CN1119950A - Traditional Chinese medicine "Zhenhuang" powder and its production method - Google Patents
Traditional Chinese medicine "Zhenhuang" powder and its production method Download PDFInfo
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- CN1119950A CN1119950A CN95107977A CN95107977A CN1119950A CN 1119950 A CN1119950 A CN 1119950A CN 95107977 A CN95107977 A CN 95107977A CN 95107977 A CN95107977 A CN 95107977A CN 1119950 A CN1119950 A CN 1119950A
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Abstract
The Chinese patent medicine for treating aphtha, pharyngitis, stomatocace and gingivitis with over 90% of total effective rate is prepared from 6 Chinese-medicinal materials such as rhubarb, pearl, bistort rhizome, cat-tail pollen, etc., through alcohol reflux and grinding.
Description
The present invention relates to a kind of Chinese medicine " Zhenhuang " powder and production method thereof.
The pars oralis pharyngis disease is a human big illness, China has 700,000,000 populations to suffer from various degree pars oralis pharyngis disease approximately according to statistics, at present, treat this disease and generally use antibiotics class medicine, as penicillin and streptomycin, tetracycline etc., use this class medicine to have the light medicine of disease and weigh, and easily make patient produce the shortcoming of drug resistance and dysbacteriosis; Also can use vitamins, as VB
2Though this class medicine is cheap, do not have efficient, quick-acting; Use the Chinese medicine BINGPENG SAN, though the energy anti-inflammatory analgetic, the insufficiency of function of removing the necrotic tissue and promoting granulation; Though the treatment of use cow-bezoar bolus for clearing away heat of the upper part of the body effectively, does not have efficiently, and often has side effects.
The objective of the invention is at the prior art above shortcomings, according to traditional Chinese medical science internal organs intenseness of heat, heat is taken advantage of heart spleen, and gas dashes in mouth and tongue, so make the principle of aphtha of the mouth and tongue, utilizes the pathogenic fire purging of the bitter energy of Radix Et Rhizoma Rhei, the heat clearing away of cold energy; The Margarita calming liver and clearing heat, the arresting convulsion of calming the nerves, convergence granulation promoting; Rhizoma Bistortae popular feeling warp, heat-clearing and toxic substances removing, removing heat from blood repercussive; Indigo Naturalis, watermelon crystal popular feeling spleen, eliminating stagnation is reduced phlegm, the function of anti-inflammatory analgetic, evacuation of pus granulation promoting, providing a kind of is principal agent with Radix Et Rhizoma Rhei, Margarita, Rhizoma Bistortae, be aided with Chinese medicine " Zhenhuang " powder and production method thereof that each herbal medicine of comprising Pollen Tyjphae, Indigo Naturalis, watermelon crystal is made, product of the present invention not only boil on the nape opposite the mouth disease of pharynx has the effect of significant heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, and diseases such as body surface and mucosal inflammation, ulcer and burn all had very high curative effect, and without any toxic and side effects, efficiently quick-acting, easy to use, cheap.
The object of the present invention is achieved like this: a kind of Chinese medicine " Zhenhuang " powder, the composition that it is characterized in that this " Zhenhuang " powder is to be principal agent with Radix Et Rhizoma Rhei, Margarita, Rhizoma Bistortae, accessory drugs comprises watermelon crystal, Indigo Naturalis, Pollen Tyjphae, its concrete proportioning of forming comprises following composition (being as the criterion unit to prepare 1000 gram " Zhenhuang " powders: restrain):
Radix Et Rhizoma Rhei: 120～200; Margarita: 80～100;
Rhizoma Bistortae: 90～150; Indigo Naturalis: 150～190;
Watermelon crystal: 80～150; Pollen Tyjphae: 100～120.
Through experiment showed, repeatedly in product of the present invention, when the consumption of Radix Et Rhizoma Rhei is lower than 120 grams, the function of tonic chord of " Zhenhuang " powder heat clearing away, pathogenic fire purging is descended, influence its curative effect; When consumption is higher than 200 grams, will cause patient's times of defecation to increase, therefore, the consumption of Radix Et Rhizoma Rhei is preferably between 120～200 grams;
When the consumption of Margarita is lower than 80 grams, will make the " Zhenhuang " powder calming liver and clearing heat, the function of tonic chord of convergence granulation promoting descends, and influences the curative effect of product putrefaction-removing granulation-promoting of the present invention; When being higher than 100 grams, do not influence the function and the curative effect of product of the present invention, also do not produce any side effect, but will significantly improve the cost of " Zhenhuang " powder, therefore, its consumption is preferably between 80～100 grams;
When the consumption of Rhizoma Bistortae is lower than 90 grams, the curative effect of product reducing swelling and alleviating pain of the present invention is descended; When being higher than 150 grams, forming proportioning from the integral body of product of the present invention and consider that its consumption should not be too high, in order to avoid influence other proportioning, so the consumption of Rhizoma Bistortae should be grasped between 90～150 grams;
When the consumption of watermelon crystal, Indigo Naturalis is lower than 80 grams and 150 grams respectively, to the effect of product heat-clearing and toxic substances removing of the present invention, anti-inflammatory analgetic be descended, when the consumption of watermelon crystal is higher than 150 grams, the cost of product of the present invention is improved, simultaneously, influence giving full play to of principal agent Margarita, Radix Et Rhizoma Rhei effect, so the consumption of watermelon crystal should be between 80～150 grams, when the consumption of Indigo Naturalis is higher than 200 grams, might produce harmful effect to the hematopoietic function of human body, therefore, the consumption of Indigo Naturalis should be between 150～190 grams.
