CN1195546C - 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途 - Google Patents

结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途 Download PDF

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Publication number
CN1195546C
CN1195546C CNB988064413A CN98806441A CN1195546C CN 1195546 C CN1195546 C CN 1195546C CN B988064413 A CNB988064413 A CN B988064413A CN 98806441 A CN98806441 A CN 98806441A CN 1195546 C CN1195546 C CN 1195546C
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insulin
tissue
cell
cells
islet
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Expired - Fee Related
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Chinese (zh)
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CN1261286A (zh
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N·S·凯尼昂
C·瑞科迪
D·W·索马斯
L·布克利
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University of Miami
Biogen MA Inc
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Biogen Inc
University of Miami
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • External Artificial Organs (AREA)
CNB988064413A 1997-06-20 1998-06-19 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途 Expired - Fee Related CN1195546C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5026797P 1997-06-20 1997-06-20
US60/050,267 1997-06-20
US7726598P 1998-03-09 1998-03-09
US60/077,265 1998-03-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005100079419A Division CN1651919A (zh) 1997-06-20 1998-06-19 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途

Publications (2)

Publication Number Publication Date
CN1261286A CN1261286A (zh) 2000-07-26
CN1195546C true CN1195546C (zh) 2005-04-06

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CNB988064413A Expired - Fee Related CN1195546C (zh) 1997-06-20 1998-06-19 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途
CNA2005100079419A Pending CN1651919A (zh) 1997-06-20 1998-06-19 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途

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CNA2005100079419A Pending CN1651919A (zh) 1997-06-20 1998-06-19 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途

Country Status (21)

Country Link
US (2) US20030072754A1 (enExample)
EP (1) EP1051191B1 (enExample)
JP (1) JP2002506446A (enExample)
KR (1) KR100634847B1 (enExample)
CN (2) CN1195546C (enExample)
AT (1) ATE339966T1 (enExample)
AU (1) AU730763B2 (enExample)
BG (1) BG64976B1 (enExample)
BR (1) BR9810620A (enExample)
CA (1) CA2294154A1 (enExample)
DE (1) DE69835965T2 (enExample)
EA (1) EA002550B1 (enExample)
EE (1) EE9900588A (enExample)
HU (1) HUP0003160A3 (enExample)
IL (1) IL133303A0 (enExample)
IS (1) IS5273A (enExample)
NO (1) NO996275L (enExample)
NZ (1) NZ502052A (enExample)
SK (1) SK180299A3 (enExample)
TR (1) TR199903142T2 (enExample)
WO (1) WO1998058669A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045958A1 (en) * 1998-03-09 1999-09-16 Biogen, Inc. Cd154 blockade therapy for modulation of immune responses to implanted devices
AU2001251612A1 (en) 2000-04-14 2001-10-30 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
AU2001275186A1 (en) * 2000-06-02 2001-12-17 Nicole Kirchhof Immunotherapeutic method to prevent islet cell rejection
IL152316A0 (en) * 2000-06-09 2003-05-29 Bristol Myers Squibb Co Pharmaceutical compositions and kits for treating transplant rejection
JP4667383B2 (ja) * 2003-06-13 2011-04-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド アグリコシル抗ｃｄ１５４（ｃｄ４０リガンド）抗体およびその使用
EA014226B1 (ru) 2004-07-26 2010-10-29 Байоджен Айдек Ма Инк. Антитела к cd154, их фрагменты и способы применения антител и фрагментов
JP2008520235A (ja) * 2004-11-22 2008-06-19 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US8636995B2 (en) 2006-08-31 2014-01-28 Cardiac Pacemakers, Inc. Methods and devices to regulate stem cell homing
US8372399B2 (en) 2006-08-31 2013-02-12 Cardiac Pacemakers, Inc. Bispecific antibodies and agents to enhance stem cell homing
US8911739B2 (en) 2009-02-10 2014-12-16 Trustees Of Columbia University In The City Of New York Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide
US9527912B2 (en) 2010-05-17 2016-12-27 The Board Of Trustees Of The Leland Stanford Junior University Prevention of immunological rejection of transplanted stem cells by leukocyte costimulatory molecule blockade
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10147463B2 (en) 2014-12-10 2018-12-04 Nxp Usa, Inc. Video processing unit and method of buffering a source video stream
US9512229B2 (en) * 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
US10986309B2 (en) 2015-06-30 2021-04-20 Nxp Usa, Inc. Video buffering and frame rate doubling device and method
BR112018076260A2 (pt) 2016-06-20 2019-03-26 Kymab Limited anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
JP4751493B2 (ja) * 1996-03-20 2011-08-17 ブリストル−マイヤーズ スクイッブ カンパニー Ｇｐ３９／ｃｄ４０およびｃｔｌａ４／ｃｄ２８／ｂ７経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物

Also Published As

Publication number Publication date
BR9810620A (pt) 2000-10-03
HK1033548A1 (en) 2001-09-07
EA200000058A1 (ru) 2000-08-28
BG104091A (en) 2000-10-31
EP1051191B1 (en) 2006-09-20
CN1261286A (zh) 2000-07-26
EP1051191A2 (en) 2000-11-15
IS5273A (is) 1999-11-26
WO1998058669A3 (en) 1999-04-29
CN1651919A (zh) 2005-08-10
TR199903142T2 (xx) 2000-09-21
EA002550B1 (ru) 2002-06-27
SK180299A3 (en) 2000-06-12
HUP0003160A3 (en) 2002-09-30
NO996275D0 (no) 1999-12-17
JP2002506446A (ja) 2002-02-26
WO1998058669A2 (en) 1998-12-30
US20030072754A1 (en) 2003-04-17
CA2294154A1 (en) 1998-12-30
ATE339966T1 (de) 2006-10-15
KR100634847B1 (ko) 2006-10-17
NO996275L (no) 2000-02-21
IL133303A0 (en) 2001-04-30
EE9900588A (et) 2000-08-15
KR20010013965A (ko) 2001-02-26
US20070292440A1 (en) 2007-12-20
AU7983098A (en) 1999-01-04
DE69835965D1 (de) 2006-11-02
NZ502052A (en) 2001-01-26
BG64976B1 (bg) 2006-11-30
AU730763B2 (en) 2001-03-15
HUP0003160A2 (hu) 2001-01-29
DE69835965T2 (de) 2007-06-14

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Owner name: BIOGEN IDEC MASSACHUSETTS, CO.,LTD.; MIAMI UNIVERS

Free format text: FORMER NAME OR ADDRESS: BIOGEN, INC.; MIAMI UNIVERSITY

Owner name: BIOGEN IDEC MASSACHUSETTS CORPORATION; MIAMI UNIVE

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Address after: Massachusetts USA

Co-patentee after: University OF MIAMI

Patentee after: Biogen Idec MA Inc.

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Patentee before: Biogen, Inc.

CP03 Change of name, title or address

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Patentee before: Biogen IDEC Ma Inc.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee