CN106177475A - A kind of Chinese medicine composition for gynaecopathia - Google Patents

A kind of Chinese medicine composition for gynaecopathia Download PDF

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Publication number
CN106177475A
CN106177475A CN201610850244.8A CN201610850244A CN106177475A CN 106177475 A CN106177475 A CN 106177475A CN 201610850244 A CN201610850244 A CN 201610850244A CN 106177475 A CN106177475 A CN 106177475A
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chinese medicine
medicine composition
radix
lotion
nanometer
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李东
陈东升
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Guizhou Bes Grass Biotechnology Co Ltd
Guizhou Cypress Thailand Biological Technology Co Ltd
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Guizhou Bes Grass Biotechnology Co Ltd
Guizhou Cypress Thailand Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The present invention provides a kind of Chinese medicine composition for gynaecopathia, and it comprises the Chinese medicine ingredients such as Aloe.The Chinese medicine composition of the present invention can make the exterior-applied formulation on any pharmaceutics, such as liquid preparation, cream agent, gel, membrane, lotion, powder, aerosol spray, suppository, transdermal absorption formulation, particularly lotion.Described Chinese medicine composition can be through nanometered disposal.

Description

A kind of Chinese medicine composition for gynaecopathia
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition for gynaecopathia.
Background technology
Gynaecopathia such as vaginitis, cervicitis etc., be clinical common disease, and this type of disease duration is long, the most repeatedly sends out Make, bring misery to patient, have a strong impact on the physical and mental health of patient.Treat this type of disease at present and mostly be antimicrobial drug, these Though medicine has effect for the moment, but can not reach the effect of wound repairing；And prolonged application can cause many side effect.In order to keep away Exempt from the generation of this type of bad phenomenon, market demand develop a kind of derive from natural, effect notable, without obvious adverse reaction Treat gynopathic external preparation, to alleviate patient suffering.
Meanwhile, nanotechnology is introduced motherland's traditional medicine, beneficially drug effect keep more comprehensively, onset rapider.Therefore The external nanometer formulation product of exploitation treatment gynaecopathia has good potential applicability in clinical practice, is highly beneficial and must to patient Want.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for gynaecopathia, it comprises the Chinese medicine ingredients such as Aloe.
In one embodiment of the invention, described Chinese medicine composition comprises Aloe, the Radix Paeoniae Alba, wikstroemia indica and Radix Notoginseng etc. Chinese medicine ingredients.
In a preferred embodiment of the invention, described Chinese medicine composition is pressed following weight portion system by following raw materials according Become:
Aloe 10-30 part, Radix Paeoniae Alba 10-30 part, wikstroemia indica 10-30 part, Radix Notoginseng 10-30 part, Radix Inulae 10-20 part, mountain Radix Sophorae Tonkinensis 10-20 part, Radix Asparagi 5-10 part, Radix Ilicis Pubescentis 5-10 part, Radix Et Rhizoma Nardostachyos 5-10 part, asparagus 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Rhizoma Atractylodis Macrocephalae 5- 10 parts, Rhizoma Polygonati 5-10 part, Rhizoma Dryopteris Crassirhizomatis 5-10 part, Fructus Toosendan 5-10 part, Fructus Ligustri Lucidi 5-10 part, Fructus Rosae Laevigatae 5-10 part, Fructus Piperis Longi 1-5 Part, threeleaf akebia 1-5 part.
The Chinese medicine composition of the present invention is for nutrition and repairs damaged cell, and bacterio static itching-relieving, to cervicitis, pruritus vulvae The gynaecopathias such as disease, vaginitis, cervical erosion, leucorrhea abnormal, gonorrhea have extraordinary curative effect.
In yet other embodiments, described gynaecopathia is cervicitis, pudendal pruritus, vaginitis, cervix uteri Erosion, leucorrhea abnormal, gonorrhea.
In yet other embodiments, described Chinese medicine composition is used for external.The Chinese medicine composition of the present invention Thing can add pharmaceutically conventional external preparation substrate, external preparation acceptable carrier is made on any pharmaceutics Exterior-applied formulation, such as liquid preparation, cream agent, gel, membrane, lotion, powder, aerosol spray, suppository, Transdermal absorption Preparation.
