CN1201781C - Medicine compositions for treating head-ache, and its prepn. method - Google Patents
Medicine compositions for treating head-ache, and its prepn. method Download PDFInfo
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- CN1201781C CN1201781C CNB02153456XA CN02153456A CN1201781C CN 1201781 C CN1201781 C CN 1201781C CN B02153456X A CNB02153456X A CN B02153456XA CN 02153456 A CN02153456 A CN 02153456A CN 1201781 C CN1201781 C CN 1201781C
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- rhizoma
- rhizoma gastrodiae
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Abstract
The present invention discloses a medical composition for treating headaches, which is characterized in that the medical composition is prepared from the following raw medicinal material of part by weight: 180 to 540 parts of glabrous greenbrier rhizome, 180 to 350 parts of tall gastrodis tuber, 135 to 405 parts of prepared fleece flower root, 90 to 270 parts of angelica, 90 to 270 parts of parsnip and 15 to 45 parts of scorpion. The present invention also discloses a preparation method of the medical composition for treating headaches.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of headache and preparation method thereof.
Migraine belongs to motherland's medical science " wind syndrome of head " category.Clinically seeing so that headache due to internal injury more, is deficiency of both the liver and kidney, and yang hyperactivity is pneumatic, holds the phlegm stagnancy fire under the arm, follow through on disturb, wind, fire, expectorant, stasis of blood visitor are in the brain network, venation is obstructed, sends out to be wind syndrome of head.Sick position is the card of deficiency in origin and excess in superficiality at the brain network, and the wind-fire expectorant stasis of blood is the mark of disease, is more common in the acute attack stage; Liver spleen renal function imbalance for sick this, be the basis of morbidity.Control with suppressing the hyperactive liver to relieve the wind syndrome, clearing away phlegm removing blood stasis, understand things pain-stopping are method.
The object of the invention is to provide a kind of pharmaceutical composition and preparation method thereof of the treatment that has no side effect headache of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
135～405 parts of 180～350 parts of Radix Polygoni Multiflori Preparata of 180～540 parts of Rhizoma Gastrodiaes of Rhizoma Smilacis Glabrae
15～45 parts of 90～270 portions of Scorpios of 90～270 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis
Get Scorpio and partly Radix Saposhnikoviae, Rhizoma Gastrodiae powder be broken into fine powder, standby.Other gets residue Radix Saposhnikoviae, Rhizoma Gastrodiae and Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, is ground into coarse granule, with 50～90% alcohol reflux 2～3 times, each 0.5～2 hour, filter merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure, pulverize, add Pulvis Talci and starch, fully mixing, encapsulated, promptly.
Pharmaceutical composition of the present invention has the clearing away phlegm of relieving dizziness, high fever, infantile convulsions, epilepsy, etc., effects such as removing blood stasis pain relieving can be used for migraine, tension headache due to the phlegm stagnation in collateral, and the pain gesture is very acute, or attack to dash and have a pain, or pain as being stabbed, or connect and the order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest expands, nausea and vomiting, being irritable and getting angry easily, treatment of conditions such as outbreak repeatedly.
