AU2017262235C1 - Crystal forms of crisaborole in free form and preparation method and use thereof - Google Patents

Crystal forms of crisaborole in free form and preparation method and use thereof Download PDF

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Publication number
AU2017262235C1
AU2017262235C1 AU2017262235A AU2017262235A AU2017262235C1 AU 2017262235 C1 AU2017262235 C1 AU 2017262235C1 AU 2017262235 A AU2017262235 A AU 2017262235A AU 2017262235 A AU2017262235 A AU 2017262235A AU 2017262235 C1 AU2017262235 C1 AU 2017262235C1
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AU
Australia
Prior art keywords
crystal form
crisaborole
crystal
free form
solvent
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AU2017262235A
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English (en)
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AU2017262235B2 (en
AU2017262235A1 (en
Inventor
Minhua Chen
Fei Lu
Nan Xia
Xiaoyu Zhang
Yanfeng Zhang
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Anacor Pharmaceuticals LLC
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Anacor Pharmaceuticals LLC
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Application filed by Anacor Pharmaceuticals LLC filed Critical Anacor Pharmaceuticals LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AU2017262235A 2016-05-09 2017-05-09 Crystal forms of crisaborole in free form and preparation method and use thereof Active AU2017262235C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610301832 2016-05-09
CN201610301832.6 2016-05-09
PCT/CN2017/083631 WO2017193914A1 (zh) 2016-05-09 2017-05-09 克立硼罗游离形式的晶型及其制备方法和用途

Publications (3)

Publication Number Publication Date
AU2017262235A1 AU2017262235A1 (en) 2018-12-06
AU2017262235B2 AU2017262235B2 (en) 2019-09-19
AU2017262235C1 true AU2017262235C1 (en) 2020-08-20

Family

ID=60266671

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017262235A Active AU2017262235C1 (en) 2016-05-09 2017-05-09 Crystal forms of crisaborole in free form and preparation method and use thereof

Country Status (13)

Country Link
US (1) US11773113B2 (enExample)
EP (1) EP3456722B1 (enExample)
JP (3) JP2019520321A (enExample)
KR (1) KR102221472B1 (enExample)
CN (2) CN108884111A (enExample)
AU (1) AU2017262235C1 (enExample)
BR (1) BR112018073017B1 (enExample)
CA (1) CA3023851C (enExample)
IL (1) IL262878A (enExample)
MX (1) MX380022B (enExample)
SG (1) SG11201809984PA (enExample)
WO (1) WO2017193914A1 (enExample)
ZA (1) ZA201807892B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10329311B1 (en) * 2017-12-21 2019-06-25 Olon S.P.A. Process for the preparation of crisaborole
BR112020013794B1 (pt) * 2018-01-09 2023-05-02 Halcyon Labs Private Limited Processo para a preparação de crisaborola de fórmula (i), compostos, uso de um composto de fórmula (iv), (iii) ou (ii), processo para a preparação de crisaborola altamente pura e sal
US10597410B2 (en) 2018-02-02 2020-03-24 Dipharma Francis S.R.L. Intermediates and process for the preparation of a crystalline form of a topical anti-inflammatory agent
CN110780005B (zh) * 2019-11-14 2022-07-29 江苏海岸药业有限公司 一种克立硼罗原料及其合成中间体的分析方法
CN111983123A (zh) * 2020-08-14 2020-11-24 江苏海岸药业有限公司 用于治疗皮肤疾病的克立硼罗制剂的体外评价方法
CN112375093A (zh) * 2020-11-13 2021-02-19 江苏知原药业股份有限公司 一种克立硼罗晶型化合物及其制备方法
CN113087733A (zh) * 2021-04-06 2021-07-09 南京科默生物医药有限公司 克立硼罗的晶型a、晶型b、晶型c、晶型d、晶型e及其制备方法
WO2024047571A1 (en) * 2022-09-01 2024-03-07 Savoi Guilherme Crisaborole cocrystal derivatives
CN115417890A (zh) * 2022-09-24 2022-12-02 中山万远新药研发有限公司 克立硼罗的新晶型及其制备方法与用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007095638A2 (en) * 2006-02-16 2007-08-23 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN191496B (enExample) * 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
GB2383042A (en) * 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
HUE026021T2 (en) * 2005-02-16 2016-05-30 Anacor Pharmaceuticals Inc Biocidal boron phthalide (boronophthalide) compounds
CN106008583A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
CN101505603A (zh) * 2005-12-30 2009-08-12 安纳考尔医药公司 含硼的小分子
US20070286822A1 (en) 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
KR101672511B1 (ko) * 2008-03-06 2016-11-03 아나코르 파마슈티칼스 인코포레이티드 소염제로써 붕소가 함유된 소분자
PL3383363T3 (pl) * 2015-11-30 2021-05-31 Anacor Pharmaceuticals, Inc. Preparaty farmaceutyczne do stosowania miejscowego do leczenia stanów związanych z zapaleniem
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007095638A2 (en) * 2006-02-16 2007-08-23 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease

Also Published As

Publication number Publication date
CN119751489A (zh) 2025-04-04
IL262878A (en) 2018-12-31
NZ786020A (en) 2025-06-27
EP3456722B1 (en) 2025-12-10
WO2017193914A1 (zh) 2017-11-16
BR112018073017B1 (pt) 2022-06-14
BR112018073017A2 (pt) 2019-02-19
CA3023851C (en) 2021-01-26
JP2023116645A (ja) 2023-08-22
RU2018142490A3 (enExample) 2020-06-10
ZA201807892B (en) 2021-06-30
CA3023851A1 (en) 2017-11-16
MX2018013742A (es) 2019-08-01
CN108884111A (zh) 2018-11-23
US20230234974A1 (en) 2023-07-27
US11773113B2 (en) 2023-10-03
EP3456722A4 (en) 2019-12-18
SG11201809984PA (en) 2018-12-28
NZ748385A (en) 2022-03-25
AU2017262235B2 (en) 2019-09-19
JP2021167327A (ja) 2021-10-21
EP3456722A1 (en) 2019-03-20
RU2018142490A (ru) 2020-06-10
KR20190005195A (ko) 2019-01-15
KR102221472B1 (ko) 2021-03-02
MX380022B (es) 2025-03-11
AU2017262235A1 (en) 2018-12-06
JP2019520321A (ja) 2019-07-18

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 23 APR 2020

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 23 APR 2020

HB Alteration of name in register

Owner name: ANACOR PHARMACEUTICALS, LLC

Free format text: FORMER NAME(S): ANACOR PHARMACEUTICALS, INC.