CN1212889A - Traditional Chinese medicine component for improving immunocompetence and having effect on multiple epidemic diseases - Google Patents

Abstract

A Chinese medicine component for increasing immunity and high effect to many diseases such as diabetes is prepared from edible fungus, astragulus root and Ramulus euonymia, and serves to reduce blood sugar and blood fat, improving microcirculation of blood, and prevent complication. It also has better curative effect to cancer.

Description

A kind of immunocompetence that improves is to the effective Chinese medicine component of multiple eqpidemic disease

The present invention relates to medical manufacturing field, more specifically say so about the Chinese medicine preparation of treatment diabetes and raising immunocompetence.

Diabetes are common frdquently encountered diseases of serious harm human health, and diabetics surpasses 100,000,000 people in the world at present, and also there is the trend that increases year by year in China nearly 20,000,000.

Diabetes do not heal all the life, its complication extensively and seriously, because insulin lacks relatively or definitely in the blood, cause sugar, fat, protein metabolism disorder, cause hyperglycemia, hyperlipidemia and blood viscosity to raise, extensively microangiopathies of the whole body appears in middle and advanced stage, and wherein 70-80% patient dies from the cardiovascular diseases.

Both at home and abroad to this sick Drug therapy, have following several problem: 1, biguanide drug: the curative effect toxic and side effects is big at present, for a long time with producing hyperlactacidemia; 2, sulfaurea drugs: for a long time with damaging liver, kidney and hemocyte, with the sulfonamides cross allergy, the later stage produces secondary failure; 3, insulin: with producing antibody, biological activity reduces for a long time, and dosage increases, and produces hyperinsulinemia, impels microangiopathies to take place and development.

The object of the present invention is to provide a kind of blood sugar lowering that has, blood fat reducing improves the blood clotting state, and the mediation microcirculation increases immunity of organism, reduces the diabetes preparation of diabetes-alleviating complication.

Solution of the present invention is based on motherland's medical science to diabetes and complication pathogeny thereof, understanding and Therapeutic Principle, again in conjunction with people in recent years to the understanding and the progress of edible fungi, utilize their superior characteristics of curing the disease separately, based on edible fungi, press the theory of Chinese medical science prescription with the modern science cognitive analysis, design, make, skim the cream off milk, promote endogenous secretion of insulin, reduce exogenous insulin periphery drag, increase biological activity, promote the metabolism of sugar, reduce fat protein and decompose, make blood pressure and blood lipoid reduce microcirculation improvement, reduce diabetes-alleviating patient cardiovascular pathological changes and develop.People Fei Te epidemic disease immunocompetence is improved.The ability of balance T cell and β cell and activity are owing to use modern science design philosophy to make the present invention simple, because raw material, component are few, therefore be convenient to grasp the mechanism of really curing the disease of various raw materials more, avoided too much, caused medication inaccurate, the problem that mechanism is obstructed because of the component kind.

The present invention is main by following three kinds of raw materials: 1. edible fungi: be mainly Grifola frondosa and Pleurotus ostreatus all can; 2. the Radix Astragali: mainly adopt Radix Astragali; 3. Ramulus Euonymi.

Edible fungi is the nourishing food of a kind of delicious food, body-building, not only edible but also can be used for producing antibiotic and various medicine.A large amount of compositions to the human body beneficial are arranged, as polysaccharide, purine, steroidal etc. in edible fungi.Can promote and regulate and control the metabolism of human body, improve the immunocompetence of body, play the effect that prevents and treat multiple disease, also have the concrete effect of the following aspects:

1, stimulate body to produce antibody, improve immunocompetence, prevent or eliminate alien bacteria, virus and paracytic invasion and attack and generation, the oxygen delivery capacity that can improve in the body blood reduces the effective consumption of body to oxygen, improves the utilization rate of oxygen.

2, edible fungi also can produce antibiotic, as isolating pleurin from pleurotus, has broad spectrum activity, and multiple pathogenic bacteria is all had higher antibacterial activity.Virus also there is certain inhibitory action.

3, the antitumor action of edible fungi, through deeply screening, finding has more than 150 kind of bacterium to contain polysaccharide, and it can stimulate body, and the generation immune function plays and suppresses the growth of tumour cell effect, and antitumor action is quite remarkable.

The Radix Astragali is the root of the pulse family herbaceos perennial Radix Astragali, contain saccharide, choline folic acid, β-sitosterol, also contain 2 ', 4 dihydroxy ,-5,6-dimethoxy and flavone, to the multiple effect that inhibition is arranged to pathogenic bacteria, can also strengthen normal contraction, the heart of depletion is had strong effect, can freely contain blood circulation blood glucose is descended, sedation, the conversion of all right activated lymphocyte delays the decline of total complement amount, the non-characteristic immunity of energy enhancing body.

Ramulus Euonymi is machaka, contains freidelin, Quercetin and oxalacetyl sodium in its branch and leaf, and stronger hypoglycemic activity is arranged, and can make the propagation of islet cells during use, and abnormal metabolic process is adjusted in pancreas β hyperplasia, strengthens secretion of insulin.

More than three kinds of raw materials quite good characteristics are all arranged on pharmacodynamics, but because its real active ingredient is considerably less in raw material itself, therefore be not enough in order to treat and to keep healthy, for example modern science is thought the bacterium of picking up the ears in the edible fungi, the very effective antibacterial anti-viral effect of wide spectrum is arranged, but since in edible fungi in the middle of the sporophore content considerably less, the into relatively large commercialization of therefore failing.