Those skilled in the art know the method that described Chinese medicine is made external preparation.It is particularly preferred that in the present invention Drug composition, through nanometered disposal, makes nano-particle.It is prepared as external preparation as above the most again.
In yet other embodiments, described preparation is lotion.In one preferred enforcement of the present invention In scheme, described lotion is nanometer lotion.
In a preferred embodiment, the preparation method of described nanometer lotion comprises the following steps:
Being mixed in proportion by described raw medicinal material, putting into and being ground into mean diameter in super micron mill is 20-120 nanometer Nano-particle；In described nano-particle, add the deionized water of 3～5 times of weight, be sufficiently stirred for making dissolving, decoct 2～4 little Time, filter, it is thus achieved that medicine juice, obtain nanometer lotion.
In a specific embodiment, the technology making nano-particle uses many multidimensional hammer high energy nanometers of an axle Ball mill, after being processed by medicinal plants oven drying at low temperature (temperature is below 40 degree), keeps the property of medicine and the activity of plant, by plant letter In single broken loading many multidimensional hammer high energy nanon ball-mills of one axle, continuously grinding 7-8 hour, the plant diameter after grinding Between 20-120 nanometer.The operation principle of many multidimensional hammer high energy nanon ball-mills of one axle is to be made into by traditional ball milling Ball is hammered into shape, produce in multi-dimensional movement rub cut, shear, impact, abrasive action.System is supported with eccentric shaft by eccentric shaft drive system The rotation of system drives on a disk equipped with the several or ten regular multidimensional in several cylindric grinding jar body top to bottom, left and right, front and rear Swinging, fierce multidimensional shock, clipping, grinding, impulsive force is tens times of conventional mill.Clash into because of multidimensional and pulverize without dead angle, Biomaterial (such as Chinese herbal medicine, food, health product) can be crushed to the micro-nano powder of 10-800 nanometer.
Above-mentioned lotion can lie low use.Before using, lotion is loaded spring bottle, connects conduit, conduit is slowly inserted the moon Road is clamp-oned medicinal liquid and (is come up after spring bottle is pressed into the end, be the most again pressed into the end, in order to revealed all by the water in bottle Extrusion).Or use similar doser, as long as described lotion can be applied to diseased region.
In the pharmaceutical composition of the present invention, Aloe is containing barbaloin etc., and the Radix Paeoniae Alba contains peoniflorin, Radix Paeoniae aglycon ketone etc., south Flos Wikstroemiae Dolichanthae contains wikstroemin, matairesinol etc., and Radix Notoginseng contains saponin, ginsenoside etc., and Radix Inulae contains volatile oil, costic acid etc., mountain bean Root contains matrine, maackiain etc., and Radix Asparagi contains agedoite, citrulline etc., and Radix Ilicis Pubescentis contains ilexide A, flavonoid glycoside etc..Radix Et Rhizoma Nardostachyos contains Radix Aucklandiae (Radix Vladimiriae) alcohol, nardosinone etc..Asparagus contains laricin, asparagus bitter principle etc..Pseudobulbus Bletillae (Rhizoma Bletillae) contains Pseudobulbus Bletillae (Rhizoma Bletillae) glycosides sugar, Pseudobulbus Bletillae (Rhizoma Bletillae) alcohol A etc..The Rhizoma Atractylodis Macrocephalae Containing atractylone, hydroxyl atractylone etc..Rhizoma Polygonati, containing remelt sugar, relies aminoacid etc..Rhizoma Dryopteris Crassirhizomatis contains filicin BB, AB, flavaspidic acid Deng.Fructus Toosendan contains melianol, Fructus Toosendan ketone etc..Fructus Ligustri Lucidi contains nuzhenide, olive hardship glycosides etc..Fructus Rosae Laevigatae is containing saponin, against not having Gallate-based etc..Fructus Piperis Longi contains the peaceful amide of Fructus Piperis Longi, tetrahydropiperic acid etc..Threeleaf akebia contains oleanolic acid, akebin etc..The present invention's Chinese medicine composition realizes bacteriostasis not only by blocking protein synthesis, and, cervicitis model scorching to rat vagina has significantly Therapeutical effect, its plant essence contained nutritious and repair to damaged cell simultaneously, make cellular-restoring activity, increase Elastic.
