CN1197589C - Sore ulcer treating ointment and its prepn - Google Patents

Abstract

The present invention discloses an ointment for treating pyocutaneous diseases and a preparation method thereof. The ointment is prepared from liquid paraffin, calamine, borneol, pearl, borax, sal ammoniac, artificial bezoar, succinum, musk, lanolin and vaseline. The preparation method comprises the steps that the pearls and the succinum are pulverized; then the musk, the artificial bezoar, one second of calamine, the pearl and the succinum are mixed and pulverized; then the borax, the sal ammoniac, the borneol and the calamine are mixed and pulverized; the medicine powder is uniformly mixed; the mixed medicine powder is pulverized by medicine micronizing technology; the vaseline sterilized and cooled after being melted; the lanolin is sterilized; the liquid paraffin is sterilized and cooled; the vaseline, the lanolin and the liquid paraffin are uniformly stirred. The present invention has the advantages of simple technology, low cost and good treatment effect on various skin diseases of impetigo herpetifomis, furuncle, carbuncle, sore, non-healing wounds, sting and biting by mosquitoes, etc.

Description

The ointment and the preparation method of treatment skin infection

Technical field

The present invention relates to the ointment of a kind of treatment boil (carbuncle, furuncle), specifically, can be applicable to this drug regimen impetigo, furuncle, carbuncle, body surface, wound and traumatic infection, ulcer do not heal, slight burn and scald, comedo, mosquito bite, nameless gall etc., are equivalent to the bacterial infection dermatoses.The invention still further relates to the preparation method of this medicine.

Background technology

At present, the medicament categories that is used for the treatment of the ointment for the treatment of boil (carbuncle, furuncle) is various, and chemical synthetic drug is because the limitation of clinical efficacy and toxic and side effects is all unsatisfactory.Chinese medicine preparation is subjected to expert and patient's favorable comment owing to evident in efficacy and low toxic and side effects.The externally-applied soft ointment for the treatment of boil (carbuncle, furuncle) in the market mainly contains golden yellow cream, YULU cream, TAIYI GAO, Rhizoma Coptidis extractum etc., mostly based on heat and toxic materials clearing away medicine such as Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendris, cooperate promoting flow of QI and blood, putrefaction removing to receive the medicine of pus or promoting tissue regeneration and wound healing, treating the carbuncle furuncle clinically all has better curative effect.

Summary of the invention

The purpose of this invention is to provide a kind of ointment for the treatment of skin infection, this agent is based on Moschus, artificial Calculus Bovis, succinum, evident in efficacy, specimen and control, act on rapidly, traditional Chinese herb medicine preparation that toxicity is extremely low.

Another object of the present invention provides the preparation method of this boil treatment ointment, and this method technology is simple, energy consumption is low, and this agent is suitable for suitability for industrialized production.

For achieving the above object, the present invention realizes by following technical measures:

Moschus---fragrance is walked to scurry, and interior thorough internal organs reach skin outward, the current twelve regular channels, and promoting the circulation of blood divides this stasis of blood to stagnate, and opens the Yong Sai of meridians, can remove all malignant boil anal fistula and swell and ache and the pus slough

Borneolum Syntheticum---have one's ideas straightened out heat clearing away, pain relieving; But external erosion prevention and muscle growing.

Artificial Calculus Bovis---relieving convulsion is had one's ideas straightened out, heat-clearing and toxic substances removing.

Succinum---tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.

Margarita---heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing.

Calamina---removing dampness granulation promoting.

Borax---heat clearing away expectorant, anticorrosion

Sal Ammoniacus---removing food stagnancy softening the hard mass, blood circulation promoting and dispersing pathogen accumulation.

Medicine of the present invention is made by following prescription, and consumption is a weight portion:

Liquid paraffin	60-140
		Calamina	90-100
Borneolum Syntheticum	40-50
		Margarita	1.0-1.5
Borax	3.0-4.0
		Sal Ammoniacus	1.0-1.5
The artificial Calculus Bovis	1.0-1.5
		Succinum	0.5-1.0
Moschus	0.5-2.0
		Lanoline	30-50
Vaseline	693-728.5

The preferred manufacturing prescription of medicine of the present invention is as follows, and consumption is a weight portion:

Liquid paraffin	80-120
		Calamina	96-98
Borneolum Syntheticum	42-45
		Margarita	1.1-1.4
Borax	3.2-3.8
		Sal Ammoniacus	1.2-1.4
The artificial Calculus Bovis	1.1-1.4
		Succinum	0.7-0.9
Moschus	0.8-1.6
		Lanoline	35-45
Vaseline	700-720

Moschus is the gas of promoting the circulation of blood branch among the present invention, and the monarch drug of dispersing swelling and dissipating binds has out all keys, the meridian dredging, and blood circulation promoting and dispersing pathogen accumulation is walked to scurry brokenly and is stagnated, and saturating muscles and bones is removed the merit of malignant boil.Moschus is with its hot temperature causing resuscitation with aromatic drugs, and penetration is strong, can make the skin pore open expansion, draws the through sick institute of all medicines, and modern pharmacology confirms that Moschus has extremely strong antiinflammatory action, institute think control sore swollen toxin from the beginning of key medicine.Be aided with artificial Calculus Bovis, Borneolum Syntheticum, Calamina.Calamina can be restrained, be subsided a swelling, and the merit of erosion prevention and muscle growing is arranged, the Borneolum Syntheticum refreshment of having one's ideas straightened out, and clearing away heat to alleviate pain, the artificial Calculus Bovis can the eliminating phlegm heat-clearing and toxic substances removing.Moschus gets helping of artificial Calculus Bovis, Borneolum Syntheticum, and then hot temperature is walked to scurry and do not had the fraud of combustion-supporting fire-toxin.Calamina, artificial Calculus Bovis, Borneolum Syntheticum get helping of Moschus, and then the power of heat-clearing and toxic substances removing, reducing swelling and alleviating pain is bigger.Margarita, succinum are detoxifcation, Borax heat clearing away expectorant, anticorrosion, and Sal Ammoniacus removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood, assistant is for making altogether.Eight flavor medicines close and use it, play the heat clearing away poison altogether, blood circulation promoting and dispersing pathogen accumulation, and blood stasis dispelling is broken to stagnate the effect of putrefaction-removing granulation-promoting.Main Ingredients and Appearance of the present invention is a mineral drug, and absorbing difficulty is the common problem of mineral drug existence, and the drug absorption key that to be drug effect brought into play.In order to increase drug absorption, at first must reduce the particle diameter of medicine.Invented the preparation method of this agent through concentrating on studies of more than ten years.This method has coarse powder, fine powder, the pure three process of air-flow powder, and its principle is to adopt high velocity air to drive medicine to pulverize with the velocity of sound collision in pulverizing chamber.Manufacture method of the present invention, its step comprises: at first, respectively Margarita, succinum are carried out fine powder and pulverize, cross the 140-160 mesh sieve.Secondly, with Moschus, artificial Calculus Bovis, 1/2 Calamina and step 1 gained Margarita fine powder, succinum fine powder facing-up, cross the 140-160 mesh sieve.The 3rd, with Borax, Sal Ammoniacus, Borneolum Syntheticum and 1/2 Calamina facing-up, cross 140 ~ 160 mesh sieves.The 4th, with step 2 gained medicated powder and step 3 gained medicated powder mix homogeneously.The 5th, mixed medicated powder is pulverized by the drug powder metallization processes, get former powder.The 6th, all ten woodss after melting fully between temperature control 80-100 ℃, were sterilized 55-65 minute for temperature control 115-125 ℃.Sterilized vaseline is cooled to 70-80 ℃.The 7th, 115-125 ℃ of sterilization of lanoline temperature control 55-65 minute.The 8th, with 145-155 ℃ of sterilization of liquid paraffin temperature control 55-65 minute.Sterilized liquid paraffin is cooled to 80-90 ℃.The 9th, in material-compound tank, drop into vaseline, lanoline, liquid paraffin and the former powder of step 5 gained handle well respectively, be stirred to and be even paste and get final product.

The present invention compares with existing Technology, has the following advantages and effect:

1, adopted the drug powder metallization processes, solved mineral drug and absorbed difficult problem, medicine is easy to see through mucosa and enters tissue, and absorbance improves greatly, has promoted curative effect of medication.

2, technology is simple, cost is low, medicine effect guarantees, be easy to absorb, be suitable for suitability for industrialized production.

3, prescription rationally.Each drug distribution of filling a prescription is extremely wide, aboundresources.

4, pharmacological research shows, the present invention all has stronger antibacterial action in vivo and in vitro, and can significantly suppress inflammatory swelling and skin hair and blood pipe permeability increases, can obviously improve the toleration of pain stimulation, analgesic activity is preferably arranged, Cavia porcellus local wound ecchymosis people is promoted the effect of dissipating, can obviously promote its healing to close up the skin ulcer of rabbit back of the body buttocks.

5, clinically, indication of the present invention not only is confined to surgery carbuncle, furuncle, all diseases of skin infection, feedback on probation by many patients, we find that the application of Herba Tubocapsici Anomali ointment is very extensive, for impetigo, furuncle, carbuncle and ulcer, nameless gall, body surface wound, traumatic infection, wound do not heal, various skin diseases such as slight burn and scald and mosquito bite, comedo, excellent curative is all arranged.

6, acute toxicity test shows, the present invention finds no any untoward reaction and produces, and shows that this medicine is safe and reliable.

The specific embodiment

Medicine embodiment consumption of the present invention following (weight portion):

The ointment of a kind of treatment boil (carbuncle, furuncle), its step is as follows:

1. pulverize

Respectively Margarita, succinum are carried out fine powder and pulverize, cross 160 mesh sieves.

2. facing-up

2.1, cross 160 mesh sieves with Moschus, artificial Calculus Bovis, Calamina and step 1 gained Margarita fine powder, succinum fine powder facing-up.

2.2, cross 160 mesh sieves with Borax, Sal Ammoniacus, Borneolum Syntheticum and Calamina facing-up.

3. mix

With 2.1 and 2.2 following medicated powder gained medicated powder mix homogeneously.

4. comminution by gas stream

Mixed medicated powder is pulverized by the drug powder metallization processes.

5. vaseline is handled: with vaseline between 80 ~ 100 ℃ of the temperature controls fully after the fusing, about 120 ℃ sterilizations of temperature control 1 hour.Sterilized vaseline is cooled to 70 ~ 80 ℃.

6. lanoline was handled: with about 120 ℃ sterilizations of lanoline temperature control 1 hour.

7. liquid paraffin is handled: about 150 ℃ sterilizations of liquid paraffin temperature control were cooled to 80 ~ 90 ℃ after 1 hour.

8. preparation: vaseline, lanoline, liquid paraffin and step 4 medicated powder of handling well is stirred in material-compound tank got final product to being even paste in 1 hour respectively.After the semi-finished product sampling observation is qualified, 38 ~ 42 ℃ of canned getting product of insulation of ointment.

Claims (6)

1, a kind of ointment for the treatment of skin infection, the unguentum that it is made by following materials of weight proportions:

White oil 60-140

Calamina 90-100

Borneolum Syntheticum 40-50

Margarita 1-1.5

Borax 3-4

Sal Ammoniacus 1-1.5

Artificial Calculus Bovis 1-1.5

Succinum 0.5-1

Moschus 0.5-2

Lanoline 30-50

Vaseline 693-728.5.

2, the ointment of treatment skin infection according to claim 1, wherein the weight proportion of each raw material is:

White oil 80-120

Calamina 96-98

Borneolum Syntheticum 42-45

Margarita 1.1-1.4

Borax 3.2-3.8

Sal Ammoniacus 1.2-1.4

Artificial Calculus Bovis 1.1-1.4

Succinum 0.7-0.9

Moschus 0.8-1.6

Lanoline 35-45

Vaseline 700-720.

3, the ointment of treatment skin infection according to claim 1, wherein the weight proportion of each raw material is:

White oil 100

Calamina 97

Borneolum Syntheticum 44.4

Margarita 1.4

Borax 3.5

Sal Ammoniacus 1.15

The artificial Calculus Bovis 1.14

Succinum 0.55

Moschus 1.04

Lanoline 40

Vaseline 709.82.

4, the ointment of treatment skin infection according to claim 1, wherein the weight proportion of each raw material is:

White oil 100

Calamina 95

Borneolum Syntheticum 40

Margarita 1.0

Borax 3.0

Sal Ammoniacus 1.0

The artificial Calculus Bovis 1.0

Succinum 0.5

Moschus 1

Lanoline 45

Vaseline 712.5.

5, the ointment of treatment skin infection according to claim 1, wherein the weight proportion of each raw material is:

White oil 100

Calamina 95

Borneolum Syntheticum 40

Margarita 1.4

Borax 3.8

Sal Ammoniacus 1.4

The artificial Calculus Bovis 1.4

Succinum 0.8

Moschus 1.5

Lanoline 45

Vaseline 709.7.

6, a kind of preparation method that realizes the ointment of the described treatment skin infection of claim 1 comprises the following steps:

A, Margarita, succinum are pulverized, cross the 140-160 mesh sieve;

B, with Moschus, artificial Calculus Bovis, Calamina and steps A gained Margarita, succinum fine powder facing-up, cross the 140-160 mesh sieve;

C, with Borax, Sal Ammoniacus, Borneolum Syntheticum and Calamina facing-up, cross the 140-160 mesh sieve;

D, with step B gained medicated powder and step C gained medicated powder mix homogeneously;

E, mixed medicated powder is pulverized by the drug powder metallization processes, former powder;

F, with vaseline in 80 ~ 100 ℃ of fusings of temperature control, temperature control 115-120 ℃ the sterilization 55-65 minute, with the sterilization vaseline be cooled to 70-80 ℃;

G, with 115-120 ℃ of lanoline temperature control sterilization 55-65 minute;

H, with 145-150 ℃ of liquid paraffin temperature control sterilization 55-65 minute, the white oil of sterilization is cooled to 80-90 ℃;

I, the former powder that drops into vaseline, lanoline, white oil and step e gained in material-compound tank are stirred to and are even paste.