CN102225171B - Traditional Chinese medicine soft capsule for treating headache and preparation method thereof - Google Patents
Traditional Chinese medicine soft capsule for treating headache and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine soft capsule for treating headache and a preparation method thereof. The traditional Chinese medicine soft capsule is prepared by the following steps: extracting and purifying six medicinal materials, namely gastrodia elata, angelica, rhizome smilacis glabrae, radix polygoni multiflori preparata, divaricate saposhnikovia root and scorpio as raw materials according to a certain process; and then adding pharmaceutically acceptable auxiliaries. The traditional Chinese preparation has the characteristics that preparation process is simple and practicable, and the capsule is safe and effective and has obvious pharmacological and pharmacodynamic effects.
Description
Technical field
The present invention relates to a kind of Chinese medicinal soft capsule agent for the treatment of headache and preparation method thereof, belong to the pharmaceutical preparations technology field.
Background technology
At present, along with the raising of living standards of the people, the rhythm of life and work is accelerated, pressure strengthens, and the sickness rate of headache raises increasingly.Headache belongs to motherland's medical science " wind syndrome of head " category, is one of neural commonly encountered diseases, and is clinical the most common with headache due to internal injury, hurt like hell during its outbreak, and pain very is easy nausea, vomits clear saliva or prolongs and facial muscle, and contracture is numb, and the course of disease is very long.Numerous doctors think that the paathogenic factor of having a headache is unsuccessful take feelings will, six climate exopathogens are attacked, QI and blood is contrary disorderly, pathogenic wind hinders key, stagnation of blood stasis as main outward at all times.Chinese medicine thinks, head be " confluence of all yang-channels ", " gas of sun all can be in the mountain peak clearly for the blood of the five internal organs elite, six internal organs ".Internal organs are safe and comfortable, and QI and blood is orderly and clearly, then the clear spirit of brain and the hardship of no headache.If feelings will is unsuccessful, disgruntled anxiety, the liver failing to maintain the normal flow of QI, strongly fragrant and fire-transformation, yang-energy is high moving, and QI and blood is disorderly contrary, and QI-blood circulation is obstructed and is formed stagnation of QI and blood; Six climate exopathogens are attacked outward, wherein " wind being the primary exopathogen ", it can press from both sides cold, folder heat or be mingled with damp invasion and attack human body, top, upper criminal mountain peak, also can cause QI-blood circulation not smooth, gradually become stagnation of QI and blood, so pathogenic wind hinders key, stagnation of blood stasis is the pathological factor of migraine phase, internal organs yang blood and qi functional disorder is the pathologic basis of migraine phase, and six climate exopathogens are attacked outward, disorder of emotion then is the most common risk factor.Modern medicine is divided into angioneurotic headache, cluster headache, tension headache etc. with headache, but not yet fully clear and definite to its cause of disease, may be relevant with factors such as heredity, endocrine, nervous, direct stimulation, sleep disorder.Therefore, Chinese medicine has good effect in the treatment to headache, can reach treating both the principal and secondary aspects of a disease, the absolute advantages that side effect is little.
Between this; we have successively applied for two patents of invention and have obtained mandate; application number is respectively 02153456.X and 200410022070.3; in these two patent application documents, mainly be from preparation prescription, the protection of the aspects such as dosage form preparation technology; the present invention carries out a large amount of experimentatioies on this basis; with further replenishment of process preparation method, improving medicine stability and bioavailability is purpose, and creationary a kind of Chinese medicine preparation for the treatment of headache of succeeding in developing.
Summary of the invention
The object of the present invention is to provide a kind of steady quality, curative effect is reliable, the Chinese medicinal soft capsule agent of the treatment headache that bioavailability is high.The soft capsule that the present invention prepares is through corresponding pharmacodynamics test research, and the result shows this Chinese medicinal soft capsule agent stable curative effect, effective, reliable.
Technical solution of the present invention is to be prepared from by following technique:
(1) get and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, soak, and after supersound process, heating extraction filters, and merging filtrate also adds ethanol, leave standstill rear centrifugalize, centrifugal liquid Recycled ethanol and concentrating under reduced pressure become the clear paste of certain relative density for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, select certain density ethanol supersound process after, heating and refluxing extraction filters, merging filtrate Recycled ethanol, and concentrating under reduced pressure becomes the clear paste of certain relative density for subsequent use;
(2) after heating and melting becomes glue in proportion with glycerol, gelatin and water, add opacifier, antiseptic, degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, the clear paste of locating to make with above-mentioned (1) mixes, be dried and crushed into dried cream powder after, add dispersant, suspending agent after stirring evenly capsule liquid, the rubber that makes in capsule liquid and (2), compacting, and get final product.
Opacifier among the preparation technology of above-mentioned soft capsule is selected is a kind of or mixture in titanium dioxide, the zinc oxide; Antiseptic is selected is one or more mixture in benzoic acid, sodium benzoate, ethyl hydroxybenzoate, sorbic acid, the potassium sorbate; What dispersant was selected is polyethylene glycols or vegetable oil; Suspending agent is selected is one or more mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
Technical solution of the present invention specifically is prepared from by following steps:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, add the water soaking that 6-12 doubly measures, and behind 40-100HZ supersound process 15-45min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes the alcohol amount of containing be 50%-80%, leave standstill 2000r-4000r centrifugalize behind the 24-48h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that the clear paste of 1.10-1.30 is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, doubly measure the soak with ethanol of 60%-90% with 6-10, and in 40-80HZ supersound process 10-30min, heating and refluxing extraction 2 times, each 1h, filter, the merging filtrate Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that the clear paste of 1.10-1.30 is for subsequent use;
(2) be after 0.3～1.2: 1.0: 1.0～1.8 heating and meltings become glue by weight with glycerol, gelatin and water, adding reaches with glycerol, gelatin, water gross weight than the antiseptic that is 2%～8% than the opacifier that is 1%～3% with glycerol, gelatin, water gross weight, degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, the clear paste of locating to make with above-mentioned (1) mixes, be dried and crushed into dried cream powder after, add dispersant, suspending agent after stirring evenly capsule liquid, capsule liquid and the above-mentioned rubber that makes are suppressed, and be get final product.
Final preferred process of preparing is as follows in the technical solution of the present invention:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.6: 1.0: 1.2 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin and water gross weight are than being 2% titanium dioxide, 5% sodium benzoate, and degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, the clear paste of locating to make with above-mentioned (1) mixes, be dried and crushed into dried cream powder after, add an amount of soybean oil, lecithin stirs evenly to get capsule liquid, the rubber that makes in capsule liquid and (2), compacting, and get final product.
Technical solution of the present invention is in the middle of the research process of reality, and two the patent 02153456.X and 200410022070.3 than in first to file mainly have following creationary useful technique effect:
1. the extraction of medical material and purification research:
A. Chinese medicine preparation of the present invention is comprised of Rhizoma Smilacis Glabrae, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, Radix Saposhnikoviae and Scorpio, its prescription is simplified proper, Rhizoma Gastrodiae and Radix Angelicae Sinensis two flavor medical materials wherein, all contain mass efficient in the water soluble ingredient of headache treating, therefore, first it is carried out water extraction, then select alcohol deposition method, to remove the impurity components such as chlorophyll, polysaccharide, finally reach the concentrated purpose of this extracting section thing effective ingredient height.In addition, we also take into full account the extraction of the pure dissolubility effective ingredient of medical material, and medicinal residues are carried out alcohol extraction with Radix Polygoni Multiflori Preparata, Radix Saposhnikoviae two flavor medical materials, have both reduced operating procedure, can extract as much as possible again the effective ingredient of various different physicochemical properties, also reach simultaneously the effect that improves extraction efficiency.
B. we are in the middle of the research process of invention, chance on need are extracted medical material and pass through ultrasonic pretreatment first after, the extraction ratio of its effective ingredient significantly improves, mainly be because the chemical composition in the medical material that prescription forms, by hyperacoustic cavitation, effect of vibration and heating effect, can be so that the destruction of crude drug cell, thus accelerate release and the stripping of effective ingredient, to be a very large saving to production cost and production capacity like this, finally be of value to the popularization of industrialization.
C. in research process of the present invention, find, the mealiness of rhizoma smilacis glabrae medicinal material is larger, be unfavorable in practice decocting, easily gelatinizing, the difficulty of medical filtration also can strengthen, be used as medicine so we beat powder according to its property entirely with it and Scorpio, can play the effect of " the auxiliary unification of medicine ", embody flexibility ratio and the novelty of Chinese medicine preparation preparation.
2. pharmacodynamic study
Because content of the present invention is to be that the basis of 02153456.X and 200410022070.3 improves at application number, so the contrast of we high spot reviews and these two public technology schemes in pharmacodynamics test.Be the content of the patent of invention file record of 02153456.X and 200410022070.3 according to application number, discovery is in the technical scheme of patent of invention file of 02153456.X at application number, the technical scheme that approaches the most with the technology of the present invention is arranged, namely prescription forms and the identical Chinese medicine preparation preparation technology of recipe quantity, in line with contrast experiment's principle parallel, reasonable, that save, thus finally we to select application number be as a comparison technology of 02153456.X patent document.We bring different must the disturbing of curative effect at the dosage form difference of forgoing under study for action, the two pharmacodynamics difference in the medicinal material extract purifying process is relatively only namely all made the mode that then dried cream powder be mixed with the same concentrations administering medical liquids according to extraction process scheme separately with the two respectively and is compared.We are mainly from analgesia, sedation in the test of pesticide effectiveness, the experiment aspects such as hemorheology and meninges microcirculation are studied, reached science, effectively illustrated the remarkable curative effect of medication of content of the present invention, the useful technique effect that the present invention reaches finally has been described.
2.1 laboratory animal: the Wistar rat, Kunming kind white mice, the male and female dual-purpose, the cleaning level is provided by The Fourth Military Medical University's Experimental Animal Center.
2.2 positive control drug: flunarizine (flunarizine hydrochloride capsules), Xian-Janssen Pharmaceutical Ltd. produces;
XUESAITONG JIAONANG, Wenshan Qihua Co., Ltd., Yunnan Baiyao Pharmaceutical Group produces;
The Qiyeshen an sheet, Hubei Li Shizhen (1518-1593 A.D.) Pharmaceutical Group company limited is produced;
Beam balls all, the Beijing TongrenTang Co., Ltd produces.
2.3 the preparation of Experimental agents group:
A. the preparation of medicine group of the present invention: (1) is got and is ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, the clear paste that makes with two places in above-mentioned (1) mixes, and is dried and crushed into dried cream powder, and is for subsequent use.
B. the preparation of application number 02153456.X medicine group: get Scorpio 30g, Radix Saposhnikoviae 50g, Rhizoma Gastrodiae 150g is ground into fine powder, and is for subsequent use.Other gets Radix Saposhnikoviae 130g, Rhizoma Gastrodiae 120g and Rhizoma Smilacis Glabrae 360g, Radix Polygoni Multiflori Preparata 270g, Radix Angelicae Sinensis 180g, be ground into coarse granule, with 70% alcohol reflux secondary, each 1 hour, filter, merging filtrate, decompression recycling ethanol continues to be condensed into thick paste, gained thick paste and Radix Saposhnikoviae, Scorpio, Rhizoma Gastrodiae fine powder mixing, drying under reduced pressure is pulverized, and is for subsequent use.
The dried cream powder that above-mentioned A, B are prepared gained is mixed with the same concentrations administering medical liquids with distilled water before use.
2.4 analgesic experiment
2.4.1 mice acetic acid is caused the effect of writhing response: 40 of mices, be divided at random 4 groups, be administered once every day, gastric infusion is 5 days continuously, behind last gastric infusion 1h, lumbar injection 0.6% glacial acetic acid 0.2ml/, observe and record the number of times of mouse writhing reaction in the 20min (abdominal part indent, stretching, extension hind leg, buttocks are raised), the results are shown in Table 1.
The analgesic activity of table 1 pair mice acetic acid twisting reaction
Annotate: compare with the normal saline group,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△P＜0.05,
△ △ △P＜0.001.
2.4.2 the impact on mice electricity irritation whipping pain threshold: 40 of mices, be divided at random 4 groups, be administered once every day, and gastric infusion is 5 days continuously, behind last gastric infusion 1h, one electrode is put on the mice foot, another electrode stimulating afterbody, after the energising, the pain threshold when observing the mice whipping, and calculate the analgesia suppression ratio, the results are shown in Table 2.
Analgesia suppression ratio=(administration group pain threshold-matched group pain threshold)/matched group pain threshold * 100%
Table 2 is on the impact of mice electricity irritation whipping pain threshold
Annotate: compare with the normal saline group,
*P＜0.05,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△P＜0.05.
2.4.3 the mice hot plate is stimulated the impact of licking the pain in foot threshold value: get female mice and place (55 ℃ of temperature) on the hot-plate instrument, mice is from placing hot-plate instrument to occurring licking the metapedes required time as the pain threshold of this Mus, allly lick the metapedes time less than 5 seconds or greater than 30 seconds or leaper, be considered as defective animal, give it up.With 40 of qualified mices, be divided at random 4 groups, gastric infusion, continuous three days, once a day, and after the last administration 1 hour, begin to measure the mice pain threshold, the results are shown in Table 3.
Table 3 stimulates the impact of licking the pain in foot threshold value on the mice hot plate
Annotate: compare with the normal saline group,
*P＜0.05,
*P＜0.01,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△ △P＜0.01.
Table 1,2,3 experimental result show, the analgesic effect of medicine group of the present invention and application number 02153456.X medicine group more all has significant difference with the normal saline matched group; Medicine group of the present invention and application number 02153456.X medicine group are relatively, at the mice acetic acid twisting with in the experiment of mice electricity irritation whipping pain threshold significant difference (P＜0.05) is arranged all, stimulating to lick in the experiment of pain in foot threshold value at the mice hot plate has more excellent analgesia trend.
2.5 blood system contrast experiment
2.5.1 on the thrombotic impact of rats in vitro
Get 40 Wistar rats, be divided at random 4 groups by body weight, every group 10, gavage is 5 continuously, every day 1 time, 1h after the administration on the 5th with 3.5% pentobarbital sodium lumbar injection 1ml/100g anesthesia, then separates right common carotid artery and left external jugular vein, tubule (long 10cm) with 2 internal diameter 1mm, be enclosed within on the polyethylene tube of internal diameter 2mm (long 8cm), put 4 trumpeter's art silk threads of a long 5cm in the polyethylene tube, heparin-saline solution (50u/ml) is full of the polyethylene tube chamber, after an end of pipe inserts left external jugular vein, inject heparin 50u/kg from polyethylene tube, clamp tube wall, with the other end insertion right common carotid artery of pipe, after operation is finished, open blood flow, then blood returns left external jugular vein from the right common carotid artery polyethylene tube of flowing through, open blood flow is middle Herba Clinopodii after 15 minutes, take out rapidly silk thread and weigh, it heavily is wet weight of thrombus that gross weight deducts silk thread, the results are shown in Table 4.
Table 4 is on the thrombotic impact of rats in vitro
Annotate: compare with the normal saline group,
*P＜0.01,
* *P＜0.001.
The experimental result demonstration of table 4, the In Vitro Anti thrombosis of medicine group of the present invention and application number 02153456.X medicine group more all has significant difference with the normal saline matched group; Medicine group of the present invention and application number 02153456.X medicine group relatively, though in the thrombotic experiment of rats in vitro there was no significant difference, it has more excellent trend.
2.5.2 the impact on rat platelet aggregation
Get 40 Wistar rats, be divided at random 4 groups by body weight, every group 10, gavage is 5 continuously, every day 1 time, 1h after the administration on the 5th, 3.5% pentobarbital sodium lumbar injection 1ml/100g anesthesia, dorsal position fixing limbs and head separate neck total, intubate is got blood 1.8ml, puts into " platelet aggregation instrument " Special test tube silication and that added in advance the 0.2ml3.8g/L sodium citrate.Begin to survey its platelet aggregation degree, the adenosine diphosphate (ADP) double sodium salt records the platelet maximum agglutination rate of every part of blood sample as derivant by the rule of operation of " QX-200 whole blood aggregometer ", the results are shown in Table 5.
Table 5 is on the impact of rat platelet aggregation
Annotate: compare with the normal saline group,
*P＜0.05,
* *P＜0.001.
The experimental result demonstration of table 5, medicine group of the present invention and application number 02153456.X medicine group more all have significant difference on the impact of rat platelet aggregation with the normal saline matched group; Medicine group of the present invention and application number 02153456.X medicine group compare, though both there was no significant differences, it has more excellent trend.
2.5.3 the impact on cold blood stasis rat hemorheology index
Get 40 Wistar rats, be divided at random 4 groups by body weight, gavage is 7 days continuously, every day 1 time, behind last administration 1h, fixedly rat extremity and head are used 70% alcohol disinfecting respectively, put ice bag around the experimental rat, freezing 1.5h, rewarming 5min in 45 ℃ of warm water, then conventional the raising after 3 days, blood sampling is also surveyed hemorheology numerical value, the results are shown in Table 6 and 7.
Table 6 is on the impact of rat whole blood viscosity
Table 7 is on the impact of hemorheology of rat index
Annotate: compare with the normal saline group,
*P＜0.05,
*P＜0.01,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△P＜0.05.
Table 6 and 7 experimental result show, the whole blood viscosity of medicine group of the present invention and 02153456.X group when middle shear rate with the comparison of normal saline matched group, have significant difference, both compare simultaneously, and medicine group of the present invention has better curative effect than the 02153456.X group in high and low shear rate situation; In addition, compare with application number 02153456.X medicine group, medicine group of the present invention is also having significant difference aspect plasma viscosity and the packed cell volume.
By the 2.5.1-2.5.3 experiment as can be known, medicine of the present invention is evident in efficacy aspect anticoagulant and thrombolytic, has better effect than the 02153456.X group, various acute and chronic blood clotting phenomenons had good inhibitory action, especially with strong points to blood stasis due to the cold coagulation, this is because the blood viscosity increase causes the easily solidifying blood vessel wall that is deposited on part headache morbidity, thereby blocks blood circulation, cause brain or whole body blood supply insufficiency, and the mechanism and the treatment means that cause having a headache match.
2.5.4 the impact on the normal mouse hypoxia endurance time
Get 40 mices, be divided at random 4 groups by body weight, continuously gavage is 5 days, every day 1 time, after the last administration 60 minutes, surveys mice anoxia enduring life span; Test is with 4 of wide mouthed bottles, and volume 200ml adds sodica calx 70g in every bottle, and the above adds a ground stoppered bottle cap, builds bottle cap and timing, stops as index take mouse breathing, and record mice life span (min) the results are shown in Table 8.
Table 8 is on the impact of normal mouse hypoxia-bearing capability
Annotate: compare with the normal saline group,
*P＜0.05,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△ △P＜0.01.
The experimental result of table 8 shows, medicine group of the present invention and 02153456.X group be on the impact of normal mouse hypoxia endurance time, with the normal saline matched group relatively, time that all can the existence of significant prolongation normal mouse, and have significant difference; Both compare simultaneously, and medicine group of the present invention is obviously organized mice life span significant prolongation than 02153456.X, and has significant difference.
2.6 sedation
2.6.1 on pentobarbital sodium above threshold dosage cause the impact of mouse sleep time
Select 40 of mices, be divided at random 4 groups, gastric infusion, continuous three days, once a day, 1 hour began to test after the last administration; Mouse peritoneal is injected pentobarbital sodium solution (55mg/kg), take injection pentobarbital sodium solution at once to righting reflex loss as incubation period, be sleep time righting reflex loss to recovery time, records incubation period and sleep time, the results are shown in Table 9.
Table 9 on pentobarbital sodium above threshold dosage cause the impact of mouse sleep time
Annotate: compare with the normal saline group,
* *P＜0.001;
The experimental result of table 9 shows, medicine group of the present invention and 02153456.X group and normal saline matched group relatively, all without the incubation period of obvious prolongation mice sleep and the effect of the length of one's sleep.
2.6.2 the pentobarbital sodium sub-threshold dose is caused the impact of mice sleep rate
Select 48 of mices, be divided at random 4 groups, gastric infusion, continuous three days, once a day, after the last administration 1 hour, mouse peritoneal is injected pentobarbital sodium solution (35mg/kg), observe and record behind the animal injection pentobarbital sodium solution in 15 minutes, the mice righting reflex loss reaches the Mus number more than 1 minute, calculate the sleep rate, the results are shown in Table 10.
Table 10 causes the impact of mice sleep rate on the pentobarbital sodium sub-threshold dose
Annotate: compare with the normal saline group,
*P＜0.05.
As shown in Table 10, medicine group of the present invention and 02153456.X group and normal saline matched group relatively, on the impact of mice sleep rate there are no significant difference; Results suggest: medicine group of the present invention can not be worked in coordination with the sedative-hypnotic effect of pentobarbital sodium.
By the 2.5.4-2.6.2 experiment as can be known, medicine of the present invention can obviously promote the hypoxia-bearing capability of laboratory animal, do not affect the mental status and the activity of laboratory animal during the simultaneously medication, be that the good oxygen lack resistant function of medicine performance is not to realize by the activity that reduces animal, point out medicine of the present invention without remarkable sedative-hypnotic effect, be applicable to the crowd of duty, and whole curative effect is better than the 02153456.X group.
2.7 on the microcirculatory impact of rat head blood vessel
Select 40 of rats, be divided at random 4 groups, gastric infusion, continuous three days, once a day, after the last administration 1 hour, with 1.00% pentobarbital sodium solution 0.5ml/100g rat abdominal cavity is anaesthetized, after the anesthesia rat ventricumbent position is fixed, cut skin of head, expose parietal bone, puncture with No. 4 pins prior to cerebellum oblongata place, extract cerebrospinal fluid 0.2ml, with Lowering the intracranial hypertension.Then rats with left bone central authorities are windowed with cranial drill, form 0.5cm diameter circular bone hole, with the hemostasis by compression of warm saline cotton balls, cut off at last cerebral dura mater, the pia mater encephali surface is done to be interrupted with 37 ℃ of artificial cerebrospinal fluids and is instiled, with anti-drying.Fixedly rat head is falling to penetrating under the light source, observes with 40 power microscopes, and the top end diameter of maximum blood vessel loop the results are shown in Table 11 near arteriole flow velocity, vein input tap footpath, tremulous pulse output tap footpath, the vein.
Table 11 is on the microcirculatory impact of rat head blood vessel
Annotate: compare with the normal saline group,
*P＜0.05,
*P＜0.01,
* *P＜0.001; Compare with application number 02153456.X medicine group,
△P＜0.05,
△ △P＜0.01.
The experimental result of table 11 shows, medicine group of the present invention and 02153456.X group are in the microcirculatory impact experiment of rat head, impact on arteriole flow velocity, input tap footpath, output tap footpath and loop top diameter more all has significant difference with the normal saline matched group; Simultaneously both compare, and the impact of rat arteriole flow velocity is had significant difference, though on the impact no difference of science of statistics of input tap footpath, output tap footpath and loop top diameter, have and improve preferably microcirculatory trend.This matches with headache part pathogeny and Therapeutic Principle.
Show according to above research contents, the technology of the present invention content is on the basis of application number 02153456.X, and the Chinese medicine preparation of the treatment headache of succeeding in developing in conjunction with the new technique of modern Chinese medicine development, it has steady quality, bioavailability is high, drug action obviously is better than the distinguishing feature of application number 02153456.X, and this will bring for the clinical practice of this invention preparation huge potentiality and development space.
The specific embodiment
Embodiment 1
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.6: 1.0: 1.2 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin and water gross weight are than being 2% titanium dioxide, 5% sodium benzoate, and degasification is made rubber for subsequent use;
(3) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, mixes with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of soybean oil, lecithin stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 2
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 27g, Radix Angelicae Sinensis 18g, the water soaking that adds 6 times of amounts, and behind 100HZ supersound process 15min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 50%, leave standstill 2000r centrifugalize behind the 32h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.10 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 27g, Radix Saposhnikoviae 18g, with the soak with ethanol of 10 times of amounts 60%, and behind 40HZ supersound process 20min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.30 clear paste is for subsequent use;
(2) be after 0.3: 1.0: 1.8 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin, water gross weight are than being 1% titanium dioxide, 8% benzoic acid, and degasification is made rubber for subsequent use;
(3) get Scorpio 3g, Rhizoma Smilacis Glabrae 36g is ground into fine powder, mixes with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of Oleum Ricini, Cera Flava stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 3
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 2700g, Radix Angelicae Sinensis 1800g, the water soaking that adds 12 times of amounts, and behind 40HZ supersound process 45min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 80%, leave standstill 4000r centrifugalize behind the 48h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.30 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 2700g, Radix Saposhnikoviae 1800g, with the soak with ethanol of 6 times of amounts 90%, and behind 80HZ supersound process 10min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.10 clear paste is for subsequent use;
(2) be after 1.2: 1.0: 1.0 heating and meltings become glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin, water gross weight are than being 3% zinc oxide, 2% ethyl hydroxybenzoate, and degasification is made rubber for subsequent use;
(3) get Scorpio 300g, Rhizoma Smilacis Glabrae 3600g is ground into fine powder, mixes with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of Macrogol 4000, aluminum monostearate stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 4
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 40min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 65%, leave standstill 3000r centrifugalize behind the 48h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 8 times of amounts 80%, and behind 80HZ supersound process 10min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.10 clear paste is for subsequent use;
(2) be after 0.8: 1.0: 1.5 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin, water gross weight are than being 2% zinc oxide, 3% sorbic acid, and degasification is made rubber for subsequent use;
(3) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, mixes with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of polyethylene glycol 6000, ethyl cellulose stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 5
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.6: 1.0: 1.2 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin, water gross weight are than being 2% titanium dioxide, 5% potassium sorbate, and degasification is made rubber for subsequent use;
(3) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, mixes with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of PEG400, propylene glycol stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 6
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 6 times of amounts, and behind 100HZ supersound process 15min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 50%, leave standstill 2000r centrifugalize behind the 32h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.10 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 10 times of amounts 60%, and behind 40HZ supersound process 20min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.25 clear paste is for subsequent use;
(2) be after 0.3: 1.0: 1.8 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin and water gross weight are than the zinc oxide that is 2%, adding and glycerol, gelatin and water gross weight are than the sodium benzoate that is 5%: the mixture of ethyl hydroxybenzoate=1: 1, degasification is made rubber for subsequent use;
(3) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), after being dried and crushed into dried cream powder, add an amount of Macrogol 2000, lecithin: the mixture of propylene glycol=2: 1 stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Embodiment 7
(1) gets and be ground into coarse grained Rhizoma Gastrodiae 270g, Radix Angelicae Sinensis 180g, the water soaking that adds 10 times of amounts, and behind 100HZ supersound process 15min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.10 clear paste is for subsequent use; Medicinal residues add Radix Polygoni Multiflori Preparata 270g, Radix Saposhnikoviae 180g, with the soak with ethanol of 10 times of amounts 75%, and behind 60HZ supersound process 20min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.5: 1.0: 1.6 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin, water gross weight are than the zinc oxide that is 2%: the mixture of titanium dioxide=1: 2, adding and glycerol, gelatin, water gross weight are than the benzoic acid that is 6%: the mixture of sorbic acid=1: 2, degasification is made rubber for subsequent use;
(3) get Scorpio 30g, Rhizoma Smilacis Glabrae 360g is ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), after being dried and crushed into dried cream powder, add an amount of soybean oil, Cera Flava: the mixture of ethyl cellulose=2: 1 stirs evenly to get capsule liquid, capsule liquid and the above-mentioned rubber that makes, compacting, and get final product.
Claims (9)
1. Chinese medicinal soft capsule agent for the treatment of headache is characterized in that it is to be prepared from by following technique:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, add the water soaking that 6-12 doubly measures, and behind 40-100HZ supersound process 15-45min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes the alcohol amount of containing be 50%-80%, leave standstill 2000r-4000r centrifugalize behind the 24-48h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that the clear paste of 1.10-1.30 is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, doubly measure the soak with ethanol of 60%-90% with 6-10, and in 40-80HZ supersound process 10-30min, heating and refluxing extraction 2 times, each 1h, filter, the merging filtrate Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that the clear paste of 1.10-1.30 is for subsequent use;
(2) after heating and melting becomes glue in proportion with glycerol, gelatin and water, add opacifier, antiseptic, degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, after stirring evenly, adding dispersant, suspending agent get capsule liquid, the rubber that makes in capsule liquid and (2), compacting namely gets soft capsule.
2. the Chinese medicinal soft capsule agent for the treatment of headache as claimed in claim 1 is characterized in that it is to be prepared from by following technique:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ and concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) after heating and melting becomes glue in proportion with glycerol, gelatin and water, add opacifier, antiseptic, degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, after stirring evenly, adding dispersant, suspending agent get capsule liquid, the rubber that makes in capsule liquid and (2), compacting namely gets soft capsule.
