CN120204220A - 治疗及/或预防纤维性疾病的胺基萘醌化合物 - Google Patents

治疗及/或预防纤维性疾病的胺基萘醌化合物 Download PDF

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Publication number
CN120204220A
CN120204220A CN202510406652.3A CN202510406652A CN120204220A CN 120204220 A CN120204220 A CN 120204220A CN 202510406652 A CN202510406652 A CN 202510406652A CN 120204220 A CN120204220 A CN 120204220A
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methyl
chloro
benzamide
dihydronaphthalen
oxy
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Chinese (zh)
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阎云
刘景平
林建煌
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Bo Wei Pharmaceutical Biotechnology Co ltd
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Bo Wei Pharmaceutical Biotechnology Co ltd
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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CN202510406652.3A 2015-11-17 2016-11-17 治疗及/或预防纤维性疾病的胺基萘醌化合物 Pending CN120204220A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562256516P 2015-11-17 2015-11-17
US62/256,516 2015-11-17
CN201680067312.1A CN108697697A (zh) 2015-11-17 2016-11-17 治疗及/或预防纤维性疾病的胺基萘醌化合物
PCT/US2016/062568 WO2017087695A1 (en) 2015-11-17 2016-11-17 Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases

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CN201680067312.1A Pending CN108697697A (zh) 2015-11-17 2016-11-17 治疗及/或预防纤维性疾病的胺基萘醌化合物

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US (2) US11833122B2 (https=)
EP (1) EP3377062B1 (https=)
JP (2) JP7085994B2 (https=)
KR (1) KR20180096609A (https=)
CN (2) CN120204220A (https=)
ES (1) ES2955665T3 (https=)
TW (1) TWI673049B (https=)
WO (1) WO2017087695A1 (https=)

Families Citing this family (3)

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BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
KR20240159339A (ko) * 2023-04-28 2024-11-05 한국원자력의학원 폐섬유화 예방 또는 치료를 위한 다코미티닙 및 닌테다닙의 병용 요법

Family Cites Families (7)

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US20040167189A1 (en) * 2002-03-22 2004-08-26 The Government Of The U.S.A., As Represented By The Secretary, Dept. Of Health And Human Services Materials and methods for inhibiting Wip1
US20050222043A1 (en) * 2002-07-25 2005-10-06 Karl Stangl Use of proteasome inhibitor in the treatment of fibrotic diseases
US8088741B2 (en) * 2004-05-10 2012-01-03 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
HUE027850T2 (en) * 2004-12-07 2016-11-28 Onyx Therapeutics Inc Preparation for proteasome inhibition
WO2010005534A2 (en) 2008-06-30 2010-01-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome inhibitors for selectively inducing apoptosis in cancer cells
CN108135871B (zh) * 2015-07-23 2022-11-04 博蔚医药生物科技股份有限公司 阻断疾病的泛素化-蛋白酶体系统的胺萘醌化合物及医药组合物
CA2993809C (en) * 2015-07-30 2023-09-05 Taipei Medical University Compounds and pharmaceutical composition associated with ubiquitination-proteasome system

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US12453708B2 (en) 2025-10-28
US20240130984A1 (en) 2024-04-25
US20180325845A1 (en) 2018-11-15
TWI673049B (zh) 2019-10-01
JP7667764B2 (ja) 2025-04-23
US11833122B2 (en) 2023-12-05
JP2022116328A (ja) 2022-08-09
ES2955665T3 (es) 2023-12-05
CN108697697A (zh) 2018-10-23
EP3377062C0 (en) 2023-09-06
KR20180096609A (ko) 2018-08-29
JP7085994B2 (ja) 2022-06-17
EP3377062B1 (en) 2023-09-06
CA3005614A1 (en) 2017-05-26
TW201720433A (zh) 2017-06-16
EP3377062A1 (en) 2018-09-26
EP3377062A4 (en) 2019-07-03
JP2019501126A (ja) 2019-01-17
WO2017087695A1 (en) 2017-05-26

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