CN1215610A - Antipyretic and antitoxic particles and preparing method thereof - Google Patents
Antipyretic and antitoxic particles and preparing method thereof Download PDFInfo
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- CN1215610A CN1215610A CN 98120420 CN98120420A CN1215610A CN 1215610 A CN1215610 A CN 1215610A CN 98120420 CN98120420 CN 98120420 CN 98120420 A CN98120420 A CN 98120420A CN 1215610 A CN1215610 A CN 1215610A
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- radix
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- flos lonicerae
- gypsum fibrosum
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Abstract
A medicine in the form of particles for treating cold is prepared from 12 Chinese-medicinal materials such as honeysuckle flower, forsythia fruit, anemarrhena rhizome, capejasmine fruit, isatis root, etc.
Description
The invention relates to the heat-clearing and toxic substances removing granule of treatment flu, is to be the oral medicine that efficacy component is prepared from Chinese medicine specifically.The invention still further relates to the preparation method of described granule.
The name of flu, the beginning sees a piece of writing in the Northern Song Dynasty " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House, all wind ": " it is low voice speaking to cough for flu ailment said due to cold or exposure, fever and headache, and tears saliva is sticky ".And before this flu that claim are " cold ", " ailment said due to cold or exposure " etc. more.Bright clearly to fall, how will catch a cold claims with cold is mutual.On the books in " General Treatise on the Cause and Symptoms of Diseases, time row sick duke or princess under an emperor " as for stronger " influenza " of infectiousness: " husband's seasonal epidemic pathogens patient, this all because of the year time get along well, temperature is cool forfeits one's integrity, the people feels epidemic pathogenic factor and gives birth to, the patient is heterogeneous dyes easy.So give take medicine and for method in case it." flu one card, because of be affected by the cold, wind heat gives birth to, its principle of treatment is the ancestor with hot warm, Xin Liang also, anemopyretic cold and influenza are all used the method for suffering cold.
Ancient times, the Chinese patent medicine of treatment flu was many with pill and powder, but because of to season hot summer easy mould evil idea rotten, how changed these prescriptions into tablet or electuary (sticking up the detoxifying pills dosage changing form as antelope is tablet) modern age.The drug development of treatment flu is more in recent years, yet quite a few is under this guide of theory of doctor trained in Western medicine " viral infection ", select the Chinese medicine of part antivirus action for use, adding antipyretic-antalgic, antianaphylactic Western medicine develop (as GANMAOTONG, strong VC Yinqiao tablets etc.).These medicines have drowsiness and side effect hyperhidrosis more, often influence the patient work and the life on daytime.And under the guidance of theory of Chinese medical science, less with the prescription that the treatment of pure Chinese medicine composition is caught a cold, the medicine that especially can be used for the treatment of " influenza " still less, so exploitation is difficult the pure Chinese medicinal preparation of side effect or select the square preferably medicine of effect in former Chinese medicine, and further improve production technology, raising curative effect, be the important topic that the Chinese medicine scientific research is done mutually.
Therefore, the object of the invention provides a kind of wind heat diseases caused by exogenous pathogenic factor Chinese patent medicine of row flu in time for the treatment of.
Another object of the present invention provides a kind of preparation method of the described medicine granule that cures cold.