3. the Chinese medicinal soft capsule agent for the treatment of headache as claimed in claim 2 is characterized in that it is to be prepared from by following technique:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.3～1.2: 1.0: 1.0～1.8 heating and meltings become glue by weight with glycerol, gelatin and water, adding reaches with glycerol, gelatin and water gross weight than the antiseptic that is 2%～8% than the opacifier that is 1%～3% with glycerol, gelatin and water gross weight, degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of vegetable oil, lecithin stirs evenly to get capsule liquid, the rubber that makes in capsule liquid and (2), compacting namely gets soft capsule.
4. the Chinese medicinal soft capsule agent for the treatment of headache as claimed in claim 3 is characterized in that it is to be prepared from by following technique:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.6: 1.0: 1.2 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin and water gross weight are than being 2% titanium dioxide, 5% sodium benzoate, and degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of soybean oil, lecithin stirs evenly to get capsule liquid, the rubber that makes in capsule liquid and (2), compacting namely gets soft capsule.
5. such as the Chinese medicinal soft capsule agent of the described treatment of the arbitrary claim of claim 1-3 headache, it is characterized in that opacifier selects one or both the mixture in titanium dioxide, the zinc oxide.
6. such as the Chinese medicinal soft capsule agent of the described treatment of the arbitrary claim of claim 1-3 headache, it is characterized in that antiseptic selects one or more the mixture in benzoic acid, sodium benzoate, ethyl hydroxybenzoate, sorbic acid, the potassium sorbate.
7. such as the Chinese medicinal soft capsule agent of the described treatment of the arbitrary claim of claim 1-3 headache, it is characterized in that dispersant selects polyethylene glycols or vegetable oil.
8. such as the Chinese medicinal soft capsule agent of the described treatment of the arbitrary claim of claim 1-3 headache, it is characterized in that suspending agent selects one or more the mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
9. the preparation technology of the Chinese medicinal soft capsule agent for the treatment of as claimed in claim 1 headache is characterized in that it is to be prepared from by following step:
(1) gets and be ground into 270 parts in coarse grained Rhizoma Gastrodiae, 180 parts of Radix Angelicae Sinensis, the water soaking that adds 8 times of amounts, and behind 80HZ supersound process 30min, heating extraction 2 times, each 1h filters, merging filtrate also adds ethanol and makes that to contain alcohol amount be 70%, leave standstill 3000r centrifugalize behind the 24h, the centrifugal liquid Recycled ethanol, and to become relative density in 60 ℃ of concentrating under reduced pressure be that 1.20 clear paste is for subsequent use; Medicinal residues add 270 parts of Radix Polygoni Multiflori Preparatas, 180 parts of Radix Saposhnikoviaes, with the soak with ethanol of 8 times of amounts 75%, and behind 60HZ supersound process 30min, heating and refluxing extraction 2 times, each 1h filters, the merging filtrate Recycled ethanol, and to be evaporated to relative density in 60 ℃ be that 1.20 clear paste is for subsequent use;
(2) be after 0.6: 1.0: 1.2 heating and melting becomes glue by weight with glycerol, gelatin and water, adding and glycerol, gelatin and water gross weight are than being 2% titanium dioxide, 5% sodium benzoate, and degasification is made rubber for subsequent use;
(3) get 360 parts of 30 parts of Scorpios, Rhizoma Smilacis Glabrae and be ground into fine powder, mix with the prepared clear paste in two places in above-mentioned (1), be dried and crushed into dried cream powder after, add an amount of soybean oil, lecithin stirs evenly to get capsule liquid, the rubber that makes in capsule liquid and (2), compacting, and get final product.
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| CN107349218A (en) * | 2017-08-15 | 2017-11-17 | 河南奕运医药科技有限公司 | A kind of external spray nose medicament of rapid recovery headache toothache and preparation method thereof |
| CN111282558A (en) * | 2018-12-10 | 2020-06-16 | 卢羿甄 | Photocatalyst and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1418681A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine compositions for treating head-ache, and its prepn. method |
| CN1562182A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Preparation of Chinese traditional medicine for curing headache and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1418681A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine compositions for treating head-ache, and its prepn. method |
| CN1562182A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Preparation of Chinese traditional medicine for curing headache and preparation method |
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