CN1201750C - Oculentum for treating eye disease and preparing method thereof - Google Patents
Oculentum for treating eye disease and preparing method thereof Download PDFInfo
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- CN1201750C CN1201750C CNB031349625A CN03134962A CN1201750C CN 1201750 C CN1201750 C CN 1201750C CN B031349625 A CNB031349625 A CN B031349625A CN 03134962 A CN03134962 A CN 03134962A CN 1201750 C CN1201750 C CN 1201750C
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- vaseline
- borax
- artificial
- lanoline
- liquid paraffin
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Abstract
The present invention discloses an ointment for treating eye diseases and a preparation method thereof. The ointment is prepared from vaseline, calamine, succinum, artificial bezoar, borneol, artificial musk, lanolin, liquid paraffin, borax, pearl and sal ammoniac. The preparation method comprises the steps that the pearl and the borax are pulverized; then the artificial musk, the artificial bezoar, the borneol and the calamine are ground; the pearl fine powder, the borax fine powder and the succinum are ground; the sal ammoniac is ground; the three kinds of medicine powder are mixed and ground, and then the mixed medicine powder is uniformly mixed with the rest of the calamine; the mixed medicine powder is pulverized by medicine micronizing technology; the liquid paraffin is sterilized; the lanolin is melted and sterilized; the vaseline is melted and sterilized; the medicines are put into a preparation tank to be uniformly stirred. The ointment of the present invention has the advantages of simple technology, low cost and good treatment effect on various eye diseases of reddish swelling of eyes, pain, itch, lacrimation, trachoma, red and rot of eyelids, etc., and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of Eye ointments for the treatment of ophthalmic, specifically, this drug regimen can be used for eye redness, sufferings, shed tears trachoma, the red multiple ophthalmic such as mashed of eyelid, be equivalent to conjunctivitis, keratitis, trachoma of modern medicine etc., the invention still further relates to the preparation method of this medicine.
Background technology
At present, the medicament categories of Eye ointments that is used for the treatment of ophthalmic diseases is also few, and chemical synthetic drug is because the limitation of clinical efficacy and toxic and side effects is all unsatisfactory.Chinese medicine preparation is subjected to expert and patient's favorable comment owing to evident in efficacy and low toxic and side effects.The Eye ointments for the treatment of ophthalmic diseases in the market mainly contains the zijin troche medicament for the eyes, respects space medicament for the eyes, goose quill medicament for the eyes, refrigerant spongaion etc. in vain; most based on heat clearing and inflammation relieving medicines such as halite, Fel Ursi, watermelon crystal, Calculus Bovis and Rhizoma Coptidis; the medicine granulation promoting that cooperates improving acuity of vision and removing nebula, removing dampness granulation promoting; treat ophthalmic diseases clinically curative effect is preferably all arranged; but the medicine on the market is because prescription is complicated, loaded down with trivial details, the absorption difference of technology; in conjunction with the existing problem that exists; the present invention improves; technology is simply ripe, absorbs fully.
Summary of the invention
The object of the present invention is to provide a kind of treatment ophthalmic cream, this cream is based on Moschus, Calculus Bovis, succinum, and Chinese medicine Eye ointments is rapidly controlled, acted on to evident in efficacy, specimen also.
Another object of the present invention provides the preparation method of this external ophthalmology Eye ointments, and this method technology is simple, with low cost, energy consumption is low, is applicable to suitability for industrialized production.
For achieving the above object, the present invention realizes by following technical measures:
Moschus---the refreshment of having one's ideas straightened out, promoting blood circulation and detumescence, the fetal abortion of stimulating the menstrual flow.Fragrance is walked to scurry, and interior thorough internal organs reach skin outward, the current twelve regular channels, the priming power sick institute that goes directly; The promoting the circulation of blood branch stasis of blood stagnates, and opens the Yong Sai of meridians, can remove all malignant boil anal fistula and swell and ache and the pus slough
Calamina---improving acuity of vision and removing nebula, the removing dampness granulation promoting.
Succinum---tranquillizing and allaying excitement, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.
Calculus Bovis---relieving convulsion is had one's ideas straightened out, heat-clearing and toxic substances removing.
Borneolum Syntheticum---have one's ideas straightened out, heat clearing away, pain relieving: but the external erosion prevention and muscle growing.
Borax---heat clearing away expectorant, anticorrosion.
Margarita---calm the nerves, endogenous wind stopping, heat-clearing and toxic substances removing makes eye bright, promoting tissue regeneration and ulcer healing.
Sal Ammoniacus---removing food stagnancy softening the hard mass, blood circulation promoting and dispersing pathogen accumulation.
Medicine of the present invention is made by following prescription, and consumption is a weight portion:
| Vaseline | 840～900 |
| Calamina | 26.7～40.7 |
| Succinum | 0.10～0.18 |
| The artificial Calculus Bovis | 0.32～0.44 |
| Borneolum Syntheticum | 10～20 |
| The artificial Moschus | 0.32～0.44 |
| Lanoline | 32～48 |
| Borax | 1.0～1.5 |
| Margarita | 0.32～0.44 |
| Sal Ammoniacus | 0.01～0.10 |
| Liquid paraffin | 32～48 |
The preferred manufacturing prescription of medicine of the present invention is as follows, and consumption is a weight portion:
| Vaseline | 850～880 |
| Calamina | 28～35 |
| Succinum | 0.12～0.16 |
| The artificial Calculus Bovis | 0.35～0.40 |
| Borneolum Syntheticum | 13～17 |
| The artificial Moschus | 0.35～0.40 |
| Lanoline | 35～43 |
| Borax | 1.1～1.4 |
| Margarita | 0.35～0.40 |
| Sal Ammoniacus | 0.04～0.07 |
| Liquid paraffin | 35～43 |
The Moschus refreshment of having one's ideas straightened out among the present invention, promoting blood circulation and detumescence, the promoting the circulation of blood branch stasis of blood stagnates, and opens the Yong Sai of meridians, and it be the gas of promoting the circulation of blood branch, the monarch drug of promoting blood circulation and detumescence, fragrance is walked to scurry, and interior thorough internal organs reach skin outward, the twelve regular channels that passes through, the priming power sick institute that goes directly; Calamina energy improving acuity of vision and removing nebula, the removing dampness granulation promoting; Borneolum Syntheticum can be had one's ideas straightened out, heat clearing away, pain relieving, but external erosion prevention and muscle growing; Calculus Bovis energy relieving convulsion is had one's ideas straightened out heat-clearing and toxic substances removing; Margarita can be calmed the nerves, endogenous wind stopping, and heat-clearing and toxic substances removing makes eye bright, promoting tissue regeneration and ulcer healing; Succinum is detoxifcation; Borax heat clearing away expectorant, anticorrosion; Sal Ammoniacus removing food stagnancy softening the hard mass, blood circulation promoting and dispersing pathogen accumulation; Eight flavor medicines close and use it, by heat clearing away, invigorate blood circulation, detumescence, pain relieving, make eye bright, effect such as granulation promoting brings into play jointly and moves back effect red, removing nebula, can be at causing the pathogenesis such as heat, poison, the stasis of blood of symptoms such as conjunctival congestion, eyelid are redly rotted, cataracta, reach the purpose of treatment; Modern pharmacology confirms that medicines such as Moschus, Calculus Bovis, Borneolum Syntheticum, Margarita, Calamina all have effects such as antibacterial, antiinflammatory; it has the collaborative mutually effect that increases curative effect; this has further confirmed drug effect of the present invention, has proved that also the present invention treats the mechanism of action of eye inflammation.Main component of the present invention is a mineral drug, and absorbing difficulty is the common problem that mineral drug is used for the existence of ophthalmic diseases, and the drug absorption key that to be drug effect brought into play.In order to increase drug absorption, at first must reduce the particle diameter of medicine.Invented the preparation method of this agent through concentrating on studies for many years.This method has coarse powder, fine powder, comminution by gas stream three process, and its principle is to adopt high velocity air to drive medicine to pulverize with the velocity of sound collision in pulverizing chamber.Manufacture method of the present invention, its step comprises: A, Margarita, Borax are carried out fine powder pulverize, cross the 150-200 mesh sieve.B, the Calamina (forging) that artificial Moschus, artificial Calculus Bovis, Borneolum Syntheticum and 1/5 quota are measured grind, and cross the 150-200 mesh sieve.C, Margarita fine powder, Borax fine powder, succinum are ground, cross the 150-200 mesh sieve.D, Sal Ammoniacus is ground, cross the 150-200 mesh sieve.E, with the medicated powder of step B gained, with the medicated powder of step C gained and with the medicated powder facing-up of step D gained, mix homogeneously.F, mixed medicated powder is pulverized by the drug powder metallization processes, former powder.G, liquid paraffin was handled in the sterilization of 130～180 ℃ of temperature controls in 60～90 minutes.H, the lanoline fusing is back in 130～180 ℃ of sterilizations of temperature control processing in 60～90 minutes.I, the vaseline fusing is back 130～180 ℃ of sterilizations of temperature control 60～90 minutes behind 150～220 mesh sieves, is stirred to vaseline and is cooled to 60～80 ℃ excessively.J, sterilized, stand-by lanoline is slowly poured in the medicated powder that step 6 crushes, the limit bevelling stirs, and is even to the two.K, will melt liquid paraffin, the lanoline of sterilization and the medicated powder that crushes add successively stir in the vaseline 60～120 minutes even to mastic.