Medicine of the present invention is the innovative product that the existing pestilence that disappears is relieved internal heat and drinks.The pestilence that disappears in " A View of Epidemic Febrile Diseases with Rashes " drink that relieves internal heat is the prescription of clearing away heat in both QI and blood.And wind-heat syndrome, especially influenza in the flu, the syndrome of WEI system of quite a few patients undergo short-term occurs defending gas two very soon and burns card after waiting.Add and subtract the treatment flu with we, be mainly used in wind heat disease and influenza.This two card seldom has the syndrome of the nutrient blood of entering, so Cornu rhinocerotis, Radix Paeoniae Rubra, the Cortex Moutan of our clearing away heat from YING and blood systems are removed, and leave out little Rhizoma Coptidis, Folium Bambusae, Radix Platycodonis, the Radix Glycyrrhizae for the treatment of flu effect, and add relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, the Flos Lonicerae of heat-clearing and toxic substances removing, Radix Isatidis, Herba Gueldenstaedtiae, Radix Gentianae; The easy impairment of YIN consumption of anemopyretic cold and influenza liquid is so add Radix Ophiopogonis to strengthen the dynamics of former side's yin nourishing medicine.Again in the side behind the plus-minus, be monarch with Flos Lonicerae, Fructus Forsythiae, Gypsum Fibrosum, the Rhizoma Anemarrhenae.Flos Lonicerae, Fructus Forsythiae relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing are gone out with wind heat epidemic disease poison; Gypsum Fibrosum, the Rhizoma Anemarrhenae cold and cool clear in, to rush down the edema caused by disorder of QI interior-heat.Radix Scutellariae, Fructus Gardeniae, Radix Isatidis, Herba Gueldenstaedtiae are minister, with the power of principal drug assistance heat-clearing and toxic substances removing.The Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, the agent of Radix Gentianae replenishing YIN and removing heat for assisting a ruler in governing a country turn round and look at and protect cloudy liquid, in case consumption of YIN caused by febrile disease.All medicines are harmonious, originally can relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, clearing heat in QI system divides interior-heat, heat-clearing and toxic substances removing, the raw material prescription of for treatment wind heat diseases caused by exogenous pathogenic factor in time the row flu the efficacious prescriptions medicine arranged. medicine of the present invention is as follows: the preferred weight proportioning of (by weight) honeysuckle 100-160 part capsule of weeping forsythia 50-100 part gypsum 500-800 part wind-weed 40-70 part mast 50-100 part Radix Isatidis 50-100 part Manyflower Gueldenstaedtid Herb 50-100 part root of large-flowered skullcap 50-100 part felwort 50-100 part radix scrophulariae 80-150 part glutinous rehmannia 50-100 part 30-60 tuber of dwarf lilyturf part aforementioned pharmaceutical compositions each component is as follows: 80 tubers of dwarf lilyturf 54 of honeysuckle 134 capsules of weeping forsythia 67 gypsums 670 wind-weeds 54 masts 67 Radix Isatidis 67 Manyflower Gueldenstaedtid Herbs 67 roots of large-flowered skullcap 67 felworts 67 radix scrophulariaes 107 glutinous rehmannia
Above-mentioned pharmaceutical composition can be prepared into any pharmaceutical dosage form according to the preparation process of routine, as tablet, powder, capsule, oral liquid, injection etc.
The preferred dosage form of medicine of the present invention is a granule.
According to the dissolubility of all flavour of a drug effective ingredient in the prescription, adopt one factor analysis of variance and q method of inspection, optimize flavour of a drug such as Radix Scutellariae and use earlier the low-concentration ethanol reflux, extract,, the new technology that medicinal residues boil with flavour of a drug merging decocting such as Gypsum Fibrosum again.This technology is compared with the simple decocting technology of oral liquid, has increased the extracted amount of effective ingredient.
Concrete technology is as follows:
Earlier Flos Lonicerae, Radix Scutellariae, Fructus Gardeniae, Radix Isatidis, Radix Rehmanniae, Radix Scrophulariae are added 70% alcohol reflux 1-3 time, each 1-3 hour, filter, device is collected alcohol extract and medicinal residues in addition; Six-elements such as Gypsum Fibrosum decoct with water 0.5-2 hour, and device is collected decocting liquid in addition; Merge medicinal residues, decoct with water again 2 times, each 20-60 minute; Merge one, two, three decocting liquid, filter, filtrate is concentrated into relative density and is about 1.08 (90-95 ℃), add 2.8 times of amounts of ethanol, fully stir, left standstill 24-72 hour, get supernatant and above-mentioned alcohol extract and merge, reclaim ethanol and be concentrated into the clear paste that relative density is about 1.20 (60-65 ℃), it is doubly minimum to add 1-2, stir evenly, left standstill 24-72 hour, get the clear paste that supernatant concentration to relative density is 1.30-138 (60-70 a ℃), with excipient such as sucrose, dextrin, granulate drying, granulate, promptly.
Medicine of the present invention improves on extraction process, and the part medical material is carried out alcohol reflux earlier, and then carries out little extraction, and the proposition amount that gets active ingredient increases, and particularly compares with the fried oral liquid that gets of single water, has improved curative effect.