Another object of the present invention utilizes existing means that three kinds of raw materials are carried out extracting with effective ingredient exactly, and is concentrated relatively, or less preparation, is convenient to user and uses, and strengthened the ratio of active ingredient simultaneously.And when processed, making chemical analysis in the raw material, synthetic again new chemical compound makes drug effect outstanding more and obvious.

Component content of the present invention (weight %): major ingredient Grifola frondosa, Pleurotus ostreatus 40-95%, be preferably 60%, Radix Astragali 3-20% is preferably 20%, Ramulus Euonymi 3-20%.Be preferably 20%.

Grifola frondosa, Pleurotus ostreatus all can cooperate with the Radix Astragali, Ramulus Euonymi separately in component of the present invention.

Another important feature of the present invention is to contain abundant choline material, and flavone compound, and flavone compound can increase the islets of langerhans blood perfusion, helps the synthetic and secretion of insulin.

Embodiment:

Get 60 kilograms of commercially available dried massee fruiting bodies, 20 kilograms of the Radixs Astragali, 20 kilograms of Ramulus Euonymis, the raw materials used intensive drying thing that is necessary for, fresh, nothing is gone mouldy, free from extraneous odour, and impurity is rejected clean, three kinds of raw materials are mixed, pulverize with pulverizer, with the sub-sieving for standby of 60 mesh sieves.

With the material powder after pulverizing, put into to boil and carry jar, added entry by 1: 8, be heated to 90-95 ℃ and carry out homogenizing, stop after 15 minutes heating, natural cooling is put into the centrifuge separation and Extraction during to 45-50 ℃.With the residue after the lixiviate first time, the water that adds 2 times is in 85-90 ℃ of down heating 20 minutes, puts centrifugally in people's centrifuge to carry out extraction second time.

With go in the residue after the lixiviate second time 2 times water in 80 ℃ down heating put into after 20 minutes that centrifuge is centrifugal to be extracted for the third time.

Above-mentioned 3 extracting solution are merged, and at this moment active ingredient is lower in extract, and one has only about 0.5%.When extracting solution is concentrated into content 20%, under 50-60 ℃, carry out spray drying.

Rapidly spray drying gained powder is incapsulated.

The experiment to diabetic rabbit blood glucose of the capsule made and matched group is seen the following form.Table 1 is mean blood glucose in three groups of each time of rabbit in the X ± SD administration 15 hours as a result.

Time (hour)	??0.5	????1	???2	????3	????4	????5	????6	????7	????8	????9	???10	???11	???12	???13	???14	????15
																	The healthy rabbits matched group	92±10	90±8	92±6	93±8	90±6	85±6	84±5	86±7	89±6	85±5	84±6	87±5	85±6	80±7	80±14	75±4*
This agent	200±10	200±6	190±5	194±8	196±4	201±5	200±7	191±4	196±5	185±4	195±4	192±6	190±4	190±6	190±5	166±6**
																	The diabetes pill group	192±10	194±5	196±7	194±6	196±4	200±5	196±6	196±4	208±6	210±4	200±6	196±6	196±4	180±5	180±5	180±2

This agent of table 2 is to the effect laboratory observation research table II of artificial diabetes

	1 day	2 days	3 days	4 days	5 days	6 days	7 days	8 days	9 days	10 days	15 days	20 days	25 days	30 days	35 days	40 days	45 days	50 days
																			The healthy rabbits matched group	77±55	82±5	80±6	81±5	83±6	80±5	81±7	80±6	80±7	80±8	81±7	82±4	83±3	80±6	82±6	83±6	80±6	81±3
Artificial diabetes blank group	190±10	190±10	195±9	198±10	196±12	19.7±10	198±10	205±6	207±5	207±10	209±11	212±5	216±10	200±12	235±12	240±15	260±12	29D±12
																			This agent group	1.70±6	170±2	195±5	163±5	150±8	162±7	110±5	108±5	106±6	103±7	100±6	98±7	98±7	85±5	76±5	88±4	80±4	82±56
The diabetes pill group	183±24	180±6	1.79±5	181±6	179±6	179±7	180±6	179±5	181±5	184±5	1.70±6	170±5	170±6	165±6	169±5	160±4	160±5	140±4

By above two tables as can be known, this component is effective really to diabetes.

Claims (5)

1, a kind of immunocompetence that improves is to the effective Chinese medicine component of multiple eqpidemic disease, and it is characterized in that: it is made up of edible fungi Grifola frondosa, Pleurotus ostreatus and Chinese herb astragalus and Ramulus Euonymi.

2, according to claims 1 described a kind of immunocompetence that improves to the effective Chinese medicine component of multiple eqpidemic disease, it is characterized in that edible fungi Grifola frondosa, its component content of Pleurotus ostreatus are (weight %) 30-80%.

3, according to claims 1 described a kind of immunocompetence that improves to the effective Chinese medicine component of multiple eqpidemic disease, it is characterized in that: Radix Astragali component content is (weight %) 5-30%.

4, according to claims 1 described a kind of immunocompetence that improves to the effective Chinese medicine component of multiple eqpidemic disease, it is characterized in that: its component content of Ramulus Euonymi is 5-30%.

5, according to claims 2 described Grifola frondosa, ratio is any between the two for Pleurotus ostreatus.