The present invention compares with existing Technology, has the following advantages and effect:
1, adopted the drug powder metallization processes, solved mineral drug and absorbed difficult problem, medicine is easy to see through mucosa and enters tissue, and absorbance improves greatly, has increased curative effect of medication.
2, characteristics of the present invention are that technology is simple, drug effect remarkable, it is fast to absorb, effect is rapid, toxic and side effects is few, with low cost, are applicable to suitability for industrialized production.
3, the present invention fills a prescription rationally, and each drug distribution in the prescription is wide, aboundresources; Technical matters maturation, easily control.
4, pharmacological research shows, the present invention have move back significantly red, the effect of removing nebula; Can show excellent curative to experimental saccadic eye movement object model; And the present invention all has stronger antibacterial and anti-inflammation functions in vivo and in vitro, and can significantly suppress inflammatory swelling and skin hair and blood pipe permeability increases, and can obviously improve the toleration of pain stimulation, and fine analgesic activity is arranged.The bound drug dynamics research shows, good absorbing of the present invention, bioavailability height.According to secular clinical proof, bioavailability height of the present invention, drug effect speed is fast, and drug effect is clear and definite, the effect that can play specimen and control.
5, acute toxicity test shows, the present invention finds no obvious toxic and side effects.
The specific embodiment
Medicine embodiment consumption of the present invention following (weight portion):
A kind of eye ointment for the treatment of ophthalmic diseases, its step is as follows:
1, pulverizes
Respectively Margarita, Borax are carried out fine powder and pulverize, cross 200 mesh sieves;
2, facing-up
2.1 the Calamina (forging) of artificial Moschus, artificial Calculus Bovis, Borneolum Syntheticum and 1/5 quota amount is ground, crosses 200 mesh sieves;
2.2 Margarita fine powder, Borax fine powder, succinum are ground, cross 200 mesh sieves;
2.3 Sal Ammoniacus is ground, crosses 200 mesh sieves;
3, mix
With 2.1,2.2 and 2.3 following medicated powder mix homogeneously;
4, comminution by gas stream
Mixed medicated powder is pulverized by jet mill, got former powder;
5, adjuvant is handled
5.1 liquid paraffin was handled in 130～180 ℃ of sterilizations of temperature control in 60～90 minutes.
5.2 lanoline fusing back was handled in 130～180 ℃ of sterilizations of temperature control in 60～90 minutes.
5.3 the vaseline fusing is back 130～180 ℃ of sterilizations of temperature control 60～90 minutes, behind 150～220 mesh sieves, be stirred to vaseline and be cooled to 60～80 ℃ excessively.
6, preparation
6.1 sterilized, stand-by lanoline is slowly poured in the above-mentioned medicated powder that crushes, and the limit bevelling stirs, and is even to the two.
6.2 with sterilized, stand-by liquid paraffin, lanoline and the medicated powder that crushes add successively stir in the vaseline 60～120 minutes even to mastic.
