CN1209118C - Ointment for treating piles and other anorectal diseases and its prepn - Google Patents
Ointment for treating piles and other anorectal diseases and its prepn Download PDFInfo
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- CN1209118C CN1209118C CNB021391882A CN02139188A CN1209118C CN 1209118 C CN1209118 C CN 1209118C CN B021391882 A CNB021391882 A CN B021391882A CN 02139188 A CN02139188 A CN 02139188A CN 1209118 C CN1209118 C CN 1209118C
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- ointment
- vaseline
- succinum
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- calamina
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Abstract
The present invention discloses an ointment for treating hemorrhoid of the anus and intestine and a preparation method thereof. The ointment is prepared from vaseline, cow-bezoar, pearl, calamine, borax, succinum, borneol, dimethylsulphoxide, lanolin and musk. The preparation method comprises the steps that the pearl and the succinum are pulverized; then the musk, the cow-bezoar, the borax, the borneol, the calamine, the pearl powder and the succinum powder are mixed; the medicine powder is uniformly mixed with the calamine; the mixed medicine powder is pulverized by medicine micronizing technology; the vaseline is sterilized and cooled after being meltedd; the lanolin is sterilized; the dimethylsulphoxide is melted; the medicines are put into a material tank to be uniformly stirred. The ointment of the present invention has the advantages of conspicuous treatment effect, simple technology and easy absorption, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of ointment for the treatment of hemorrhoid class anorectal, specifically, this drug regimen can be used for treating swelling and pain of hemorrhoid, anal fissure, the anal eczema due to heat, poison, the stasis of blood.The invention still further relates to the preparation method of this medicine.
Background technology
At present, the medicament categories that is used for the treatment of hemorrhoid class anorectal disorder is various, and chemical synthetic drug is because the limitation of clinical efficacy and toxic and side effects is all unsatisfactory.Chinese medicine preparation is subjected to expert and patient's favorable comment owing to evident in efficacy and low toxic and side effects.The Chinese medicine preparation for the treatment of hemorrhoid class anorectal disorder in the market has ointment, suppository, patch, ointment, lotion, oral formulations etc., and manufacturer is also numerous.The hemorrhoid class Chinese medicine ointment of controlling of selling on the domestic market at present mainly contains the Pien Tze Huang ZHICHUANG GAO that ZhangZhou Pien Tze Huang group company produces, and its composition is aided with Margarita, succinum, Borneolum Syntheticum etc. for based on Pien Tze Huang; Many traditional medicines enterprise all controls hemorrhoid class medicine in developmental research, the YUNNAN BAIYAO ZHICHUANG GAO of also having produced as Yunnan BAIYAO group company.
Summary of the invention
The purpose of this invention is to provide a kind of ointment for the treatment of hemorrhoid class anorectal, this agent is evident in efficacy, specimen and control, act on rapidly, traditional Chinese herb medicine preparation that toxicity is extremely low.
Another object of the present invention provides the preparation method of the ointment of hemorrhoid class anorectal treatment disease, and technology is simple, energy consumption is low, be easy to absorb, be suitable for suitability for industrialized production.
For achieving the above object, the present invention reaches by following technical measures:
Moschus---the refreshment of having one's ideas straightened out, promoting blood circulation and detumescence, the fetal abortion of stimulating the menstrual flow.Fragrance is walked to scurry, the current twelve regular channels, the priming power sick institute that goes directly.
Borneolum Syntheticum---have one's ideas straightened out heat clearing away, pain relieving; But external erosion prevention and muscle growing.
Calculus Bovis---relieving convulsion is had one's ideas straightened out, heat-clearing and toxic substances removing.
Succinum---tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.
Margarita---calm the nerves endogenous wind stopping, heat clearing away, detoxifcation, granulation promoting.
Calamina---improving acuity of vision and removing nebula, the convergence granulation promoting.
Borax---heat clearing away expectorant, anticorrosion
Medicine of the present invention is made by following component, and consumption is a weight portion:
| Vaseline | 700-900 |
| Calculus Bovis | 0.1-1.0 |
| Margarita | 0.1-1.0 |
| Calamina | 50-100 |
| Borax | 5-15 |
| Succinum | 0.1-1.0 |
| Borneolum Syntheticum | 14.6-71.0 |
| Dimethyl sulfoxine | 10-50 |
| Lanoline | 20-60 |
| Moschus | 0.1-1.0 |
The preferred manufacturing prescription of medicine of the present invention is as follows, and consumption is a weight portion:
| Vaseline | 750-850 |
| Calculus Bovis | 0.3-0.8 |
| Margarita | 0.3-0.8 |
| Calamina | 60-80 |
| Borax | 8-12 |
| Succinum | 0.3-0.8 |
| Borneolum Syntheticum | 20-50 |
| Dimethyl sulfoxine | 20-40 |
| Lanoline | 30-40 |
| Moschus | 0.3-0.8 |
Moschus of the present invention is the gas of promoting the circulation of blood branch, and the monarch drug of promoting blood circulation and detumescence has out all keys, the meridian dredging, and promoting blood circulation and detumescence is except that the merit of malignant boil.Moschus is with its hot temperature causing resuscitation with aromatic drugs, and penetration is strong, can make the skin pore open expansion, draws the through sick institute of all medicines, and modern pharmacology confirms that Moschus has extremely strong antiinflammatory action, institute think control the hemorrhoid toxic swelling from the beginning of key medicine.Be aided with Calculus Bovis, Borneolum Syntheticum, Calamina.Calamina can be restrained, be subsided a swelling, and the merit of erosion prevention and muscle growing is arranged, the Borneolum Syntheticum refreshment of having one's ideas straightened out, and clearing away heat to alleviate pain, Calculus Bovis can the eliminating phlegm heat-clearing and toxic substances removing.Moschus gets helping of Calculus Bovis, Borneolum Syntheticum, and then hot temperature is walked to scurry and do not had the fraud of combustion-supporting fire-toxin.Calamina, Calculus Bovis, Borneolum Syntheticum get helping of Moschus, and then the power of heat-clearing and toxic substances removing, reducing swelling and alleviating pain is bigger.Margarita, succinum are detoxifcation, Borax heat clearing away expectorant, anticorrosion, and assistant is for making altogether.Seven flavor medicine closes and uses it, plays the heat clearing away poison altogether, reducing swelling and alleviating pain, and the effect of putrefaction-removing granulation-promoting is used for the treatment of swelling and pain of hemorrhoid due to heat, poison, the stasis of blood, anal fissure, anal eczema etc., and evident in efficacy, effect is rapidly.Main Ingredients and Appearance of the present invention is a mineral drug, and absorbing difficulty is the common problem of mineral drug existence, and the drug absorption key that to be drug effect brought into play.In order to increase drug absorption, at first must reduce the particle diameter of medicine.Invented the preparation method of this agent through concentrating on studies of more than ten years.This technology has coarse powder, fine powder, the pure three process of air-flow powder, and its principle is to adopt high velocity air to drive medicine to pulverize with the velocity of sound collision in pulverizing chamber.Manufacture method of the present invention, its step comprises: at first, respectively Margarita, succinum are carried out fine powder and pulverize, cross the 100-120 mesh sieve.Secondly, with Moschus, Calculus Bovis, Borax, Borneolum Syntheticum, 1/5 Calamina and step 1 gained Margarita fine powder, succinum fine powder facing-up, cross the 100-120 mesh sieve.The 3rd, with the Calamina mix homogeneously of step 2 gained medicated powder and 4/5.The 4th, mixed medicated powder is pulverized by the drug powder metallization processes, get former powder.The 5th, with vaseline between temperature control 80-100 ℃ fully the fusing after, temperature control 115-120 ℃ sterilization.Sterilized vaseline is cooled to 70-80 ℃.The 6th, 115-120 ℃ of sterilization of lanoline temperature control.The 7th, with 55-65 ℃ of extremely all fusing of dimethyl sulfoxine temperature control.The 8th, the vaseline of handling well is put into material-compound tank, put into a half and begin to stir; Borneolum Syntheticum is molten altogether with dimethyl sulfoxine of handling well and lanoline, filter and drop in the material-compound tank and stir; Get the former powder of step 4 gained and add material-compound tank, continue to be stirred to after adding and be even paste promptly.
The present invention compares with existing Technology, has the following advantages and effect:
1, adopted the drug powder metallization processes, solved mineral drug and absorbed difficult problem, medicine is easy to see through mucosa and enters tissue, and absorbance improves greatly, has promoted curative effect of medication.
2, characteristics of the present invention are that technology is simple, cost is low, medicine effect guarantees, are easy to absorb, be suitable for suitability for industrialized production.
3, the present invention fills a prescription rationally, and each drug distribution of filling a prescription is extremely wide, aboundresources.
4, pharmacological research shows, the present invention has significant antiinflammatory, analgesia and anastalsis, can bring into play excellent curative to experimental hemorrhoid animal model.
5, the clinical 915 routine case observations that pass through find that the present invention treats inside and outside and diseases such as mixed hemorrhoid (comprising the operation back), anal fissure, anal eczema have significant curative effect.Result such as following table:
| The sick kind | The example number | Obvious effective rate | Effective percentage | Inefficiency | Total effective rate |
| Hemorrhoid | 624 | 71.69％ | 23.08％ | 4.96％ | 95.04％ |
| Anal fissure | 223 | 69.96％ | 22.4％ | 7.64％ | 92.36％ |
| Anal eczema | 68 | 39.71％ | 48.53％ | 11.76％ | 88.24％ |
5, acute toxicity test shows, the present invention finds no obvious toxic-side effects.
The specific embodiment
Medicine embodiment consumption of the present invention following (weight portion):
A kind of ointment for the treatment of hemorrhoid class anorectal disorder, its manufacturing step is:
1. pulverize
Respectively Margarita, succinum are carried out fine powder and pulverize, cross 120 mesh sieves.
2. facing-up
Moschus, Calculus Bovis, Borax, Borneolum Syntheticum, 1/5 Calamina and step 1 gained Margarita fine powder, succinum fine powder are carried out facing-up, cross 120 mesh sieves.
3. mix
With step 2 gained medicated powder and 4/5 Calamina mix homogeneously.
4. comminution by gas stream
Mixed medicated powder is pulverized by the drug powder metallization processes, got former powder.
5. vaseline is handled: will all ten woodss between 80～100 ℃ of temperature controls fully after the fusing, temperature control was sterilized 1 hour for about 120 ℃.Sterilized vaseline put be chilled to about 70～80 ℃.Stand-by.
6. lanoline is handled: lanoline temperature control in sterilization tank was sterilized 1 hour for about 120 ℃.
7. dimethyl sulfoxine is handled: dimethyl sulfoxine is placed at about 60 ℃ extremely all fusings of temperature control in the baking oven.Stand-by.
8. preparation:
8.1 the vaseline of handling well is put into material-compound tank, stirs.
8.2 Borneolum Syntheticum is slowly added the dimethyl sulfoxine of handling well, and the limit edged is stirred to the Borneolum Syntheticum dissolving.
8.3 the lanoline of handling well is added in the common molten thing of Borneolum Syntheticum and dimethyl sulfoxine, and the limit edged stirs.
8.4 the immiscible material of Borneolum Syntheticum, dimethyl sulfoxine, lanoline is filtered by filter mesh sieve, drops in the material-compound tank again and stir.
Add material-compound tank 8.5 get the former powder of step 4 gained, add the back and continue to stir 1 hour to being even paste promptly.
Claims (6)
1, a kind of ointment for the treatment of hemorrhoid class anorectal, the ointment that it is made by the following weight proportion raw material:
Vaseline 700-900
Calculus Bovis 0.1-1
Margarita 0.1-1
Calamina 50-100
Borax 5-15
Succinum 0.1-1
Borneolum Syntheticum 15-71
Dimethyl sulfoxine 10-50
Lanoline 20-60
Moschus 0.1-1.
2, the ointment of treatment hemorrhoid class anorectal according to claim 1, wherein the weight proportion of each raw material is:
Vaseline 750-850
Calculus Bovis 0.3-0.8
Margarita 0.3-0.8
Calamina 60-80
Borax 8-12
Succinum 0.3-0.8
Borneolum Syntheticum 20-50
Dimethyl sulfoxine 20-40
Lanoline 30-40
Moschus 0.3-0.8.
3, the ointment of treatment hemorrhoid class anorectal according to claim 1, wherein the weight proportion of each raw material is:
Vaseline 800
Calculus Bovis 0.5
Margarita 0.38
Calamina 83.57
Borax 10
Succinum 0.15
Borneolum Syntheticum 40
Dimethyl sulfoxine 25
Lanoline 40
Moschus 0.4.
4, the ointment of treatment hemorrhoid class anorectal according to claim 1, wherein the weight proportion of each raw material is:
Vaseline 780
Calculus Bovis 0.4
Margarita 0.5
Calamina 90
Borax 8
Succinum 0.5
Borneolum Syntheticum 50.1
Dimethyl sulfoxine 20
Lanoline 50
Moschus 0.5.