The using method of product " Zhenhuang " powder of the present invention is: external, directly spray in the affected part, and one is for several times.
Another object of the present invention is achieved in that a kind of production method of Chinese medicine " Zhenhuang " powder, it is characterized in that this production method comprises following technical process:
1, the Radix Et Rhizoma Rhei of aequum, Rhizoma Bistortae cleaned, after the drying, is ground into the coarse granule shape, extract wherein active ingredient with the reflow of alcohol method then;
2, the said extracted gains concentrated, after the drying, pulverize, and cross sieve No. seven, standby;
3,, and cross sieve No. seven with Margarita, watermelon crystal, Indigo Naturalis, Pollen Tyjphae pulverize separately, standby;
4, will be except that Margarita by 2,3 technical process gained medicament mixed evenly after, with the Margarita facing-up, after No. seven sieves, after the technical process of disinfection by ultraviolet light, sterilization, packing promptly gets product of the present invention---" Zhenhuang " powder.
Product " Zhenhuang " powder of the present invention compared with prior art has the following advantages: 1. through the San Jia of Hebei province provincial hospital clinical observation aphtha, pharyngitis, gingivitis 100 examples, existing marketed drug 45 examples of contrast, observation group's (being " Zhenhuang " powder) effective percentage 90%, matched group total effective rate 62.22%.Statistical procedures Z
2=16.8114, there is significant differences P＜0.01; 2. treatment must aim at the pathogenesis of disease, treating both the principal and secondary aspects of a disease, the traditional Chinese medical science is thought " the damp and hot stifling rotten point of then mouthful giving birth to, burning hot going up burnt or hyperactivity of deficient fire then becomes ulcer ", it is distinguishing feature that the present invention reuses Radix Et Rhizoma Rhei, because of the Radix Et Rhizoma Rhei purging with bitter and cold drugs, lets out damp and hotly clearly, and last disease is captured, and be equipped with Rhizoma Bistortae, drying looses swells, and supplements and complements each other, and strikes home, prescription focused on heat clearing away in the past, wet and did not remove, and heat is not loose, poison also is difficult to resolve, in the side Radix Et Rhizoma Rhei let out wet again can pathogenic fire purging, one to rush down top three clear, therefore, As the medicine took effect, the symptoms lessened, gets twice the result with half the effort; 3. discard the dross and select the essential, medical herbs is purified more can bring into play drug effect; 4. local application makes diseased region drug level height, has avoided the liver first-pass effect again; 5. product of the present invention is without any side effects, safe and reliable.
Below in conjunction with specific embodiments of the invention in detail the present invention is described in detail:
Product " Zhenhuang " powder of the present invention comprises the composition proportioning of following medicine following (to prepare 1000 gram " Zhenhuang " powders is benchmark, unit: restrain):
1, Radix Et Rhizoma Rhei: 120; Margarita: 100;
Rhizoma Bistortae: 130; Indigo Naturalis: 150;
Watermelon crystal: 150.
2, Radix Et Rhizoma Rhei: 160; Margarita: 100;
Rhizoma Bistortae: 150; Indigo Naturalis: 170;
Watermelon crystal: 100.
3, Radix Et Rhizoma Rhei: 190; Margarita: 100;
Rhizoma Bistortae: 100; Indigo Naturalis: 180;
Watermelon crystal: 120.
To be used for the toxicity test that rabbit, Cavia porcellus carry out toxicity test and agents area than obtained medicine by above-mentioned three assembly, the result shows that product of the present invention is without any side effects.Above-mentioned three assembly are carried out the drug effect zoology test than obtained medicine, and the result shows that product of the present invention all has antibacterial action to staphylococcus aureus, Staphylococcus albus and Klebsiella pneumoniae, and is particularly powerful to the antibacterial action of fungus; Can reduce inflammatory sign occurrence rate to the guinea pig skin traumatic ulcer, and have the effect of accelerating wound healing; Different inflammatory animal models had tangible antiinflammatory action.
Be used for animal is carried out the antiulcer test than the medicine of gained with above-mentioned three assembly, the result shows, with the 3rd assembly than obtained effect of drugs the best.
Most preferred embodiment (to prepare 1000 gram " Zhenhuang " powders is benchmark, unit: gram):
Radix Et Rhizoma Rhei: 190; Margarita: 100; Rhizoma Bistortae: 100;
Indigo Naturalis: 180; Watermelon crystal: 120; Pollen Tyjphae: 120;
Colophonium: 20; Borneolum Syntheticum: 30; Crystal sugar: 80.
Adding Pollen Tyjphae, rosiny purpose are in order to improve the function of product blood circulation promoting and blood stasis dispelling of the present invention, anti-inflammatory analgetic, because of Borneolum Syntheticum has sensible, kind function of scurrying, therefore adding Borneolum Syntheticum can make other each herbal medicines in the product composition proportioning of the present invention bring into play its effect better, the purpose that adds crystal sugar is in order to transfer its bitter cold abnormal smells from the patient, invigorating the spleen and replenishing QI reaches infantile malnutrition and stagnates with damp eliminating heat.
Concrete production method comprises following technical process:
1, aequum Radix Et Rhizoma Rhei, Rhizoma Bistortae are weighed up respectively after, clean, and dry, be ground into the coarse granule shape again, extract wherein active ingredient with the reflow of alcohol method;
2, behind the active ingredient concentrate drying with above-mentioned gained,, standby after No. seven sieves;
3, the Margarita of aequum is weighed up after, wrap with cloth, add 5 times of amount bean curd and boil altogether with water, take out after 2 hours, clean smashing to pieces, a little is ground into superfine powder to add water, reuse 30% sulphuric acid hydrolysis is modulated into Margarita powder, and is after sieving, standby;
4, required crystal sugar weighing is good, use oven dried, 70 ℃ of temperature, after taking-up is pulverized after 2 hours, standby;
5, each herbal medicine mix homogeneously that will be except that Margarita was put into ball mill and Margarita powder facing-up 3 hours, crossed 160 mesh sieves, again through the disinfection by ultraviolet light sterilization, divided the technical process of the bottle of packing at last, promptly got product of the present invention---" Zhenhuang " powder.
Product of the present invention is the darker yellow green powder, and is dry loose, fragrant odour, bitter in the mouth cold.
Show that through stability test product room temperature of the present invention was placed 18 months down, testing result meets quality standard.
Use according to three tame provincial hospitals, " Zhenhuang " powder clinical observation test, the result shows that product of the present invention truly has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the effect of putrefaction-removing granulation-promoting, be applicable to the accumulation of heat in the heart and spleen that the traditional Chinese medical science is thought, hyperactivity of fire caused by deficiency of YIN, the oral cavity that flaming up of stomach-fire and wind heat cause, pharyngeal and body surface and mucosal inflammation, ulcer etc., as aphtha of the mouth and tongue, gingival swelling and pain, fester, symptoms such as red swelling of the pharynx causalgia, to oral ulcer, acute/chronic pharyngitis, gingivitis, periodontitis and body surface, pars oralis pharyngis various diseases such as mucosal ulcer all have very high curative effect, total effective rate reaches 90%, especially oral ulcer there is specially good effect, pain can disappear in patient's medication 3～5 minutes, and effect is remarkable.
The using method of product of the present invention is for directly to spray " Zhenhuang " powder in the affected part, and one for several times.
Claims (6)
1, a kind of Chinese medicine " Zhenhuang " powder, the composition that it is characterized in that this " Zhenhuang " powder are to be principal agent with Radix Et Rhizoma Rhei, Margarita, Rhizoma Bistortae.
2, " Zhenhuang " powder according to claim 1 is characterized in that the accessory drugs of this " Zhenhuang " powder comprises Indigo Naturalis, Pollen Tyjphae, watermelon crystal.
3, " Zhenhuang " powder according to claim 1 is characterized in that the composition proportioning of this " Zhenhuang " powder comprises following composition (being as the criterion unit to prepare 1000 gram " Zhenhuang " powders: restrain):
Radix Et Rhizoma Rhei: 120～200; Margarita: 80～100;
Rhizoma Bistortae: 90～150; Indigo Naturalis: 150～190;
Watermelon crystal: 80～150; Pollen Tyjphae: 100～120.
4, " Zhenhuang " powder according to claim 1 is characterized in that the best composition proportioning of this " Zhenhuang " powder comprises following each composition (being as the criterion unit to prepare 1000 gram " Zhenhuang " powders: restrain):
Radix Et Rhizoma Rhei: 190; Margarita: 100; Rhizoma Bistortae: 100;
Indigo Naturalis: 180; Watermelon crystal: 120; Pollen Tyjphae: 120;
Colophonium: 20; Crystal sugar: 80.
5, a kind of preparation production method of " Zhenhuang " powder according to claim 1 is characterized in that this production method comprises following technical process:
1) with Radix Et Rhizoma Rhei, the Rhizoma Bistortae of aequum, clean respectively, after the drying, be ground into the coarse granule shape, extract its active ingredient with the reflow of alcohol method then;
2) with above-mentionedly extract obtainedly concentrating, after the drying, pulverizing,, standby after No. seven sieves;
3), and cross sieve respectively No. seven with Margarita, Indigo Naturalis, watermelon crystal, Pollen Tyjphae, the crystal sugar pulverize separately of aequum, standby;
4),, afterwards, cross sieve No. seven, after the technical process of disinfection by ultraviolet light, sterilization, packing promptly gets product of the present invention---" Zhenhuang " powder again with the Margarita facing-up with behind each herbal medicine mix homogeneously of above-mentioned all the other except that Margarita.
6, the production method of " Zhenhuang " powder according to claim 5, the technical process 2 that it is characterized in that this production method) in, the concrete treatment process process of Margarita is: required Margarita is wrapped with cloth, adding 5 times of amount bean curd and water boils altogether, take out after 2 hours, clean and smash to pieces, a little is ground into superfine powder to add water, reuse 30% sulphuric acid hydrolysis is modulated into Margarita powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95107977A CN1052645C (en) | 1995-08-08 | 1995-08-08 | Traditional Chinese medicine "Zhenhuang" powder and its production method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95107977A CN1052645C (en) | 1995-08-08 | 1995-08-08 | Traditional Chinese medicine "Zhenhuang" powder and its production method |
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| Publication Number | Publication Date |
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| CN1119950A true CN1119950A (en) | 1996-04-10 |
| CN1052645C CN1052645C (en) | 2000-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN95107977A Expired - Fee Related CN1052645C (en) | 1995-08-08 | 1995-08-08 | Traditional Chinese medicine "Zhenhuang" powder and its production method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063337C (en) * | 1996-07-04 | 2001-03-21 | 陈继忠 | Chinese medicine preparation for stomatocace |
| CN1070060C (en) * | 1996-11-05 | 2001-08-29 | 李佩洲 | Powder medicine for curing recurrence aphtha |
| CN1098093C (en) * | 1998-12-29 | 2003-01-08 | 陈方明 | Kouchuangjin (wiping out aphtha) and its preparation technology |
| CN102327328A (en) * | 2011-09-28 | 2012-01-25 | 广东紫金正天药业有限公司 | Bistort rhizome-containing composition and application thereof |
| CN103505656A (en) * | 2013-10-04 | 2014-01-15 | 张成娟 | Chinese medicine preparation for treating stomatitis |
| CN104189362A (en) * | 2014-08-22 | 2014-12-10 | 郭怡芳 | Medicine for treating oral cancer and preparation method of medicine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033940A (en) * | 1988-12-14 | 1989-07-19 | 贺先楼 | The compound method of the Chinese medicine pill of treatment cold and sore throat |
| CN1090188A (en) * | 1993-01-20 | 1994-08-03 | 张祥德 | Xuanmei oral liquid |
| CN1093914A (en) * | 1993-07-04 | 1994-10-26 | 钟定铨 | Ten thousand answer acute throat trouble to loose and manufacture method |
| CN1045169C (en) * | 1993-11-03 | 1999-09-22 | 邢春生 | Adhesive plaster capable of detoxicating and resolving a mass |
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1995
- 1995-08-08 CN CN95107977A patent/CN1052645C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063337C (en) * | 1996-07-04 | 2001-03-21 | 陈继忠 | Chinese medicine preparation for stomatocace |
| CN1070060C (en) * | 1996-11-05 | 2001-08-29 | 李佩洲 | Powder medicine for curing recurrence aphtha |
| CN1098093C (en) * | 1998-12-29 | 2003-01-08 | 陈方明 | Kouchuangjin (wiping out aphtha) and its preparation technology |
| CN102327328A (en) * | 2011-09-28 | 2012-01-25 | 广东紫金正天药业有限公司 | Bistort rhizome-containing composition and application thereof |
| CN103505656A (en) * | 2013-10-04 | 2014-01-15 | 张成娟 | Chinese medicine preparation for treating stomatitis |
| CN103505656B (en) * | 2013-10-04 | 2015-02-25 | 张成娟 | Chinese medicine preparation for treating stomatitis |
| CN104189362A (en) * | 2014-08-22 | 2014-12-10 | 郭怡芳 | Medicine for treating oral cancer and preparation method of medicine |
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| Publication number | Publication date |
|---|---|
| CN1052645C (en) | 2000-05-24 |
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