CN120842408A - 人源化或嵌合cd3抗体 - Google Patents

人源化或嵌合cd3抗体

Info

Publication number
CN120842408A
CN120842408A CN202511003204.5A CN202511003204A CN120842408A CN 120842408 A CN120842408 A CN 120842408A CN 202511003204 A CN202511003204 A CN 202511003204A CN 120842408 A CN120842408 A CN 120842408A
Authority
CN
China
Prior art keywords
seq
cdr2
cdr1
antibody
cdr3 sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202511003204.5A
Other languages
English (en)
Chinese (zh)
Inventor
R·拉德马克
I·阿尔廷塔斯
P·恩格伯特斯
J·舒尔曼
P·帕伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genmab AS
Original Assignee
Genmab AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
Application filed by Genmab AS filed Critical Genmab AS
Publication of CN120842408A publication Critical patent/CN120842408A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202511003204.5A 2015-07-15 2016-07-14 人源化或嵌合cd3抗体 Pending CN120842408A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500414 2015-07-15
DKPA201500413 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
EPPCT/EP2016/050296 2016-01-08
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies
CN201680054638.0A CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680054638.0A Division CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Publications (1)

Publication Number Publication Date
CN120842408A true CN120842408A (zh) 2025-10-28

Family

ID=57757079

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202511003204.5A Pending CN120842408A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN202210585379.1A Active CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN201680054638.0A Active CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202210585379.1A Active CN114989302B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN201680054638.0A Active CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Country Status (19)

Country Link
US (3) US11359015B2 (https=)
EP (1) EP3322727B1 (https=)
JP (3) JP2018526981A (https=)
KR (2) KR102786353B1 (https=)
CN (3) CN120842408A (https=)
AU (2) AU2016293073B2 (https=)
BR (1) BR112018000696A2 (https=)
CA (1) CA2992380A1 (https=)
DK (1) DK3322727T3 (https=)
EA (1) EA201890305A1 (https=)
ES (1) ES3063317T3 (https=)
FI (1) FI3322727T3 (https=)
IL (2) IL256562B2 (https=)
MX (2) MX395317B (https=)
NZ (1) NZ739028A (https=)
PT (1) PT3322727T (https=)
SI (1) SI3322727T1 (https=)
UA (1) UA128057C2 (https=)
WO (1) WO2017009442A1 (https=)

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KR20230066040A (ko) 2020-09-10 2023-05-12 젠맵 에이/에스 만성 림프구성 백혈병을 치료하기 위한 cd3 및 cd20에 대한 이중특이적 항체
US20240034812A1 (en) 2020-09-10 2024-02-01 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
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Also Published As

Publication number Publication date
NZ739028A (en) 2023-05-26
WO2017009442A1 (en) 2017-01-19
PT3322727T (pt) 2026-03-16
KR102786353B1 (ko) 2025-03-26
IL310467A (en) 2024-03-01
SI3322727T1 (sl) 2026-04-30
CN108368172A (zh) 2018-08-03
NZ778205A (en) 2025-05-02
EP3322727B1 (en) 2025-12-31
US11359015B2 (en) 2022-06-14
IL256562A (en) 2018-02-28
CA2992380A1 (en) 2017-01-19
JP2022023862A (ja) 2022-02-08
AU2023201733A1 (en) 2023-07-13
IL256562B2 (en) 2024-07-01
KR20250048113A (ko) 2025-04-07
MX395317B (es) 2025-03-25
CN114989302A (zh) 2022-09-02
US20220389101A1 (en) 2022-12-08
JP7604351B2 (ja) 2024-12-23
ES3063317T3 (en) 2026-04-16
JP2025038049A (ja) 2025-03-18
US20190284278A1 (en) 2019-09-19
MX2018000347A (es) 2018-03-14
KR20180030635A (ko) 2018-03-23
DK3322727T3 (da) 2026-03-30
JP2018526981A (ja) 2018-09-20
FI3322727T3 (fi) 2026-03-17
CN114989302B (zh) 2025-08-05
US20220380464A1 (en) 2022-12-01
MX2022011002A (es) 2022-10-07
AU2016293073B2 (en) 2022-12-22
EP3322727A1 (en) 2018-05-23
BR112018000696A2 (en) 2018-09-18
IL256562B1 (en) 2024-03-01
NZ778208A (en) 2025-05-02
AU2016293073A1 (en) 2018-02-01
US20230027394A1 (en) 2023-01-26
EA201890305A1 (ru) 2018-07-31
UA128057C2 (uk) 2024-03-27
CN108368172B (zh) 2022-06-14

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