5, the ointment of treatment hemorrhoid class anorectal according to claim 1, wherein the weight proportion of each raw material is:
Vaseline 780
Calculus Bovis 0.8
Margarita 0.8
Calamina 80
Borax 7
Succinum 0.8
Borneolum Syntheticum 54.8
Dimethyl sulfoxine 28
Lanoline 47
Moschus 0.8
6, a kind of preparation method that realizes the ointment of the described treatment hemorrhoid of claim 1 class anorectal comprises the following steps:
A, Margarita, succinum are pulverized, cross the 100-120 mesh sieve;
B, with Moschus, Calculus Bovis, Borax, Borneolum Syntheticum, 1/5 Calamina and steps A gained Margarita powder, Succinum powder facing-up, cross the 100-120 mesh sieve;
C, with step B gained medicated powder and 4/5 Calamina mix homogeneously;
D, mixed medicated powder is pulverized by the drug powder metallization processes, former powder;
E, with vaseline after temperature control 80-100 ℃ fusing, temperature control 115-120 ℃ sterilization is cooled to 70～80 ℃ with sterilized vaseline;
F, with lanoline in temperature control 115-120 ℃ sterilization;
G, with 55-65 ℃ of dimethyl sulfoxine temperature control to fusing;
H, at first vaseline is put into material-compound tank, put into a half and stir; Secondly with Borneolum Syntheticum, dimethyl sulfoxine and lanoline congruent melting, filter and drop in the material-compound tank and stir; The 3rd is that the former powder of step D gained is added material-compound tank, stirs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021391882A CN1209118C (en) | 2002-10-18 | 2002-10-18 | Ointment for treating piles and other anorectal diseases and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021391882A CN1209118C (en) | 2002-10-18 | 2002-10-18 | Ointment for treating piles and other anorectal diseases and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403098A CN1403098A (en) | 2003-03-19 |
| CN1209118C true CN1209118C (en) | 2005-07-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021391882A Expired - Lifetime CN1209118C (en) | 2002-10-18 | 2002-10-18 | Ointment for treating piles and other anorectal diseases and its prepn |
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| Country | Link |
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| CN (1) | CN1209118C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872158A (en) * | 2012-07-02 | 2013-01-16 | 马应龙药业集团股份有限公司 | External drug combination for curing eczema and preparation method thereof |
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| CN1970009B (en) * | 2006-11-29 | 2010-04-07 | 高德山 | Chinese medicinal suppository for treating piles quickly |
| CN102670849B (en) * | 2011-03-18 | 2013-11-27 | 浙江科技学院 | Anal fistula suppository |
| CN102920840A (en) * | 2012-08-23 | 2013-02-13 | 张桐亮 | Traditional Chinese medicinal preparation for treating hemorrhoids |
| CN103860591B (en) * | 2013-04-24 | 2016-01-13 | 刘少梅 | A kind of come off for hemorrhoid after the external Miao medicine and preparation method thereof of promoting tissue regeneration and ulcer healing |
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| CN103784569B (en) * | 2014-02-17 | 2016-03-23 | 大连圣弘医药有限公司 | A kind ofly treat Chinese medicine of hemorrhoid disease and preparation method thereof |
| CN104013672B (en) * | 2014-06-20 | 2017-09-29 | 宿州市逢源生物科技有限公司 | It is a kind of to treat ointment of hemorrhoid and its preparation method and application |
| CN107617051A (en) * | 2017-09-28 | 2018-01-23 | 张洪林 | A kind of medicine for hemorrhoid treating |
| CN108283669A (en) * | 2018-03-31 | 2018-07-17 | 河南九术医药科技有限公司 | A kind of Chinese herbal medicine acne cream |
| CN108619362A (en) * | 2018-06-29 | 2018-10-09 | 利辛县运杰家庭农场 | A kind of acne cream and preparation method thereof |
| CN110302342B (en) * | 2019-08-15 | 2021-06-01 | 刘振武 | Ointment for treating hemorrhoids and preparation method thereof |
| CN110755548A (en) * | 2019-12-04 | 2020-02-07 | 张友弼 | Formula and preparation method of hemorrhoid ointment |
| CN113521166B (en) * | 2020-12-02 | 2022-05-03 | 马应龙药业集团股份有限公司 | A cream for treating anorectal diseases such as hemorrhoid, and its preparation method |
| CN114652750B (en) * | 2022-03-08 | 2023-05-26 | 马应龙药业集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of colorectal cancer prevention medicines |
-
2002
- 2002-10-18 CN CNB021391882A patent/CN1209118C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872158A (en) * | 2012-07-02 | 2013-01-16 | 马应龙药业集团股份有限公司 | External drug combination for curing eczema and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1403098A (en) | 2003-03-19 |
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Owner name: MAYINGLONG PHARMACEUTICAL GROUP CO.,LTD. Free format text: FORMER NAME OR ADDRESS: WUHAN MAYINGLONG PHARMACEUTICAL GROUP CORP., LTD. |
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Address after: No. 1, South Bay, Nanhu Lake, Wuhan, Hubei, Wuchang Patentee after: MAYINGLONG PHARMACEUTICAL GROUP Co.,Ltd. Address before: No. 1, South Bay, Nanhu Lake, Wuhan, Hubei, Wuchang Patentee before: Wuhan Mayinglong Pharmaceutical Group Co.,Ltd. |
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