EA002550B1 - Лечение посредством блокады cd154 при трансплантации ткани панкреатических островков - Google Patents
Лечение посредством блокады cd154 при трансплантации ткани панкреатических островков Download PDFInfo
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- EA002550B1 EA002550B1 EA200000058A EA200000058A EA002550B1 EA 002550 B1 EA002550 B1 EA 002550B1 EA 200000058 A EA200000058 A EA 200000058A EA 200000058 A EA200000058 A EA 200000058A EA 002550 B1 EA002550 B1 EA 002550B1
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- insulin
- tissue
- binding
- recipient
- cells
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- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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Landscapes
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Applications Claiming Priority (3)
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| US5026797P | 1997-06-20 | 1997-06-20 | |
| US7726598P | 1998-03-09 | 1998-03-09 | |
| PCT/US1998/012892 WO1998058669A2 (en) | 1997-06-20 | 1998-06-19 | Cd154 blockade therapy for pancreatic islet tissue transplantation |
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| EA200000058A1 EA200000058A1 (ru) | 2000-08-28 |
| EA002550B1 true EA002550B1 (ru) | 2002-06-27 |
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| EA200000058A EA002550B1 (ru) | 1997-06-20 | 1998-06-19 | Лечение посредством блокады cd154 при трансплантации ткани панкреатических островков |
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| WO1999045958A1 (en) * | 1998-03-09 | 1999-09-16 | Biogen, Inc. | Cd154 blockade therapy for modulation of immune responses to implanted devices |
| AU2001251612A1 (en) | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Roles of jak/stat family members in tolerance induction |
| AU2001275186A1 (en) * | 2000-06-02 | 2001-12-17 | Nicole Kirchhof | Immunotherapeutic method to prevent islet cell rejection |
| IL152316A0 (en) * | 2000-06-09 | 2003-05-29 | Bristol Myers Squibb Co | Pharmaceutical compositions and kits for treating transplant rejection |
| JP4667383B2 (ja) * | 2003-06-13 | 2011-04-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | アグリコシル抗ｃｄ１５４（ｃｄ４０リガンド）抗体およびその使用 |
| EA014226B1 (ru) | 2004-07-26 | 2010-10-29 | Байоджен Айдек Ма Инк. | Антитела к cd154, их фрагменты и способы применения антител и фрагментов |
| JP2008520235A (ja) * | 2004-11-22 | 2008-06-19 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法 |
| WO2007047539A2 (en) * | 2005-10-14 | 2007-04-26 | Medtronic, Inc. | Localized delivery to the lymphatic system |
| US8636995B2 (en) | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| US8911739B2 (en) | 2009-02-10 | 2014-12-16 | Trustees Of Columbia University In The City Of New York | Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide |
| US9527912B2 (en) | 2010-05-17 | 2016-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Prevention of immunological rejection of transplanted stem cells by leukocyte costimulatory molecule blockade |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US10147463B2 (en) | 2014-12-10 | 2018-12-04 | Nxp Usa, Inc. | Video processing unit and method of buffering a source video stream |
| US9512229B2 (en) * | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| KR101810778B1 (ko) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
| US10986309B2 (en) | 2015-06-30 | 2021-04-20 | Nxp Usa, Inc. | Video buffering and frame rate doubling device and method |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227298A (en) * | 1990-08-17 | 1993-07-13 | The Trustees Of Columbia University In The City Of New York | Method for microencapuslation of cells or tissue |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| JP4751493B2 (ja) * | 1996-03-20 | 2011-08-17 | ブリストル−マイヤーズ スクイッブ カンパニー | Ｇｐ３９／ｃｄ４０およびｃｔｌａ４／ｃｄ２８／ｂ７経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物 |
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1998
- 1998-06-19 KR KR1019997011991A patent/KR100634847B1/ko not_active Expired - Fee Related
- 1998-06-19 WO PCT/US1998/012892 patent/WO1998058669A2/en not_active Ceased
- 1998-06-19 AU AU79830/98A patent/AU730763B2/en not_active Ceased
- 1998-06-19 NZ NZ502052A patent/NZ502052A/xx unknown
- 1998-06-19 DE DE69835965T patent/DE69835965T2/de not_active Expired - Fee Related
- 1998-06-19 JP JP50490799A patent/JP2002506446A/ja not_active Ceased
- 1998-06-19 CA CA002294154A patent/CA2294154A1/en not_active Abandoned
- 1998-06-19 SK SK1802-99A patent/SK180299A3/sk unknown
- 1998-06-19 HU HU0003160A patent/HUP0003160A3/hu unknown
- 1998-06-19 BR BR9810620-1A patent/BR9810620A/pt not_active Application Discontinuation
- 1998-06-19 EP EP98930436A patent/EP1051191B1/en not_active Expired - Lifetime
- 1998-06-19 TR TR1999/03142T patent/TR199903142T2/xx unknown
- 1998-06-19 AT AT98930436T patent/ATE339966T1/de not_active IP Right Cessation
- 1998-06-19 CN CNB988064413A patent/CN1195546C/zh not_active Expired - Fee Related
- 1998-06-19 IL IL13330398A patent/IL133303A0/xx unknown
- 1998-06-19 CN CNA2005100079419A patent/CN1651919A/zh active Pending
- 1998-06-19 EE EEP199900588A patent/EE9900588A/xx unknown
- 1998-06-19 EA EA200000058A patent/EA002550B1/ru not_active IP Right Cessation
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1999
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- 1999-12-17 NO NO996275A patent/NO996275L/no unknown
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2000
- 2000-01-18 BG BG104091A patent/BG64976B1/bg unknown
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2002
- 2002-10-11 US US10/270,783 patent/US20030072754A1/en not_active Abandoned
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2006
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Also Published As
| Publication number | Publication date |
|---|---|
| BR9810620A (pt) | 2000-10-03 |
| HK1033548A1 (en) | 2001-09-07 |
| EA200000058A1 (ru) | 2000-08-28 |
| BG104091A (en) | 2000-10-31 |
| EP1051191B1 (en) | 2006-09-20 |
| CN1261286A (zh) | 2000-07-26 |
| EP1051191A2 (en) | 2000-11-15 |
| IS5273A (is) | 1999-11-26 |
| WO1998058669A3 (en) | 1999-04-29 |
| CN1651919A (zh) | 2005-08-10 |
| TR199903142T2 (xx) | 2000-09-21 |
| SK180299A3 (en) | 2000-06-12 |
| HUP0003160A3 (en) | 2002-09-30 |
| NO996275D0 (no) | 1999-12-17 |
| JP2002506446A (ja) | 2002-02-26 |
| WO1998058669A2 (en) | 1998-12-30 |
| US20030072754A1 (en) | 2003-04-17 |
| CA2294154A1 (en) | 1998-12-30 |
| ATE339966T1 (de) | 2006-10-15 |
| KR100634847B1 (ko) | 2006-10-17 |
| NO996275L (no) | 2000-02-21 |
| CN1195546C (zh) | 2005-04-06 |
| IL133303A0 (en) | 2001-04-30 |
| EE9900588A (et) | 2000-08-15 |
| KR20010013965A (ko) | 2001-02-26 |
| US20070292440A1 (en) | 2007-12-20 |
| AU7983098A (en) | 1999-01-04 |
| DE69835965D1 (de) | 2006-11-02 |
| NZ502052A (en) | 2001-01-26 |
| BG64976B1 (bg) | 2006-11-30 |
| AU730763B2 (en) | 2001-03-15 |
| HUP0003160A2 (hu) | 2001-01-29 |
| DE69835965T2 (de) | 2007-06-14 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |