CN119330822A - 高纯度l-乳酸镁的结晶 - Google Patents
高纯度l-乳酸镁的结晶 Download PDFInfo
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- CN119330822A CN119330822A CN202411348765.4A CN202411348765A CN119330822A CN 119330822 A CN119330822 A CN 119330822A CN 202411348765 A CN202411348765 A CN 202411348765A CN 119330822 A CN119330822 A CN 119330822A
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- Prior art keywords
- lactate
- magnesium
- crystals
- fermentation
- clarified
- Prior art date
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Links
- OVGXLJDWSLQDRT-CEOVSRFSSA-L magnesium;(2s)-2-hydroxypropanoate Chemical compound [Mg+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O OVGXLJDWSLQDRT-CEOVSRFSSA-L 0.000 title claims abstract description 109
- 238000002425 crystallisation Methods 0.000 title description 43
- 230000008025 crystallization Effects 0.000 title description 42
- 239000013078 crystal Substances 0.000 claims abstract description 175
- 238000000034 method Methods 0.000 claims abstract description 94
- 239000010815 organic waste Substances 0.000 claims abstract description 45
- 230000008569 process Effects 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 33
- 238000000855 fermentation Methods 0.000 claims description 85
- 230000004151 fermentation Effects 0.000 claims description 85
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 80
- 239000000626 magnesium lactate Substances 0.000 claims description 47
- 229960004658 magnesium lactate Drugs 0.000 claims description 47
- 239000002245 particle Substances 0.000 claims description 46
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 42
- 239000006185 dispersion Substances 0.000 claims description 42
- 239000004310 lactic acid Substances 0.000 claims description 40
- 235000014655 lactic acid Nutrition 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims description 36
- 239000012535 impurity Substances 0.000 claims description 34
- 235000015229 magnesium lactate Nutrition 0.000 claims description 34
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 27
- 238000009826 distribution Methods 0.000 claims description 27
- 229940116871 l-lactate Drugs 0.000 claims description 25
- JVTAAEKCZFNVCJ-UWTATZPHSA-M (R)-lactate Chemical compound C[C@@H](O)C([O-])=O JVTAAEKCZFNVCJ-UWTATZPHSA-M 0.000 claims description 22
- 238000001704 evaporation Methods 0.000 claims description 16
- 230000008020 evaporation Effects 0.000 claims description 16
- 239000000725 suspension Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 239000002699 waste material Substances 0.000 claims description 12
- 150000001720 carbohydrates Chemical class 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000005119 centrifugation Methods 0.000 claims description 8
- 150000003895 L-lactate salts Chemical class 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- OVGXLJDWSLQDRT-JCWNAWFTSA-L magnesium;(2r)-2-hydroxypropanoate Chemical compound [Mg+2].C[C@@H](O)C([O-])=O.C[C@@H](O)C([O-])=O OVGXLJDWSLQDRT-JCWNAWFTSA-L 0.000 claims description 5
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 3
- 238000005345 coagulation Methods 0.000 claims description 3
- 230000015271 coagulation Effects 0.000 claims description 3
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- 238000005188 flotation Methods 0.000 claims description 3
- 239000000178 monomer Substances 0.000 claims description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
- 238000004062 sedimentation Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 12
- 229920000747 poly(lactic acid) Polymers 0.000 abstract description 12
- 239000004626 polylactic acid Substances 0.000 abstract description 10
- 235000010633 broth Nutrition 0.000 description 58
- 229940001447 lactate Drugs 0.000 description 43
- 239000006228 supernatant Substances 0.000 description 25
- 239000000047 product Substances 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 239000010794 food waste Substances 0.000 description 16
- 239000002609 medium Substances 0.000 description 16
- 239000002028 Biomass Substances 0.000 description 11
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- 238000000879 optical micrograph Methods 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 239000011521 glass Substances 0.000 description 9
- 239000012452 mother liquor Substances 0.000 description 9
- 229930182843 D-Lactic acid Natural products 0.000 description 8
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 8
- 229940022769 d- lactic acid Drugs 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 239000012978 lignocellulosic material Substances 0.000 description 7
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 150000003893 lactate salts Chemical class 0.000 description 6
- -1 magnesium alkali salts Chemical class 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 238000001953 recrystallisation Methods 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 5
- KSHMINBVGAHXNS-UHFFFAOYSA-L magnesium;2-hydroxypropanoate;dihydrate Chemical compound O.O.[Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O KSHMINBVGAHXNS-UHFFFAOYSA-L 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 238000007873 sieving Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 159000000003 magnesium salts Chemical class 0.000 description 4
- 239000000419 plant extract Substances 0.000 description 4
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- 102000004169 proteins and genes Human genes 0.000 description 4
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- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- 238000001471 micro-filtration Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000001728 nano-filtration Methods 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229920002488 Hemicellulose Polymers 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical group [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002154 agricultural waste Substances 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
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- 229920005610 lignin Polymers 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- 239000000347 magnesium hydroxide Substances 0.000 description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229940091250 magnesium supplement Drugs 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 235000013348 organic food Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 239000010908 plant waste Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 241000609240 Ambelania acida Species 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 150000003894 D-lactate salts Chemical class 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000002902 bimodal effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
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- 150000002215 flavonoids Chemical class 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- 238000003307 slaughter Methods 0.000 description 1
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- 235000017281 sodium acetate Nutrition 0.000 description 1
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- 239000001648 tannin Substances 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 239000001393 triammonium citrate Substances 0.000 description 1
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- 238000000108 ultra-filtration Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/08—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Applications Claiming Priority (6)
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| US202163139894P | 2021-01-21 | 2021-01-21 | |
| US63/139,894 | 2021-01-21 | ||
| US202163280150P | 2021-11-17 | 2021-11-17 | |
| US63/280,150 | 2021-11-17 | ||
| PCT/IL2022/050081 WO2022157768A1 (en) | 2021-01-21 | 2022-01-19 | Crystallization of high-purity magnesium l-lactate |
| CN202280009092.2A CN116829529B (zh) | 2021-01-21 | 2022-01-19 | 高纯度l-乳酸镁的结晶 |
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| CN202280009092.2A Division CN116829529B (zh) | 2021-01-21 | 2022-01-19 | 高纯度l-乳酸镁的结晶 |
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| CN119330822A true CN119330822A (zh) | 2025-01-21 |
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| CN119562940A (zh) * | 2022-07-27 | 2025-03-04 | 三W有限公司 | L-乳酸或其盐的对映体富集 |
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| CN101018756B (zh) | 2004-06-17 | 2011-06-08 | 普拉克生化公司 | 由含乳酸镁的介质制备乳酸或乳酸盐的方法 |
| KR20110105845A (ko) * | 2008-12-26 | 2011-09-27 | 도레이 카부시키가이샤 | 락트산 및 폴리락트산의 제조 방법 |
| EP2399658A1 (en) * | 2010-06-24 | 2011-12-28 | Biosyn Arzneimittel GmbH | Method for producing pharmacologically pure crystals |
| BR112013014646A2 (pt) | 2010-12-13 | 2016-08-02 | Toray Industries | método para produção de um sal de ácido lático |
| EP2604696A1 (en) | 2011-12-16 | 2013-06-19 | PURAC Biochem BV | Process for the fermentative production of lactic acid from a plant extract in the presence of a caustic magnesium salt |
| FR2994569B1 (fr) * | 2012-08-17 | 2016-11-04 | Roquette Freres | Procede de fabrication de compositions riches en cristaux de mannitol sous forme delta, compositions et cristaux obtenus ainsi que leurs utilisations |
| WO2016016233A1 (en) | 2014-07-28 | 2016-02-04 | Purac Biochem Bv | Method for the preparation of lactic acid |
| CN104789607B (zh) | 2015-04-21 | 2018-01-12 | 北京化工大学 | 一种发酵‑分离耦合制备乳酸和/或乳酸盐的方法 |
| CN105018538B (zh) | 2015-07-07 | 2018-10-23 | 北京化工大学 | 一种基于结晶法发酵分离耦合生产乳酸镁的方法 |
| US10920250B2 (en) | 2016-04-12 | 2021-02-16 | Purac Biochem Bv | Magnesium lactate fermentation process |
| KR102218931B1 (ko) | 2016-05-30 | 2021-02-24 | 푸락 바이오켐 비.브이. | 고체 발효 생성물로부터 바이오매스를 분리하는 방법 |
| CN106083565A (zh) * | 2016-06-06 | 2016-11-09 | 宁乡新阳化工有限公司 | 乳酸镁的生产方法 |
| WO2019068642A1 (en) | 2017-10-02 | 2019-04-11 | Metabolic Explorer | PROCESS FOR PRODUCING ORGANIC ACID SALTS FROM A FERMENTATION BROTH |
| CN113166786B (zh) | 2018-11-26 | 2025-01-24 | 三W有限公司 | 从具有高含量杂质的发酵液中纯化乳酸镁 |
| EP4090443A1 (en) | 2020-01-15 | 2022-11-23 | Purac Biochem B.V. | Method for purifying magnesium chloride solutions |
| MX2022010137A (es) | 2020-02-19 | 2022-11-10 | Triplew Ltd | Metodos y sistemas para la produccion de acido lactico y el reciclaje del acido polilactico. |
| AU2022322001A1 (en) | 2021-08-03 | 2024-02-29 | TripleW Ltd. | Process for producing recycled lactate salt |
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| EP4281432A1 (en) | 2023-11-29 |
| KR20230135613A (ko) | 2023-09-25 |
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| EP4281432A4 (en) | 2024-12-25 |
| US20240300880A1 (en) | 2024-09-12 |
| KR20260003312A (ko) | 2026-01-06 |
| FI4281432T3 (fi) | 2026-04-16 |
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| CA3207836A1 (en) | 2022-07-28 |
| EP4281432B1 (en) | 2026-03-11 |
| AU2022211203A9 (en) | 2024-07-18 |
| DK4281432T3 (da) | 2026-04-20 |
| JP7720646B2 (ja) | 2025-08-08 |
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