CN1196778C - 消毒型条皂 - Google Patents

消毒型条皂 Download PDF

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CN1196778C
CN1196778C CNB971994749A CN97199474A CN1196778C CN 1196778 C CN1196778 C CN 1196778C CN B971994749 A CNB971994749 A CN B971994749A CN 97199474 A CN97199474 A CN 97199474A CN 1196778 C CN1196778 C CN 1196778C
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soap bar
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antiseptic soap
soap
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戴维·诺曼·佩恩
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Reckitt Benckiser Healthcare UK Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
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    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D9/00—Compositions of detergents based essentially on soap
    • C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
    • C11D9/22—Organic compounds, e.g. vitamins
    • C11D9/28—Organic compounds, e.g. vitamins containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract

一种消毒型条皂包含：a)0.35%至0.75%重量百分比具有消毒活性的带有氯和甲基取代基的苯酚；b)0.15%至0.25%重量百分比三氯羟基二苯醚(或其一种盐)；和c)低于0.05%重量百分比的EDTA螯合剂。

Description

消毒型条皂
技术领域
本发明涉及一种具有消毒活性的条皂，特别是关于一种具有较低含量螯合剂的条皂。
背景技术
世界各国都生产很多所谓的药皂产品，其中多数仍以条皂形式销售。这种产品如果含有一种或多种杀菌剂，则通常被称为消毒型皂；尽管其在使用中的实际功效并不显著。
这样，很多产品就含有高于需要量的杀菌剂(导致成本增加和不必要的浪费)或其含量在使用中没有实际功效。
众所周知，使用螯合剂可以改进多种杀菌剂的活性，而厂家经常在消毒型皂这种产品中不加鉴别地使用此类化学剂。
实际上，螯合剂通常被用作皂基的稳定剂，并且在成品皂的制造过程中再添加一次，因为厂家相信螯合剂能提高杀菌剂的活性。
但是，使用螯合剂也有很多缺点，主要是其成本过高，螯合剂还有可能成为刺激剂，且对环境有影响(例如螯合剂对河流中的生物等的影响)。
因此，市场对具有良好的和可测量的消毒剂活性、但使用尽可能最低含量的杀菌剂和螯合剂的条皂产品一直有需求。
发明内容
我们现在发现，在条皂中活性剂的一种特定组合能在不使用高含量EDTA螯合剂的前提下产生令人满意的杀菌活性(包括对皮肤的显著作用)。
因此，本发明提供了一种消毒型条皂，其包含：
a)0.35％至0.75％(重量百分比)具有杀菌活性的带有氯和甲基取代基的苯酚；
b)0.15％至0.25％(重量百分比)三氯羟基二苯醚(或其盐)；和
c)低于0.075％(最好是低于0.05％)(重量百分比)EDTA螯合剂。
除包含在皂基中作为稳定剂的以外，本发明的消毒型条皂最好不含有螯合剂。
可作为本发明消毒型条皂的皂基稳定剂的螯合剂包括EDTA(乙二胺四乙酸及其可溶性盐)。本发明消毒型条皂最好含有低于0.05％(重量百分比)的EDTA，EDTA的最佳浓度为约0.025％(重量百分比)。
本发明消毒型条皂所使用的具有杀菌活性的带有氯和甲基取代基的苯酚最好是具有式I的化合物
Figure C9719947400051
其中：R1是氯或氢，和
R2是甲基或氢。
优选的式I化合物包括PCMC(4-氯代-3-甲基苯酚)、PCMX(4-氯代-3，5-二甲基苯酚)、DCMX(2，4-二氯代3，5-二甲基苯酚)或其混合物。
本发明消毒型条皂最好含有0.4％至0.6％(重量百分比)的式I化合物，而更优选的为约0.5％。
本发明消毒型条皂最好含有约0.2％(重量百分比)的三氯羟基二苯醚(2-羟基-4，2′，4′-三氯代二苯醚)或其盐。
本发明消毒型条皂还含有常规皂基，这种皂基通常含有衍生自天然物质的皂化脂肪酸。适合的皂基实例包括牛油与椰子油脂肪酸以80∶20的比例配成的混合物或蒸馏出来的棕榈油脂肪酸与蒸馏出来的棕榈核脂肪酸以80∶20的比例配成的混合物。如上所述，皂基还可进一步含有作为稳定剂的螯合剂或，但该螯合剂的总含量最好不超过0.05％(重量百分比)，EDTA的总含量优选不超过0.025％(重量百分比)。皂基还可进一步含有作为稳定剂的双(1-羟基亚乙基)磷酸。
本发明消毒型条皂还可进一步含有增色剂和芳香剂(如松树油)等常规添加剂。
本发明消毒型条皂可采用任何的常规方法制造，如各种组分在料斗中混合，经过轧制研磨、挤出、切割和打印，成为最终的形状。
具体实施方式
下面举例对本发明进行说明。
实例1
按照以下配比制造消毒型条皂：
                           ％(重量百分比)
PCMX                       0.5
三氯羟基二苯醚             0.2
松树油(芳香剂)             1.5
增色剂*                    0.12
水*                        0.13
DFA皂片                    至100％
DFA皂片：
从棕榈油中蒸馏出的脂肪酸80+/-3％
从棕榈核油中蒸馏出的脂肪酸20+/-3％
添加剂：EDTA四钠盐0.025％。
此外，添加作为稳定剂的EHDP[双(1-羟基亚乙基)磷酸]，含量为0.2％。
*增色剂和水预先混合，作为增色溶液。
将上述各组分放入料斗中混合，然后将其在室温和常压下进行轧制，混合从轧机出来后仍在室温下进入压条机(挤压机)，从挤压机出来后被切割和打印成需要的形状。
这种条皂具有良好的消毒活性，且对皮肤的作用是显著的。
实例2
本发明条皂的直接活性可通过以下实验得到证明。
在标准硬水中溶解一块牛油皂基，制成标准皂溶液，使其浓度为8％(与洗手时的泡沫浓度基本相同)。制备好三种溶液，每种溶液中含0.04％(重量百分比)的PCMX(相当于在条皂中含0.5％)和分别含0.008％、0.016％或0.024％(重量百分比)的三氯羟基二苯醚(相当于条皂中含0.1％、0.2％和0.3％)。
请志愿者把一只手指浸入盛满胰化胨豆琼脂的盘子中心，经过30秒钟后，用5毫升上述溶液之一洗手1分钟，用清水冲洗干净，然后再把手指浸润到一个琼脂盘子中。
然后用含有金黄色葡萄球菌或大肠杆菌的悬浮液擦拭琼脂盘子，把盘子放在30℃的温度下进行隔夜孕育。第二天对盘子进行检查，察看是否存在抑制区。
在上述实验中，未经洗涤的手和在相当于0.1％(重量百分比)的三氯羟基二苯醚的皂的溶液中洗涤过的手均未产生抑制区；这表明没有对皮肤产生直接作用。
在上述实验中，在相当于含有0.2％或0.3％(重量百分比)三氯羟基二苯醚的皂溶液中洗涤过的手均产生明显的抑制区；这表明对皮肤有直接的杀菌效果。
这表明，三氯羟基二苯醚的浓度必须高于0.1％(重量百分比)才能制成具有直接消毒活性的条皂，而三氯羟基二苯醚的浓度不必超过0.2％(重量百分比)(即使不添加EDTA)。

Claims (9)