Drug prepared has the suffering table that cools completely, the function of heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst.Be applicable to anemopyretic cold (upper respiratory tract infection) and hyperpyrexia (syndrome in QI system).Through pharmacodynamic experiment research, prove that the curative effect of medicine of the present invention (commodity in the experimental data are called the heat-clearing and toxic substances removing electuary) obviously is better than single oral liquid with little extraction preparation:
1, antivirus test: the heat-clearing and toxic substances removing electuary has extremely strong antivirus action.This product 0.015mg/ml (in extractum) still can suppress to close bleb virus (RSV) and adenovirus (III type), and 0.03mg/ml can suppress influenza virus (Asia first I type), and 0.31mg/ml can suppress parainfluenza virus (Sendai virus).And influenza virus is only had partial inhibition during QINGRE JIEDU KOUFUYE 2mg/ml, involutory bleb virus and adenovirus minimum but concentration is 100mg/ml, to then unrestraint effect of parainfluenza virus.
2, bacteriostatic test: the heat-clearing and toxic substances removing electuary has very strong inhibitory action to the respiratory tract common pathogen.Golden Portugal bacterium, bacillus pyocyaneus, bacillus canalis capsulatus and colibacillary growth are had obvious inhibitory action, and minimum inhibitory concentration is 38.5mg/ml; The strongest to the Hemolytic streptococcus inhibitory action, minimum inhibitory concentration is 9.6mg/ml.And QINGRE JIEDU KOUFUYE obviously weakens the bacteriostasis of above-mentioned pathogenic bacterium, and minimum inhibitory concentration is 77.0mg/ml.
3, separate heat test: the heat-clearing and toxic substances removing electuary has than the strong solution heat effect.1.73g/kg (in extractum) heavy dose of rabbit body temperature due to the yeast is raise has obvious antipyretic effect, compares with matched group that there were significant differences.1.15g/kg low dose of antipyretic effect is relatively poor; And the antipyretic effect of QINGRE JIEDU KOUFUYE is compared with electuary, and at same dosage, with obviously weakening in the time, fall is between the large and small dosage of electuary.
4, immunity test: the heat-clearing and toxic substances removing electuary has the effect of the humoral immune function of raising, and hemolysin generates and hemolytic plaque test in the mice body, when ig this product 1.15 and 2.30g/kg, all can obviously improve the mouse humoral immune function.External breeder reaction test to ConA and the inductive T of LPS, bone-marrow-derived lymphocyte, the dosage of this product are 0.76 and during 3.10mg/ml, and the propagation of the inductive bone-marrow-derived lymphocyte of LPS is had facilitation.
Clinical verification confirms the excellent effect of medicine of the present invention too:
1, treatment flu (wind-heat syndrome): the heat-clearing and toxic substances removing electuary has significant curative effect to flu (wind-heat syndrome).244 example flu (wind-heat syndrome) patients have carried out clinical verification, and 161 examples are organized in the treatment of heat-clearing and toxic substances removing electuary, QINGRE JIEDU KOUFUYE matched group 83 examples.Treatment group total effective rate is 95.03%, and cure rate is 74.14%; The matched group total effective rate is 81.15%, and cure rate is 55.88%.Compared significant difference (p＜0.05) for two groups.
2, treatment hyperpyrexia (syndrome in QI system): the heat-clearing and toxic substances removing electuary has significant curative effect to hyperpyrexia (syndrome in QI system).86 routine hyperpyrexia (syndrome in QI system) patients have carried out clinical verification, and 55 examples are organized in the treatment of heat-clearing and toxic substances removing electuary, QINGRE JIEDU KOUFUYE matched group 31 examples.Treatment group total effective rate is 90.9%, and the clinic control rate is 12.73%; The matched group total effective rate is 80.65%, and the clinic control rate is 6.45%, two group and has compared significant difference (p＜0.05).
3, treatment influenza: the heat-clearing and toxic substances removing electuary has significant curative effect to influenza.98 routine influenza patients have carried out clinical verification, and 64 examples are organized in the treatment of heat-clearing and toxic substances removing electuary, QINGRE JIEDU KOUFUYE matched group 34 examples.The total effective rate of treatment group is 93.75%, and cure rate is 73.44%; The total effective rate of matched group is 79.41%, and cure rate is 52.94%, two group and has compared significant difference (p＜0.05).
