CN119613509A - 因子h结合蛋白变体及其使用方法 - Google Patents

因子h结合蛋白变体及其使用方法 Download PDF

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Publication number
CN119613509A
CN119613509A CN202411821930.3A CN202411821930A CN119613509A CN 119613509 A CN119613509 A CN 119613509A CN 202411821930 A CN202411821930 A CN 202411821930A CN 119613509 A CN119613509 A CN 119613509A
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CN
China
Prior art keywords
fhbp
amino acid
variant
substitution
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202411821930.3A
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English (en)
Chinese (zh)
Inventor
P·T·比尔宁克
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Childrens Hospital Oakland Research Center
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Childrens Hospital Oakland Research Center
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Application filed by Childrens Hospital Oakland Research Center filed Critical Childrens Hospital Oakland Research Center
Publication of CN119613509A publication Critical patent/CN119613509A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202411821930.3A 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法 Pending CN119613509A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462028123P 2014-07-23 2014-07-23
US62/028,123 2014-07-23
PCT/US2015/041616 WO2016014719A1 (en) 2014-07-23 2015-07-22 Factor h binding protein variants and methods of use thereof
CN201580043542.XA CN106715464B (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580043542.XA Division CN106715464B (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法

Publications (1)

Publication Number Publication Date
CN119613509A true CN119613509A (zh) 2025-03-14

Family

ID=55163727

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202411821930.3A Pending CN119613509A (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法
CN201580043542.XA Active CN106715464B (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法
CN202110192031.1A Pending CN112851768A (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201580043542.XA Active CN106715464B (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法
CN202110192031.1A Pending CN112851768A (zh) 2014-07-23 2015-07-22 因子h结合蛋白变体及其使用方法

Country Status (15)

Country Link
US (10) US10266572B2 (https=)
EP (2) EP4074726A3 (https=)
JP (4) JP6796057B2 (https=)
KR (2) KR102761870B1 (https=)
CN (3) CN119613509A (https=)
AU (5) AU2015292615B2 (https=)
BR (1) BR112017001417B1 (https=)
CA (2) CA3212723A1 (https=)
CO (1) CO2017000558A2 (https=)
CR (1) CR20170020A (https=)
ES (1) ES2922554T3 (https=)
MX (3) MX382409B (https=)
NZ (2) NZ766005A (https=)
RU (1) RU2714248C2 (https=)
WO (1) WO2016014719A1 (https=)

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TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物
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CO2017000558A2 (es) 2017-06-20
AU2025202774A1 (en) 2025-05-08
US12129282B2 (en) 2024-10-29
CN106715464A (zh) 2017-05-24
US20250136648A1 (en) 2025-05-01
AU2019264600A1 (en) 2019-12-05
BR112017001417B1 (pt) 2023-11-07
KR102752259B1 (ko) 2025-01-13
EP3172224B1 (en) 2022-06-29
CR20170020A (es) 2017-08-10
NZ766003A (en) 2024-01-26
JP7719046B2 (ja) 2025-08-05
US20170183384A1 (en) 2017-06-29
JP6796057B2 (ja) 2020-12-02
WO2016014719A1 (en) 2016-01-28
US12269849B2 (en) 2025-04-08
CN106715464B (zh) 2021-03-16
CN112851768A (zh) 2021-05-28
CA3212723A1 (en) 2016-01-28
MX2017001038A (es) 2018-02-09
US20200109179A1 (en) 2020-04-09
MX2023000204A (es) 2023-02-09
MX382409B (es) 2025-03-13
EP3172224A1 (en) 2017-05-31
US20240101610A1 (en) 2024-03-28
AU2019264600B2 (en) 2021-04-01
US20190225655A1 (en) 2019-07-25
US10836799B2 (en) 2020-11-17
KR20170028442A (ko) 2017-03-13
US20240025951A1 (en) 2024-01-25
RU2020105192A (ru) 2020-02-12
AU2015292615B2 (en) 2019-10-24
US11834476B2 (en) 2023-12-05
RU2017104742A (ru) 2018-08-29
KR102761870B1 (ko) 2025-02-05
RU2714248C2 (ru) 2020-02-13
EP4074726A2 (en) 2022-10-19
US20210340191A1 (en) 2021-11-04
EP4074726A3 (en) 2022-11-23
US10487122B2 (en) 2019-11-26
KR20230155595A (ko) 2023-11-10
JP7221917B2 (ja) 2023-02-14
NZ766444A (en) 2024-01-26
ES2922554T3 (es) 2022-09-16
CA2955802C (en) 2023-10-31
US20200095288A1 (en) 2020-03-26
AU2025202774A9 (en) 2026-03-05
EP3172224A4 (en) 2018-04-18
AU2021203828B2 (en) 2023-04-13
JP2023011916A (ja) 2023-01-24
AU2015292615A1 (en) 2017-03-16
RU2017104742A3 (https=) 2019-02-27
NZ729206A (en) 2022-07-01
AU2023204391A1 (en) 2023-08-03
US10995122B2 (en) 2021-05-04
JP2025108722A (ja) 2025-07-23
NZ766005A (en) 2024-03-22
BR112017001417A2 (pt) 2017-11-21
MX2021005373A (es) 2021-07-06
JP2021000121A (ja) 2021-01-07
US20250154206A1 (en) 2025-05-15
CA2955802A1 (en) 2016-01-28
US11673920B2 (en) 2023-06-13
US10266572B2 (en) 2019-04-23
AU2023204391B2 (en) 2025-01-23
AU2021203828A1 (en) 2021-07-08
JP2017522877A (ja) 2017-08-17
US20210101942A1 (en) 2021-04-08

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