1、一种消毒型条皂，其包含有：
a)0.35％至0.75％重量百分比的具有杀菌活性的带有氯和甲基取代基的苯酚，其由下列式(I)表示：
其中：
R1是氯或氢，和
R2是甲基或氢；
b)0.15％至0.25％重量百分比的三氯羟基二苯醚或其盐；和
c)低于0.05％重量百分比的EDTA螯合剂或其可溶性盐。
2、如权利要求1所述的一种消毒型条皂，其中所述的条皂还含有作为稳定剂的双(1-羟基亚乙基)磷酸。
3、如权利要求1所述的一种消毒型条皂，其中EDTA的浓度为0.025％重量百分比。
4、如权利要求1所述的一种消毒型条皂，其中式(I)的化合物是选自4-氯代-3-甲基苯酚、4-氯代-3，5-二甲基苯酚、2，4-二氯代-3，5-二甲基苯酚或它们的混合物。
5、如权利要求1所述的一种消毒型条皂，其包含0.4％至0.6％重量百分比的式(I)的化合物。
6、如权利要求5所述的一种消毒型条皂，其包含0.5％重量百分比的式(I)的化合物。
7、如权利要求1所说的一种消毒型条皂，其含有0.2％重量百分比的2-羟基-4，2’，4’-三氯代二苯醚或其盐。
8、如权利要求1所说的一种消毒型条皂，其中皂基含有从天然物质中衍生的皂化脂肪酸。
9、如权利要求8所说的一种消毒型条皂，其中形成皂基的脂肪酸是牛油与椰子油脂肪酸以80∶20的比例配成的混合物，或是蒸馏出来的棕榈油脂肪酸与蒸馏出来的棕榈核脂肪酸以80∶20的比例配成的混合物。
CNB971994749A 1996-11-09 1997-09-26 消毒型条皂 Expired - Lifetime CN1196778C (zh)

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KR20050072899A (ko) * 2004-01-07 2005-07-12 주식회사 엘지생활건강 항균비누 조성물
DE102008004890A1 (de) * 2008-01-17 2009-07-23 Lanxess Deutschland Gmbh Verfahren zur Einarbeitung antimikrobieller Produkte in Seifenmassen
CN102186341B (zh) 2008-10-20 2013-12-25 荷兰联合利华有限公司 抗菌组合物
EA019746B1 (ru) 2009-09-24 2014-05-30 Юнилевер Нв Противомикробная композиция, содержащая эвгенол, терпинеол и тимол, и способ дезинфицирования поверхности
CN101731213B (zh) * 2009-12-18 2013-08-07 江苏省河浪生物科技有限公司 消毒防霉液的生产工艺
EA022986B1 (ru) 2010-12-07 2016-04-29 Юнилевер Нв Композиция для ухода за полостью рта
CN103998011B (zh) 2011-11-03 2016-11-23 荷兰联合利华有限公司 个人清洁组合物
WO2014037167A1 (en) * 2012-09-07 2014-03-13 Unilever N.V. Soap composition
CN111286426B (zh) * 2019-12-24 2021-01-15 纳爱斯浙江科技有限公司 一种中性皂基易漂洗型液体洗涤剂组合物

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US3968210A (en) * 1973-06-18 1976-07-06 Ciba-Geigy Corporation Synergistic germicidal compositions containing 3,5-dimethyl-4-chlorophenol
US4326978A (en) * 1979-11-16 1982-04-27 Ciba-Geigy Corporation Soap bar with antimicrobial action
US5698475A (en) * 1996-05-28 1997-12-16 Dotolo Research Corporation Cleaner impregnated towel

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GB9721108D0 (en) 1997-12-03
EP0937131A1 (en) 1999-08-25
AU4467197A (en) 1998-06-03
GB2319181A (en) 1998-05-20
BR9712926A (pt) 1999-12-07
AU726203B2 (en) 2000-11-02
CN1236387A (zh) 1999-11-24
ATE198619T1 (de) 2001-01-15
JP2001504153A (ja) 2001-03-27
ZA979898B (en) 1998-06-01
KR20000053143A (ko) 2000-08-25
AR010284A1 (es) 2000-06-07
FR2755698B1 (fr) 2002-03-01
ID21518A (id) 1999-06-24
DE69703895T2 (de) 2001-05-23
IN185463B (zh) 2001-01-27
NZ335326A (en) 2000-10-27
FR2755698A1 (fr) 1998-05-15
GB9623377D0 (en) 1997-01-08
CA2270594A1 (en) 1998-05-22
ES2153689T3 (es) 2001-03-01
WO1998021306A1 (en) 1998-05-22
DE69703895D1 (de) 2001-02-15
ITTO970975A1 (it) 1999-05-07

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