Experimental example 1: analgesic experiment
1. to the influence of hot plate induced mice pain: select female mice, body weight 18-22g, (55 ℃ of temperature) selected and licked qualified mice of metapedes time (licking the metapedes time is 5 seconds-30 seconds) on hot-plate instrument, select 80 altogether, according to licking metapedes time random packet, every group 10, large, medium and small three dosage of difference gastric infusion pharmaceutical composition of the present invention, positive control drug is selected acetaminophen for use, dosage is all 0.2ml/10g, and be equal to the normal saline of dosage, respectively at measuring the time that mice licks metapedes in 30 minutes, 60 minutes after the administration, experimental result sees the following form:
Influence (X+SD) to hot plate induced mice pain
Licked before group dosage (g/kg) administration behind the time administration of metapedes 30 fens
Normal saline group---22.5+6.17 19.8+4.87
Low dose of 0.105 23.2+5.18 26.1+8.46
Middle dosage group 0.21 22.3+5.52 25.9+14.19
△
Heavy dose of group 0.42 21.5+6.08 43.1+13.65
△ △
Acetaminophen group 20mg/kg 22.4+5.40 45.8+14.70
△ △
Compare △ p＜0.05 △ △ p＜0.01 with the normal saline group
2. the Dichlorodiphenyl Acetate induced mice is turned round the influence of body
Get 80 male and female half and half of Kunming mouse, be divided into 8 groups at random, 10 every group, irritate the large, medium and small dosage that stomach is given pharmaceutical composition of the present invention, acetaminophen and be equal to the normal saline of dosage, dosage is with experiment one, and experimental result sees the following form:
The Dichlorodiphenyl Acetate induced mice is turned round the influence (X+SD) of body
Group dosage (g/kg) is turned round body first and is turned round in the 20 minutes time that body occurs and turn round the body number of times
Normal saline group--4.3+1.16 43.4+6.92
Small dose group 0.105 5.9+0.99
△ △21.8+8.47
△ △
Middle dosage group 0.21 7.9+3.75
△ △17.5+6.19
△ △
Heavy dose of group 0.42 8.2+3.0
△ △14.7+5.81
△ △
Acetaminophen group 20mg/kg 10.1+2.02
△ △10.9+5.86
△ △
Compare △ p＜0.05 △ △ p＜0.01 with the normal saline group
Experimental example 2: to the influence of rat cerebral tissue's water content
Get 80 of healthy rats, male and female half and half, irritate stomach respectively and give the big of pharmaceutical composition of the present invention, in, little three concentration, flunarizine and be equal to the normal saline of dosage, dosage is all 1ml/100g, successive administration 10 days, 1h etherization after administration in the 11st day is opened rat neck, ligation rat bilateral carotid, form acute imperfection cerebral ischemic model, not ligation of Sham-operated control group rat bilateral carotid is behind the ligation 3h, the sacrificed by decapitation rat, open cranium and get brain and claim cutaneous horn heavy, then brain is put into baking oven and dried to constant weight for 110 ℃, dry by the fire and claim dry weight after 72 hours in electronic balance, calculate the brain percentage of moisture, experimental result sees the following form:
Influence (X+SD) to rat cerebral tissue's water content
The heavy moisture percentage of the heavy brain stem of group dosage (g/kg) cutaneous horn
Normal saline group---1.8622+0.106 0.3521+0.111 79.09+0.30
Sham operated rats--1.717+0.137 0.379+0.028 77.41+0.35
★
Small dose group 0.21 1.8719+0.096 0.4123+0.031 77.99+0.86
△ △
Middle dosage group 0.24 1.901+0.063 0.4153+0.014 78.14+0.80
△ △
Heavy dose of group 0.42 1.934+0.071 0.4361+0.018 77.45+0.42
△ △
Flunarizine group 0.166mg/kg 1.9512+0.075 0.4350+0.011 77.70+0.48
△ △
Compare △ △ p＜0.01 with the normal saline group, compare ★ p＜0.01 with normal saline modeling group
Embodiment 1:
Rhizoma Smilacis Glabrae 360g Rhizoma Gastrodiae 270g Radix Polygoni Multiflori Preparata 270g
Radix Angelicae Sinensis 180g Radix Saposhnikoviae 180g Scorpio 30g
Get Scorpio and Radix Saposhnikoviae 50g, Rhizoma Gastrodiae 150g is ground into fine powder, and is standby.Other gets residue Radix Saposhnikoviae, Rhizoma Gastrodiae and Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, is ground into coarse granule, with 70% alcohol reflux secondary, each 1 hour, filter merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure is pulverized, and adds Pulvis Talci 6g and starch to 400g, abundant mixing, encapsulated, make 1000, promptly.
Embodiment 2:
Rhizoma Smilacis Glabrae 300g Rhizoma Gastrodiae 200 Radix Polygoni Multiflori Preparata 200g
Radix Angelicae Sinensis 200g Radix Saposhnikoviae 200g Scorpio 20g
Get Scorpio and Radix Saposhnikoviae 50g, Rhizoma Gastrodiae 150g is ground into fine powder, and is standby.Other gets residue Radix Saposhnikoviae, Rhizoma Gastrodiae and Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, is ground into coarse granule, with 70% alcohol reflux secondary, each 1 hour, filter merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure is pulverized, and adds Pulvis Talci 6g and starch to 400g, abundant mixing, encapsulated, make 1000, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of headache is characterized in that this pharmaceutical composition made by following bulk drugs:
200 parts of 200 parts of Radix Polygoni Multiflori Preparata of 300 parts of Rhizoma Gastrodiaes of Rhizoma Smilacis Glabrae
20 parts of 200 portions of Scorpios of 200 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis.
2,, it is characterized in that this pharmaceutical composition made by bulk drugs as described below according to the described a kind of pharmaceutical composition for the treatment of headache of claim 1:
270 parts of 270 parts of Radix Polygoni Multiflori Preparata of 360 parts of Rhizoma Gastrodiaes of Rhizoma Smilacis Glabrae
30 parts of 180 portions of Scorpios of 180 parts of Radix Saposhnikoviaes of Radix Angelicae Sinensis.
3, a kind of preparation of drug combination method for the treatment of headache as claimed in claim 1 or 2 is characterized in that this method is: get Scorpio and partly Radix Saposhnikoviae, Rhizoma Gastrodiae powder be broken into fine powder, standby.Other gets residue Radix Saposhnikoviae, Rhizoma Gastrodiae and Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, is ground into coarse granule, with 50～90% alcohol reflux 2～3 times, each 0.5～2 hour, filter merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure, pulverize, add adjuvant, fully mixing, encapsulated, promptly.
4, according to the described a kind of preparation of drug combination method for the treatment of headache of claim 3, it is characterized in that this method is: get 50 parts of Scorpio and Radix Saposhnikoviaes, Rhizoma Gastrodiae is ground into fine powder for 150 parts, and is standby.Other gets residue Radix Saposhnikoviae, Rhizoma Gastrodiae and Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, is ground into coarse granule, with 70% alcohol reflux secondary, each 1 hour, filter merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure, pulverize, add Pulvis Talci and starch, fully mixing, encapsulated, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02153456XA CN1201781C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating head-ache, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02153456XA CN1201781C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating head-ache, and its prepn. method |
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| Publication Number | Publication Date |
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| CN1418681A CN1418681A (en) | 2003-05-21 |
| CN1201781C true CN1201781C (en) | 2005-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB02153456XA Expired - Lifetime CN1201781C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating head-ache, and its prepn. method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225173A (en) * | 2011-06-08 | 2011-10-26 | 陕西步长制药有限公司 | Traditional Chinese preparation for treating headache and preparation method thereof |
| CN102225175A (en) * | 2011-06-08 | 2011-10-26 | 陕西步长制药有限公司 | Traditional Chinese medicine dropping pill for treating headache and preparation method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358492C (en) * | 2004-03-17 | 2008-01-02 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing headache and preparation method |
| CN102225172B (en) * | 2011-06-08 | 2012-12-12 | 陕西步长制药有限公司 | Traditional Chinese medicine oral liquid for treating headache and preparation thereof |
| CN102225171B (en) * | 2011-06-08 | 2013-04-10 | 陕西步长高新制药有限公司 | Traditional Chinese medicine soft capsule for treating headache and preparation method thereof |
| CN102225174A (en) * | 2011-06-08 | 2011-10-26 | 陕西步长制药有限公司 | Application of pharmaceutical composition in preparation of medicine for treating coronary cardiopathy |
-
2002
- 2002-11-29 CN CNB02153456XA patent/CN1201781C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225173A (en) * | 2011-06-08 | 2011-10-26 | 陕西步长制药有限公司 | Traditional Chinese preparation for treating headache and preparation method thereof |
| CN102225175A (en) * | 2011-06-08 | 2011-10-26 | 陕西步长制药有限公司 | Traditional Chinese medicine dropping pill for treating headache and preparation method thereof |
| CN102225175B (en) * | 2011-06-08 | 2012-08-08 | 陕西步长制药有限公司 | Traditional Chinese medicine dropping pill for treating headache and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1418681A (en) | 2003-05-21 |
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Owner name: QIYUANYIDE MEDICINES INST., BEIJING Free format text: FORMER OWNER: ZHANG HUIFANG Effective date: 20030812 |
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Effective date of registration: 20030812 Address after: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant after: Beijing Qi Yuan Yi De Pharmaceuticals Research Center Address before: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant before: Zhang Huifang |
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Owner name: SHANXI BUCHANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XIANYANG BUCHANG PHARMACEUTICAL CO., LTD. Effective date: 20100108 |
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Effective date of registration: 20100108 Address after: Shaanxi province Xianyang City Weiyang Road West No. 123 Patentee after: Shaanxi Buchang Pharmaceuticals Co.,Ltd. Address before: The west section of Xianyang City Weiyang Road No. 123 Patentee before: BUCHANG Group |
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