Local irritation test research shows safety of the present invention, without the untoward reaction such as skin irritation, allergy.Clinical multiple woman Section's patient's result on trial shows, the present invention has significant therapeutic effect to multiple gynecological disease, and effective percentage reaches more than 95%, makes Have no side effect by safety, and there is wound repairing, the effect of trophocyte.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
Aloe 20 grams, the Radix Paeoniae Alba 20 grams, wikstroemia indica 20 grams, Radix Notoginseng 20 grams, Radix Inulae 15 grams, Radix Sophorae Tonkinensis 15 grams, Radix Asparagi 5 Gram, Radix Ilicis Pubescentis 10 grams, Radix Et Rhizoma Nardostachyos 10 grams, asparagus 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Rhizoma Polygonati 5 grams, Rhizoma Dryopteris Crassirhizomatis 5 grams, Fructus Toosendan 5 Gram, Fructus Ligustri Lucidi 5 grams, Fructus Rosae Laevigatae 5 grams, Fructus Piperis Longi 3 grams, threeleaf akebia 3 grams.
Being mixed in proportion by described raw medicinal material, putting into and being ground into mean diameter in super micron mill is 20-120 nanometer Nano-particle；In described nano-particle, add the deionized water of 4 times of weight, be sufficiently stirred for making dissolving, decoct 3 hours, filter, Obtain medicine juice, obtain nanometer lotion.
Embodiment 2:
Aloe 20 grams, the Radix Paeoniae Alba 20 grams, wikstroemia indica 20 grams, Radix Notoginseng 20 grams, Radix Inulae 15 grams, Radix Sophorae Tonkinensis 15 grams, Radix Asparagi 10 Gram, Radix Ilicis Pubescentis 5 grams, Radix Et Rhizoma Nardostachyos 5 grams, asparagus 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Rhizoma Polygonati 5 grams, Rhizoma Dryopteris Crassirhizomatis 5 grams, Fructus Toosendan 5 grams, Fructus Ligustri Lucidi 5 grams, Fructus Rosae Laevigatae 5 grams, Fructus Piperis Longi 5 grams, threeleaf akebia 5 grams.
Being mixed in proportion by described raw medicinal material, putting into and being ground into mean diameter in super micron mill is 20-120 nanometer Nano-particle；In described nano-particle, add the deionized water of 4 times of weight, be sufficiently stirred for making dissolving, decoct 5 hours, filter, Obtain medicine juice, obtain nanometer lotion.
Embodiment 3
Pharmacological testing
The present embodiment uses the nanometer lotion of embodiment 1, calls nanometer lotion of the present invention in the following text.
The therapeutical effect scorching to rat vagina: the female rats of body weight 200-250g, injects Staphylococcus aureus from vagina Bacterium (3 × 105And escherichia coli (1.6 × 10 CFU/ml)6CFU/ml) mixed bacteria liquid, bacterium solution injection rate is 0.05ml/100g body Heavily, 1 time is inoculated the next day.Within 5th day and the 7th day, take vaginal secretions respectively and do microscopy, antibacterial culturing, and respectively be isolated by golden yellow Color staphylococcus and escherichia coli, then be inoculated in respectively in culture medium, after cultivating, do identification of strains.Microscopy and identification of strains It is positive for infecting successful rat.Take the successful rat of infection and be randomly divided into 4 groups, model control group, nanometer of the present invention Lotion group, ofloxacin ointment group, often group 10.It is injected separately into relative medicine, model comparison in each rat vagina of administration group Organize saline injection in each rat vagina, every day 1 time, continuous 5 days.Within after drug withdrawal the 1st day and the 4th day, take rat vagina secretion Thing is identified, identifies that pathogen is feminine gender and is set to and turns out cloudy for 2 times.Within after drug withdrawal the 5th day, rat is dissected, takes vagina specimen and carry out Perusal；Vagina specimen is marked by hyperemia, edema, hemorrhage 3 indexs: without hyperemia, edema, hemorrhage comment 0 point；Vagina glues Film is still smooth mild hyperaemia, is chosen as 1 point；It is congested that vaginal mucosa still smooths moderate, it is seen that petechial hemorrhage point, is chosen as 2 points；Vagina Uneven mucosa is sliding, and severe is congested, it is seen that bleed profusely a little, organizes Mild edema, is chosen as 3 points.Score value with model control group is fixed Being 100% (degree of inflammation), medicine group compares with model control group, can draw medicine group inflammation suppression ratio.Check inflammation with t Scoring is added up, and uses χ2Negative conversion rate is added up by inspection.Result shows (being shown in Table 1), and the nanometer lotion of the present invention is to rat Vaginitis has significant therapeutic effect, and effect is significantly better than ofloxacin group.
