyl
atorvastatin
combination
bis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN961980109A
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English (en)
Chinese (zh)
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CN1201389A (zh
Inventor
T·M·A·博坎
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Warner Lambert Co LLC
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Warner Lambert Co LLC
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Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of CN1201389A publication Critical patent/CN1201389A/zh
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Publication of CN1217656C publication Critical patent/CN1217656C/zh
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN961980109A 1995-11-02 1996-10-02 用于调节脂浓度的方法和药物组合物 Expired - Fee Related CN1217656C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US615595P 1995-11-02 1995-11-02
US60/006,155 1995-11-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005100517235A Division CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Publications (2)

Publication Number Publication Date
CN1201389A CN1201389A (zh) 1998-12-09
CN1217656C true CN1217656C (zh) 2005-09-07

Family

ID=21719566

Family Applications (2)

Application Number Title Priority Date Filing Date
CN961980109A Expired - Fee Related CN1217656C (zh) 1995-11-02 1996-10-02 用于调节脂浓度的方法和药物组合物
CNA2005100517235A Pending CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005100517235A Pending CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Country Status (26)

Country Link
US (3) US6124309A (https=)
EP (1) EP0858336B1 (https=)
JP (1) JPH11515025A (https=)
KR (2) KR100449604B1 (https=)
CN (2) CN1217656C (https=)
AR (1) AR004527A1 (https=)
AT (1) ATE348607T1 (https=)
AU (1) AU720853B2 (https=)
BG (1) BG64018B1 (https=)
BR (1) BR9611410A (https=)
CZ (1) CZ127198A3 (https=)
DE (1) DE69636783T2 (https=)
EA (1) EA000514B1 (https=)
ES (1) ES2279526T3 (https=)
GE (1) GEP20001898B (https=)
HU (1) HUP9901865A3 (https=)
IL (1) IL123902A (https=)
IS (1) IS4720A (https=)
NO (1) NO981961L (https=)
NZ (2) NZ319906A (https=)
PL (1) PL186714B1 (https=)
RO (1) RO120816B1 (https=)
SK (1) SK284142B6 (https=)
UA (1) UA46069C2 (https=)
WO (1) WO1997016184A1 (https=)
ZA (1) ZA969187B (https=)

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US6124309A (en) 2000-09-26
JPH11515025A (ja) 1999-12-21
HUP9901865A3 (en) 2000-06-28
CZ127198A3 (cs) 1998-12-16
AU720853B2 (en) 2000-06-15
HK1016509A1 (en) 1999-11-05
EA000514B1 (ru) 1999-10-28
GEP20001898B (en) 2000-01-05
UA46069C2 (uk) 2002-05-15
BG64018B1 (bg) 2003-10-31
ES2279526T3 (es) 2007-08-16
ATE348607T1 (de) 2007-01-15
HUP9901865A2 (hu) 1999-10-28
IL123902A0 (en) 1998-10-30
RO120816B1 (ro) 2006-08-30
KR100449604B1 (ko) 2004-11-16
PL186714B1 (pl) 2004-02-27
US6143755A (en) 2000-11-07
AU7253996A (en) 1997-05-22
CN1201389A (zh) 1998-12-09
DE69636783D1 (de) 2007-02-01
PL326365A1 (en) 1998-09-14
IL123902A (en) 2003-01-12
ZA969187B (en) 1997-05-29
CN1679953A (zh) 2005-10-12
KR20040029459A (ko) 2004-04-06
EA199800420A1 (ru) 1998-10-29
KR19990067270A (ko) 1999-08-16
NZ319906A (en) 2000-02-28
NO981961L (no) 1998-05-04
SK284142B6 (sk) 2004-10-05
AR004527A1 (es) 1998-12-16
EP0858336A1 (en) 1998-08-19
NO981961D0 (no) 1998-04-30
WO1997016184A1 (en) 1997-05-09
EP0858336B1 (en) 2006-12-20
IS4720A (is) 1998-04-17
SK55798A3 (en) 1999-06-11
NZ512484A (en) 2003-02-28
BR9611410A (pt) 1999-01-05
DE69636783T2 (de) 2007-10-18
BG102417A (en) 1999-01-29
US6093719A (en) 2000-07-25

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