Embodiment
[prescription]
Flos Lonicerae 134g Fructus Forsythiae 67g Gypsum Fibrosum 610g
Rhizoma Anemarrhenae 54g Fructus Gardeniae 67g Radix Isatidis 67g
Herba Gueldenstaedtiae 67g Radix Scutellariae 67g Radix Gentianae 67g
Radix Scrophulariae 107g Radix Rehmanniae 80g 54g Radix Ophiopogonis
[method for making]
More than 12 flavors, Flos Lonicerae, Radix Scutellariae, Fructus Gardeniae, Radix Isatidis, Radix Rehmanniae, Radix Scrophulariae add 70% alcohol reflux 2 times, each 2 hours, filter, device is collected alcohol extract and medicinal residues in addition; Six-elements such as Gypsum Fibrosum add decoction 30 minutes, and device is collected decocting liquid in addition; Merge medicinal residues, decoct with water each 30 minutes again 2 times; Merge one, two, three decocting liquid, filter, filtrate is concentrated into relative density and is about 1.08 (90-95 ℃), adds 2.8 times of amounts of ethanol, fully stirs, and leaves standstill 24 hours; Get supernatant and above-mentioned alcohol extract and merge, reclaim ethanol and be concentrated into the clear paste that relative density is about 1.20 (60-65 ℃), water gaging such as add, stir evenly, left standstill 24 hours; Get the clear paste that supernatant concentration to relative density is 1.30-1.38 (60-70 a ℃); 1 part of qinghuo reagent adds 3 parts of cane sugar powders, 1 part in dextrin, granulation, drying, and granulate is made 1500g, promptly.
Claims (3)
1, a kind of medicine of fever, detoxicating and treating flu is characterized in that the crude drug component and the weight proportion that prepare this medicine are:
Flos Lonicerae 100-160 part Fructus Forsythiae 50-100 part
Gypsum Fibrosum 500-800 part Rhizoma Anemarrhenae 40-70 part
Fructus Gardeniae 50-100 part Radix Isatidis 50-100 part
Herba Gueldenstaedtiae 50-100 part Radix Scutellariae 50-100 part
Radix Gentianae 50-100 part Radix Scrophulariae 80-150 part
Radix Rehmanniae 50-100 part 30-60 Radix Ophiopogonis part
2,, it is characterized in that the crude drug component and the weight proportion that prepare this medicine are according to the medicine of claim 1:
Flos Lonicerae 134 Fructus Forsythiaes 67 Gypsum Fibrosum 670
The Rhizoma Anemarrhenae 54 Fructus Gardeniae 67 Radix Isatidis 67
Herba Gueldenstaedtiae 67 Radix Scutellariaes 67 Radix Gentianaes 67
80 Radix Ophiopogonis 54 of Radix Scrophulariae 107 Radix Rehmanniae
3, a kind of preparation method of heat-clearing and toxic substances removing granule, the prescription and the method for making that it is characterized in that preparing this medicine are as follows:
[prescription]
Flos Lonicerae 134g Fructus Forsythiae 67g Gypsum Fibrosum 610g
Rhizoma Anemarrhenae 54g Fructus Gardeniae 67g Radix Isatidis 67g
Herba Gueldenstaedtiae 67g Radix Scutellariae 67g Radix Gentianae 67g
Radix Scrophulariae 107g Radix Rehmanniae 80g 54g Radix Ophiopogonis
[method for making]
More than 12 flavors, Flos Lonicerae, Radix Scutellariae, Fructus Gardeniae, Radix Isatidis, Radix Rehmanniae, Radix Scrophulariae add 70% alcohol reflux 2 times, each 2 hours, filter, device is collected alcohol extract and medicinal residues in addition; Six-elements such as Gypsum Fibrosum add decoction 30 minutes, and device is collected decocting liquid in addition; Merge medicinal residues, decoct with water each 30 minutes again 2 times; Merge one, two, three decocting liquid, filter, filtrate is concentrated into relative density and is about 1.08 (90-95 ℃), adds 2.8 times of amounts of ethanol, fully stirs, and leaves standstill 24 hours; Get supernatant and above-mentioned alcohol extract and merge, reclaim ethanol and be concentrated into the clear paste that relative density is about 1.20 (60-65 ℃), water gaging such as add, stir evenly, left standstill 24 hours; Get the clear paste that supernatant concentration to relative density is 1.30-1.38 (60-70 a ℃); 1 part of qinghuo reagent adds 3 parts of cane sugar powders, 1 part in dextrin, granulation, drying, and granulate is made 1500g, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98120420A CN1059122C (en) | 1998-10-16 | 1998-10-16 | Antipyretic and antitoxic particles and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98120420A CN1059122C (en) | 1998-10-16 | 1998-10-16 | Antipyretic and antitoxic particles and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN1215610A true CN1215610A (en) | 1999-05-05 |
| CN1059122C CN1059122C (en) | 2000-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98120420A Expired - Lifetime CN1059122C (en) | 1998-10-16 | 1998-10-16 | Antipyretic and antitoxic particles and preparing method thereof |
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| Country | Link |
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| CN (1) | CN1059122C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317004C (en) * | 2005-10-18 | 2007-05-23 | 滕焕昭 | Chinese medicine prepn for treating infantile respiratory tract infection |
| CN1331497C (en) * | 2005-09-29 | 2007-08-15 | 王传德 | Recipe of |
| CN102210776A (en) * | 2011-06-09 | 2011-10-12 | 鲍旭刚 | Medicament for treating common cold, and preparation method thereof |
| CN102895503A (en) * | 2011-11-03 | 2013-01-30 | 青岛康地恩药业股份有限公司 | Granule for treatment of heat toxin symptom caused by chicken escherichia coli infection and preparation method thereof |
| CN102920902A (en) * | 2011-11-03 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Avian colibacillosis treatment traditional Chinese medicine and preparation method thereof |
| CN104435822A (en) * | 2014-11-15 | 2015-03-25 | 罗荣芳 | Traditional Chinese medicine preparation for clearing away heat and toxic materials |
| CN104435792A (en) * | 2014-06-26 | 2015-03-25 | 南京华宽信息咨询中心 | Anti-sendai virus soft capsule |
| CN106620188A (en) * | 2016-12-22 | 2017-05-10 | 江西济民可信药业有限公司 | Method for preparing granules with effects of clearing heat and removing toxicity |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389753C (en) * | 2004-11-02 | 2008-05-28 | 北京正大绿洲医药科技有限公司 | Oral drop pills with heat-clearing and detoxification function |
-
1998
- 1998-10-16 CN CN98120420A patent/CN1059122C/en not_active Expired - Lifetime
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331497C (en) * | 2005-09-29 | 2007-08-15 | 王传德 | Recipe of |
| CN1317004C (en) * | 2005-10-18 | 2007-05-23 | 滕焕昭 | Chinese medicine prepn for treating infantile respiratory tract infection |
| CN102210776A (en) * | 2011-06-09 | 2011-10-12 | 鲍旭刚 | Medicament for treating common cold, and preparation method thereof |
| CN102895503A (en) * | 2011-11-03 | 2013-01-30 | 青岛康地恩药业股份有限公司 | Granule for treatment of heat toxin symptom caused by chicken escherichia coli infection and preparation method thereof |
| CN102920902A (en) * | 2011-11-03 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Avian colibacillosis treatment traditional Chinese medicine and preparation method thereof |
| CN102895503B (en) * | 2011-11-03 | 2014-12-31 | 青岛蔚蓝生物股份有限公司 | Granule for treatment of heat toxin symptom caused by chicken escherichia coli infection and preparation method thereof |
| CN104435792A (en) * | 2014-06-26 | 2015-03-25 | 南京华宽信息咨询中心 | Anti-sendai virus soft capsule |
| CN104435822A (en) * | 2014-11-15 | 2015-03-25 | 罗荣芳 | Traditional Chinese medicine preparation for clearing away heat and toxic materials |
| CN104435822B (en) * | 2014-11-15 | 2018-02-06 | 马梅青 | A kind of clearing heat and detoxicating Chinese medicine preparation |
| CN106620188A (en) * | 2016-12-22 | 2017-05-10 | 江西济民可信药业有限公司 | Method for preparing granules with effects of clearing heat and removing toxicity |
| CN106620188B (en) * | 2016-12-22 | 2018-11-20 | 江西济民可信药业有限公司 | A kind of preparation method of clearing heat and detoxicating particle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1059122C (en) | 2000-12-06 |
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