Claims (6)
1, a kind of treatment ophthalmic cream, the eye ointment that it is made by following materials of weight proportions:
Vaseline 840～900
Calamina 26.7～40.7
Succinum 0.10～0.18
The artificial Calculus Bovis 0.32～0.44
Borneolum Syntheticum 10～20
The artificial Moschus 0.32～0.44
Lanoline 32～48
Borax 1.0～1.5
Margarita 0.32～0.44
Sal Ammoniacus 0.01～0.10
Liquid paraffin 32～48
2, a kind of treatment ophthalmic cream according to claim 1 is characterized in that the weight proportion of each raw material is:
Vaseline 850～880
Calamina 28～35
Succinum 0.12～0.16
The artificial Calculus Bovis 0.35～0.40
Borneolum Syntheticum 13～17
The artificial Moschus 0.35～0.40
Lanoline 35～43
Borax 1.1～1.4
Margarita 0.35～0.40
Sal Ammoniacus 0.04～0.07
Liquid paraffin 35～43
3, a kind of treatment ophthalmic cream according to claim 1 is characterized in that the weight proportion of each raw material is:
Vaseline 870
Calamina 32.7
Succinum 0.15
The artificial Calculus Bovis 0.38
Borneolum Syntheticum 14.75
The artificial Moschus 0.38
Lanoline 40
Borax 1.2
Margarita 0.38
Sal Ammoniacus 0.05
Liquid paraffin 40
4, a kind of treatment ophthalmic cream according to claim 1 is characterized in that the weight proportion of each raw material is:
Vaseline 872
Calamina 34
Succinum 0.16
The artificial Calculus Bovis 0.40
Borneolum Syntheticum 15
The artificial Moschus 0.40
Lanoline 38.14
Borax 1.3
Margarita 0.40
Sal Ammoniacus 0.06
Liquid paraffin 38.14
5, a kind of treatment ophthalmic cream according to claim 1 is characterized in that the weight proportion of each raw material is:
Vaseline 860
Calamina 34.3
Succinum 0.15
The artificial Calculus Bovis 0.36
Borneolum Syntheticum 17
The artificial Moschus 0.36
Lanoline 43
Borax 1.4
Margarita 0.36
Sal Ammoniacus 0.07
Liquid paraffin 43
6, a kind of preparation method that realizes the described treatment ophthalmic of claim 1 cream comprises the following steps:
A, Margarita, Borax carry out fine powder to be pulverized, and crosses the 150-200 mesh sieve;
The Calamina of B, artificial Moschus, artificial Calculus Bovis, Borneolum Syntheticum and 1/5 quota amount grinds, and crosses the 150-200 mesh sieve;
C, Margarita fine powder, Borax fine powder, succinum grind, and cross the 150-200 mesh sieve;
D, Sal Ammoniacus grind, and cross the 150-200 mesh sieve;
The medicated powder of E, step B gained, with the medicated powder of step C gained and with the medicated powder facing-up of step D gained, mix homogeneously;
F, mixed medicated powder are pulverized by the drug powder metallization processes, get former powder;
G, liquid paraffin was handled in the sterilization of 130～180 ℃ of temperature controls in 60～90 minutes;
H, the lanoline fusing is back in 130～180 ℃ of sterilizations of temperature control processing in 60～90 minutes;
I, the vaseline fusing is back 130～180 ℃ of sterilizations of temperature control 60～90 minutes behind 150～220 mesh sieves, is stirred to vaseline and is cooled to 60～80 ℃ excessively;
J, sterilized, stand-by lanoline is slowly poured in the medicated powder that above-mentioned steps F crushes, the limit bevelling stirs, and is even to the two;
K, with sterilized liquid paraffin, lanoline and the medicated powder that crushes add successively stir in the vaseline 60～120 minutes even to mastic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031349625A CN1201750C (en) | 2003-09-30 | 2003-09-30 | Oculentum for treating eye disease and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031349625A CN1201750C (en) | 2003-09-30 | 2003-09-30 | Oculentum for treating eye disease and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1528346A CN1528346A (en) | 2004-09-15 |
| CN1201750C true CN1201750C (en) | 2005-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031349625A Expired - Lifetime CN1201750C (en) | 2003-09-30 | 2003-09-30 | Oculentum for treating eye disease and preparing method thereof |
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| CN (1) | CN1201750C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074616A (en) * | 2016-08-18 | 2016-11-09 | 贵州盛世保康茶开发有限公司 | The Seedling man collyrium of improving eyesight removing nebula |
| CN106728014A (en) * | 2016-11-30 | 2017-05-31 | 柳州草子吉生物科技有限公司 | Treat Chinese medicine composition of eye keratitis and preparation method thereof |
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- 2003-09-30 CN CNB031349625A patent/CN1201750C/en not_active Expired - Lifetime
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| CN1528346A (en) | 2004-09-15 |
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| PB01 | Publication | ||
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| C14 | Grant of patent or utility model | ||
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| C56 | Change in the name or address of the patentee |
Owner name: MAYINGLONG PHARMACEUTICAL GROUP CO.,LTD. Free format text: FORMER NAME OR ADDRESS: WUHAN MAYINGLONG PHARMACEUTICAL GROUP CORP., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: No. 1, South Bay, Nanhu Lake, Wuhan, Hubei, Wuchang Patentee after: MAYINGLONG PHARMACEUTICAL GROUP Co.,Ltd. Address before: No. 1, South Bay, Nanhu Lake, Wuhan, Hubei, Wuchang Patentee before: Wuhan Mayinglong Pharmaceutical Group Co.,Ltd. |
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Granted publication date: 20050518 |