The table 1. therapeutical effect to rat vagina inflammation
X ± s.n=10.**P<0.01.
Embodiment 4
Local irritation test
Take adult rabbit 8, male and female half and half, every animal sub-cage rearing, first raise 3-4 days at laboratory condition.Then Rabbit spinal column both sides dorsal body setae electric shaver-for women is shaved off, every lateral area 5 × 10cm2.Go through whether depilation district has redness And damage, if any abandoning it, it is impossible to test.Use the test method of multiple dosing, smear nanometer of the present invention in depilation district Lotion, every day 2 times, smears 7 days continuously.Last washes away smear with warm water after smearing 24 hours, little respectively at l, 24,48,72 Local skin reaction, such as erythema, edema, desquamation, incrustation etc., if having petechia, skin peptide coarse or poor, note is observed time after Record time of origin and regression time.Test result indicate that, after smearing nanometer lotion of the present invention continuously 7 days, each rabbit skin is equal Do not show obvious skin irritation and anaphylaxis.Show product safety of the present invention, have no adverse reaction.
Embodiment 5
Clinic trial is tested
With the nanometer lotion of the embodiment of the present invention 1, trying out through multiple gynecological patient, concrete case and the course for the treatment of are shown in Table 2.Institute Have outside the patient present invention and be coated with at disease damage, every day 1 time.Patient does not the most use other external used medicine any during treating.Curative effect Standard: cure: clinical symptoms performance all disappears, pathogen microscopy is negative；Effective: clinical symptoms performance is basic to disappear, sick Substance microscopy is the weak positive；Effective: clinical symptoms performance partial disappearance, pathogen microscopy is the weak positive；Invalid: clinical symptoms table Showing the most constant or increase the weight of, pathogen microscopy is positive.Cure rate=healing number/total case X100%；Effective percentage=(cure number + effective number+efficiently individual quantity)/total case X100%.The results are shown in Table 2.Clinic trial result shows, multiple gynecological patient make All effective with nanometer lotion of the present invention, most effective percentage reach more than 90%, and cure rate is all more than 80%.
The table 2 nanometer of the present invention gynopathic clinical effectiveness of lotion for treatment
All there is not the untoward reaction such as skin irritation, allergy during the application present invention in all patients.Therefore the present invention is A kind of preferably gynopathic external preparation for the treatment of, evident in efficacy, safe and reliable.

Claims (8)

1., for a Chinese medicine composition for gynaecopathia, it comprises the Chinese medicine ingredients such as Aloe.
2. the Chinese medicine composition of claim 1, comprises the Chinese medicine ingredients such as Aloe, the Radix Paeoniae Alba, wikstroemia indica and Radix Notoginseng.
3. the Chinese medicine composition of claim 1-2, is made up by following weight portion of following raw materials according: Aloe 10-30 part, Radix Paeoniae Alba 10- 30 parts, wikstroemia indica 10-30 part, Radix Notoginseng 10-30 part, Radix Inulae 10-20 part, Radix Sophorae Tonkinensis 10-20 part, Radix Asparagi 5-10 part, Mao Dong Blue or green 5-10 part, Radix Et Rhizoma Nardostachyos 5-10 part, asparagus 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Polygonati 5-10 part, Rhizoma Dryopteris Crassirhizomatis 5- 10 parts, Fructus Toosendan 5-10 part, Fructus Ligustri Lucidi 5-10 part, Fructus Rosae Laevigatae 5-10 part, Fructus Piperis Longi 1-5 part, threeleaf akebia 1-5 part.
