CN119751489A - 克立硼罗游离形式的晶型及其制备方法和用途 - Google Patents

克立硼罗游离形式的晶型及其制备方法和用途 Download PDF

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Publication number
CN119751489A
CN119751489A CN202411806904.3A CN202411806904A CN119751489A CN 119751489 A CN119751489 A CN 119751489A CN 202411806904 A CN202411806904 A CN 202411806904A CN 119751489 A CN119751489 A CN 119751489A
Authority
CN
China
Prior art keywords
crisaborole
free form
crystalline form
solvent
ray powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202411806904.3A
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English (en)
Chinese (zh)
Inventor
陈敏华
张炎锋
陆飞
夏楠
张晓宇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anakol Pharmaceutical Co ltd
Original Assignee
Anakol Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60266671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN119751489(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anakol Pharmaceutical Co ltd filed Critical Anakol Pharmaceutical Co ltd
Publication of CN119751489A publication Critical patent/CN119751489A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202411806904.3A 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途 Pending CN119751489A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2016103018326 2016-05-09
CN201610301832 2016-05-09
CN201780009362.9A CN108884111A (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途
PCT/CN2017/083631 WO2017193914A1 (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780009362.9A Division CN108884111A (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途

Publications (1)

Publication Number Publication Date
CN119751489A true CN119751489A (zh) 2025-04-04

Family

ID=60266671

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202411806904.3A Pending CN119751489A (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途
CN201780009362.9A Pending CN108884111A (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780009362.9A Pending CN108884111A (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途

Country Status (13)

Country Link
US (1) US11773113B2 (enExample)
EP (1) EP3456722B1 (enExample)
JP (3) JP2019520321A (enExample)
KR (1) KR102221472B1 (enExample)
CN (2) CN119751489A (enExample)
AU (1) AU2017262235C1 (enExample)
BR (1) BR112018073017B1 (enExample)
CA (1) CA3023851C (enExample)
IL (1) IL262878A (enExample)
MX (1) MX380022B (enExample)
SG (1) SG11201809984PA (enExample)
WO (1) WO2017193914A1 (enExample)
ZA (1) ZA201807892B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10329311B1 (en) * 2017-12-21 2019-06-25 Olon S.P.A. Process for the preparation of crisaborole
PL3737685T3 (pl) * 2018-01-09 2023-10-02 Halcyon Labs Private Limited Sposób wytwarzania kryzaborolu i jego związków pośrednich
US10597410B2 (en) 2018-02-02 2020-03-24 Dipharma Francis S.R.L. Intermediates and process for the preparation of a crystalline form of a topical anti-inflammatory agent
CN110780005B (zh) * 2019-11-14 2022-07-29 江苏海岸药业有限公司 一种克立硼罗原料及其合成中间体的分析方法
CN111983123A (zh) * 2020-08-14 2020-11-24 江苏海岸药业有限公司 用于治疗皮肤疾病的克立硼罗制剂的体外评价方法
CN112375093A (zh) * 2020-11-13 2021-02-19 江苏知原药业股份有限公司 一种克立硼罗晶型化合物及其制备方法
CN113087733A (zh) * 2021-04-06 2021-07-09 南京科默生物医药有限公司 克立硼罗的晶型a、晶型b、晶型c、晶型d、晶型e及其制备方法
WO2024047571A1 (en) * 2022-09-01 2024-03-07 Savoi Guilherme Crisaborole cocrystal derivatives
CN115417890A (zh) * 2022-09-24 2022-12-02 中山万远新药研发有限公司 克立硼罗的新晶型及其制备方法与用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN191496B (enExample) * 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
GB2383042A (en) * 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
CA2597982C (en) 2005-02-16 2014-07-08 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
KR20080110984A (ko) 2005-12-30 2008-12-22 아나코르 파마슈티칼스 인코포레이티드 보론함유 소분자
CN101505603A (zh) * 2005-12-30 2009-08-12 安纳考尔医药公司 含硼的小分子
RS54108B1 (sr) * 2006-02-16 2015-12-31 Anacor Pharmaceuticals Inc. Mali molekuli koji sadrže boron kao agensi protiv zapaljenja
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
US20070286822A1 (en) 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
EP2564857B1 (en) * 2008-03-06 2017-05-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
DK3383363T3 (da) * 2015-11-30 2021-01-18 Anacor Pharmaceuticals Inc Topiske farmaceutiske formuleringer til behandling af inflammatorisk-relaterede tilstande
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor

Also Published As

Publication number Publication date
AU2017262235C1 (en) 2020-08-20
BR112018073017A2 (pt) 2019-02-19
US11773113B2 (en) 2023-10-03
EP3456722B1 (en) 2025-12-10
EP3456722A4 (en) 2019-12-18
WO2017193914A1 (zh) 2017-11-16
JP2019520321A (ja) 2019-07-18
SG11201809984PA (en) 2018-12-28
JP2021167327A (ja) 2021-10-21
KR102221472B1 (ko) 2021-03-02
NZ748385A (en) 2022-03-25
MX380022B (es) 2025-03-11
KR20190005195A (ko) 2019-01-15
JP2023116645A (ja) 2023-08-22
IL262878A (en) 2018-12-31
BR112018073017B1 (pt) 2022-06-14
RU2018142490A (ru) 2020-06-10
MX2018013742A (es) 2019-08-01
CA3023851A1 (en) 2017-11-16
RU2018142490A3 (enExample) 2020-06-10
NZ786020A (en) 2025-06-27
EP3456722A1 (en) 2019-03-20
US20230234974A1 (en) 2023-07-27
AU2017262235A1 (en) 2018-12-06
AU2017262235B2 (en) 2019-09-19
ZA201807892B (en) 2021-06-30
CA3023851C (en) 2021-01-26
CN108884111A (zh) 2018-11-23

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