4. the Chinese medicine composition of claim 1-3, wherein said gynaecopathia is cervicitis, pudendal pruritus, vaginitis, cervix uteri gruel Rotten, leucorrhea abnormal, gonorrhea etc..
5. the Chinese medicine composition of claim 1-4, wherein said Chinese medicine composition is used for external, can make any medicament Exterior-applied formulation on, such as liquid preparation, cream agent, gel, membrane, lotion, powder, aerosol spray, suppository, transdermal Absorbable preparation.
6. the Chinese medicine composition of claim 5, wherein said Chinese medicine composition through nanometered disposal, makes nano-particle, then It is prepared as external preparation again.
7. the Chinese medicine composition of claim 5-6, wherein said lotion is nanometer lotion.
8. the Chinese medicine composition of claim 7, the preparation method of wherein said nanometer lotion comprises the following steps:
Described raw medicinal material is mixed in proportion, puts into and super micron mill is ground into the nanometer that mean diameter is 20-120 nanometer Granule；In described nano-particle, add the deionized water of 3～5 times of weight, decoct 2～4 hours, filter, it is thus achieved that medicine juice, to obtain final product Nanometer lotion.
CN201610850244.8A 2016-09-26 2016-09-26 A kind of Chinese medicine composition for gynaecopathia Pending CN106177475A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588780A (en) * 2020-07-09 2020-08-28 广西妙韵圆生药业有限公司 Traditional Chinese medicine composition for treating cervical HPV (human papillomavirus) infection and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101648003A (en) * 2008-08-13 2010-02-17 北京和润创新医药科技发展有限公司 Medicinal composition for treating gynecological inflammation and application thereof
CN102526441A (en) * 2012-03-22 2012-07-04 常熟市虞山绿茶有限公司 Traditional Chinese medicine flushing liquor special for gynecological inflammation treatment
CN103751230A (en) * 2013-09-11 2014-04-30 王青 Application of gingko extract nanometer liposome in gynecological disease treatment
CN103751105A (en) * 2013-09-11 2014-04-30 王青 Application of ginkgolic acid nanometer liposome in treatment of gynecological diseases and venereal diseases
CN105833223A (en) * 2016-05-05 2016-08-10 南京素德问医药科技有限公司 Dressing for treating gynecological diseases
CN105943802A (en) * 2016-07-07 2016-09-21 王瑜琳 External used traditionalChinese medicine composition for treating gynecological inflammation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101648003A (en) * 2008-08-13 2010-02-17 北京和润创新医药科技发展有限公司 Medicinal composition for treating gynecological inflammation and application thereof
CN102526441A (en) * 2012-03-22 2012-07-04 常熟市虞山绿茶有限公司 Traditional Chinese medicine flushing liquor special for gynecological inflammation treatment
CN103751230A (en) * 2013-09-11 2014-04-30 王青 Application of gingko extract nanometer liposome in gynecological disease treatment
CN103751105A (en) * 2013-09-11 2014-04-30 王青 Application of ginkgolic acid nanometer liposome in treatment of gynecological diseases and venereal diseases
CN105833223A (en) * 2016-05-05 2016-08-10 南京素德问医药科技有限公司 Dressing for treating gynecological diseases
CN105943802A (en) * 2016-07-07 2016-09-21 王瑜琳 External used traditionalChinese medicine composition for treating gynecological inflammation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吴芸等: "纳米技术在中药领域的研究进展", 《中草药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588780A (en) * 2020-07-09 2020-08-28 广西妙韵圆生药业有限公司 Traditional Chinese medicine composition for treating cervical HPV (human papillomavirus) infection and preparation method thereof
CN111588780B (en) * 2020-07-09 2021-07-27 广西妙韵圆生药业有限公司 Traditional Chinese medicine composition for treating cervical HPV (human papillomavirus) infection and preparation method thereof

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